Strain Name:
C57BL/6J-MtgxR3924Btlr/Mmmh
Stock Number:
040915-MU
Citation ID:
RRID:MMRRC_040915-MU
Other Names:
R3924 (G1), C57BL/6J-MtgxR3924Btlr
Major Collection:

Gene Information

Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Usp28
Name: ubiquitin specific peptidase 28
Synonyms: 9830148O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235323
VEGA: 9
Homologene: 10840
Luzp1
Name: leucine zipper protein 1
Synonyms: 2700072H04Rik, Luzp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 269593
Homologene: 11545
Thrap3
Name: thyroid hormone receptor associated protein 3
Synonyms: 9330151F09Rik, B230333E16Rik, Trap150
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230753
Homologene: 31289
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: Ayu21-9, Gt(Ayu21)9Imeg, AMH-Cre, PEPP2, 2810431N21Rik, Tg(AMH-cre)1Flor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 109135
Homologene: 10377
Csad
Name: cysteine sulfinic acid decarboxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 246277
VEGA: 15
Homologene: 41086
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: RPA194, 194kDa, Rpo1-4, 2900087K15Rik, 3010014K16Rik, mRPA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20019
Homologene: 7033
Rsbn1l
Name: round spermatid basic protein 1-like
Synonyms: C330002G24Rik, 8430412F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 242860
Homologene: 19435
Flii
Name: flightless I actin binding protein
Synonyms: Fliih, 3632430F08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Dlat
Name: dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
Synonyms: 6332404G05Rik, PDC-E2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235339
HGNC: HGNC:2896
Homologene: 6814
Nptx1
Name: neuronal pentraxin 1
Synonyms: Np1, D11Bwg1004e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18164
HGNC: HGNC:7952
Homologene: 1891
Gpr155
Name: G protein-coupled receptor 155
Synonyms: F730029F15Rik, DEPDC3, PGR22, 1110017O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68526
Homologene: 16584
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: 5730402G09Rik, 2310001G17Rik, Ccp1, 4930445M19Rik, 2900054O13Rik, Nna1, 1700020N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 67269
Homologene: 9067
Dach1
Name: dachshund family transcription factor 1
Synonyms: E130112M23Rik, Dac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTPL1, PTP-BL, Ptpri
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: Myhs-p, 4832426G23Rik, Myhsp, MyHC-pn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Fa2h
Name: fatty acid 2-hydroxylase
Synonyms: G630055L08Rik, Faxdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 338521
Homologene: 56284
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20192
Homologene: 68151
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: 1110004P15Rik, 2310047C17Rik, DY6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Shkbp1
Name: Sh3kbp1 binding protein 1
Synonyms: SB1, B930062H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 192192
Homologene: 26700
Fmo9
Name: flavin containing monooxygenase 9
Synonyms: 4831428F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240894
Homologene: 134192
Lmbrd2
Name: LMBR1 domain containing 2
Synonyms: 9930036E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 320506
VEGA: 15
Homologene: 44696
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: 4732433M03Rik, CPS, D1Ucla3, CPSase I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Slc35g2
Name: solute carrier family 35, member G2
Synonyms: LOC245020, Tmem22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 245020
Homologene: 11893
Lpcat4
Name: lysophosphatidylcholine acyltransferase 4
Synonyms: Aytl3, Agpat7, LPEAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 99010
Homologene: 27544
Onecut2
Name: one cut domain, family member 2
Synonyms: Oc2, OC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225631
HGNC: HGNC:8139
Homologene: 113592
Cdkl1
Name: cyclin-dependent kinase-like 1 (CDC2-related kinase)
Synonyms: 4933411O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 71091
VEGA: 12
HGNC: HGNC:1781
Homologene: 55805
Olfr1501
Name: olfactory receptor 1501
Synonyms: MOR212-3, GA_x6K02T2RE5P-4171358-4170411
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258626
Homologene: 64899
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4930428C11Rik, Wdr96, D19Ertd652e, 4930463G05Rik, 4632415N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 100048534
Homologene: 36425
Lilrb4a
Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4A
Synonyms: HM18, Gp49b, ILT3, CD85K, Lilrb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14728
VEGA: 10
HGNC: HGNC:6608
Homologene: 86756
Sipa1
Name: signal-induced proliferation associated gene 1
Synonyms: SPA-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20469
VEGA: 19
Homologene: 7940
4930550C14Rik
Name: RIKEN cDNA 4930550C14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 75311
VEGA: 9
Homologene: 12595
Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
Synonyms: Itih-3, Intin3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16426
HGNC: HGNC:6168
Homologene: 1669
Zfp946
Name: zinc finger protein 946
Synonyms: 1300003B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 74149
Mcm8
Name: minichromosome maintenance 8 homologous recombination repair factor
Synonyms: 5730432L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66634
Homologene: 12001
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: Fam5b, 6430517E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 240843
Homologene: 10905
Amn
Name: amnionless
Synonyms: 5033428N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 93835
VEGA: 12
Homologene: 12804
Qrfpr
Name: pyroglutamylated RFamide peptide receptor
Synonyms: Gpr103, AQ27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229214
Homologene: 18865
Aldh3b3
Name: aldehyde dehydrogenase 3 family, member B3
Synonyms: 1700055N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 73458
HGNC: HGNC:411
Homologene: 133295
Dtd2
Name: D-tyrosyl-tRNA deacylase 2
Synonyms: 4930578F06Rik, 6530401N04Rik, B830049N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 328092
Homologene: 12634
CT573034.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
Gabra4
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
Synonyms: Gabra-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 14397
HGNC: HGNC:4078
Homologene: 631
Arpin
Name: actin-related protein 2/3 complex inhibitor
Synonyms: 2610034B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 70420
Homologene: 128480
Dpf1
Name: D4, zinc and double PHD fingers family 1
Synonyms: Neud4, neuro-d4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 29861
Homologene: 3415
Asl
Name: argininosuccinate lyase
Synonyms: 2510006M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 109900
HGNC: HGNC:746
Homologene: 32
Rasd2
Name: RASD family, member 2
Synonyms: TEM-2, TEM2, 4930526B11Rik, Rhes
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 75141
Homologene: 8628
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 67,172,879 bp
  • A to G, chromosome 1 at 158,246,208 bp
  • A to G, chromosome 1 at 166,664,652 bp
  • T to A, chromosome 2 at 73,370,076 bp
  • G to T, chromosome 2 at 112,246,716 bp
  • A to G, chromosome 2 at 113,028,703 bp
  • T to A, chromosome 2 at 132,817,691 bp
  • T to C, chromosome 3 at 36,221,923 bp
  • G to T, chromosome 3 at 98,122,034 bp
  • A to T, chromosome 4 at 126,166,921 bp
  • T to C, chromosome 4 at 136,542,857 bp
  • A to G, chromosome 5 at 20,919,787 bp
  • A to G, chromosome 5 at 71,642,253 bp
  • T to C, chromosome 5 at 103,550,741 bp
  • A to G, chromosome 5 at 130,019,869 bp
  • A to G, chromosome 6 at 71,929,450 bp
  • A to G, chromosome 6 at 140,570,379 bp
  • A to G, chromosome 7 at 27,342,402 bp
  • A to G, chromosome 7 at 29,311,673 bp
  • A to G, chromosome 7 at 79,929,687 bp
  • A to G, chromosome 8 at 75,221,974 bp
  • A to G, chromosome 8 at 111,393,515 bp
  • T to C, chromosome 9 at 49,030,923 bp
  • A to G, chromosome 9 at 50,658,190 bp
  • G to T, chromosome 9 at 53,432,405 bp
  • A to T, chromosome 9 at 100,552,727 bp
  • G to A, chromosome 10 at 51,491,057 bp
  • A to G, chromosome 11 at 60,720,076 bp
  • A to T, chromosome 11 at 67,297,137 bp
  • G to T, chromosome 11 at 119,547,507 bp
  • G to C, chromosome 12 at 52,004,951 bp
  • G to T, chromosome 12 at 69,756,599 bp
  • T to C, chromosome 12 at 111,275,680 bp
  • A to T, chromosome 13 at 59,500,407 bp
  • A to G, chromosome 13 at 62,370,230 bp
  • A to G, chromosome 14 at 30,923,451 bp
  • A to G, chromosome 14 at 97,915,903 bp
  • T to C, chromosome 15 at 9,149,537 bp
  • T to C, chromosome 15 at 102,178,556 bp
  • G to T, chromosome 17 at 22,455,701 bp
  • A to G, chromosome 18 at 64,341,520 bp
  • A to G, chromosome 19 at 3,968,491 bp
  • G to A, chromosome 19 at 5,660,379 bp
  • G to A, chromosome 19 at 9,006,328 bp
  • T to C, chromosome 19 at 13,838,766 bp
  • T to C, chromosome 19 at 47,797,116 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3924 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040915-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.