Strain Name:
C57BL/6J-MtgxR3944Btlr/Mmmh
Stock Number:
040925-MU
Citation ID:
RRID:MMRRC_040925-MU
Other Names:
R3944 (G1), C57BL/6J-MtgxR3944Btlr
Major Collection:

Gene Information

Slc6a12
Name: solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
Synonyms: BGT1, Gabt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14411
Homologene: 128225
Tmem59l
Name: transmembrane protein 59-like
Synonyms: 5330410G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67937
Homologene: 8104
Prdm2
Name: PR domain containing 2, with ZNF domain
Synonyms: E330024L24Rik, KMT8, 4833427P12Rik, Riz, LOC381568, Riz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 110593
HGNC: HGNC:9347
Homologene: 40822
Tab1
Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
Synonyms: Map3k7ip1, Tak1-binding protein 1, b2b449Clo, 2310012M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66513
VEGA: 15
Homologene: 4461
Eefsec
Name: eukaryotic elongation factor, selenocysteine-tRNA-specific
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 65967
Homologene: 11073
Rp9
Name: retinitis pigmentosa 9 (human)
Synonyms: PAP-1, Rp9h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 55934
VEGA: 9
Homologene: 10290
Akap12
Name: A kinase (PRKA) anchor protein (gravin) 12
Synonyms: Srcs5, SSeCKS, Tsga12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 83397
VEGA: 10
HGNC: HGNC:370
Homologene: 3740
Gpat4
Name: glycerol-3-phosphate acyltransferase 4
Synonyms: Agpat6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102247
Homologene: 32425
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: Tweek, FSA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 21453
Homologene: 68049
Smg6
Name: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103677
Homologene: 23024
Vps8
Name: VPS8 CORVET complex subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 209018
Homologene: 44592
Pan3
Name: PAN3 poly(A) specific ribonuclease subunit
Synonyms: 2700050F09Rik, A430027N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72587
Homologene: 6372
Lyl1
Name: lymphoblastomic leukemia 1
Synonyms: bHLHa18, Lyl-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17095
VEGA: 8
HGNC: HGNC:6734
Homologene: 4078
2700049A03Rik
Name: RIKEN cDNA 2700049A03 gene
Synonyms: Ta3, talpid3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76967
Homologene: 8839
Tbl3
Name: transducin (beta)-like 3
Synonyms: 9430070M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213773
Homologene: 4711
Marchf6
Name: membrane associated ring-CH-type finger 6
Synonyms: F830029L24Rik, March6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223455
VEGA: 15
Homologene: 4301
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Khdc1b
Name: KH domain containing 1B
Synonyms: Khdc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98582
Homologene: 134524
H2-T23
Name: histocompatibility 2, T region locus 23
Synonyms: H-2T23, Qa-1, Qa1, T18c(37), T18c, 37c, 37b, T23d, T23b, Qed-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15040
HGNC: HGNC:4962
Homologene: 134018
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: Polydom, 4833413O10Rik, D430029O09Rik, 1110021D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64817
Homologene: 23386
2610507B11Rik
Name: RIKEN cDNA 2610507B11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72503
Homologene: 34730
Dscam
Name: DS cell adhesion molecule
Synonyms: Down syndrome cell adhesion molecule, 4932410A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Synonyms: aromatic compound inducible, CP12, P450-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13077
VEGA: 9
HGNC: HGNC:2596
Homologene: 68082
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Vmn1r204
Name: vomeronasal 1 receptor 204
Synonyms: Gm11301
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 632793
Homologene: 110880
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Birc1f, Naip-rs4A, Naip-rs4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Krt4
Name: keratin 4
Synonyms: Krt2-4, K4, Krt-2.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16682
VEGA: 15
HGNC: HGNC:6441
Homologene: 20523
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: NG2, Cspg4a, AN2, 4732461B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Cntn4
Name: contactin 4
Synonyms: BIG-2A, Axcam
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 269784
HGNC: HGNC:2174
Homologene: 14257
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 671232
VEGA: 9
Homologene: 19835
Olfr686
Name: olfactory receptor 686
Synonyms: GA_x6K02T2PBJ9-7832633-7831680, MOR35-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259072
Homologene: 17487
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
Elmo3
Name: engulfment and cell motility 3
Synonyms: CED-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234683
Homologene: 23475
Mmp1b
Name: matrix metallopeptidase 1b (interstitial collagenase)
Synonyms: Mcol-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83996
HGNC: HGNC:7155
Homologene: 130791
Olfr1090
Name: olfactory receptor 1090
Synonyms: GA_x6K02T2Q125-48247345-48246404, MOR188-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258844
Homologene: 17413
Dao
Name: D-amino acid oxidase
Synonyms: Dao-1, Dao1, DAO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13142
HGNC: HGNC:2671
Homologene: 37553
6430548M08Rik
Name: RIKEN cDNA 6430548M08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234797
Homologene: 8825
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628422
Zfp932
Name: zinc finger protein 932
Synonyms: 2310001H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69504
Homologene: 137770
Kif19a
Name: kinesin family member 19A
Synonyms: N-8 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 286942
Homologene: 17709
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240776
Homologene: 16121
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: cytoplasmic linker protein 50, Rsn, Clip 170, Clip50, CLIP-170, restin, 4631429H07Rik, 1110007I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56430
Homologene: 74455
Vill
Name: villin-like
Synonyms: Villp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22351
Homologene: 22650
Vmn2r14
Name: vomeronasal 2, receptor 14
Synonyms: EG231591
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231591
Homologene: 129606
Calu
Name: calumenin
Synonyms: 9530075H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12321
HGNC: HGNC:1458
Homologene: 936
Pabpc1l
Name: poly(A) binding protein, cytoplasmic 1-like
Synonyms: ePAB, 1810053B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381404
Homologene: 77989
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224576
Homologene: 135824
Cdh10
Name: cadherin 10
Synonyms: T2-cadherin, A830016G23Rik, C030003B10Rik, C030011H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320873
HGNC: HGNC:1749
Homologene: 68530
Spout1
Name: SPOUT domain containing methyltransferase 1
Synonyms: D2Wsu81e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227695
Homologene: 6704
Ribc2
Name: RIB43A domain with coiled-coils 2
Synonyms: Trib, 4930579A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67747
VEGA: 15
Homologene: 9230
Gnl1
Name: guanine nucleotide binding protein-like 1
Synonyms: Gna-rs1, Gnal1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14670
HGNC: HGNC:4413
Homologene: 3862
Ifnlr1
Name: interferon lambda receptor 1
Synonyms: CRF2-12, Il28ra, IFNLR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242700
Homologene: 52086
Gcm1
Name: glial cells missing homolog 1
Synonyms: glial cell deficient, Gcm a, GCMa, Gcm1-rs1, Gcm 1, glide
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 14531
VEGA: 9
HGNC: HGNC:4197
Homologene: 2702
Mpi
Name: mannose phosphate isomerase
Synonyms: Mpi1, 1110002E17Rik, Mpi-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110119
HGNC: HGNC:7216
Homologene: 1825
Akr1c12
Name: aldo-keto reductase family 1, member C12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 622402
Homologene: 121208
Rassf6
Name: Ras association (RalGDS/AF-6) domain family member 6
Synonyms: 1600016B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 73246
Homologene: 37125
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 21,384,806 bp
  • A to G, chromosome 1 at 46,137,485 bp
  • T to C, chromosome 1 at 140,584,287 bp
  • A to G, chromosome 2 at 30,174,136 bp
  • A to G, chromosome 2 at 86,754,181 bp
  • A to G, chromosome 2 at 164,042,327 bp
  • A to G, chromosome 3 at 37,030,061 bp
  • T to A, chromosome 4 at 58,084,807 bp
  • T to A, chromosome 4 at 113,942,753 bp
  • T to A, chromosome 4 at 135,701,228 bp
  • C to T, chromosome 4 at 143,131,815 bp
  • G to T, chromosome 5 at 90,604,326 bp
  • A to T, chromosome 5 at 109,216,064 bp
  • T to A, chromosome 5 at 110,009,954 bp
  • T to C, chromosome 5 at 114,017,642 bp
  • C to A, chromosome 5 at 121,303,525 bp
  • T to C, chromosome 5 at 123,617,829 bp
  • A to T, chromosome 5 at 147,450,730 bp
  • T to C, chromosome 6 at 29,361,711 bp
  • T to A, chromosome 6 at 88,298,094 bp
  • T to G, chromosome 6 at 106,618,414 bp
  • A to T, chromosome 6 at 121,354,280 bp
  • A to T, chromosome 7 at 41,864,461 bp
  • A to T, chromosome 7 at 105,203,955 bp
  • G to A, chromosome 8 at 23,180,155 bp
  • A to G, chromosome 8 at 70,487,301 bp
  • A to C, chromosome 8 at 84,704,002 bp
  • T to C, chromosome 8 at 105,309,220 bp
  • T to C, chromosome 8 at 120,152,502 bp
  • G to A, chromosome 9 at 7,384,708 bp
  • A to C, chromosome 9 at 22,449,858 bp
  • T to A, chromosome 9 at 56,886,123 bp
  • T to C, chromosome 9 at 57,545,253 bp
  • T to C, chromosome 9 at 57,681,868 bp
  • C to T, chromosome 9 at 78,059,816 bp
  • T to C, chromosome 9 at 119,068,431 bp
  • T to C, chromosome 9 at 122,750,604 bp
  • A to G, chromosome 10 at 4,357,347 bp
  • A to T, chromosome 11 at 59,132,547 bp
  • G to A, chromosome 11 at 74,929,541 bp
  • T to A, chromosome 11 at 78,269,524 bp
  • A to T, chromosome 11 at 114,786,735 bp
  • G to T, chromosome 12 at 71,164,546 bp
  • A to T, chromosome 12 at 71,164,547 bp
  • T to A, chromosome 13 at 4,279,340 bp
  • G to A, chromosome 13 at 22,556,844 bp
  • T to C, chromosome 13 at 100,294,739 bp
  • A to G, chromosome 15 at 18,964,249 bp
  • A to G, chromosome 15 at 31,488,814 bp
  • T to C, chromosome 15 at 80,153,740 bp
  • A to G, chromosome 15 at 85,135,250 bp
  • G to A, chromosome 15 at 101,921,250 bp
  • A to T, chromosome 16 at 21,470,123 bp
  • A to T, chromosome 16 at 96,820,997 bp
  • A to T, chromosome 17 at 20,267,651 bp
  • A to G, chromosome 17 at 24,700,708 bp
  • G to T, chromosome 17 at 35,988,521 bp
  • A to G, chromosome 17 at 36,030,643 bp
  • C to A, chromosome 18 at 60,822,837 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3944 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040925-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.