Strain Name:
C57BL/6J-MtgxR3977Btlr/Mmmh
Stock Number:
040940-MU
Citation ID:
RRID:MMRRC_040940-MU
Other Names:
R3977 (G1), C57BL/6J-MtgxR3977Btlr
Major Collection:

Strain Information

Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: my, b2b1562Clo, 6030440P17Rik, ne, 8430406N05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Rc3h1
Name: RING CCCH (C3H) domains 1
Synonyms: roquin, 5730557L09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381305
Homologene: 19036
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108096
Homologene: 56603
Bicral
Name: BRD4 interacting chromatin remodeling complex associated protein like
Synonyms: Gltscr1l, BC032203
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210982
VEGA: 17
Homologene: 19366
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210711
Homologene: 11749
Brpf3
Name: bromodomain and PHD finger containing, 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268936
Homologene: 16092
Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms: D730028O18Rik, D130059B05Rik, BIG1, ARFGEP1, P200
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211673
Homologene: 4687
Cln3
Name: CLN3 lysosomal/endosomal transmembrane protein, battenin
Synonyms: battenin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12752
HGNC: HGNC:2074
Homologene: 37259
Prmt2
Name: protein arginine N-methyltransferase 2
Synonyms: Hrmt1l1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15468
HGNC: HGNC:5186
Homologene: 55587
Hr
Name: lysine demethylase and nuclear receptor corepressor
Synonyms: rh-bmh, bldy, N, rh, ba
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15460
HGNC: HGNC:5172
Homologene: 3774
Entr1
Name: endosome associated trafficking regulator 1
Synonyms: C330016H24Rik, Sdccag3, C630038K21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68112
Homologene: 74578
Hk1
Name: hexokinase 1
Synonyms: Hk-1, Hk1-s, mHk1-s
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15275
HGNC: HGNC:4922
Homologene: 100530
Raph1
Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Synonyms: lamellipodin, Lpd, C730009O10Rik, 9430025M21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77300
Homologene: 71030
Ppp1r12b
Name: protein phosphatase 1, regulatory subunit 12B
Synonyms: 9530009M10Rik, 1810037O03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329251
HGNC: HGNC:7619
Homologene: 135710
Sycp2l
Name: synaptonemal complex protein 2-like
Synonyms: EG621792, Gm40956, LOC218175
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 637277
Homologene: 52882
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Tnr
Name: tenascin R
Synonyms: J1-tenascin, janusin, restrictin, TN-R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21960
Homologene: 124416
Ogfod2
Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 2
Synonyms: 1300006G11Rik, 5730405M13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66627
Homologene: 32588
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Ccdc96
Name: coiled-coil domain containing 96
Synonyms: 4921513E08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66717
Homologene: 32639
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: MDC-L, D430033C21Rik, C130072N01Rik, Dtgn1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Krt2
Name: keratin 2
Synonyms: Krt2-17, Krt2-2, Krt2e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16681
HGNC: HGNC:6439
Trp53rkb
Name: transformation related protein 53 regulating kinase B
Synonyms: mNori-2p, 4933401B08Rik, Trp53rk, PRPK, 5630401H01Rik, Nori-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76367
Homologene: 6042
Man1c1
Name: mannosidase, alpha, class 1C, member 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230815
Homologene: 69303
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 628185
Homologene: 86604
Or10q3
Name: olfactory receptor family 10 subfamily Q member 3
Synonyms: GA_x6K02T2RE5P-2222521-2221490, Olfr1419, MOR266-10
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 257938
Homologene: 79473
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433070
Gbp2b
Name: guanylate binding protein 2b
Synonyms: Mag-1, LIMIT, Mpa-1, Gbp-1, Gbp1, Mpa1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14468
Homologene: 137233
Or11a4
Name: olfactory receptor family 11 subfamily A member 4
Synonyms: Olfr96, MOR121-1, GA_x6K02T2PSCP-1665046-1665987
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258507
HGNC: HGNC:8176
Homologene: 27189
Zfp974
Name: zinc finger protein 974
Synonyms: 1700049G17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73430
Tas2r103
Name: taste receptor, type 2, member 103
Synonyms: EG667992, mGR03, mt2r63, T2R3, TRB2, Tas2r3, Tas2r10
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 667992
Homologene: 130076
Tfap2d
Name: transcription factor AP-2, delta
Synonyms: Tcfap2d
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226896
Homologene: 17700
Ace
Name: angiotensin I converting enzyme
Synonyms: CD143
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11421
HGNC: HGNC:2707
Homologene: 37351
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: 70zpep, Ptpn8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Fmo3
Name: flavin containing monooxygenase 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14262
HGNC: HGNC:3771
Homologene: 128199
Or2w1b
Name: olfactory receptor family 2 subfamily W member 1B
Synonyms: GA_x6K02T2QHY8-12126170-12125935, MOR256-31, Olfr1369
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 404504
HGNC: HGNC:8281
AC154303.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Nras
Name: neuroblastoma ras oncogene
Synonyms: N-ras
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18176
HGNC: HGNC:7989
Homologene: 55661
Cdk3
Name: cyclin dependent kinase 3
Synonyms: Cdk3-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69681
HGNC: HGNC:1772
Smpd1
Name: sphingomyelin phosphodiesterase 1, acid lysosomal
Synonyms: ASM, A-SMase, Zn-SMase, aSMase, acid sphingomyelinase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20597
Homologene: 457
Oasl1
Name: 2'-5' oligoadenylate synthetase-like 1
Synonyms: 7530414C13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231655
HGNC: HGNC:8090
Homologene: 2769
Or10v1
Name: olfactory receptor family 10 subfamily V member 1
Synonyms: Olfr1420, GA_x6K02T2RE5P-2247227-2248156, MOR266-4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258405
Homologene: 17234
Trbv13-3
Name: T cell receptor beta, variable 13-3
Synonyms: Tcrb-V8.1, Gm16777
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100124677
Hoxc13
Name: homeobox C13
Synonyms: N
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15422
HGNC: HGNC:5125
Homologene: 7770
Il19
Name: interleukin 19
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329244
HGNC: HGNC:5990
Homologene: 17813
Or4c3
Name: olfactory receptor family 4 subfamily C member 3
Synonyms: MOR236-1, GA_x6K02T2Q125-51454183-51453257, Olfr1264
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258206
Homologene: 66365
Slc23a4
Name: solute carrier family 23 member 4
Synonyms: LOC243753, 2010107G12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243753
Homologene: 134124
Or6c5
Name: olfactory receptor family 6 subfamily C member 5
Synonyms: MOR111-2, GA_x6K02T2PULF-10924432-10925370, Olfr774, MOR111-11
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258232
Homologene: 105326
Pkmyt1
Name: protein kinase, membrane associated tyrosine/threonine 1
Synonyms: Myt1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268930
VEGA: 17
Homologene: 31227
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 10,209,634 bp
  • C to G, chromosome 1 at 19,104,494 bp
  • A to T, chromosome 1 at 60,498,523 bp
  • A to T, chromosome 1 at 130,936,033 bp
  • A to G, chromosome 1 at 134,765,975 bp
  • A to G, chromosome 1 at 159,892,023 bp
  • A to G, chromosome 1 at 160,959,399 bp
  • T to G, chromosome 1 at 162,958,578 bp
  • T to A, chromosome 2 at 26,384,793 bp
  • C to A, chromosome 2 at 90,021,745 bp
  • C to T, chromosome 2 at 166,795,526 bp
  • A to G, chromosome 3 at 53,652,070 bp
  • A to G, chromosome 3 at 103,060,225 bp
  • A to G, chromosome 3 at 103,873,641 bp
  • A to T, chromosome 3 at 104,457,844 bp
  • A to G, chromosome 3 at 142,603,709 bp
  • G to C, chromosome 4 at 134,703,438 bp
  • T to C, chromosome 5 at 36,485,166 bp
  • C to T, chromosome 5 at 114,932,898 bp
  • C to A, chromosome 5 at 124,113,209 bp
  • C to T, chromosome 6 at 34,953,788 bp
  • A to G, chromosome 6 at 41,130,145 bp
  • A to G, chromosome 6 at 133,036,317 bp
  • A to G, chromosome 6 at 142,258,972 bp
  • T to C, chromosome 7 at 27,920,687 bp
  • T to C, chromosome 7 at 85,958,137 bp
  • T to C, chromosome 7 at 105,555,901 bp
  • G to A, chromosome 7 at 126,580,136 bp
  • A to G, chromosome 7 at 128,698,583 bp
  • C to A, chromosome 10 at 51,621,101 bp
  • A to G, chromosome 10 at 62,290,319 bp
  • A to T, chromosome 10 at 76,217,651 bp
  • A to G, chromosome 10 at 106,830,629 bp
  • C to T, chromosome 10 at 129,238,508 bp
  • T to C, chromosome 11 at 103,457,604 bp
  • C to T, chromosome 11 at 105,981,838 bp
  • G to A, chromosome 11 at 116,216,945 bp
  • T to A, chromosome 13 at 21,115,861 bp
  • A to G, chromosome 13 at 41,141,964 bp
  • G to T, chromosome 14 at 57,017,188 bp
  • A to G, chromosome 14 at 68,610,994 bp
  • A to G, chromosome 14 at 70,563,584 bp
  • T to C, chromosome 15 at 101,811,127 bp
  • T to C, chromosome 15 at 102,921,240 bp
  • T to A, chromosome 17 at 18,597,679 bp
  • T to A, chromosome 17 at 22,603,115 bp
  • A to G, chromosome 17 at 23,735,331 bp
  • A to G, chromosome 17 at 28,807,042 bp
  • T to C, chromosome 17 at 37,225,158 bp
  • T to A, chromosome 17 at 46,830,991 bp
  • C to A, chromosome 19 at 11,870,505 bp
  • T to A, chromosome 19 at 11,896,516 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3977 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040940-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.