Strain Name:
C57BL/6J-MtgxR3979Btlr/Mmmh
Stock Number:
040942-MU
Citation ID:
RRID:MMRRC_040942-MU
Other Names:
R3979 (G1), C57BL/6J-MtgxR3979Btlr
Major Collection:

Gene Information

Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: PSGAP-s, PSGAP-m, A930033B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78514
Homologene: 12695
Ptprz1
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Sparcl1
Name: SPARC-like 1
Synonyms: Sc1, hevin, mast9, Ecm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13602
Homologene: 3438
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242022
Homologene: 18454
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Bicral
Name: BRD4 interacting chromatin remodeling complex associated protein like
Synonyms: BC032203, Gltscr1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 210982
VEGA: 17
Homologene: 19366
Katna1
Name: katanin p60 (ATPase-containing) subunit A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 23924
HGNC: HGNC:6216
Homologene: 56014
Rock2
Name: Rho-associated coiled-coil containing protein kinase 2
Synonyms: Rock-II, B230113H15Rik, Rho-kinase, ROKalpha, Rock2m
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 19878
VEGA: 12
Homologene: 21010
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22222
Homologene: 7582
Bop1
Name: block of proliferation 1
Synonyms: Erb1p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12181
VEGA: 15
Homologene: 6612
Arfgef1
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)
Synonyms: D730028O18Rik, ARFGEP1, P200, BIG1, D130059B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211673
Homologene: 4687
Tasor
Name: transcription activation suppressor
Synonyms: 4933409E02Rik, D14Abb1e, MommeD6, Fam208a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218850
VEGA: 14
Homologene: 9062
Tcof1
Name: treacle ribosome biogenesis factor 1
Synonyms: treacle
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 21453
Homologene: 68049
Chrna2
Name: cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)
Synonyms: Acra-2, Acra2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110902
HGNC: HGNC:1956
Homologene: 20193
Hr
Name: lysine demethylase and nuclear receptor corepressor
Synonyms: N, ba, rh, rh-bmh, bldy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15460
HGNC: HGNC:5172
Homologene: 3774
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329559
Homologene: 11129
Dnajb6
Name: DnaJ heat shock protein family (Hsp40) member B6
Synonyms: Mrj, mDj4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23950
Homologene: 38058
Cachd1
Name: cache domain containing 1
Synonyms: 1190007F10Rik, Vwcd1, B430218L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320508
Homologene: 10854
Itpr3
Name: inositol 1,4,5-triphosphate receptor 3
Synonyms: Itpr-3, Ip3r3, tf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 16440
HGNC: HGNC:6182
Homologene: 1675
Sycp2l
Name: synaptonemal complex protein 2-like
Synonyms: LOC218175, EG621792, Gm40956
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 637277
Homologene: 52882
Cfap70
Name: cilia and flagella associated protein 70
Synonyms: 5330402L21Rik, Ttc18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 76670
Homologene: 17048
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Rdh19
Name: retinol dehydrogenase 19
Synonyms: RDH-S, Rdhs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216453
Homologene: 129514
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 192188
Homologene: 23022
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Capn12
Name: calpain 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60594
Homologene: 77333
Tcaf2
Name: TRPM8 channel-associated factor 2
Synonyms: Fam115c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232748
Homologene: 17147
Abcb11
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms: PFIC2, ABC16, PGY4, Lith1, sister of P-glycoprotein, Bsep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
4932441B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Chl1
Name: cell adhesion molecule L1-like
Synonyms: CALL, A530023M13Rik, close homolog of L1, LICAM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12661
HGNC: HGNC:1939
Homologene: 21314
Micalcl
Name: MICAL C-terminal like
Synonyms: 4921517J23Rik, Ebitein1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100504195
Homologene: 13149
Wdr90
Name: WD repeat domain 90
Synonyms: 3230401M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106618
Homologene: 27066
Gm12166
Name: predicted gene 12166
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100039624
Krt24
Name: keratin 24
Synonyms: 2310075C18Rik, 2310058N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 75706
Homologene: 10379
Dab2
Name: disabled 2, mitogen-responsive phosphoprotein
Synonyms: D15Wsu122e, 5730435J12Rik, p96, D630005B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13132
HGNC: HGNC:2662
Homologene: 1026
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: Dtgn1, MDC-L, D430033C21Rik, C130072N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Man1c1
Name: mannosidase, alpha, class 1C, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230815
Homologene: 69303
H2-M10.4
Name: histocompatibility 2, M region locus 10.4
Synonyms: 15H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224753
Homologene: 117973
Zfp563
Name: zinc finger protein 563
Synonyms: zinc finger protein, Zfp413
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240068
Homologene: 77346
Klk1b4
Name: kallikrein 1-related pepidase b4
Synonyms: mGk-4, Ngfa, Ngfa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18048
HGNC: HGNC:6364
Homologene: 68141
Olfr1196
Name: olfactory receptor 1196
Synonyms: GA_x6K02T2Q125-50181139-50180195, MOR225-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258456
Homologene: 123770
Ak3
Name: adenylate kinase 3
Synonyms: AK-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 56248
Homologene: 21744
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 628185
Homologene: 86604
Vax2
Name: ventral anterior homeobox 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 24113
Homologene: 8048
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 433070
Tas2r103
Name: taste receptor, type 2, member 103
Synonyms: TRB2, T2R3, mt2r63, mGR03, Tas2r3, Tas2r10, EG667992
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 667992
Homologene: 130076
Iffo1
Name: intermediate filament family orphan 1
Synonyms: 4733401N06Rik, Iffo, A930037G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320678
Homologene: 18706
Neil3
Name: nei like 3 (E. coli)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234258
Homologene: 10094
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: 70zpep, Ptpn8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Olfr1369-ps1
Name: olfactory receptor 1369, pseudogene 1
Synonyms: GA_x6K02T2QHY8-12126170-12125935, MOR256-31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 404504
HGNC: HGNC:8281
AC154303.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Zhx1
Name: zinc fingers and homeoboxes 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22770
Homologene: 5225
Nras
Name: neuroblastoma ras oncogene
Synonyms: N-ras
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18176
HGNC: HGNC:7989
Homologene: 55661
Gm5577
Name: predicted gene 5577
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 434064
Rarres1
Name: retinoic acid receptor responder (tazarotene induced) 1
Synonyms: 5430417P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109222
HGNC: HGNC:9867
Homologene: 2166
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 10,209,634 bp
  • A to G, chromosome 2 at 69,323,976 bp
  • A to T, chromosome 2 at 76,745,394 bp
  • T to C, chromosome 2 at 88,700,448 bp
  • G to A, chromosome 2 at 91,176,828 bp
  • T to A, chromosome 2 at 120,862,687 bp
  • C to T, chromosome 2 at 164,910,638 bp
  • A to G, chromosome 3 at 53,652,070 bp
  • A to G, chromosome 3 at 67,495,810 bp
  • A to G, chromosome 3 at 103,060,225 bp
  • A to G, chromosome 3 at 103,873,641 bp
  • A to T, chromosome 4 at 100,970,888 bp
  • G to C, chromosome 4 at 134,703,438 bp
  • T to C, chromosome 5 at 29,751,008 bp
  • T to C, chromosome 5 at 104,092,781 bp
  • T to C, chromosome 6 at 23,007,263 bp
  • A to G, chromosome 6 at 42,642,547 bp
  • T to C, chromosome 6 at 83,737,547 bp
  • G to A, chromosome 6 at 88,005,080 bp
  • T to A, chromosome 6 at 103,715,284 bp
  • A to G, chromosome 6 at 125,160,589 bp
  • A to G, chromosome 6 at 133,036,317 bp
  • T to C, chromosome 7 at 28,892,613 bp
  • G to A, chromosome 7 at 44,211,593 bp
  • G to A, chromosome 7 at 80,759,934 bp
  • A to G, chromosome 7 at 112,407,678 bp
  • T to C, chromosome 8 at 53,623,664 bp
  • T to C, chromosome 8 at 77,420,725 bp
  • T to C, chromosome 10 at 7,752,754 bp
  • C to A, chromosome 10 at 51,621,101 bp
  • T to C, chromosome 10 at 86,863,456 bp
  • A to G, chromosome 10 at 106,830,629 bp
  • A to T, chromosome 10 at 127,850,075 bp
  • T to A, chromosome 11 at 46,052,026 bp
  • A to G, chromosome 11 at 99,282,770 bp
  • A to G, chromosome 12 at 16,972,736 bp
  • T to A, chromosome 13 at 21,115,861 bp
  • A to G, chromosome 13 at 41,141,964 bp
  • A to G, chromosome 13 at 65,035,160 bp
  • T to A, chromosome 14 at 20,439,719 bp
  • T to C, chromosome 14 at 27,477,130 bp
  • G to T, chromosome 14 at 57,017,188 bp
  • T to A, chromosome 14 at 66,148,953 bp
  • A to G, chromosome 14 at 68,610,994 bp
  • A to G, chromosome 14 at 70,563,584 bp
  • A to G, chromosome 15 at 6,435,163 bp
  • T to C, chromosome 15 at 58,053,240 bp
  • A to G, chromosome 15 at 76,453,876 bp
  • T to A, chromosome 17 at 18,597,679 bp
  • T to A, chromosome 17 at 22,603,115 bp
  • A to G, chromosome 17 at 25,859,278 bp
  • A to C, chromosome 17 at 27,085,131 bp
  • A to G, chromosome 17 at 27,091,572 bp
  • G to A, chromosome 17 at 33,105,727 bp
  • A to G, chromosome 17 at 36,461,985 bp
  • T to A, chromosome 17 at 46,830,991 bp
  • C to T, chromosome 18 at 60,831,533 bp
  • T to A, chromosome 19 at 29,047,718 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3979 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040942-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.