Strain Name:
C57BL/6J-MtgxR4088Btlr/Mmmh
Stock Number:
040981-MU
Citation ID:
RRID:MMRRC_040981-MU
Other Names:
R4088 (G1), C57BL/6J-MtgxR4088Btlr
Major Collection:

Gene Information

Sf1
Name: splicing factor 1
Synonyms: WBP4, Zfp162, MZFM, CW17R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 22668
Homologene: 134065
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231051
Homologene: 46480
Mrtfb
Name: myocardin related transcription factor B
Synonyms: Mrtfb, Mkl2, Gt4-1, MRTF-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 239719
Homologene: 40917
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: C030017F07Rik, Bravo, C130076O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Gpr26
Name: G protein-coupled receptor 26
Synonyms: 9630036A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233919
HGNC: HGNC:4481
Homologene: 17764
Alox12b
Name: arachidonate 12-lipoxygenase, 12R type
Synonyms: Aloxe2, e-LOX2, 12R-LOX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11686
HGNC: HGNC:430
Homologene: 884
Baz1b
Name: bromodomain adjacent to zinc finger domain, 1B
Synonyms: WSTF, Wbscr9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22385
HGNC: HGNC:961
Homologene: 22651
Ddx4
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Synonyms: VASA, Mvh, mvh / m'vasa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 13206
VEGA: 13
Homologene: 49227
Kif13b
Name: kinesin family member 13B
Synonyms: 5330429L19Rik, N-3 kinesin, GAKIN, C130021D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16554
VEGA: 14
Homologene: 9073
Pcnt
Name: pericentrin (kendrin)
Synonyms: m275Asp, Pcnt2, m239Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18541
VEGA: 10
Osbpl8
Name: oxysterol binding protein-like 8
Synonyms: ORP-8, D330025H14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 237542
VEGA: 10
Homologene: 68813
Kif15
Name: kinesin family member 15
Synonyms: N-10 kinesin, 3110023M17Rik, Knsl7, 3930402I10Rik, HKLP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 209737
VEGA: 9
Homologene: 23210
Cdc73
Name: cell division cycle 73, Paf1/RNA polymerase II complex component
Synonyms: Hrpt2, C130030P16Rik, 8430414L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 214498
Homologene: 11571
Oprm1
Name: opioid receptor, mu 1
Synonyms: MOP-R, MOR-1, Oprm, MOP receptor, mor, muOR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18390
HGNC: HGNC:8156
Homologene: 37368
Zfp281
Name: zinc finger protein 281
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226442
Homologene: 8270
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: E130010M05Rik, [a]4(IV)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Washc5
Name: WASH complex subunit 5
Synonyms: strumpellin, E430025E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223593
VEGA: 15
Homologene: 8898
Esyt3
Name: extended synaptotagmin-like protein 3
Synonyms: D9Ertd280e, Fam62c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 272636
Homologene: 18626
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: 2810027M23Rik, auxilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 72685
Homologene: 8865
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 545370
Homologene: 23741
Plekhh2
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 213556
VEGA: 17
Homologene: 35317
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Cyp2b9
Name: cytochrome P450, family 2, subfamily b, polypeptide 9
Synonyms: phenobarbitol inducible, type a, Cyp2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13094
Homologene: 74933
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 192188
Homologene: 23022
Vmn1r58
Name: vomeronasal 1 receptor 58
Synonyms: V1rd4, V3R4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 81014
Homologene: 41799
Trim14
Name: tripartite motif-containing 14
Synonyms: 5830400N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74735
Homologene: 13241
Cdhr2
Name: cadherin-related family member 2
Synonyms: Pcdh24, LOC268663
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 268663
Homologene: 134510
Khdrbs2
Name: KH domain containing, RNA binding, signal transduction associated 2
Synonyms: SLM-1, 6330586C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 170771
Homologene: 15772
Npsr1
Name: neuropeptide S receptor 1
Synonyms: Gpr154, VRR1, 9330128H10Rik, PGR14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 319239
Homologene: 45515
Olfr344
Name: olfactory receptor 344
Synonyms: GA_x6K02T2NLDC-33262744-33263673, MOR136-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258621
Trim65
Name: tripartite motif-containing 65
Synonyms: 4732463G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 338364
Homologene: 27844
Traf3ip3
Name: TRAF3 interacting protein 3
Synonyms: 6030423D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 215243
Homologene: 11885
Ubtfl1
Name: upstream binding transcription factor, RNA polymerase I-like 1
Synonyms: Hmgpi, B020006M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 546118
Homologene: 110115
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cav2.3, Cchra1, alpha1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Sypl2
Name: synaptophysin-like 2
Synonyms: Mg29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 17306
Homologene: 7421
Zdhhc14
Name: zinc finger, DHHC domain containing 14
Synonyms: B530001K09Rik, New1cp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224454
VEGA: 17
Homologene: 62301
Hsdl2
Name: hydroxysteroid dehydrogenase like 2
Synonyms: 2610207I16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 72479
Nfasc
Name: neurofascin
Synonyms: D430023G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 269116
Homologene: 24945
Thsd4
Name: thrombospondin, type I, domain containing 4
Synonyms: ADAMTSL6, B230114P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 207596
Homologene: 49796
Arsk
Name: arylsulfatase K
Synonyms: 2810429K17Rik, 4833414G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 77041
Homologene: 12670
A430110L20Rik
Name: RIKEN cDNA A430110L20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329307
Cep250
Name: centrosomal protein 250
Synonyms: B230210E21Rik, Cep2, Inmp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Ndufs3
Name: NADH:ubiquinone oxidoreductase core subunit S3
Synonyms: 0610010M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68349
HGNC: HGNC:7710
Homologene: 3346
Zfp9
Name: zinc finger protein 9
Synonyms: Zfp-9, 1810048F22Rik, Krox-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22750
Homologene: 49280
Taar3
Name: trace amine-associated receptor 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 493809
HGNC: HGNC:4513
Homologene: 117490
Slc26a9
Name: solute carrier family 26, member 9
Synonyms: anion transporter/exchanger-9, E030002L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 320718
Homologene: 14179
Map4k2
Name: mitogen-activated protein kinase kinase kinase kinase 2
Synonyms: BL44, Rab8ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 26412
HGNC: HGNC:6864
Homologene: 3370
Dnajc28
Name: DnaJ heat shock protein family (Hsp40) member C28
Synonyms: ORF28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 246738
HGNC: HGNC:1297
Homologene: 9869
Sbk2
Name: SH3-binding domain kinase family, member 2
Synonyms: LOC381836
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381836
Homologene: 30927
Gkn3
Name: gastrokine 3
Synonyms: 1190003M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 68888
Homologene: 87422
Fam86
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 32,333,524 bp
  • T to A, chromosome 1 at 82,523,922 bp
  • A to G, chromosome 1 at 131,767,849 bp
  • A to T, chromosome 1 at 132,595,591 bp
  • T to A, chromosome 1 at 136,626,121 bp
  • A to G, chromosome 1 at 143,608,514 bp
  • A to G, chromosome 1 at 150,703,216 bp
  • A to T, chromosome 1 at 154,412,183 bp
  • T to C, chromosome 1 at 181,227,709 bp
  • A to G, chromosome 1 at 193,181,320 bp
  • T to A, chromosome 2 at 36,569,018 bp
  • G to A, chromosome 2 at 76,917,770 bp
  • C to T, chromosome 2 at 90,898,345 bp
  • G to A, chromosome 2 at 155,992,632 bp
  • A to G, chromosome 3 at 108,217,676 bp
  • T to A, chromosome 4 at 46,523,709 bp
  • T to A, chromosome 4 at 59,610,636 bp
  • T to A, chromosome 4 at 101,639,396 bp
  • A to G, chromosome 5 at 25,287,713 bp
  • T to A, chromosome 5 at 135,216,940 bp
  • C to T, chromosome 6 at 87,383,525 bp
  • G to T, chromosome 6 at 118,464,769 bp
  • T to C, chromosome 7 at 4,957,628 bp
  • C to A, chromosome 7 at 5,410,655 bp
  • T to C, chromosome 7 at 26,173,456 bp
  • G to T, chromosome 7 at 131,967,076 bp
  • T to C, chromosome 9 at 18,409,968 bp
  • G to A, chromosome 9 at 24,313,769 bp
  • T to C, chromosome 9 at 59,997,222 bp
  • T to C, chromosome 9 at 99,324,237 bp
  • T to A, chromosome 9 at 122,986,189 bp
  • T to C, chromosome 10 at 6,830,234 bp
  • A to G, chromosome 10 at 23,949,859 bp
  • T to C, chromosome 10 at 76,428,014 bp
  • A to G, chromosome 10 at 86,922,185 bp
  • T to C, chromosome 10 at 111,289,790 bp
  • G to T, chromosome 11 at 69,158,385 bp
  • G to A, chromosome 11 at 116,126,479 bp
  • T to C, chromosome 12 at 44,572,202 bp
  • A to G, chromosome 13 at 54,717,888 bp
  • T to G, chromosome 13 at 76,098,414 bp
  • A to G, chromosome 13 at 112,613,761 bp
  • T to C, chromosome 14 at 64,767,455 bp
  • C to A, chromosome 15 at 59,339,862 bp
  • A to T, chromosome 16 at 5,253,035 bp
  • T to C, chromosome 16 at 13,384,200 bp
  • G to A, chromosome 16 at 91,616,867 bp
  • A to G, chromosome 17 at 5,726,856 bp
  • T to C, chromosome 17 at 84,617,999 bp
  • T to A, chromosome 18 at 12,504,308 bp
  • A to T, chromosome 19 at 6,353,156 bp
  • G to A, chromosome 19 at 6,368,440 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4088 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040981-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.