Strain Name:
C57BL/6J-MtgxR4131Btlr/Mmmh
Stock Number:
040994-MU
Citation ID:
RRID:MMRRC_040994-MU
Other Names:
R4131 (G1), C57BL/6J-MtgxR4131Btlr
Major Collection:

Gene Information

Abca12
Name: ATP-binding cassette, sub-family A (ABC1), member 12
Synonyms: 4833417A11Rik, 4832428G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74591
Homologene: 45441
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: Tarpp, R3hdm3, D9Bwg1012e, 0710001E13Rik, ARPP-21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74100
Homologene: 32306
Psmd1
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Synonyms: S1, P112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70247
HGNC: HGNC:9554
Homologene: 2100
Nup35
Name: nucleoporin 35
Synonyms: 2310006I24Rik, 5330402E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69482
Homologene: 44517
Zbtb40
Name: zinc finger and BTB domain containing 40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230848
Homologene: 8912
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: 6330570A01Rik, mGlu7a receptor, Tg(SMN2)89Ahmb, Gpr1g, E130018M02Rik, SMN2, mGluR7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Igha
Name: immunoglobulin heavy constant alpha
Synonyms: Igh-2, IgA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238447
Adam12
Name: a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Synonyms: Mltna, ADAM12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11489
HGNC: HGNC:190
Homologene: 74862
Tnks1bp1
Name: tankyrase 1 binding protein 1
Synonyms: TAB182
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228140
Homologene: 14117
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Art3
Name: ADP-ribosyltransferase 3
Synonyms: 4930569O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 109979
HGNC: HGNC:725
Homologene: 911
Itgb2l
Name: integrin beta 2-like
Synonyms: 5033406G21Rik, pactolus
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 16415
Olfr884
Name: olfactory receptor 884
Synonyms: MOR162-11P, MOR162-11P, Olfr1550-ps1, MOR162-9P, GA_x6K02T2PVTD-31726544-31727473, MOR162-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 257996
Homologene: 79400
Megf10
Name: multiple EGF-like-domains 10
Synonyms: 3000002B06Rik, LOC240312
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70417
Homologene: 23771
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20192
Homologene: 68151
Phactr1
Name: phosphatase and actin regulator 1
Synonyms: Rpel1, 9630030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218194
Homologene: 33597
Klra2
Name: killer cell lectin-like receptor, subfamily A, member 2
Synonyms: Ly49b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16633
Homologene: 133782
Heca
Name: hdc homolog, cell cycle regulator
Synonyms: LOC380629
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 380629
VEGA: 10
Homologene: 32300
Cmklr1
Name: chemokine-like receptor 1
Synonyms: Gpcr27, ChemR23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14747
HGNC: HGNC:2121
Homologene: 129967
Ces1c
Name: carboxylesterase 1C
Synonyms: Es-1, Ces-N, Es1, Es-N, Es-4, Ee-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13884
HGNC: HGNC:1863
Homologene: 117484
Clpx
Name: caseinolytic mitochondrial matrix peptidase chaperone subunit
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270166
HGNC: HGNC:2088
Homologene: 4851
Prelid2
Name: PRELI domain containing 2
Synonyms: C330008K14Rik, 1700003A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 77619
VEGA: 18
Homologene: 45749
Olfr503
Name: olfactory receptor 503
Synonyms: MOR34-9, MOR34-12, GA_x6K02T2PBJ9-10874315-10875286, Olfr1548, MOR34-8P, MOR34-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259143
Homologene: 121509
Try4
Name: trypsin 4
Synonyms: 0910001B19Rik, Td
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22074
HGNC: HGNC:9486
Homologene: 106639
Sema4g
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 26456
Homologene: 22682
Pdzd9
Name: PDZ domain containing 9
Synonyms: 4930408O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67983
Homologene: 27865
Klk1b3
Name: kallikrein 1-related peptidase b3
Synonyms: Ngfg, mGk-3, Ngfg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18050
HGNC: HGNC:6364
Homologene: 68141
Rassf6
Name: Ras association (RalGDS/AF-6) domain family member 6
Synonyms: 1600016B17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 73246
Homologene: 37125
A4gnt
Name: alpha-1,4-N-acetylglucosaminyltransferase
Synonyms: alpha4GnT, LOC333424
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 333424
Homologene: 87446
C1d
Name: C1D nuclear receptor co-repressor
Synonyms: SUN-CoR, 1110036E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 57316
Homologene: 4619
Cisd3
Name: CDGSH iron sulfur domain 3
Synonyms: Mel13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217149
Homologene: 35399
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 71,319,871 bp
  • T to C, chromosome 1 at 86,078,700 bp
  • G to A, chromosome 2 at 80,656,099 bp
  • A to G, chromosome 2 at 85,044,447 bp
  • C to T, chromosome 2 at 112,926,983 bp
  • G to T, chromosome 4 at 136,995,396 bp
  • C to T, chromosome 5 at 90,609,787 bp
  • A to T, chromosome 5 at 92,392,562 bp
  • C to A, chromosome 5 at 113,614,484 bp
  • T to A, chromosome 6 at 41,305,401 bp
  • G to T, chromosome 6 at 110,646,348 bp
  • T to A, chromosome 6 at 131,228,217 bp
  • T to A, chromosome 7 at 44,201,687 bp
  • C to G, chromosome 7 at 108,544,537 bp
  • A to T, chromosome 7 at 120,662,869 bp
  • C to T, chromosome 7 at 133,912,924 bp
  • A to G, chromosome 8 at 93,100,684 bp
  • T to A, chromosome 9 at 38,047,874 bp
  • A to G, chromosome 9 at 65,316,655 bp
  • A to G, chromosome 9 at 99,620,618 bp
  • T to A, chromosome 9 at 112,155,308 bp
  • A to G, chromosome 10 at 17,902,239 bp
  • C to T, chromosome 10 at 27,041,174 bp
  • C to T, chromosome 11 at 17,264,054 bp
  • T to C, chromosome 11 at 97,688,431 bp
  • C to A, chromosome 12 at 113,258,829 bp
  • A to T, chromosome 13 at 43,037,477 bp
  • A to G, chromosome 16 at 96,437,389 bp
  • T to G, chromosome 18 at 41,951,159 bp
  • G to A, chromosome 18 at 57,180,535 bp
  • T to A, chromosome 19 at 44,998,919 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4131 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040994-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.