Strain Name:
C57BL/6J-MtgxR4182Btlr/Mmmh
Stock Number:
041018-MU
Citation ID:
RRID:MMRRC_041018-MU
Other Names:
R4182 (G1), C57BL/6J-MtgxR4182Btlr
Major Collection:

Gene Information

Dnajc21
Name: DnaJ heat shock protein family (Hsp40) member C21
Synonyms: 9930116P15Rik, 4930461P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 78244
Homologene: 6752
Arhgap12
Name: Rho GTPase activating protein 12
Synonyms: 2810011M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 75415
Homologene: 23089
Nme1
Name: NME/NM23 nucleoside diphosphate kinase 1
Synonyms: non-metastatic cells 1, protein (NM23A) expressed in, NM23-M1, NDPK-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18102
HGNC: HGNC:7849
Homologene: 128514
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Ttc39b
Name: tetratricopeptide repeat domain 39B
Synonyms: 9130422G05Rik, 1810054D07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69863
Homologene: 25228
Ddx1
Name: DEAD box helicase 1
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104721
VEGA: 12
HGNC: HGNC:2734
Homologene: 3627
Cfap20
Name: cilia and flagella associated protein 20
Synonyms: 2600014O15Rik, Gtl3, T10-2A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14894
Homologene: 7350
Pdcd6ip
Name: programmed cell death 6 interacting protein
Synonyms: AIP1, Alix
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18571
HGNC: HGNC:8766
Homologene: 22614
Zfp982
Name: zinc finger protein 982
Synonyms: Gm13152
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 195531
Cux2
Name: cut-like homeobox 2
Synonyms: Cux2, 1700051K22Rik, ENSMUSG00000072641, Cux-2, Cutl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13048
Homologene: 22426
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 2610202E01Rik, 8030475K17Rik, A330041G23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Saal1
Name: serum amyloid A-like 1
Synonyms: 5031425D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78935
Homologene: 34706
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: D330020E01Rik, 3632410F03Rik, nephrocystin 3, pcy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Zfp560
Name: zinc finger protein 560
Synonyms: 2310030G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 434377
Homologene: 103820
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: RGC2, A230067G21Rik, AS250
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241694
Homologene: 28131
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, VLGR1, Mass1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Des
Name: desmin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13346
HGNC: HGNC:2770
Homologene: 56469
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 621430
Homologene: 115466
Slc19a1
Name: solute carrier family 19 (folate transporter), member 1
Synonyms: reduced folate carrier, RFC1, RFC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 20509
Homologene: 57139
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546980
Homologene: 115466
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
H2-T24
Name: histocompatibility 2, T region locus 24
Synonyms: H-2T24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15042
Homologene: 69019
Ddx59
Name: DEAD box helicase 59
Synonyms: 4833411G06Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 59, 1210002B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67997
Homologene: 12222
Susd5
Name: sushi domain containing 5
Synonyms: LOC382111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382111
VEGA: 9
Homologene: 19526
Naaa
Name: N-acylethanolamine acid amidase
Synonyms: 2210023K21Rik, Asahl, 3830414F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67111
HGNC: HGNC:736
Homologene: 8686
Fam217a
Name: family with sequence similarity 217, member A
Synonyms: 1700026J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71864
VEGA: 13
Homologene: 82344
Grsf1
Name: G-rich RNA sequence binding factor 1
Synonyms: D5Wsu31e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231413
HGNC: HGNC:4610
Homologene: 20482
Vmn1r72
Name: vomeronasal 1 receptor 72
Synonyms: V1rg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 252905
Homologene: 74318
Gbp9
Name: guanylate-binding protein 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 236573
Homologene: 128731
Tll1
Name: tolloid-like
Synonyms: b2b2476Clo, Tll-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21892
Homologene: 49202
Olfr97
Name: olfactory receptor 97
Synonyms: GA_x6K02T2PSCP-1672287-1671355, MOR156-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258505
Homologene: 133051
Tmem115
Name: transmembrane protein 115
Synonyms: Pl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56395
Homologene: 135207
Heatr3
Name: HEAT repeat containing 3
Synonyms: C030036P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234549
Homologene: 45429
Olfr112
Name: olfactory receptor 112
Synonyms: MOR218-4, 4930580F03Rik, GA_x6K02T2PSCP-2023769-2022807
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258096
Olfr1312
Name: olfactory receptor 1312
Synonyms: GA_x6K02T2Q125-73090482-73089529, MOR245-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258359
Homologene: 128122
Lurap1l
Name: leucine rich adaptor protein 1-like
Synonyms: WI-13707, 1110029A09Rik, D4Bwg0951e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 52829
Homologene: 12281
Tgfb2
Name: transforming growth factor, beta 2
Synonyms: Tgfb-2, Tgf-beta2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21808
Homologene: 2432
Clnkos
Name: cytokine-dependent hematopoietic cell linker, opposite strand
Synonyms: 1700021O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Gm13570
Name: predicted gene 13570
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 667103
Homologene: 120881
Pcdhgb6
Name: protocadherin gamma subfamily B, 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93703
HGNC: HGNC:8713
Homologene: 49573
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to G, chromosome 1 at 75,362,584 bp
  • T to A, chromosome 1 at 136,439,861 bp
  • T to A, chromosome 1 at 186,629,025 bp
  • A to T, chromosome 2 at 60,098,457 bp
  • G to T, chromosome 2 at 112,042,528 bp
  • G to A, chromosome 2 at 146,435,994 bp
  • A to G, chromosome 3 at 56,008,427 bp
  • A to G, chromosome 3 at 97,213,683 bp
  • G to A, chromosome 4 at 80,953,858 bp
  • T to C, chromosome 4 at 83,237,301 bp
  • A to G, chromosome 4 at 147,512,693 bp
  • T to A, chromosome 5 at 38,747,850 bp
  • G to A, chromosome 5 at 88,664,156 bp
  • C to T, chromosome 5 at 92,272,554 bp
  • T to A, chromosome 5 at 105,083,595 bp
  • C to T, chromosome 5 at 121,868,492 bp
  • C to T, chromosome 7 at 11,670,068 bp
  • A to G, chromosome 7 at 46,710,652 bp
  • A to T, chromosome 7 at 85,957,187 bp
  • A to G, chromosome 7 at 87,001,891 bp
  • C to T, chromosome 8 at 64,041,511 bp
  • T to C, chromosome 8 at 88,171,002 bp
  • A to T, chromosome 8 at 95,424,656 bp
  • A to G, chromosome 9 at 20,347,448 bp
  • T to C, chromosome 9 at 104,038,464 bp
  • A to G, chromosome 9 at 107,535,283 bp
  • T to C, chromosome 9 at 113,700,010 bp
  • A to G, chromosome 9 at 114,095,985 bp
  • C to T, chromosome 10 at 77,058,841 bp
  • G to A, chromosome 11 at 93,960,804 bp
  • A to T, chromosome 12 at 13,231,503 bp
  • T to C, chromosome 13 at 34,910,256 bp
  • T to C, chromosome 13 at 81,581,707 bp
  • T to C, chromosome 15 at 10,459,933 bp
  • A to T, chromosome 17 at 36,015,484 bp
  • T to G, chromosome 17 at 37,231,848 bp
  • A to G, chromosome 17 at 37,564,028 bp
  • T to C, chromosome 18 at 6,111,734 bp
  • A to G, chromosome 18 at 37,727,283 bp
  • C to T, chromosome 19 at 56,350,327 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4182 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041018-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.