Strain Name:
C57BL/6J-MtgxR4182Btlr/Mmmh
Stock Number:
041018-MU
Citation ID:
RRID:MMRRC_041018-MU
Other Names:
R4182 (G1), C57BL/6J-MtgxR4182Btlr
Major Collection:

Strain Information

Dnajc21
Name: DnaJ heat shock protein family (Hsp40) member C21
Synonyms: 9930116P15Rik, 4930461P20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78244
Homologene: 6752
Arhgap12
Name: Rho GTPase activating protein 12
Synonyms: 2810011M08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75415
Homologene: 23089
Nme1
Name: NME/NM23 nucleoside diphosphate kinase 1
Synonyms: NM23-M1, NDPK-A, non-metastatic cells 1, protein (NM23A) expressed in
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18102
HGNC: HGNC:7849
Homologene: 128514
Nbea
Name: neurobeachin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Ttc39b
Name: tetratricopeptide repeat domain 39B
Synonyms: 9130422G05Rik, 1810054D07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69863
Homologene: 25228
Ddx1
Name: DEAD box helicase 1
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104721
VEGA: 12
HGNC: HGNC:2734
Homologene: 3627
Cfap20
Name: cilia and flagella associated protein 20
Synonyms: T10-2A2, 2600014O15Rik, Gtl3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14894
Homologene: 7350
Pdcd6ip
Name: programmed cell death 6 interacting protein
Synonyms: Alix, AIP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18571
HGNC: HGNC:8766
Homologene: 22614
Zfp982
Name: zinc finger protein 982
Synonyms: Gm13152
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 195531
Cux2
Name: cut-like homeobox 2
Synonyms: Cux-2, Cux2, ENSMUSG00000072641, Cutl2, 1700051K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13048
Homologene: 22426
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 8030475K17Rik, A330041G23Rik, 2610202E01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Saal1
Name: serum amyloid A-like 1
Synonyms: 5031425D22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78935
Homologene: 34706
Nphp3
Name: nephronophthisis 3 (adolescent)
Synonyms: D330020E01Rik, pcy, nephrocystin 3, 3632410F03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74025
HGNC: HGNC:7907
Homologene: 32697
Zfp560
Name: zinc finger protein 560
Synonyms: 2310030G09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434377
Homologene: 103820
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: A230067G21Rik, RGC2, AS250
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241694
Homologene: 28131
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mass1, Mgr1, Gpr98
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Des
Name: desmin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13346
HGNC: HGNC:2770
Homologene: 56469
Vmn2r79
Name: vomeronasal 2, receptor 79
Synonyms: EG621430
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 621430
Homologene: 115466
Slc19a1
Name: solute carrier family 19 (folate transporter), member 1
Synonyms: RFC1, RFC-1, reduced folate carrier
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20509
Homologene: 57139
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
H2-T24
Name: histocompatibility 2, T region locus 24
Synonyms: H-2T24
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15042
Homologene: 69019
Ddx59
Name: DEAD box helicase 59
Synonyms: 4833411G06Rik, 1210002B07Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67997
Homologene: 12222
Susd5
Name: sushi domain containing 5
Synonyms: LOC382111
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382111
VEGA: 9
Homologene: 19526
Naaa
Name: N-acylethanolamine acid amidase
Synonyms: 2210023K21Rik, 3830414F09Rik, Asahl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67111
HGNC: HGNC:736
Homologene: 8686
Fam217a
Name: family with sequence similarity 217, member A
Synonyms: 1700026J04Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71864
VEGA: 13
Homologene: 82344
Grsf1
Name: G-rich RNA sequence binding factor 1
Synonyms: D5Wsu31e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231413
HGNC: HGNC:4610
Homologene: 20482
Vmn1r72
Name: vomeronasal 1 receptor 72
Synonyms: V1rg1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252905
Homologene: 74318
Gbp9
Name: guanylate-binding protein 9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 236573
Homologene: 128731
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21892
Homologene: 49202
Or1o2
Name: olfactory receptor family 1 subfamily O member 2
Synonyms: MOR156-2, GA_x6K02T2PSCP-1672287-1671355, Olfr97
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258505
Homologene: 133051
Tmem115
Name: transmembrane protein 115
Synonyms: Pl6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56395
Homologene: 135207
Heatr3
Name: HEAT repeat containing 3
Synonyms: C030036P15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234549
Homologene: 45429
Or14j9
Name: olfactory receptor family 14 subfamily J member 9
Synonyms: MOR218-4, GA_x6K02T2PSCP-2023769-2022807, 4930580F03Rik, Olfr112
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258096
Or4f59
Name: olfactory receptor family 4 subfamily F member 59
Synonyms: GA_x6K02T2Q125-73090482-73089529, MOR245-20, Olfr1312
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258359
Homologene: 128122
Lurap1l
Name: leucine rich adaptor protein 1-like
Synonyms: 1110029A09Rik, WI-13707, D4Bwg0951e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 52829
Homologene: 12281
Tgfb2
Name: transforming growth factor, beta 2
Synonyms: Tgf-beta2, Tgfb-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21808
Homologene: 2432
Clnkos
Name: cytokine-dependent hematopoietic cell linker, opposite strand
Synonyms: 1700021O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Gm13570
Name: predicted gene 13570
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 667103
Homologene: 120881
Pcdhgb6
Name: protocadherin gamma subfamily B, 6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93703
HGNC: HGNC:8713
Homologene: 49573
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to G, chromosome 1 at 75,362,584 bp
  • T to A, chromosome 1 at 136,439,861 bp
  • T to A, chromosome 1 at 186,629,025 bp
  • A to T, chromosome 2 at 60,098,457 bp
  • G to T, chromosome 2 at 112,042,528 bp
  • G to A, chromosome 2 at 146,435,994 bp
  • A to G, chromosome 3 at 56,008,427 bp
  • A to G, chromosome 3 at 97,213,683 bp
  • G to A, chromosome 4 at 80,953,858 bp
  • T to C, chromosome 4 at 83,237,301 bp
  • A to G, chromosome 4 at 147,512,693 bp
  • T to A, chromosome 5 at 38,747,850 bp
  • G to A, chromosome 5 at 88,664,156 bp
  • C to T, chromosome 5 at 92,272,554 bp
  • T to A, chromosome 5 at 105,083,595 bp
  • C to T, chromosome 5 at 121,868,492 bp
  • C to T, chromosome 7 at 11,670,068 bp
  • A to G, chromosome 7 at 46,710,652 bp
  • A to T, chromosome 7 at 85,957,187 bp
  • A to G, chromosome 7 at 87,001,891 bp
  • C to T, chromosome 8 at 64,041,511 bp
  • T to C, chromosome 8 at 88,171,002 bp
  • A to T, chromosome 8 at 95,424,656 bp
  • A to G, chromosome 9 at 20,347,448 bp
  • T to C, chromosome 9 at 104,038,464 bp
  • A to G, chromosome 9 at 107,535,283 bp
  • T to C, chromosome 9 at 113,700,010 bp
  • A to G, chromosome 9 at 114,095,985 bp
  • C to T, chromosome 10 at 77,058,841 bp
  • G to A, chromosome 11 at 93,960,804 bp
  • A to T, chromosome 12 at 13,231,503 bp
  • T to C, chromosome 13 at 34,910,256 bp
  • T to C, chromosome 13 at 81,581,707 bp
  • T to C, chromosome 15 at 10,459,933 bp
  • A to T, chromosome 17 at 36,015,484 bp
  • T to G, chromosome 17 at 37,231,848 bp
  • A to G, chromosome 17 at 37,564,028 bp
  • T to C, chromosome 18 at 6,111,734 bp
  • A to G, chromosome 18 at 37,727,283 bp
  • C to T, chromosome 19 at 56,350,327 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4182 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041018-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.