Strain Name:
C57BL/6J-MtgxR4232Btlr/Mmmh
Stock Number:
041051-MU
Citation ID:
RRID:MMRRC_041051-MU
Other Names:
R4232 (G1), C57BL/6J-MtgxR4232Btlr
Major Collection:

Gene Information

Aven
Name: apoptosis, caspase activation inhibitor
Synonyms: mAven-L, 1700013A01Rik, mAven-S, 1700056A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 74268
Homologene: 10683
Ptk2
Name: PTK2 protein tyrosine kinase 2
Synonyms: FAK, Fadk, FRNK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 14083
VEGA: 15
HGNC: HGNC:9611
Homologene: 7314
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11426
Homologene: 136191
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: EG406236, Hsn2, Prkwnk1, 6430573H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232341
Homologene: 14253
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: NF-kappaB p50, p50/p105, NF-kappaB, p50, NF kappaB1, p50 subunit of NF kappaB, nuclear factor kappaB p50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: ARHGAP10, 5530401C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71435
Homologene: 10822
Atg14
Name: autophagy related 14
Synonyms: D14Ertd436e, Barkor, D14Ertd114e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 100504663
VEGA: 14
Homologene: 45423
Hnrnpr
Name: heterogeneous nuclear ribonucleoprotein R
Synonyms: hnRNPR, 2610528B01Rik, Hnrpr, 2610003J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74326
HGNC: HGNC:5047
Homologene: 4251
Glod4
Name: glyoxalase domain containing 4
Synonyms: 2700085E05Rik, 1700082G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67201
Homologene: 9376
Mtbp
Name: Mdm2, transformed 3T3 cell double minute p53 binding protein
Synonyms: MDM2BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105837
HGNC: HGNC:7417
Homologene: 11102
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 2310003F20Rik, 4930400K19Rik, Garnl1, Tulip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 56784
VEGA: 12
Homologene: 84805
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Mrtfa
Name: myocardin related transcription factor A
Synonyms: Mal, Mkl1, MRTF-A, Bsac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223701
Homologene: 32487
Usp39
Name: ubiquitin specific peptidase 39
Synonyms: D6Wsu157e, SAD1, CGI-21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 28035
Homologene: 13183
Samd8
Name: sterile alpha motif domain containing 8
Synonyms: 1110053F04Rik, Smsr, 1700010P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 67630
Homologene: 41670
Tiprl
Name: TIP41, TOR signalling pathway regulator-like (S. cerevisiae)
Synonyms: 1810011K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226591
Homologene: 7140
Tsc22d4
Name: TSC22 domain family, member 4
Synonyms: 0610009M14Rik, Thg-1pit, 1700023B23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 78829
Homologene: 11390
Dnaja3
Name: DnaJ heat shock protein family (Hsp40) member A3
Synonyms: Tid-1, 1810053A11Rik, 1200003J13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 83945
Homologene: 36170
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: B230373P09Rik, MDHC7, Dnahc1, E030034C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
P2rx6
Name: purinergic receptor P2X, ligand-gated ion channel, 6
Synonyms: P2xm, P2rxl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 18440
HGNC: HGNC:8538
Homologene: 3975
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Tmprss7
Name: transmembrane serine protease 7
Synonyms: matriptase-3, B230219I23Rik, LOC385645
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 208171
Homologene: 18178
Zfp831
Name: zinc finger protein 831
Synonyms: ENSMUSG00000050600, OTTMUSG00000017459
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 100043757
Homologene: 19013
Tnr
Name: tenascin R
Synonyms: J1-tenascin, restrictin, janusin, TN-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21960
Homologene: 124416
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: EGFL2, flamingo, mfmi1, Adgrc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 229003
Homologene: 14118
Fam71b
Name: family with sequence similarity 71, member B
Synonyms: OTTMUSG00000005491
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 432552
Homologene: 51067
Rin2
Name: Ras and Rab interactor 2
Synonyms: 4632403N06Rik, 2010003K16Rik, RASSF4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 74030
Homologene: 32430
Vmn2r19
Name: vomeronasal 2, receptor 19
Synonyms: EG232358
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232358
Homologene: 84037
Rtp4
Name: receptor transporter protein 4
Synonyms: 5830458K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 67775
Homologene: 56944
Ttc21a
Name: tetratricopeptide repeat domain 21A
Synonyms: 4921538N17Rik, Thm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74052
Homologene: 14728
Shcbp1
Name: Shc SH2-domain binding protein 1
Synonyms: mPAL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20419
Homologene: 32123
Kif14
Name: kinesin family member 14
Synonyms: D1Ertd367e, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 381293
Homologene: 8916
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 628422
Dtx3
Name: deltex 3, E3 ubiquitin ligase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 80904
Homologene: 12754
Prss40
Name: protease, serine 40
Synonyms: Tesp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21756
Homologene: 69043
Ip6k2
Name: inositol hexaphosphate kinase 2
Synonyms: Ihpk2, 1500005N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 76500
Homologene: 56929
Olfr850
Name: olfactory receptor 850
Synonyms: GA_x6K02T2PVTD-13214162-13213224, MOR147-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258516
Homologene: 121552
Wscd2
Name: WSC domain containing 2
Synonyms: 4933413A10Rik, C530024P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 320916
Homologene: 35372
Fkbp7
Name: FK506 binding protein 7
Synonyms: FKBP23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14231
HGNC: HGNC:3723
Homologene: 22568
Galnt7
Name: polypeptide N-acetylgalactosaminyltransferase 7
Synonyms: ppGaNTase-T7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 108150
HGNC: HGNC:4129
Homologene: 9685
Dvl3
Name: dishevelled segment polarity protein 3
Synonyms: b2b2866Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13544
HGNC: HGNC:3087
Homologene: 20928
Ugt1a10
Name: UDP glycosyltransferase 1 family, polypeptide A10
Synonyms: A13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 394430
Homologene: 133281
4930567H17Rik
Name: RIKEN cDNA 4930567H17 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 619303
Homologene: 134521
Olfr1535
Name: olfactory receptor 1535
Synonyms: MOR256-63, Olfr1365, GA_x6K02T2QHY8-11688984-11689964, MOR256-36, MOR256-36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 404335
Homologene: 131356
Ubqln3
Name: ubiquilin 3
Synonyms: 4933400K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 244178
Homologene: 9700
Dnajb3
Name: DnaJ heat shock protein family (Hsp40) member B3
Synonyms: Hsj3, Msj1, MSJ-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 15504
Homologene: 56409
Pgpep1l
Name: pyroglutamyl-peptidase I-like
Synonyms: C330024D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 78444
Homologene: 25138
Ajuba
Name: ajuba LIM protein
Synonyms: Jub
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16475
VEGA: 14
Homologene: 7789
Cflar
Name: CASP8 and FADD-like apoptosis regulator
Synonyms: Cash, Flip, 2310024N18Rik, Casper, A430105C05Rik, c-Flip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12633
HGNC: HGNC:1876
Homologene: 7652
B430218F22Rik
Name: RIKEN cDNA B430218F22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
Pcdhga5
Name: protocadherin gamma subfamily A, 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93713
HGNC: HGNC:8703
Homologene: 69263
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,560,792 bp
  • A to T, chromosome 1 at 58,740,993 bp
  • C to A, chromosome 1 at 88,056,210 bp
  • A to G, chromosome 1 at 88,205,252 bp
  • T to A, chromosome 1 at 136,516,363 bp
  • T to C, chromosome 1 at 159,886,215 bp
  • A to G, chromosome 1 at 165,222,587 bp
  • A to G, chromosome 2 at 20,887,137 bp
  • A to T, chromosome 2 at 76,663,317 bp
  • A to G, chromosome 2 at 112,627,768 bp
  • C to T, chromosome 2 at 145,860,446 bp
  • G to C, chromosome 2 at 174,705,654 bp
  • A to T, chromosome 2 at 181,229,902 bp
  • A to G, chromosome 3 at 108,413,772 bp
  • A to G, chromosome 3 at 135,603,770 bp
  • T to C, chromosome 4 at 123,432,392 bp
  • T to C, chromosome 4 at 136,339,189 bp
  • A to G, chromosome 5 at 113,560,984 bp
  • T to C, chromosome 5 at 137,751,370 bp
  • G to A, chromosome 6 at 72,319,818 bp
  • A to T, chromosome 6 at 119,949,261 bp
  • G to A, chromosome 6 at 123,329,912 bp
  • T to A, chromosome 7 at 41,837,587 bp
  • T to C, chromosome 7 at 68,237,079 bp
  • T to A, chromosome 7 at 104,141,803 bp
  • T to A, chromosome 8 at 4,736,372 bp
  • T to C, chromosome 8 at 57,652,966 bp
  • G to T, chromosome 9 at 19,477,726 bp
  • T to C, chromosome 9 at 54,419,909 bp
  • G to A, chromosome 9 at 108,805,648 bp
  • G to A, chromosome 9 at 108,972,813 bp
  • A to T, chromosome 9 at 119,942,618 bp
  • A to G, chromosome 10 at 127,193,189 bp
  • C to A, chromosome 11 at 46,407,405 bp
  • A to G, chromosome 11 at 76,233,261 bp
  • T to A, chromosome 12 at 53,139,671 bp
  • C to T, chromosome 12 at 55,640,644 bp
  • T to C, chromosome 13 at 21,555,461 bp
  • T to C, chromosome 13 at 118,386,840 bp
  • A to G, chromosome 14 at 21,780,145 bp
  • T to C, chromosome 14 at 31,304,916 bp
  • T to C, chromosome 14 at 47,551,345 bp
  • T to C, chromosome 14 at 54,569,526 bp
  • CATGA to CATGAATGA, chromosome 15 at 55,620,677 bp
  • C to A, chromosome 15 at 73,309,849 bp
  • T to A, chromosome 15 at 81,023,595 bp
  • T to A, chromosome 16 at 4,699,871 bp
  • T to C, chromosome 16 at 17,570,767 bp
  • A to G, chromosome 16 at 20,524,233 bp
  • A to G, chromosome 16 at 23,613,083 bp
  • A to T, chromosome 16 at 45,656,573 bp
  • A to G, chromosome 18 at 37,695,948 bp
  • C to T, chromosome X at 70,394,529 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4232 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041051-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.