Strain Name:
C57BL/6J-MtgxR4255Btlr/Mmmh
Stock Number:
041068-MU
Citation ID:
RRID:MMRRC_041068-MU
Other Names:
R4255 (G1), C57BL/6J-MtgxR4255Btlr
Major Collection:

Gene Information

Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: RPTPkappa, PTPk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Adgrg1
Name: adhesion G protein-coupled receptor G1
Synonyms: Gpr56, Cyt28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 14766
HGNC: HGNC:4512
Homologene: 4156
Terf1
Name: telomeric repeat binding factor 1
Synonyms: Trbf1, Pin2, Trf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 21749
Homologene: 7570
Trmt13
Name: tRNA methyltransferase 13
Synonyms: Ccdc76, A930028L21Rik, 4631408H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229780
Homologene: 6875
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: Bat2l2, Bat2d, 9630039I18Rik, 1810043M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226562
Homologene: 41015
Mtbp
Name: Mdm2, transformed 3T3 cell double minute p53 binding protein
Synonyms: MDM2BP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105837
HGNC: HGNC:7417
Homologene: 11102
Srbd1
Name: S1 RNA binding domain 1
Synonyms: D530025C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 78586
VEGA: 17
Homologene: 9994
Slc38a1
Name: solute carrier family 38, member 1
Synonyms: NAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105727
VEGA: 15
Homologene: 12745
Tefm
Name: transcription elongation factor, mitochondrial
Synonyms: 1110002N22Rik, FLJ22729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 68550
Homologene: 11657
Fndc3b
Name: fibronectin type III domain containing 3B
Synonyms: 1600019O04Rik, fad104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 72007
Homologene: 11244
Gpc6
Name: glypican 6
Synonyms: 6720429C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 23888
HGNC: HGNC:4454
Homologene: 55922
Sdf4
Name: stromal cell derived factor 4
Synonyms: Cab45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 20318
Homologene: 32121
Brca2
Name: breast cancer 2, early onset
Synonyms: Fancd1, RAB163
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Slc12a9
Name: solute carrier family 12 (potassium/chloride transporters), member 9
Synonyms: CIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 83704
Homologene: 5429
Baz2b
Name: bromodomain adjacent to zinc finger domain, 2B
Synonyms: 5830435C13Rik, D2Ertd794e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 407823
HGNC: HGNC:963
Homologene: 8394
Fgf17
Name: fibroblast growth factor 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 14171
VEGA: 14
HGNC: HGNC:3673
Homologene: 2872
Stag3
Name: stromal antigen 3
Synonyms: stromalin 3, SA-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 50878
Homologene: 40844
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 77505
Homologene: 131117
Myo7a
Name: myosin VIIA
Synonyms: Hdb, nmf371, Myo7, USH1B, polka
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Fgfr4
Name: fibroblast growth factor receptor 4
Synonyms: Fgfr-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14186
HGNC: HGNC:3691
Homologene: 20461
Spata31d1c
Name: spermatogenesis associated 31 subfamily D, member 1C
Synonyms: 4932441B19Rik, Fam75d1c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 238683
VEGA: 13
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b3491Clo, b2b1565Clo, Mdnah5, b2b1154Clo, b2b1537Clo, b2b1134Clo, Dnahc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Ttn
Name: titin
Synonyms: D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, mdm, 1100001C23Rik, shru, connectin, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: FPC, tigmin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Ush2a
Name: usherin
Synonyms: MUSH2A, Ushrn, Ush2a, LOC269160, A930037M10Rik, LOC381317, A930011D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22283
Homologene: 66151
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: Myhsp, 4832426G23Rik, Myhs-p, MyHC-pn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Rabl6
Name: RAB, member RAS oncogene family-like 6
Synonyms: Rbel1b, Rbel1, Rbel1a, B230208H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227624
Homologene: 11674
Abcb11
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
Synonyms: sister of P-glycoprotein, Bsep, PGY4, ABC16, PFIC2, Lith1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Ankrd7
Name: ankyrin repeat domain 7
Synonyms: 4930532L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 75196
Homologene: 35506
Peg12
Name: paternally expressed 12
Synonyms: Frat3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 27412
Myo1h
Name: myosin 1H
Synonyms: 4631401O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231646
Homologene: 82639
Olfr320
Name: olfactory receptor 320
Synonyms: MOR285-5, GA_x6K02T2NKPP-730312-729392, GA_x6K02T2NKPP-733777-732813, Olfr320, MOR285-4, Olfr321-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216783
Homologene: 133825
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 94229
Homologene: 23340
Actc1
Name: actin, alpha, cardiac muscle 1
Synonyms: Actc-1, alphac-actin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11464
HGNC: HGNC:143
Homologene: 68446
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 435626
Homologene: 52359
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: D130067I03Rik, 1700074E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 210417
Homologene: 18180
Ufsp2
Name: UFM1-specific peptidase 2
Synonyms: 1810047C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 192169
Homologene: 10151
Vnn3
Name: vanin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 26464
Homologene: 48295
Olfr1394
Name: olfactory receptor 1394
Synonyms: GA_x6K02T2QP88-6274566-6273628, MOR280-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 258273
Homologene: 138305
Pak1ip1
Name: PAK1 interacting protein 1
Synonyms: 5930415H02Rik, PIP1, p21-activated protein kinase-interacting protein 1, Gdpd1, 5830431I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 68083
Homologene: 39574
Olfr46
Name: olfactory receptor 46
Synonyms: MOR253-8, IF5, GA_x6K02T2PBJ9-42759973-42760905, ID12, IB7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18345
Homologene: 110491
Dagla
Name: diacylglycerol lipase, alpha
Synonyms: Nsddr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 269060
HGNC: HGNC:1165
Homologene: 4468
Fmo4
Name: flavin containing monooxygenase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226564
HGNC: HGNC:3772
Homologene: 68219
C87977
Name: expressed sequence C87977
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 97187
Homologene: 103830
Epn1
Name: epsin 1
Synonyms: Ibp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13854
Homologene: 32172
Pcdha9
Name: protocadherin alpha 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 192161
HGNC: HGNC:8664
Homologene: 130700
Rasd2
Name: RASD family, member 2
Synonyms: Rhes, TEM2, 4930526B11Rik, TEM-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 75141
Homologene: 8628
Igkv3-2
Name: immunoglobulin kappa variable 3-2
Synonyms: V(kappa)21A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 626583
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 15,805,679 bp
  • A to G, chromosome 1 at 20,593,934 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • G to A, chromosome 1 at 129,760,287 bp
  • C to A, chromosome 1 at 162,706,326 bp
  • A to G, chromosome 1 at 162,794,326 bp
  • C to T, chromosome 1 at 188,759,843 bp
  • C to T, chromosome 2 at 25,584,779 bp
  • T to C, chromosome 2 at 59,920,572 bp
  • A to G, chromosome 2 at 62,281,936 bp
  • T to C, chromosome 2 at 69,306,605 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • T to C, chromosome 2 at 114,049,216 bp
  • T to C, chromosome 3 at 27,501,407 bp
  • G to T, chromosome 3 at 116,582,688 bp
  • T to A, chromosome 4 at 144,207,484 bp
  • A to G, chromosome 4 at 156,000,757 bp
  • T to C, chromosome 5 at 114,330,137 bp
  • C to T, chromosome 5 at 137,321,432 bp
  • T to C, chromosome 5 at 138,290,881 bp
  • A to G, chromosome 5 at 150,541,169 bp
  • T to A, chromosome 6 at 18,869,881 bp
  • T to A, chromosome 6 at 70,699,061 bp
  • T to A, chromosome 7 at 5,097,638 bp
  • A to G, chromosome 7 at 62,463,731 bp
  • T to G, chromosome 7 at 98,071,964 bp
  • T to A, chromosome 7 at 105,712,998 bp
  • C to A, chromosome 7 at 140,610,587 bp
  • T to C, chromosome 8 at 45,985,462 bp
  • G to A, chromosome 8 at 75,221,910 bp
  • T to G, chromosome 8 at 95,005,902 bp
  • T to C, chromosome 10 at 23,865,822 bp
  • A to G, chromosome 10 at 28,206,245 bp
  • G to A, chromosome 11 at 49,160,435 bp
  • A to T, chromosome 11 at 58,683,965 bp
  • A to G, chromosome 11 at 67,299,734 bp
  • A to T, chromosome 11 at 80,140,249 bp
  • A to G, chromosome 13 at 41,011,156 bp
  • G to A, chromosome 13 at 55,166,251 bp
  • C to G, chromosome 13 at 65,035,688 bp
  • T to C, chromosome 13 at 65,035,717 bp
  • C to A, chromosome 14 at 70,641,722 bp
  • A to G, chromosome 14 at 117,951,141 bp
  • T to A, chromosome 15 at 28,438,102 bp
  • C to A, chromosome 15 at 55,620,685 bp
  • T to C, chromosome 15 at 96,585,550 bp
  • A to T, chromosome 17 at 86,102,922 bp
  • A to G, chromosome 18 at 37,012,790 bp
  • G to A, chromosome 19 at 10,256,952 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4255 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041068-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.