Strain Name:
C57BL/6J-MtgxR4332Btlr/Mmmh
Stock Number:
041099-MU
Citation ID:
RRID:MMRRC_041099-MU
Other Names:
R4332 (G1), C57BL/6J-MtgxR4332Btlr
Major Collection:

Gene Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320790
Homologene: 19067
Slc6a6
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21366
Homologene: 2291
Tfr2
Name: transferrin receptor 2
Synonyms: Tfr2, Trfr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 50765
Homologene: 2428
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 6430526O11Rik, 2900074J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237898
Homologene: 13066
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320365
Homologene: 113770
Api5
Name: apoptosis inhibitor 5
Synonyms: AAC-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11800
HGNC: HGNC:594
Homologene: 4809
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207932
Homologene: 45941
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70354
Homologene: 18923
Armc10
Name: armadillo repeat containing 10
Synonyms: 2810037C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67211
Homologene: 12097
Itsn2
Name: intersectin 2
Synonyms: Sh3p18, Ese2, Eh domain, SH3 domain regulator of endocytosis 2, Sh3d1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Farsb
Name: phenylalanyl-tRNA synthetase, beta subunit
Synonyms: PheRS alpha, Frsb, Farsl, Farslb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23874
Homologene: 4160
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Zcchc7
Name: zinc finger, CCHC domain containing 7
Synonyms: 4930572I07Rik, D4Wsu132e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 319885
Homologene: 22217
Tmprss7
Name: transmembrane serine protease 7
Synonyms: LOC385645, B230219I23Rik, matriptase-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208171
Homologene: 18178
Dhx36
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 36
Synonyms: Ddx36, 2810407E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72162
Homologene: 6356
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 672511
Homologene: 45439
Ogfrl1
Name: opioid growth factor receptor-like 1
Synonyms: 2210417C17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70155
Homologene: 11595
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241516
Homologene: 110349
Olfr305
Name: olfactory receptor 305
Synonyms: GA_x6K02T2NHDJ-9744055-9745014, MOR219-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258609
Homologene: 128128
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Gm11492
Name: predicted gene 11492
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Olfr711
Name: olfactory receptor 711
Synonyms: GA_x6K02T2PBJ9-9352783-9351839, MOR103-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259037
Homologene: 128111
4933405L10Rik
Name: RIKEN cDNA 4933405L10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71046
Homologene: 19274
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: enteropeptidase, enterokinase, A130097D21Rik, Prss7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Zfp110
Name: zinc finger protein 110
Synonyms: NRIF, 2900024E01Rik, Nrif1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 65020
Homologene: 129707
Serpinb11
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11
Synonyms: 2310046M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66957
Homologene: 41653
Itprid1
Name: ITPR interacting domain containing 1
Synonyms: D530004J12Rik, Ccdc129
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232016
Homologene: 52344
Pabpc2
Name: poly(A) binding protein, cytoplasmic 2
Synonyms: Pabp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 18459
Homologene: 56509
Pcdhb1
Name: protocadherin beta 1
Synonyms: PcdhbA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93872
HGNC: HGNC:8680
Homologene: 8348
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192166
Homologene: 5149
Il12a
Name: interleukin 12a
Synonyms: IL-12p35, p35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 16159
HGNC: HGNC:5969
Homologene: 681
Rbm12b1
Name: RNA binding motif protein 12 B1
Synonyms: 3000004N20Rik, Rbm12b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72397
Homologene: 28658
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434117
Homologene: 113703
Best3
Name: bestrophin 3
Synonyms: mBest4, Vmd2l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382427
VEGA: 10
Homologene: 33850
Gpr149
Name: G protein-coupled receptor 149
Synonyms: PGR10, 9630018L10Rik, Ieda, R35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229357
Homologene: 16359
Gmfg
Name: glia maturation factor, gamma
Synonyms: 2310057N07Rik, 0610039G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 63986
HGNC: HGNC:4374
Homologene: 37978
Kyat3
Name: kynurenine aminotransferase 3
Synonyms: Kat3, KATIII, Ccbl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229905
Homologene: 2994
Gm7367
Name: predicted pseudogene 7367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 664849
P2rx3
Name: purinergic receptor P2X, ligand-gated ion channel, 3
Synonyms: P2X3, 4930513E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228139
HGNC: HGNC:8534
Homologene: 1922
Stambpl1
Name: STAM binding protein like 1
Synonyms: 8230401J17Rik, 1700095N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76630
Homologene: 23253
Gm9312
Name: predicted gene 9312
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Efna2
Name: ephrin A2
Synonyms: Elf-1, Ephrin-A2, Epl6, ephrin A6, LERK-6, Cek7-L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13637
HGNC: HGNC:3222
Homologene: 1075
Olfr259
Name: olfactory receptor 259
Synonyms: GA_x6K02T2N869-1820-882, MOR172-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258766
Homologene: 106833
Rdh8
Name: retinol dehydrogenase 8
Synonyms: LOC235033, prRDH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235033
VEGA: 9
Homologene: 41062
Vmn2r129
Name: vomeronasal 2, receptor 129
Synonyms: V2r8, V2r9, Vmn2r-ps160, Vmn2r-ps159
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22314
Gm6866
Name: predicted gene 6866
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628304
Homologene: 80005
Gm15946
Name: predicted gene 15946
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 108168333
Gm2061
Name: predicted gene 2061
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100039138
VEGA: 1
Lppr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Leprel2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
1700006J14Rik
Name: RIKEN cDNA 1700006J14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
1700060O08Rik
Name: RIKEN cDNA 1700060O08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 23,375,829 bp
  • T to C, chromosome 1 at 78,469,266 bp
  • G to A, chromosome 1 at 107,369,564 bp
  • G to A, chromosome 1 at 185,455,207 bp
  • G to T, chromosome 1 at 194,807,555 bp
  • G to T, chromosome 2 at 27,215,114 bp
  • A to G, chromosome 2 at 82,977,857 bp
  • G to A, chromosome 2 at 85,024,861 bp
  • A to G, chromosome 2 at 87,107,745 bp
  • A to G, chromosome 2 at 94,422,374 bp
  • C to T, chromosome 2 at 125,740,737 bp
  • C to T, chromosome 3 at 62,484,991 bp
  • C to A, chromosome 3 at 62,604,373 bp
  • C to A, chromosome 3 at 68,695,261 bp
  • A to T, chromosome 3 at 117,322,825 bp
  • A to G, chromosome 3 at 142,725,426 bp
  • G to T, chromosome 4 at 8,854,143 bp
  • G to T, chromosome 4 at 12,145,655 bp
  • A to G, chromosome 4 at 44,895,038 bp
  • G to A, chromosome 4 at 156,338,311 bp
  • T to A, chromosome 5 at 21,661,581 bp
  • A to G, chromosome 5 at 137,571,734 bp
  • C to T, chromosome 5 at 150,381,663 bp
  • G to A, chromosome 6 at 55,968,235 bp
  • G to A, chromosome 6 at 91,723,471 bp
  • A to G, chromosome 6 at 121,657,447 bp
  • A to G, chromosome 6 at 124,842,136 bp
  • T to A, chromosome 7 at 10,052,995 bp
  • T to A, chromosome 7 at 12,844,571 bp
  • A to T, chromosome 7 at 28,437,572 bp
  • G to T, chromosome 7 at 41,216,118 bp
  • T to C, chromosome 7 at 60,155,616 bp
  • A to C, chromosome 7 at 86,363,872 bp
  • T to C, chromosome 7 at 106,972,147 bp
  • T to C, chromosome 8 at 105,709,724 bp
  • C to T, chromosome 9 at 20,822,629 bp
  • G to A, chromosome 10 at 80,188,481 bp
  • T to A, chromosome 10 at 117,002,524 bp
  • T to C, chromosome 10 at 120,364,212 bp
  • C to T, chromosome 11 at 85,103,978 bp
  • T to G, chromosome 11 at 87,567,904 bp
  • A to G, chromosome 11 at 119,436,676 bp
  • T to A, chromosome 12 at 4,712,611 bp
  • A to T, chromosome 12 at 24,252,094 bp
  • A to C, chromosome 12 at 54,062,069 bp
  • T to G, chromosome 16 at 45,686,327 bp
  • T to C, chromosome 16 at 79,034,334 bp
  • A to G, chromosome 16 at 90,774,537 bp
  • T to C, chromosome 17 at 12,962,895 bp
  • T to C, chromosome 18 at 37,265,530 bp
  • A to G, chromosome 18 at 39,775,340 bp
  • A to G, chromosome 19 at 34,234,005 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4332 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041099-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.