Strain Name:
C57BL/6J-MtgxR4361Btlr/Mmmh
Stock Number:
041112-MU
Citation ID:
RRID:MMRRC_041112-MU
Other Names:
R4361 (G1), C57BL/6J-MtgxR4361Btlr
Major Collection:

Gene Information

Tyr
Name: tyrosinase
Synonyms: skc35, Oca1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22173
Homologene: 30969
Kcnmb4
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 4
Synonyms: Slowpoke beta 4, 2900045G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 58802
HGNC: HGNC:6289
Homologene: 8721
Dtx4
Name: deltex 4, E3 ubiquitin ligase
Synonyms: RNF155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 207521
VEGA: 19
Homologene: 27781
Nup98
Name: nucleoporin 98
Synonyms: Nup96
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269966
HGNC: HGNC:8068
Homologene: 35472
Ahctf1
Name: AT hook containing transcription factor 1
Synonyms: 6230412P20Rik, Elys
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226747
Homologene: 9142
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: 2900041G10Rik, KPI-2, cprk, KPI2, A330101P12Rik, BREK, AATYK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231876
Homologene: 8948
Ift80
Name: intraflagellar transport 80
Synonyms: 4921524P20Rik, Wdr56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68259
Homologene: 12253
Gins1
Name: GINS complex subunit 1 (Psf1 homolog)
Synonyms: Psf1, 2810418N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69270
Homologene: 44516
Limk1
Name: LIM-domain containing, protein kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 16885
HGNC: HGNC:6613
Homologene: 1738
Fgfr3
Name: fibroblast growth factor receptor 3
Synonyms: HBGFR, Fgfr-3, sam3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14184
HGNC: HGNC:3690
Homologene: 55437
Dram2
Name: DNA-damage regulated autophagy modulator 2
Synonyms: 2010305N14Rik, 2610318G18Rik, Tmem77
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67171
Homologene: 23565
Dnajc1
Name: DnaJ heat shock protein family (Hsp40) member C1
Synonyms: MTJ1, Dnajl1, ERdj1, 4733401K02Rik, D230036H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13418
Homologene: 7293
Eps15
Name: epidermal growth factor receptor pathway substrate 15
Synonyms: 2410112D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13858
HGNC: HGNC:3419
Homologene: 128359
Retreg3
Name: reticulophagy regulator family member 3
Synonyms: 4933404C01Rik, 1300010M03Rik, Fam134c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67998
Homologene: 23585
Zfp597
Name: zinc finger protein 597
Synonyms: 4933407K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71063
Homologene: 33641
Rnf6
Name: ring finger protein (C3H2C3 type) 6
Synonyms: 5730419H05Rik, 1200013I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74132
Homologene: 14036
Nav1
Name: neuron navigator 1
Synonyms: POMFIL3, 9930003A20Rik, C230080M11Rik, unc53H1, steerin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215690
Homologene: 10719
Man1a2
Name: mannosidase, alpha, class 1A, member 2
Synonyms: Man1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17156
HGNC: HGNC:6822
Homologene: 55982
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, POMFIL1, 4732483H20Rik, unc53H3, steerin 3, 9630020C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 260315
Homologene: 56688
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: A830008O07Rik, 1700010C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Gm884
Name: predicted gene 884
Synonyms: LOC380730
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380730
Homologene: 134511
Lrrc46
Name: leucine rich repeat containing 46
Synonyms: 1700006D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69297
Homologene: 12307
Trmt1l
Name: tRNA methyltransferase 1 like
Synonyms: Trm1-like, 1190005F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98685
Homologene: 12801
Myf6
Name: myogenic factor 6
Synonyms: MRF4, herculin, bHLHc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17878
VEGA: 10
HGNC: HGNC:7566
Homologene: 1850
Gne
Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Synonyms: 2310066H07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50798
Homologene: 3996
Myom2
Name: myomesin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Kcnt1
Name: potassium channel, subfamily T, member 1
Synonyms: slo2, Slack, C030030G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227632
Homologene: 11055
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94229
Homologene: 23340
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
1700003E16Rik
Name: RIKEN cDNA 1700003E16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71837
Homologene: 52846
Klk1b11
Name: kallikrein 1-related peptidase b11
Synonyms: mGK-11, Klk11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16613
HGNC: HGNC:6364
Homologene: 68141
Dhrs2
Name: dehydrogenase/reductase member 2
Synonyms: SDR family, 5430405K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 71412
Homologene: 69438
Has2
Name: hyaluronan synthase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 15117
HGNC: HGNC:4819
Homologene: 3892
Ren1
Name: renin 1 structural
Synonyms: Ren1d, Ren-A, Rn-1, Ren, Rnr, Ren-1, Ren1c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19701
HGNC: HGNC:9958
Homologene: 20151
Gm12253
Name: predicted gene 12253
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 624860
Homologene: 83331
Ccdc157
Name: coiled-coil domain containing 157
Synonyms: 4930562D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216516
Homologene: 72271
Veph1
Name: ventricular zone expressed PH domain-containing 1
Synonyms: Veph, 2810471M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72789
Homologene: 11624
Sgce
Name: sarcoglycan, epsilon
Synonyms: e-SG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20392
Homologene: 31205
Aadac
Name: arylacetamide deacetylase
Synonyms: Aada, 5033417E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67758
HGNC: HGNC:17
Homologene: 37436
Mab21l2
Name: mab-21-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23937
HGNC: HGNC:6758
Homologene: 7824
Tex26
Name: testis expressed 26
Synonyms: 4930588N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75860
Homologene: 51841
Cdc42ep5
Name: CDC42 effector protein (Rho GTPase binding) 5
Synonyms: CEP5, 2010007O02Rik, 1700027J19Rik, Borg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 58804
Homologene: 10984
Sp110
Name: Sp110 nuclear body protein
Synonyms: 52kDa, Ipr1, 5031415C07Rik, 5830484A20Rik, Ifi75
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Scrn2
Name: secernin 2
Synonyms: SES2, D11Moh48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217140
Homologene: 26698
Pramel16
Name: PRAME like 16
Synonyms: Gm13109, Pramef25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329984
Homologene: 83161
Gpc2
Name: glypican 2 (cerebroglycan)
Synonyms: 2410016G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71951
HGNC: HGNC:4450
Homologene: 17657
Eif4a1
Name: eukaryotic translation initiation factor 4A1
Synonyms: initiation factor eIF-4A long form, Eif4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13681
HGNC: HGNC:3282
Homologene: 103998
Irx5
Name: Iroquois homeobox 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54352
Homologene: 38105
Cyp11b1
Name: cytochrome P450, family 11, subfamily b, polypeptide 1
Synonyms: Cyp11b-1, Cyp11b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 110115
Homologene: 106948
Tex38
Name: testis expressed 38
Synonyms: 4930544O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75173
Homologene: 47752
Gabra4
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
Synonyms: Gabra-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14397
HGNC: HGNC:4078
Homologene: 631
Fam122c
Name: family with sequence similarity 122, member C
Synonyms: 4930527G05Rik, 4930432H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 73866
Homologene: 87062
RP24-278K24.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
RP23-406B13.9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Magea3
Name: MAGE family member A3
Synonyms: Mage-a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 17139
Homologene: 23188
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,147,663 bp
  • T to A, chromosome 1 at 85,589,148 bp
  • A to T, chromosome 1 at 88,254,965 bp
  • A to G, chromosome 1 at 133,359,041 bp
  • G to A, chromosome 1 at 135,607,437 bp
  • A to G, chromosome 1 at 151,435,875 bp
  • A to G, chromosome 1 at 179,795,740 bp
  • A to G, chromosome 2 at 18,308,928 bp
  • A to T, chromosome 2 at 25,878,032 bp
  • T to C, chromosome 2 at 62,243,385 bp
  • A to G, chromosome 2 at 150,925,901 bp
  • T to A, chromosome 3 at 60,039,761 bp
  • T to C, chromosome 3 at 66,159,316 bp
  • A to T, chromosome 3 at 68,963,649 bp
  • C to T, chromosome 3 at 86,547,190 bp
  • T to C, chromosome 3 at 100,656,042 bp
  • T to C, chromosome 3 at 106,566,215 bp
  • C to A, chromosome 4 at 44,059,947 bp
  • G to A, chromosome 4 at 108,624,750 bp
  • T to C, chromosome 4 at 109,380,031 bp
  • A to G, chromosome 4 at 115,780,223 bp
  • A to G, chromosome 4 at 143,950,863 bp
  • T to C, chromosome 5 at 33,723,332 bp
  • C to T, chromosome 5 at 71,633,545 bp
  • T to C, chromosome 5 at 134,670,464 bp
  • A to T, chromosome 5 at 138,278,290 bp
  • T to A, chromosome 5 at 144,147,664 bp
  • C to A, chromosome 5 at 146,211,279 bp
  • A to T, chromosome 5 at 149,460,923 bp
  • C to T, chromosome 6 at 4,707,265 bp
  • A to G, chromosome 6 at 83,162,706 bp
  • A to G, chromosome 7 at 4,151,780 bp
  • A to G, chromosome 7 at 43,995,954 bp
  • G to T, chromosome 7 at 87,429,076 bp
  • T to A, chromosome 7 at 102,145,714 bp
  • G to A, chromosome 8 at 15,112,018 bp
  • G to T, chromosome 8 at 92,358,397 bp
  • G to T, chromosome 8 at 125,768,298 bp
  • GGGGGCAG to GG, chromosome 10 at 107,494,432 bp
  • T to C, chromosome 10 at 109,852,986 bp
  • A to T, chromosome 10 at 116,473,505 bp
  • C to T, chromosome 11 at 4,146,550 bp
  • T to A, chromosome 11 at 58,434,861 bp
  • G to A, chromosome 11 at 69,667,464 bp
  • C to T, chromosome 11 at 97,032,238 bp
  • G to A, chromosome 11 at 97,034,670 bp
  • T to A, chromosome 11 at 101,103,887 bp
  • CTTTT to CTTTTT, chromosome 11 at 103,617,501 bp
  • G to A, chromosome 14 at 55,241,189 bp
  • T to C, chromosome 14 at 66,938,401 bp
  • G to T, chromosome 15 at 56,681,948 bp
  • T to A, chromosome 15 at 71,490,827 bp
  • T to A, chromosome 15 at 74,839,016 bp
  • T to G, chromosome 15 at 98,863,670 bp
  • A to T, chromosome 16 at 3,865,900 bp
  • C to A, chromosome 19 at 12,485,296 bp
  • G to A, chromosome X at 53,293,499 bp
  • C to A, chromosome X at 154,948,853 bp
  • A to C, chromosome X at 154,948,854 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
(Deceased) Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4361 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041112-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.