Strain Name:
C57BL/6J-MtgxR4378Btlr/Mmmh
Stock Number:
041121-MU
Citation ID:
RRID:MMRRC_041121-MU
Other Names:
R4378 (G1), C57BL/6J-MtgxR4378Btlr
Major Collection:

Gene Information

Amigo1
Name: adhesion molecule with Ig like domain 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229715
Homologene: 46421
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: 2610027H02Rik, alphaII-spectrin, alpha-fodrin, Spna-2, Spna2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20740
Homologene: 2353
Sirt1
Name: sirtuin 1
Synonyms: Sir2, Sir2alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 93759
Homologene: 56556
Prtg
Name: protogenin
Synonyms: Igdcc5, A230098A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235472
Homologene: 54453
Taok3
Name: TAO kinase 3
Synonyms: 2900006A08Rik, A430105I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330177
Homologene: 83279
Exoc4
Name: exocyst complex component 4
Synonyms: Sec8, Sec8l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20336
Homologene: 40654
Zfp516
Name: zinc finger protein 516
Synonyms: Zfp26l, C330029B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Phc1
Name: polyhomeotic 1
Synonyms: Edr1, Mph1, rae28, Rae-28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13619
HGNC: HGNC:3182
Homologene: 107079
Ube4b
Name: ubiquitination factor E4B
Synonyms: UFD2a, Ufd2p, 4933406G05Rik, UFD2, D4Bwg0973e, 4930551I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 63958
Homologene: 107623
Rps6ka5
Name: ribosomal protein S6 kinase, polypeptide 5
Synonyms: 6330404E13Rik, 3110005L17Rik, MSK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73086
VEGA: 12
Homologene: 48302
Cmas
Name: cytidine monophospho-N-acetylneuraminic acid synthetase
Synonyms: D6Bwg0250e, CMP-sialic acid synthetase, CMP-Neu5Ac synthase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12764
Homologene: 7670
Hsph1
Name: heat shock 105kDa/110kDa protein 1
Synonyms: HSP110, hsp110/105, Hsp105, hsp-E7I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 15505
Homologene: 21322
Trhr
Name: thyrotropin releasing hormone receptor
Synonyms: TRH-R1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22045
VEGA: 15
Homologene: 20707
Nars
Name: asparaginyl-tRNA synthetase
Synonyms: ASNRS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70223
VEGA: 18
HGNC: HGNC:7643
Homologene: 68404
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, 1810009A16Rik, p600, D930005K06Rik, Zubr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Kirrel1, 6720469N11Rik, Neph1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170643
Homologene: 10089
Ppp4r3b
Name: protein phosphatase 4 regulatory subunit 3B
Synonyms: Smek2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104570
Homologene: 68886
Amigo2
Name: adhesion molecule with Ig like domain 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105827
VEGA: 15
Homologene: 18649
Primpol
Name: primase and polymerase (DNA-directed)
Synonyms: Ccdc111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 408022
Homologene: 14065
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 21683
Homologene: 3955
Cyp4f40
Name: cytochrome P450, family 4, subfamily f, polypeptide 40
Synonyms: EG631304
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 631304
VEGA: 17
Homologene: 117991
Gm7271
Name: predicted gene 7271
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 639545
Gxylt2
Name: glucoside xylosyltransferase 2
Synonyms: LOC232313, Glt8d4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232313
Homologene: 16823
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: 4930503E15Rik, Gm1557, LOC380658
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 74978
Homologene: 46007
Vmn2r88
Name: vomeronasal 2, receptor 88
Synonyms: V2r3, V2r13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 669149
Homologene: 129606
Sobp
Name: sine oculis binding protein
Synonyms: Jxc1, 5330439J01Rik, 2900009C16Rik, jc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 109205
Homologene: 41216
Qrich2
Name: glutamine rich 2
Synonyms: LOC217341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217341
Homologene: 12951
Axl
Name: AXL receptor tyrosine kinase
Synonyms: Tyro7, Ark, Ufo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26362
HGNC: HGNC:905
Homologene: 7583
Armc2
Name: armadillo repeat containing 2
Synonyms: 2610018I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 213402
Homologene: 41848
Tec
Name: tec protein tyrosine kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21682
Homologene: 1302
Elmo1
Name: engulfment and cell motility 1
Synonyms: CED-12, 6330578D22Rik, C230095H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 140580
Homologene: 56685
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625109
Homologene: 129606
Olfr3
Name: olfactory receptor 3
Synonyms: GA_x6K02T2NLDC-33507606-33506665, Y71, MOR136-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18328
HGNC: HGNC:8208
Homologene: 66579
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240427
Homologene: 9192
Cdc42ep3
Name: CDC42 effector protein (Rho GTPase binding) 3
Synonyms: 3200001F04Rik, UB1, Cep3, Borg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 260409
VEGA: 17
Homologene: 4708
Mapk7
Name: mitogen-activated protein kinase 7
Synonyms: ERK5, b2b2346Clo, Erk5-T, big MAP kinase 1, BMK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23939
HGNC: HGNC:6880
Homologene: 2060
Tnfrsf4
Name: tumor necrosis factor receptor superfamily, member 4
Synonyms: ACT35, Txgp1, Ox40, CD134
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22163
Homologene: 2496
Zfp612
Name: zinc finger protein 612
Synonyms: B230354B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234725
Homologene: 27083
Adora1
Name: adenosine A1 receptor
Synonyms: ARA1, A1-AR, A1AR, Ri, A1R, AA1R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11539
HGNC: HGNC:262
Homologene: 20165
Olfr1165-ps
Name: olfactory receptor 1165, pseudogene
Synonyms: GA_x6K02T2Q125-49593880-49592930, MOR174-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258642
RP23-199D18.5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Ighv1-56
Name: immunoglobulin heavy variable 1-56
Synonyms: Gm16791
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 382695
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 134,203,210 bp
  • T to C, chromosome 2 at 30,025,569 bp
  • T to C, chromosome 2 at 36,812,469 bp
  • G to T, chromosome 2 at 88,101,485 bp
  • C to T, chromosome 3 at 87,089,151 bp
  • A to G, chromosome 3 at 93,910,479 bp
  • C to T, chromosome 3 at 108,191,753 bp
  • C to T, chromosome 4 at 139,410,440 bp
  • C to T, chromosome 4 at 149,383,798 bp
  • T to C, chromosome 4 at 156,014,250 bp
  • T to A, chromosome 5 at 72,823,531 bp
  • A to G, chromosome 5 at 76,500,533 bp
  • T to C, chromosome 5 at 117,209,571 bp
  • C to A, chromosome 5 at 149,636,007 bp
  • T to A, chromosome 6 at 33,815,687 bp
  • G to T, chromosome 6 at 73,118,026 bp
  • A to G, chromosome 6 at 100,733,200 bp
  • T to C, chromosome 6 at 122,335,007 bp
  • T to C, chromosome 6 at 142,772,285 bp
  • G to A, chromosome 7 at 25,758,837 bp
  • G to A, chromosome 8 at 46,576,183 bp
  • G to T, chromosome 8 at 110,089,051 bp
  • T to C, chromosome 9 at 42,366,708 bp
  • T to C, chromosome 9 at 72,842,760 bp
  • T to C, chromosome 10 at 41,993,082 bp
  • C to T, chromosome 10 at 43,021,304 bp
  • C to T, chromosome 10 at 63,338,949 bp
  • A to T, chromosome 10 at 103,202,364 bp
  • A to G, chromosome 10 at 130,452,600 bp
  • A to G, chromosome 11 at 9,293,644 bp
  • T to A, chromosome 11 at 29,209,450 bp
  • G to A, chromosome 11 at 61,493,667 bp
  • T to C, chromosome 11 at 116,446,915 bp
  • A to T, chromosome 12 at 100,597,937 bp
  • C to T, chromosome 12 at 115,242,948 bp
  • A to T, chromosome 13 at 20,373,116 bp
  • T to A, chromosome 14 at 51,413,289 bp
  • A to G, chromosome 15 at 44,197,627 bp
  • A to G, chromosome 15 at 97,245,978 bp
  • A to G, chromosome 17 at 32,668,029 bp
  • A to G, chromosome 17 at 79,334,979 bp
  • A to G, chromosome 18 at 64,501,353 bp
  • T to C, chromosome 18 at 78,856,618 bp
  • T to A, chromosome 18 at 82,987,180 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4378 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041121-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.