Strain Name:
C57BL/6J-MtgxR4413Btlr/Mmmh
Stock Number:
041136-MU
Citation ID:
RRID:MMRRC_041136-MU
Other Names:
R4413 (G1), C57BL/6J-MtgxR4413Btlr
Major Collection:

Strain Information

Usp7
Name: ubiquitin specific peptidase 7
Synonyms: 2210010O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 252870
Homologene: 2592
Zfp462
Name: zinc finger protein 462
Synonyms: Gt4-2, 9430078C22Rik, Zfpip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242466
Homologene: 41430
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: 5033413A03Rik, SRm300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75956
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Nav2
Name: neuron navigator 2
Synonyms: POMFIL2, RAINB2, Unc53H2, HELAD1, 5330421F07Rik, Rainb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78286
Homologene: 52330
Ppp2r1a
Name: protein phosphatase 2, regulatory subunit A, alpha
Synonyms: PR65, protein phosphatase PP2A, 6330556D22Rik, PP2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 51792
HGNC: HGNC:9302
Homologene: 68559
Syn3
Name: synapsin III
Synonyms: Synapsin IIIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 27204
Homologene: 68320
Bcdin3d
Name: BCDIN3 domain containing
Synonyms: 4930556P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75284
VEGA: 15
Homologene: 12594
Gpsm1
Name: G-protein signalling modulator 1 (AGS3-like, C. elegans)
Synonyms: 1810037C22Rik, Ags3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67839
Homologene: 16987
Noct
Name: nocturnin
Synonyms: Ccr4, Ccrn4l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12457
Homologene: 7661
Ntn1
Name: netrin 1
Synonyms: Netrin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18208
HGNC: HGNC:8029
Homologene: 21008
Exoc1
Name: exocyst complex component 1
Synonyms: Sec3p, SEC3, A730011E05Rik, 2810407P21Rik, Sec3l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69940
Homologene: 41241
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269700
Homologene: 28297
Kcna4
Name: potassium voltage-gated channel, shaker-related subfamily, member 4
Synonyms: Kv1.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16492
HGNC: HGNC:6222
Homologene: 20514
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Sohlh2
Name: spermatogenesis and oogenesis specific basic helix-loop-helix 2
Synonyms: 4933406N12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74434
Homologene: 9864
Gstm4
Name: glutathione S-transferase, mu 4
Synonyms: Gstb-4, Gstb4, 1110004G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14865
HGNC: HGNC:4636
Homologene: 37357
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Taf5
Name: TATA-box binding protein associated factor 5
Synonyms: 6330528C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226182
VEGA: 19
Homologene: 5064
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Rhbdl2
Name: rhomboid like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230726
Homologene: 49508
Fbxl13
Name: F-box and leucine-rich repeat protein 13
Synonyms: 4921539K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320118
Homologene: 27057
Izumo3
Name: IZUMO family member 3
Synonyms: 1700011H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69314
Homologene: 122080
Lrrc10
Name: leucine rich repeat containing 10
Synonyms: D330003I11Rik, Hrlrrp, Serdin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237560
VEGA: 10
Homologene: 17154
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Or10x1
Name: olfactory receptor family 10 subfamily X member 1
Synonyms: GA_x6K02T2P20D-20787051-20786119, MOR267-11, Olfr417
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258238
Homologene: 17358
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628422
Vmn2r99
Name: vomeronasal 2, receptor 99
Synonyms: EG665376
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665376
Homologene: 115024
Slc10a1
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 1
Synonyms: sodium bile acid cotransporting polypeptide, Ntcp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20493
VEGA: 12
Homologene: 31126
Mrm1
Name: mitochondrial rRNA methyltransferase 1
Synonyms: A530065E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217038
Homologene: 40307
Vmn1r115
Name: vomeronasal 1 receptor 115
Synonyms: Gm8549
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 667273
Homologene: 104166
Adprhl1
Name: ADP-ribosylhydrolase like 1
Synonyms: Arh2, D330008N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234072
Homologene: 16311
Tnk2
Name: tyrosine kinase, non-receptor, 2
Synonyms: P21cdc42Hs kinase, Ack, activated p21cdc42Hs kinase, ACK1, Pyk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 51789
Homologene: 4224
Plekhg3
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Synonyms: MGC40768
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 263406
VEGA: 12
Homologene: 77478
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 625109
Homologene: 129606
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: THAM, Dpp-4, Cd26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 434117
Homologene: 113703
Tas2r136
Name: taste receptor, type 2, member 136
Synonyms: mt2r52, Tas2r36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353165
Homologene: 136304
Mcpt4
Name: mast cell protease 4
Synonyms: myonase, MMCP-4B, MMCP-4A, MMCP-4, Mcp-4, Mcp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 17227
VEGA: 14
Homologene: 130645
Ubxn6
Name: UBX domain protein 6
Synonyms: 2210415J11Rik, 1200008L11Rik, Ubxdc2, Ubxd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66530
Homologene: 11538
Dusp6
Name: dual specificity phosphatase 6
Synonyms: 1300019I03Rik, MKP-3, MKP3, PYST1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 67603
VEGA: 10
HGNC: HGNC:3072
Homologene: 55621
Atp10d
Name: ATPase, class V, type 10D
Synonyms: IMAGE:1069176, D5Buc24e, 9830145H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231287
Tex45
Name: testis expressed 45
Synonyms: 1700019B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76406
Homologene: 52367
Mrgprx3-ps
Name: MAS-related GPR, member X3, pseudogene
Synonyms: LOC269919, Gm660, Gm19419
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100502859
Gm12992
Name: predicted gene 12992
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 545681
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 174,369,474 bp
  • G to A, chromosome 2 at 26,319,831 bp
  • G to A, chromosome 2 at 62,387,140 bp
  • A to G, chromosome 2 at 76,725,776 bp
  • A to G, chromosome 2 at 91,167,587 bp
  • T to A, chromosome 2 at 107,295,373 bp
  • A to T, chromosome 3 at 19,966,353 bp
  • A to G, chromosome 3 at 36,958,681 bp
  • C to T, chromosome 3 at 51,250,335 bp
  • C to A, chromosome 3 at 55,197,002 bp
  • T to A, chromosome 3 at 108,043,328 bp
  • T to A, chromosome 3 at 114,108,316 bp
  • A to G, chromosome 4 at 55,012,672 bp
  • T to C, chromosome 4 at 92,146,899 bp
  • A to T, chromosome 4 at 123,810,087 bp
  • A to G, chromosome 4 at 131,900,228 bp
  • A to T, chromosome 5 at 21,582,053 bp
  • A to G, chromosome 5 at 72,264,179 bp
  • A to G, chromosome 5 at 76,542,019 bp
  • A to G, chromosome 5 at 121,350,481 bp
  • C to A, chromosome 6 at 132,778,009 bp
  • A to C, chromosome 7 at 10,050,308 bp
  • C to T, chromosome 7 at 20,844,282 bp
  • T to A, chromosome 7 at 41,861,936 bp
  • T to C, chromosome 7 at 47,309,998 bp
  • T to A, chromosome 7 at 49,398,109 bp
  • T to A, chromosome 8 at 3,483,529 bp
  • T to C, chromosome 8 at 13,246,114 bp
  • C to A, chromosome 10 at 86,055,592 bp
  • C to T, chromosome 10 at 99,263,924 bp
  • A to G, chromosome 10 at 117,045,814 bp
  • A to G, chromosome 10 at 130,452,600 bp
  • C to T, chromosome 11 at 68,385,910 bp
  • G to T, chromosome 11 at 84,819,228 bp
  • C to T, chromosome 11 at 118,025,168 bp
  • A to C, chromosome 12 at 76,577,764 bp
  • T to C, chromosome 12 at 80,958,132 bp
  • A to T, chromosome 14 at 56,060,536 bp
  • A to G, chromosome 15 at 99,470,733 bp
  • C to A, chromosome 16 at 8,708,914 bp
  • C to T, chromosome 16 at 32,669,501 bp
  • T to A, chromosome 17 at 19,379,260 bp
  • C to T, chromosome 17 at 20,959,497 bp
  • A to G, chromosome 17 at 23,810,468 bp
  • A to T, chromosome 17 at 56,069,303 bp
  • T to A, chromosome 19 at 47,071,014 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4413 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041136-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.