Strain Name:
C57BL/6J-MtgxR4017Btlr/Mmmh
Stock Number:
041611-MU
Citation ID:
RRID:MMRRC_041611-MU
Other Names:
R4017 (G1), C57BL/6J-MtgxR4017Btlr
Major Collection:

Gene Information

Dnm2
Name: dynamin 2
Synonyms: Dyn2, b2b2159Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 13430
HGNC: HGNC:2974
Homologene: 90883
Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: 2610028O16Rik, D11Ertd530e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 52615
Homologene: 32256
Npr1
Name: natriuretic peptide receptor 1
Synonyms: NPR-A, GC-A, NPRA, guanylyl cyclase-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18160
HGNC: HGNC:7943
Homologene: 37367
Ptch1
Name: patched 1
Synonyms: Ptc1, Patched 1, A230106A15Rik, wig, Ptc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP2, C330012H03Rik, IMP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 319765
Homologene: 4774
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 545085
VEGA: 15
Homologene: 9972
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: ARHGAP10, 5530401C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 71435
Homologene: 10822
BC004004
Name: cDNA sequence BC004004
Synonyms: 2400006G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 80748
Homologene: 12728
Aff1
Name: AF4/FMR2 family, member 1
Synonyms: Mllt2h, Af4, 9630032B01Rik, Rob
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 17355
HGNC: HGNC:7135
Homologene: 4340
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Kdm5a
Name: lysine (K)-specific demethylase 5A
Synonyms: Rbbp2, Jarid1a, RBP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Atf1
Name: activating transcription factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 11908
HGNC: HGNC:783
Homologene: 3790
Epb41
Name: erythrocyte membrane protein band 4.1
Synonyms: 4.1R, Elp1, Elp-1, D4Ertd442e, Epb4.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 269587
HGNC: HGNC:3377
Homologene: 44324
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: Dnec1, dynein heavy chain, retrograde transport, MAP1C, 9930018I23Rik, Swl, Loa, Dnchc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, skax26, Cd, ska26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, Dnahc7a, LOC381341
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 627872
Homologene: 41287
Arih2
Name: ariadne RBR E3 ubiquitin protein ligase 2
Synonyms: TRIAD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 23807
HGNC: HGNC:690
Homologene: 48424
Ppp6r1
Name: protein phosphatase 6, regulatory subunit 1
Synonyms: 2010309P17Rik, B430201G11Rik, Pp6r1, Saps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243819
Homologene: 86982
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: Pcn, Plc, perlecan, per
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Eif2a
Name: eukaryotic translation initiation factor 2A
Synonyms: D3Ertd194e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229317
HGNC: HGNC:3254
Homologene: 5969
Paf1
Name: Paf1, RNA polymerase II complex component
Synonyms: 5730511K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 54624
Homologene: 5441
Fnip1
Name: folliculin interacting protein 1
Synonyms: A730024A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216742
Homologene: 28173
Zfp940
Name: zinc finger protein 940
Synonyms: BC027344
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233057
HGNC: null
Homologene: 138421
Rnf157
Name: ring finger protein 157
Synonyms: 2610036E23Rik, A130073L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217340
Homologene: 28235
Trim9
Name: tripartite motif-containing 9
Synonyms: C030048G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 94090
VEGA: 12
Homologene: 9045
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: 3110001A05Rik, 3110027P15Rik, 1810064L21Rik, Ugcgl2, A230065J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 66435
Homologene: 56875
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2.3, 1110034K09Rik, Nax, Scn6a, Nav2, NaG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20272
Homologene: 55706
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Kif1a
Name: kinesin family member 1A
Synonyms: C630002N23Rik, ATSV, Kns1, LOC381283, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380698
Homologene: 70869
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, MUC9, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Klhl10
Name: kelch-like 10
Synonyms: 4921517C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 66720
Homologene: 12018
Actn3
Name: actinin alpha 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 11474
HGNC: HGNC:165
Homologene: 862
Saxo1
Name: stabilizer of axonemal microtubules 1
Synonyms: Fam154a, 4930500O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 75811
Homologene: 27548
Olfr748
Name: olfactory receptor 748
Synonyms: MOR106-9P, GA_x6K02T2PMLR-6454789-6455712
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258113
HGNC: null
Homologene: 134081
Apold1
Name: apolipoprotein L domain containing 1
Synonyms: LOC381823
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 381823
Homologene: 12781
Dctpp1
Name: dCTP pyrophosphatase 1
Synonyms: 2410015N17Rik, RS21-C6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 66422
Homologene: 11329
Olfr1112
Name: olfactory receptor 1112
Synonyms: MOR264-6, GA_x6K02T2Q125-48676316-48677272
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258655
HGNC: null
Homologene: 64901
Cpeb4
Name: cytoplasmic polyadenylation element binding protein 4
Synonyms: 4930447D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67579
Homologene: 12736
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 53,447,526 bp
  • T to C, chromosome 1 at 93,076,292 bp
  • G to T, chromosome 2 at 20,892,104 bp
  • A to G, chromosome 2 at 22,578,170 bp
  • GTGGCT to GT, chromosome 2 at 29,154,061 bp
  • A to G, chromosome 2 at 40,802,984 bp
  • A to T, chromosome 2 at 66,741,985 bp
  • A to G, chromosome 2 at 87,192,502 bp
  • T to A, chromosome 3 at 58,545,355 bp
  • T to C, chromosome 3 at 90,456,232 bp
  • A to T, chromosome 4 at 86,557,996 bp
  • A to T, chromosome 4 at 131,982,445 bp
  • C to A, chromosome 4 at 137,511,172 bp
  • T to C, chromosome 5 at 103,783,259 bp
  • T to A, chromosome 6 at 120,394,106 bp
  • G to T, chromosome 6 at 134,520,550 bp
  • A to G, chromosome 6 at 134,983,906 bp
  • C to A, chromosome 7 at 4,633,744 bp
  • G to A, chromosome 7 at 28,395,404 bp
  • T to C, chromosome 7 at 29,845,934 bp
  • G to A, chromosome 7 at 127,257,113 bp
  • G to A, chromosome 7 at 141,863,630 bp
  • A to G, chromosome 9 at 21,494,604 bp
  • A to G, chromosome 9 at 108,608,067 bp
  • A to G, chromosome 11 at 31,924,671 bp
  • A to G, chromosome 11 at 54,509,987 bp
  • A to G, chromosome 11 at 59,132,622 bp
  • G to T, chromosome 11 at 80,013,466 bp
  • G to A, chromosome 11 at 100,445,674 bp
  • A to T, chromosome 11 at 116,359,241 bp
  • G to A, chromosome 12 at 70,346,352 bp
  • G to T, chromosome 12 at 110,643,190 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • A to T, chromosome 14 at 50,710,876 bp
  • T to C, chromosome 14 at 119,026,433 bp
  • A to T, chromosome 15 at 8,079,214 bp
  • T to C, chromosome 15 at 100,232,718 bp
  • T to C, chromosome 16 at 22,063,676 bp
  • T to C, chromosome 17 at 29,298,732 bp
  • G to T, chromosome 19 at 4,867,546 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4017 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041611-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.