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Strain Name:
C57BL/6J-MtgxR4091Btlr/Mmmh
Stock Number:
041626-MU
Citation ID:
RRID:MMRRC_041626-MU
Other Names:
R4091 (G1), C57BL/6J-MtgxR4091Btlr
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Nsmf
Name: NMDA receptor synaptonuclear signaling and neuronal migration factor
Synonyms: Jacob, Nelf
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56876
Homologene: 10648
Gpr37l1
Name: G protein-coupled receptor 37-like 1
Synonyms: CAG-18, D0Kist8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171469
Homologene: 3500
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Lcat
Name: lecithin cholesterol acyltransferase
Synonyms: D8Wsu61e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16816
HGNC: HGNC:6522
Homologene: 68042
Dnajc11
Name: DnaJ heat shock protein family (Hsp40) member C11
Synonyms: E030019A03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230935
Homologene: 14558
Smarcc1
Name: SWI/SNF related BAF chromatin remodeling complex subunit C1
Synonyms: BAF155, SRG3, msp3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20588
Homologene: 68296
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,147,663 bp
  • C to T, chromosome 1 at 132,937,652 bp
  • T to C, chromosome 1 at 135,161,563 bp
  • A to T, chromosome 1 at 188,995,720 bp
  • T to C, chromosome 2 at 25,060,859 bp
  • G to A, chromosome 2 at 43,679,872 bp
  • T to A, chromosome 2 at 60,432,593 bp
  • T to C, chromosome 2 at 68,745,378 bp
  • T to A, chromosome 2 at 131,133,488 bp
  • G to A, chromosome 3 at 37,030,589 bp
  • A to T, chromosome 3 at 79,644,761 bp
  • C to A, chromosome 4 at 32,643,611 bp
  • A to G, chromosome 4 at 43,665,987 bp
  • A to G, chromosome 4 at 151,978,093 bp
  • C to A, chromosome 4 at 152,547,018 bp
  • C to G, chromosome 5 at 13,796,380 bp
  • A to C, chromosome 5 at 109,054,750 bp
  • T to C, chromosome 5 at 117,383,415 bp
  • T to C, chromosome 6 at 3,376,887 bp
  • G to T, chromosome 6 at 87,463,035 bp
  • G to A, chromosome 6 at 110,914,340 bp
  • T to A, chromosome 7 at 24,420,867 bp
  • T to A, chromosome 7 at 44,632,991 bp
  • G to A, chromosome 7 at 108,868,443 bp
  • C to A, chromosome 7 at 127,905,418 bp
  • G to A, chromosome 8 at 70,165,102 bp
  • A to G, chromosome 8 at 88,806,691 bp
  • A to G, chromosome 8 at 105,939,906 bp
  • A to G, chromosome 9 at 7,131,881 bp
  • T to A, chromosome 9 at 39,258,034 bp
  • A to T, chromosome 9 at 70,634,060 bp
  • T to A, chromosome 9 at 79,702,364 bp
  • T to A, chromosome 9 at 99,464,527 bp
  • G to T, chromosome 9 at 106,241,801 bp
  • T to A, chromosome 9 at 110,164,829 bp
  • T to A, chromosome 10 at 12,710,171 bp
  • G to A, chromosome 10 at 81,565,584 bp
  • C to T, chromosome 10 at 123,038,510 bp
  • A to T, chromosome 10 at 130,391,369 bp
  • G to A, chromosome 11 at 50,291,829 bp
  • T to C, chromosome 11 at 102,839,416 bp
  • A to G, chromosome 12 at 4,855,279 bp
  • T to C, chromosome 12 at 40,844,267 bp
  • G to A, chromosome 12 at 104,116,366 bp
  • A to T, chromosome 13 at 12,231,057 bp
  • T to A, chromosome 13 at 19,729,465 bp
  • A to G, chromosome 14 at 31,036,003 bp
  • T to G, chromosome 14 at 33,125,880 bp
  • T to A, chromosome 14 at 51,415,426 bp
  • A to T, chromosome 14 at 66,029,723 bp
  • CT to CTTGGATT, chromosome 15 at 10,537,562 bp
  • G to A, chromosome 15 at 10,537,566 bp
  • A to T, chromosome 16 at 4,634,640 bp
  • T to A, chromosome 17 at 20,735,516 bp
  • C to T, chromosome 17 at 24,397,482 bp
  • T to C, chromosome 17 at 30,769,839 bp
  • A to G, chromosome 18 at 36,366,547 bp
  • C to T, chromosome 19 at 4,171,683 bp
  • T to A, chromosome 19 at 6,473,414 bp
  • C to T, chromosome 19 at 8,404,545 bp
  • A to T, chromosome 19 at 12,209,779 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4091 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041626-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.