Strain Name:
C57BL/6J-MtgxR4490Btlr/Mmmh
Stock Number:
041746-MU
Citation ID:
RRID:MMRRC_041746-MU
Other Names:
R4490 (G1), C57BL/6J-MtgxR4490Btlr
Major Collection:

Gene Information

Abl2
Name: v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
Synonyms: Arg, Abll
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11352
HGNC: HGNC:77
Homologene: 5278
Gpr55
Name: G protein-coupled receptor 55
Synonyms: LOC227326, CTFL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227326
HGNC: HGNC:4511
Homologene: 36184
Rxra
Name: retinoid X receptor alpha
Synonyms: 9530071D11Rik, RXR alpha 1, RXRalpha1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20181
Homologene: 2220
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: C030045D06Rik, Depdc2, 6230420N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109294
Homologene: 23523
Kpnb1
Name: karyopherin (importin) beta 1
Synonyms: Impnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16211
HGNC: HGNC:6400
Homologene: 1707
Cog6
Name: component of oligomeric golgi complex 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67542
Homologene: 10802
Dmtf1
Name: cyclin D binding myb-like transcription factor 1
Synonyms: Dmp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 23857
Homologene: 8017
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRTe, SMRT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Nckap5l
Name: NCK-associated protein 5-like
Synonyms: C230021P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 380969
Homologene: 18924
Pgm3
Name: phosphoglucomutase 3
Synonyms: 2810473H05Rik, GlcNAc-P mutase, Pgm-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 109785
HGNC: HGNC:8907
Homologene: 9205
Adgrb2
Name: adhesion G protein-coupled receptor B2
Synonyms: Bai2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230775
HGNC: HGNC:944
Homologene: 1288
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: Mtmr15, 6030441H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330554
Homologene: 45598
Crmp1
Name: collapsin response mediator protein 1
Synonyms: DRP-1, Ulip3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12933
HGNC: HGNC:2365
Homologene: 20347
Atad1
Name: ATPase family, AAA domain containing 1
Synonyms: Thorase, 4921525H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67979
VEGA: 19
Homologene: 5960
Dapk1
Name: death associated protein kinase 1
Synonyms: DAP-Kinase, 2810425C21Rik, D13Ucla1, 2310039H24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Prdm4
Name: PR domain containing 4
Synonyms: 1700031E19Rik, 2810470D21Rik, SC1, SC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72843
VEGA: 10
HGNC: HGNC:9348
Homologene: 8235
Tsc1
Name: TSC complex subunit 1
Synonyms: tuberous sclerosis 1, hamartin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64930
Homologene: 314
Gm14325
Name: predicted gene 14325
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329575
Homologene: 134324
Klb
Name: klotho beta
Synonyms: betaKlotho
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 83379
Homologene: 12820
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: LOC380889, Hdhc3, HL-19, DLP12, HL19, DHC3, 4921531P07Rik, Dnahc12, Dnahc7l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Prdm1
Name: PR domain containing 1, with ZNF domain
Synonyms: Blimp1, b2b1765Clo, Blimp-1, PRDI-BF1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12142
HGNC: HGNC:9346
Homologene: 925
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: Mlsn1, LTRPC1, 4732499L03Rik, melastatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Cngb3
Name: cyclic nucleotide gated channel beta 3
Synonyms: Cngbeta2, CCNC2, CNG6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 30952
HGNC: HGNC:2153
Homologene: 40908
Impg1
Name: interphotoreceptor matrix proteoglycan 1
Synonyms: SPACR, IMP150, A930015H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 63859
HGNC: HGNC:6055
Homologene: 1201
Rin2
Name: Ras and Rab interactor 2
Synonyms: 2010003K16Rik, RASSF4, 4632403N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74030
Homologene: 32430
Usp29
Name: ubiquitin specific peptidase 29
Synonyms: Ocat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57775
Homologene: 49641
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56552
Homologene: 135915
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239420
Homologene: 65982
Elmod3
Name: ELMO/CED-12 domain containing 3
Synonyms: RBM29, Rbed1, ELMOD3, C330008I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232089
Homologene: 12978
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: 8430408C20Rik, ATP6a2, V-ATPase a2, Atp6n2, Tj6, TJ6s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21871
Homologene: 56523
Ranbp6
Name: RAN binding protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 240614
HGNC: HGNC:9851
Homologene: 18935
Ccndbp1
Name: cyclin D-type binding-protein 1
Synonyms: GCIP, DIP1, stage specific embryonic cDNA-8, Maid, SSEC-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17151
HGNC: HGNC:1587
Homologene: 7826
Herc6
Name: hect domain and RLD 6
Synonyms: CEB1, Herc5, 4930427L17Rik, 2510038N07Rik, 1700121D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67138
Homologene: 70768
Spice1
Name: spindle and centriole associated protein 1
Synonyms: D16Ertd480e, Ccdc52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212514
Homologene: 16931
Gbp2
Name: guanylate binding protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14469
HGNC: HGNC:4183
Homologene: 10289
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: Kv12.1, ELK1, C130090D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 211468
Homologene: 14332
Far2
Name: fatty acyl CoA reductase 2
Synonyms: Mlstd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330450
Homologene: 69247
Arl5c
Name: ADP-ribosylation factor-like 5C
Synonyms: Arl12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217151
Homologene: 28456
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: 2610204M08Rik, EG629699
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Irgm1
Name: immunity-related GTPase family M member 1
Synonyms: Irgm, Ifi1, LRG-47, Iigp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15944
Homologene: 134089
Cage1
Name: cancer antigen 1
Synonyms: 4933427I01Rik, CAGE1, Ctag3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71213
Homologene: 18484
Zfp9
Name: zinc finger protein 9
Synonyms: 1810048F22Rik, Zfp-9, Krox-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22750
Homologene: 49280
Olfr32
Name: olfactory receptor 32
Synonyms: MOR227-7P, MTPCR05, GA_x6K02T2Q125-51573576-51572650, MOR227-9_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18331
HGNC: HGNC:8290
Homologene: 110550
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,162,263 bp
  • C to T, chromosome 1 at 85,941,818 bp
  • T to C, chromosome 1 at 156,633,779 bp
  • T to C, chromosome 1 at 164,217,395 bp
  • G to T, chromosome 2 at 27,741,195 bp
  • A to G, chromosome 2 at 28,670,925 bp
  • A to T, chromosome 2 at 90,138,917 bp
  • A to G, chromosome 2 at 121,012,395 bp
  • A to G, chromosome 2 at 145,822,274 bp
  • T to C, chromosome 2 at 177,832,983 bp
  • C to T, chromosome 3 at 52,992,842 bp
  • A to G, chromosome 3 at 142,623,764 bp
  • T to C, chromosome 4 at 19,415,684 bp
  • T to C, chromosome 4 at 130,012,328 bp
  • A to G, chromosome 5 at 9,140,379 bp
  • A to G, chromosome 5 at 37,276,331 bp
  • A to G, chromosome 5 at 65,375,794 bp
  • T to C, chromosome 5 at 124,646,734 bp
  • A to G, chromosome 5 at 125,036,815 bp
  • A to T, chromosome 6 at 57,654,495 bp
  • T to C, chromosome 6 at 72,587,620 bp
  • A to G, chromosome 6 at 118,465,312 bp
  • T to C, chromosome 6 at 124,050,738 bp
  • T to C, chromosome 6 at 148,173,409 bp
  • T to C, chromosome 7 at 6,961,950 bp
  • C to T, chromosome 7 at 64,208,912 bp
  • A to T, chromosome 7 at 64,369,180 bp
  • T to A, chromosome 9 at 80,394,059 bp
  • T to C, chromosome 9 at 86,561,840 bp
  • G to T, chromosome 10 at 44,446,907 bp
  • A to T, chromosome 10 at 85,900,899 bp
  • G to A, chromosome 11 at 48,866,128 bp
  • A to G, chromosome 11 at 97,171,598 bp
  • G to A, chromosome 11 at 97,995,836 bp
  • T to C, chromosome 12 at 112,600,204 bp
  • A to G, chromosome 13 at 38,023,417 bp
  • A to G, chromosome 13 at 60,718,128 bp
  • T to C, chromosome 14 at 26,734,603 bp
  • C to T, chromosome 15 at 48,314,033 bp
  • G to A, chromosome 15 at 99,426,130 bp
  • T to C, chromosome 16 at 44,382,113 bp
  • T to C, chromosome 17 at 52,961,877 bp
  • A to G, chromosome 19 at 29,810,333 bp
  • A to G, chromosome 19 at 32,695,797 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4490 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041746-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.