Strain Name:
C57BL/6J-MtgxR4730Btlr/Mmmh
Stock Number:
041990-MU
Citation ID:
RRID:MMRRC_041990-MU
Other Names:
R4730 (G1), C57BL/6J-MtgxR4730Btlr
Major Collection:

Strain Information

Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: 2610028O16Rik, D11Ertd530e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52615
Homologene: 32256
Prrx1
Name: paired related homeobox 1
Synonyms: K-2, Prx1, mHox, Pmx1, mHox, A230024N07Rik, MHox1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18933
HGNC: HGNC:9142
Homologene: 7896
P4htm
Name: prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Synonyms: 4933406E20Rik, P4h-tm
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74443
Homologene: 41765
Strn4
Name: striatin, calmodulin binding protein 4
Synonyms: ZIN, zinedin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 97387
Homologene: 8378
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: MTK1, MAPKKK4, D17Rp17, RP17, D17Rp17e, Mekk4, T-associated sex reversal, Tas
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Slc4a2
Name: solute carrier family 4 (anion exchanger), member 2
Synonyms: B3RP, Ae2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20535
Homologene: 128699
Aff1
Name: AF4/FMR2 family, member 1
Synonyms: Af4, Rob, 9630032B01Rik, Mllt2h
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17355
HGNC: HGNC:7135
Homologene: 4340
Lin9
Name: lin-9 DREAM MuvB core complex component
Synonyms: 2700022J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72568
Homologene: 35252
Ptprg
Name: protein tyrosine phosphatase receptor type G
Synonyms: 5430405N12Rik, RPTPgamma
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19270
HGNC: HGNC:9671
Homologene: 2129
Usp53
Name: ubiquitin specific peptidase 53
Synonyms: Sp6, Phxr3, mbo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99526
Homologene: 34521
Nfrkb
Name: nuclear factor related to kappa B binding protein
Synonyms: A530090G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235134
HGNC: HGNC:7802
Homologene: 4492
Sh3d19
Name: SH3 domain protein D19
Synonyms: Kryn
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 27059
Homologene: 19064
Trim66
Name: tripartite motif-containing 66
Synonyms: D7H11orf29, Tif1d
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330627
Homologene: 28044
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: C730024G01Rik, 2700017A04Rik, Brctx, Brctd1, Ankrd32
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105377
Homologene: 13000
Dab1
Name: disabled 1
Synonyms: C630028C02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13131
HGNC: HGNC:2661
Homologene: 32084
Syt14
Name: synaptotagmin XIV
Synonyms: B230320I09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329324
Homologene: 17719
Setd1a
Name: SET domain containing 1A
Synonyms: KMT2F
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233904
Homologene: 52251
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 386750
Homologene: 8955
Nucb1
Name: nucleobindin 1
Synonyms: MTEST82, B230337F23Rik, Calnuc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18220
HGNC: HGNC:8043
Homologene: 4507
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Rnf4
Name: ring finger protein 4
Synonyms: Gtrgeo8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19822
Homologene: 37711
Pigk
Name: phosphatidylinositol glycan anchor biosynthesis, class K
Synonyms: 3000001O05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329777
HGNC: HGNC:8965
Homologene: 4002
Hmg20a
Name: high mobility group 20A
Synonyms: 1200004E06Rik, 5730490E10Rik, Hmgxb1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66867
VEGA: 9
HGNC: HGNC:5001
Homologene: 32399
Nav1
Name: neuron navigator 1
Synonyms: POMFIL3, 9930003A20Rik, C230080M11Rik, unc53H1, steerin-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215690
Homologene: 10719
Tubgcp3
Name: tubulin, gamma complex component 3
Synonyms: Spc98p, GCP3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 259279
Homologene: 4609
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Arhgef28
Name: Rho guanine nucleotide exchange factor 28
Synonyms: RIP2, RhoGEF, Rho specific exchange factor, D13Bwg1089e, 9230110L08Rik, p190RhoGEF, Rgnef
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Or5t17
Name: olfactory receptor family 5 subfamily T member 17
Synonyms: GA_x6K02T2Q125-48487992-48488966, MOR179-4, Olfr1102
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228228
Homologene: 88426
Ulk4
Name: unc-51-like kinase 4
Synonyms: 4932415A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 209012
Homologene: 41205
Duox1
Name: dual oxidase 1
Synonyms: NOXEF1, THOX1, LNOX1, 9930101G15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99439
HGNC: HGNC:3062
Homologene: 68136
Syna
Name: syncytin a
Synonyms: syncytin-A, Gm52
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 214292
Homologene: 86751
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382090
Homologene: 8930
Col4a2
Name: collagen, type IV, alpha 2
Synonyms: Col4a-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12827
HGNC: HGNC:2203
Homologene: 1390
Obox6
Name: oocyte specific homeobox 6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252830
Bbs10
Name: Bardet-Biedl syndrome 10
Synonyms: 1300007O09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71769
VEGA: 10
Homologene: 49781
Sytl2
Name: synaptotagmin-like 2
Synonyms: Slp2-a, Slp2, Slp2-d, Slp2-c, Slp2-b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83671
Homologene: 131343
Gzmc
Name: granzyme C
Synonyms: CCP2, Ctla-5, Ctla5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14940
VEGA: 14
HGNC: HGNC:4709
Homologene: 105844
Engase
Name: endo-beta-N-acetylglucosaminidase
Synonyms: D230014K01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217364
Homologene: 13666
Phtf1
Name: putative homeodomain transcription factor 1
Synonyms: Phft
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18685
HGNC: HGNC:8939
Homologene: 4817
Gucy1b2
Name: guanylate cyclase 1, soluble, beta 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239134
HGNC: HGNC:4686
Homologene: 136630
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: brm, Snf2l2, 2610209L14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67155
Homologene: 2308
Plxnc1
Name: plexin C1
Synonyms: vespr, 2510048K12Rik, CD232
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Grip2
Name: glutamate receptor interacting protein 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243547
Homologene: 16327
Tmprss11g
Name: transmembrane protease, serine 11g
Synonyms: 9930032O22Rik, Desc4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320454
Homologene: 82239
Or6c33
Name: olfactory receptor family 6 subfamily C member 33
Synonyms: GA_x6K02T2PULF-11688441-11689379, MOR116-1, Olfr820
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258670
Homologene: 17337
Lrfn5
Name: leucine rich repeat and fibronectin type III domain containing 5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238205
Homologene: 17582
Mtif2
Name: mitochondrial translational initiation factor 2
Synonyms: IF-2mt, 2410112O06Rik, 2310038D14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76784
HGNC: HGNC:7441
Homologene: 1840
Edem2
Name: ER degradation enhancer, mannosidase alpha-like 2
Synonyms: 9530090G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108687
Homologene: 10075
Spon1
Name: spondin 1, (f-spondin) extracellular matrix protein
Synonyms: D330035F22Rik, FSP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233744
Homologene: 4453
Or9g19
Name: olfactory receptor family 9 subfamily G member 19
Synonyms: GA_x6K02T2Q125-47248551-47249468, MOR213-2, Olfr1013
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258757
Homologene: 74096
Sgpp1
Name: sphingosine-1-phosphate phosphatase 1
Synonyms: mSPP1, SPP1, SPP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 81535
VEGA: 12
Homologene: 101696
Scarf2
Name: scavenger receptor class F, member 2
Synonyms: Srec2, SREC-II
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224024
VEGA: 16
Homologene: 17817
Phb2
Name: prohibitin 2
Synonyms: Bap37, Bcap37, repressor of estrogen receptor activity, REA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12034
Homologene: 5263
Hs3st1
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 1
Synonyms: 3-OST, D5Wsu110e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15476
HGNC: HGNC:5194
Homologene: 3751
Esp4
Name: exocrine gland secreted peptide 4
Synonyms: Gm20580
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100126777
VEGA: 17
Homologene: 136356
Or5k1b
Name: olfactory receptor family 5 subfamily K member 1B
Synonyms: GA_x54KRFPKG5P-54930346-54929417, MOR184-2, Olfr172
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259003
Homologene: 45084
Or5g25
Name: olfactory receptor family 5 subfamily G member 25
Synonyms: GA_x6K02T2Q125-47127746-47126790, MOR175-2, Olfr1002
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258566
Homologene: 104131
Gm3867
Name: predicted gene 3867
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 105244994
Runx1t1
Name: RUNX1 translocation partner 1
Synonyms: ETO, MTG8, Cbfa2t1h
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12395
HGNC: HGNC:1535
Homologene: 3801
Vmn1r91
Name: vomeronasal 1 receptor 91
Synonyms: Gm8442
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667067
Homologene: 104166
Gm6818
Name: predicted gene 6818
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 627975
Homologene: 80005
Gm4705
Name: predicted gene 4705
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100043876
Homologene: 105146
Kcnk13
Name: potassium channel, subfamily K, member 13
Synonyms: LOC381712, LOC380778, F730021E22Rik, THIK-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217826
HGNC: HGNC:6275
Homologene: 69351
Ighv1-26
Name: immunoglobulin heavy variable 1-26
Synonyms: Gm16717
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629884
Gm15591
Name: predicted gene 15591
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Lta
Name: lymphotoxin A
Synonyms: lymphotoxin alpha, LT-[a], LT-alpha, LT[a], TNF-beta, LT, TNF beta, lymphotoxin, Tnfb, Tnfsf1b, LTalpha, Ltx, hlb382
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16992
HGNC: HGNC:6709
Homologene: 497
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 135,607,311 bp
  • A to G, chromosome 1 at 163,312,613 bp
  • T to A, chromosome 1 at 180,665,851 bp
  • C to T, chromosome 1 at 192,930,786 bp
  • T to C, chromosome 2 at 85,647,992 bp
  • G to T, chromosome 2 at 85,770,061 bp
  • C to T, chromosome 2 at 87,002,166 bp
  • T to G, chromosome 2 at 122,333,831 bp
  • T to C, chromosome 2 at 155,705,698 bp
  • G to T, chromosome 3 at 73,049,519 bp
  • T to A, chromosome 3 at 86,116,864 bp
  • G to T, chromosome 3 at 103,987,435 bp
  • T to C, chromosome 3 at 122,962,933 bp
  • C to T, chromosome 3 at 152,742,566 bp
  • C to T, chromosome 4 at 13,837,830 bp
  • C to T, chromosome 4 at 104,731,751 bp
  • C to T, chromosome 5 at 24,434,880 bp
  • G to T, chromosome 5 at 34,350,803 bp
  • A to T, chromosome 5 at 39,614,805 bp
  • G to T, chromosome 5 at 86,489,232 bp
  • A to T, chromosome 5 at 86,489,233 bp
  • A to G, chromosome 5 at 103,843,073 bp
  • T to A, chromosome 5 at 134,558,586 bp
  • T to C, chromosome 6 at 91,785,712 bp
  • T to C, chromosome 6 at 124,713,123 bp
  • A to T, chromosome 7 at 15,834,813 bp
  • A to G, chromosome 7 at 16,828,794 bp
  • A to T, chromosome 7 at 20,101,770 bp
  • C to T, chromosome 7 at 38,402,494 bp
  • G to A, chromosome 7 at 45,495,276 bp
  • A to G, chromosome 7 at 90,381,249 bp
  • A to G, chromosome 7 at 109,483,069 bp
  • A to G, chromosome 7 at 114,033,071 bp
  • A to G, chromosome 7 at 127,797,330 bp
  • A to G, chromosome 8 at 11,437,590 bp
  • T to C, chromosome 8 at 12,657,654 bp
  • G to A, chromosome 8 at 15,931,146 bp
  • A to T, chromosome 8 at 45,033,477 bp
  • T to C, chromosome 9 at 31,410,251 bp
  • T to A, chromosome 9 at 36,257,254 bp
  • T to A, chromosome 9 at 56,467,419 bp
  • A to G, chromosome 9 at 87,244,342 bp
  • A to G, chromosome 9 at 108,579,772 bp
  • T to C, chromosome 9 at 121,263,725 bp
  • G to A, chromosome 10 at 94,867,468 bp
  • A to G, chromosome 10 at 111,301,134 bp
  • G to A, chromosome 10 at 130,017,547 bp
  • T to A, chromosome 11 at 29,540,834 bp
  • T to C, chromosome 11 at 80,002,162 bp
  • A to G, chromosome 11 at 118,482,922 bp
  • C to T, chromosome 12 at 61,840,719 bp
  • A to G, chromosome 12 at 75,734,939 bp
  • A to G, chromosome 12 at 100,061,715 bp
  • A to G, chromosome 12 at 114,788,789 bp
  • T to C, chromosome 13 at 77,046,632 bp
  • C to T, chromosome 13 at 97,978,142 bp
  • G to A, chromosome 14 at 12,213,713 bp
  • C to T, chromosome 14 at 56,231,632 bp
  • A to G, chromosome 14 at 62,407,759 bp
  • A to G, chromosome 16 at 17,803,013 bp
  • C to T, chromosome 16 at 32,751,214 bp
  • A to G, chromosome 16 at 45,737,013 bp
  • T to C, chromosome 16 at 58,760,742 bp
  • T to A, chromosome 17 at 12,248,974 bp
  • C to T, chromosome 17 at 35,204,089 bp
  • A to C, chromosome 17 at 40,602,554 bp
  • C to A, chromosome 17 at 40,602,555 bp
  • G to T, chromosome 17 at 66,413,774 bp
  • A to G, chromosome 19 at 26,630,673 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4730 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
041990-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.