Strain Name:
C57BL/6J-MtgxR4384Btlr/Mmmh
Stock Number:
042002-MU
Citation ID:
RRID:MMRRC_042002-MU
Other Names:
R4384 (G1), C57BL/6J-MtgxR4384Btlr
Major Collection:

Gene Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: D0Jmb2, E030044M24Rik, NMHC II-A, Myhn1, Myhn-1, myosin IIA, Fltn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Rubcn
Name: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
Synonyms: 1700021K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 100502698
Homologene: 15687
Gad2
Name: glutamic acid decarboxylase 2
Synonyms: GAD65, Gad-2, 6330404F12Rik, GAD(65)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14417
HGNC: HGNC:4093
Homologene: 20223
Med1
Name: mediator complex subunit 1
Synonyms: TRAP 220, TRAP220, CRSP210, DRIP205, Pparbp, l11Jus15, PBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Arhgef10
Name: Rho guanine nucleotide exchange factor (GEF) 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234094
Homologene: 22827
Eps8
Name: epidermal growth factor receptor pathway substrate 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13860
HGNC: HGNC:3420
Homologene: 3272
Adam23
Name: a disintegrin and metallopeptidase domain 23
Synonyms: MDC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 23792
HGNC: HGNC:202
Homologene: 2826
Esrrg
Name: estrogen-related receptor gamma
Synonyms: estrogen-related receptor 3, ERR3, Errg, NR3B3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26381
HGNC: HGNC:3474
Homologene: 55581
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm, Shrm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 27428
Homologene: 9263
Csnk1g1
Name: casein kinase 1, gamma 1
Synonyms: 9130020E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214897
HGNC: HGNC:2454
Homologene: 48692
Ncapg2
Name: non-SMC condensin II complex, subunit G2
Synonyms: 5830426I05Rik, Mtb, Luzp5, mCAP-G2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 76044
VEGA: 12
Homologene: 9820
Trpc4ap
Name: transient receptor potential cation channel, subfamily C, member 4 associated protein
Synonyms: Trp4-associated protein TAP1, Trrp4ap, D2Ertd113e, 4833429F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56407
Homologene: 9224
Gpat4
Name: glycerol-3-phosphate acyltransferase 4
Synonyms: Agpat6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102247
Homologene: 32425
Set
Name: SET nuclear oncogene
Synonyms: StF-IT-1, 5730420M11Rik, 2610030F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56086
Homologene: 55707
Sdad1
Name: SDA1 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231452
Homologene: 6036
Mdm2
Name: transformed mouse 3T3 cell double minute 2
Synonyms: Mdm-2, 1700007J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17246
HGNC: HGNC:6973
Homologene: 1793
Dennd4c
Name: DENN/MADD domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329877
Homologene: 23057
Sdha
Name: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Synonyms: SDHF, SDH2, FP, 2310034D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66945
Homologene: 3073
E2f8
Name: E2F transcription factor 8
Synonyms: 4432406C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108961
Homologene: 11654
Ddias
Name: DNA damage-induced apoptosis suppressor
Synonyms: noxin, 4632434I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74041
Homologene: 51655
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Sema4d
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Synonyms: semaphorin H, M-sema G, coll-4, CD100, Semcl2, Semaj, Semacl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20354
Homologene: 21282
Slc6a11
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Synonyms: GAT4, D930045G19Rik, E130202I16Rik, Gabt4, Gat3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243616
Homologene: 129935
Klhl12
Name: kelch-like 12
Synonyms: C3ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240756
Homologene: 23317
Gpr12
Name: G-protein coupled receptor 12
Synonyms: Gpcr20, Gpcr12, Gpcr01
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14738
HGNC: HGNC:4466
Homologene: 3868
Boc
Name: biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 117606
Homologene: 32819
Luc7l
Name: Luc7-like
Synonyms: 2410018D03Rik, 1810045C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66978
HGNC: HGNC:6723
Homologene: 100558
Tm9sf3
Name: transmembrane 9 superfamily member 3
Synonyms: 2810031D16Rik, 1810073M23Rik, Smbp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107358
VEGA: 19
Homologene: 10588
Stard3nl
Name: STARD3 N-terminal like
Synonyms: 0610035N01Rik, 6530409L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76205
Homologene: 11501
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: 4930429G18Rik, C030002J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 78787
Homologene: 90902
Nmd3
Name: NMD3 ribosome export adaptor
Synonyms: C87860
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 97112
Homologene: 6127
Brip1
Name: BRCA1 interacting protein C-terminal helicase 1
Synonyms: BACH1, 8030460J03Rik, 3110009N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237911
Homologene: 32766
Trpm2
Name: transient receptor potential cation channel, subfamily M, member 2
Synonyms: Trrp7, LTRPC2, TRPC7, 9830168K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 28240
Homologene: 20709
Trpc1
Name: transient receptor potential cation channel, subfamily C, member 1
Synonyms: Trrp1, Trp1, Mtrp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22063
Homologene: 2478
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22371
Homologene: 466
Frmd4a
Name: FERM domain containing 4A
Synonyms: C230040M21Rik, 2700017I06Rik, Gm13190
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209630
Homologene: 9971
Zfp329
Name: zinc finger protein 329
Synonyms: 2810439M05Rik, 4632409L22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67230
Homologene: 23459
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268527
Homologene: 8780
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: B830017A01Rik, 3110047P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319807
Homologene: 14974
Vmn2r27
Name: vomeronasal 2, receptor27
Synonyms: EG232367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232367
Calr3
Name: calreticulin 3
Synonyms: Crt2, 1700031L01Rik, 6330586I20Rik, calsperin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73316
Homologene: 57091
Rwdd3
Name: RWD domain containing 3
Synonyms: 3110037C01Rik, 2510027J23Rik, RSUME
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66568
Homologene: 22899
Meikin
Name: meiotic kinetochore factor
Synonyms: 4930404A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74847
Homologene: 54900
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, A230044C21Rik, Caps2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320405
Homologene: 23060
Zfp616
Name: zinc finger protein 616
Synonyms: Gm12330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327963
Homologene: 88945
Tada3
Name: transcriptional adaptor 3
Synonyms: ADA3, 1110004B19Rik, Tada3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101206
Homologene: 4633
Cntnap3
Name: contactin associated protein-like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238680
VEGA: 13
Homologene: 129602
Mylip
Name: myosin regulatory light chain interacting protein
Synonyms: Mir, 9430057C20Rik, Idol
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218203
VEGA: 13
Homologene: 8309
Acer2
Name: alkaline ceramidase 2
Synonyms: 2410116I05Rik, Asah3l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230379
Homologene: 14986
Olfr912
Name: olfactory receptor 912
Synonyms: GA_x6K02T2PVTD-32283590-32284522, MOR165-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258806
VEGA: 9
Homologene: 115510
Olfr341
Name: olfactory receptor 341
Synonyms: GA_x6K02T2NLDC-33174915-33173974, MOR136-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258952
Homologene: 74160
Marchf2
Name: membrane associated ring-CH-type finger 2
Synonyms: 9530046H09Rik, March2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224703
Homologene: 9539
Tvp23a
Name: trans-golgi network vesicle protein 23A
Synonyms: Fam18a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 383103
Homologene: 19919
E030018B13Rik
Name: RIKEN cDNA E030018B13 gene
Synonyms: LOC381994
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381994
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 63,566,628 bp
  • T to G, chromosome 1 at 134,487,654 bp
  • G to A, chromosome 1 at 188,043,711 bp
  • C to T, chromosome 2 at 4,594,563 bp
  • G to A, chromosome 2 at 22,685,410 bp
  • A to G, chromosome 2 at 30,069,014 bp
  • A to G, chromosome 2 at 36,479,998 bp
  • A to G, chromosome 2 at 155,640,507 bp
  • T to C, chromosome 3 at 69,724,398 bp
  • T to C, chromosome 3 at 121,158,757 bp
  • A to G, chromosome 4 at 86,811,450 bp
  • T to A, chromosome 4 at 86,874,568 bp
  • T to A, chromosome 5 at 63,806,571 bp
  • T to C, chromosome 5 at 92,298,257 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • G to T, chromosome 5 at 146,583,105 bp
  • T to A, chromosome 6 at 23,412,988 bp
  • G to T, chromosome 6 at 113,370,379 bp
  • A to G, chromosome 6 at 114,247,727 bp
  • A to G, chromosome 6 at 124,224,156 bp
  • T to A, chromosome 6 at 125,655,116 bp
  • T to A, chromosome 6 at 137,499,592 bp
  • G to A, chromosome 7 at 12,811,657 bp
  • G to A, chromosome 7 at 48,867,099 bp
  • A to G, chromosome 7 at 63,919,393 bp
  • G to A, chromosome 7 at 92,858,223 bp
  • T to A, chromosome 8 at 14,930,157 bp
  • A to G, chromosome 8 at 23,174,586 bp
  • T to A, chromosome 8 at 72,428,164 bp
  • T to C, chromosome 9 at 38,582,053 bp
  • T to C, chromosome 9 at 66,019,908 bp
  • C to A, chromosome 9 at 95,732,108 bp
  • A to G, chromosome 10 at 77,917,725 bp
  • T to C, chromosome 10 at 117,696,439 bp
  • C to T, chromosome 11 at 54,417,787 bp
  • G to T, chromosome 11 at 74,083,179 bp
  • A to T, chromosome 11 at 86,148,429 bp
  • G to A, chromosome 11 at 98,152,862 bp
  • A to G, chromosome 12 at 16,682,330 bp
  • T to C, chromosome 12 at 116,439,877 bp
  • T to C, chromosome 13 at 11,605,233 bp
  • A to T, chromosome 13 at 19,370,457 bp
  • T to C, chromosome 13 at 45,389,958 bp
  • A to G, chromosome 13 at 51,702,883 bp
  • A to G, chromosome 13 at 64,748,460 bp
  • A to T, chromosome 13 at 74,326,985 bp
  • A to T, chromosome 14 at 20,550,085 bp
  • A to T, chromosome 15 at 77,791,712 bp
  • A to G, chromosome 16 at 10,428,682 bp
  • T to A, chromosome 16 at 14,142,641 bp
  • A to G, chromosome 16 at 32,856,902 bp
  • A to T, chromosome 16 at 44,491,182 bp
  • T to A, chromosome 16 at 96,709,216 bp
  • T to C, chromosome 17 at 26,279,962 bp
  • C to A, chromosome 17 at 33,696,193 bp
  • T to C, chromosome 19 at 41,247,933 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4384 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042002-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.