Strain Detail Sheet
Strain Name:
FVB/N-Tg(tetO-Stat5a*S710F,-luc)11676Kuw/Mmmh
Stock Number:
042093-MU
Citation ID:
RRID:MMRRC_042093-MU
Other Names:
Tg(tetO-Stat5a*S710F,-luc)11676Kuw
Stat5a
Name: signal transducer and activator of transcription 5A
Synonyms: STAT5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
MGI: MGI:103036
NCBI: 20850
Ensembl: ENSMUSG00000004043
VEGA: OTTMUSG00000002125
HGNC: HGNC:11366
Homologene: 20680
CCDS: CCDS25439.1, CCDS48933.1
Tg(tetO-Stat5a*S710F,-luc)11676Kuw
Name: transgene insertion 11676, Kay-Uwe Wagner
Synonyms: TetO-Stat5(S710F)Flag-IRES-luciferase
Type: Transgene
Species: Mus musculus (mouse)
Chromosome:
Alteration at locus: Transgenic
MGI: MGI:5300600
Genetic Alterations
The tetracycline operator drives inducible expression of the FLAG-tagged mouse cDNA with a point mutation that results in an amino acid substitution of phenylalanine for serine at position 710 (S710F) and an IRES-luciferase reporter. Lines 11651 and 11676 were generated.
see: MGI:5300600
Genotype Determination
- Genotyping Protocol(s)
- Center protocol and contact for technical support will be shipped with mice.
ES Cell Line
Not specified
Phenotype
Homozygous: none
Hemizygous: none
Cre-excised Phenotype: undetermined
Strain Development
see MGI number 5300600
http://www.informatics.jax.org/allele/key/815309?page=alleleDetail&key=815309
The tetracycline operator drives inducible expression of the FLAG-tagged mouse cDNA with a point mutation that results in an amino acid substitution of phenylalanine for serine at position 710 (S710F) and an IRES-luciferase reporter. Lines 11651 and 11676 were generated.
Suggested Control Mice
Wild-type littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
- Apoptosis
- Cancer
- Cell Biology
- Developmental Biology
- Hematology
- Internal Organ
- Models for Human Disease
- Research Tools
Donor
Kay-Uwe Wagner, Ph.D., University of Nebraska Medical Center.
Colony Surveillance Program and Current Health Reports
Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .Coat Color
white
Other
please refer to MGI:5300600 for additional questions.
there are no unusual characteristics.
http://www.informatics.jax.org/allele/key/815309?page=alleleDetail&key=815309
MMRRC Breeding System
Backcross
Generation
20+
Overall Breeding Performance
Excellent
NOTE: "Hemizygote" as used here refers to males carrying a mutation on the X Chromosome or mice of either sex carrying an inserted transgene with no homologous allele on the other chromosome.
| Viability and Fertility: | Female | Male | Comments |
|---|---|---|---|
| Homozygotes are viable: | Yes | Yes | |
| Homozygotes are fertile: | Yes | Yes | |
| Hetero/Hemizygotes are fertile: | Yes | Yes | |
| Age Reproductive Decline: | 8 to 12 months | Greater than 12 months |
Bred to Homozygosity
No
Average litter size
10-14
Recommended wean age
3-4 weeks
Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.
- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.
- If you register interest in this strain, you will be notified when it becomes available for ordering.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the
Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.