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Strain Name:
C57BL/6J-MtgxR4811Btlr/Mmmh
Stock Number:
042430-MU
Citation ID:
RRID:MMRRC_042430-MU
Other Names:
R4811 (G1), C57BL/6J-MtgxR4811Btlr
Major Collection:

Strain Information

Myo5a
Name: myosin VA
Synonyms: MVa, MyoVA, Myo5, flail, 9630007J19Rik, Dbv
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Nrp2
Name: neuropilin 2
Synonyms: NP2, Npn-2, Npn2, NP-2, 1110048P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Sh3gl2
Name: SH3-domain GRB2-like 2
Synonyms: EEN-B1, endophilin I, Sh3d2a, 9530001L19Rik, B930049H17Rik, endophilin A1, EEN1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20404
Homologene: 20652
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Ddx23
Name: DEAD box helicase 23
Synonyms: 4921506D17Rik, 3110082M05Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74351
Homologene: 3542
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 62,719,081 bp
  • A to T, chromosome 1 at 68,254,544 bp
  • G to A, chromosome 1 at 74,349,405 bp
  • G to A, chromosome 1 at 93,205,896 bp
  • T to A, chromosome 1 at 98,509,264 bp
  • A to G, chromosome 2 at 88,093,532 bp
  • A to C, chromosome 2 at 120,740,070 bp
  • T to A, chromosome 2 at 164,464,424 bp
  • T to C, chromosome 3 at 86,776,141 bp
  • T to A, chromosome 3 at 101,279,957 bp
  • A to G, chromosome 4 at 45,928,020 bp
  • T to C, chromosome 4 at 59,082,404 bp
  • A to G, chromosome 4 at 85,398,166 bp
  • A to G, chromosome 4 at 88,121,389 bp
  • T to A, chromosome 4 at 122,959,382 bp
  • T to C, chromosome 4 at 133,486,370 bp
  • A to G, chromosome 4 at 138,967,187 bp
  • T to A, chromosome 4 at 139,669,000 bp
  • A to G, chromosome 5 at 31,074,690 bp
  • T to G, chromosome 5 at 69,564,509 bp
  • A to C, chromosome 5 at 97,095,983 bp
  • C to T, chromosome 5 at 120,795,383 bp
  • T to C, chromosome 5 at 122,360,019 bp
  • T to A, chromosome 5 at 147,530,058 bp
  • T to G, chromosome 6 at 85,844,420 bp
  • T to C, chromosome 7 at 4,442,653 bp
  • T to C, chromosome 7 at 13,337,813 bp
  • T to A, chromosome 7 at 25,097,686 bp
  • T to C, chromosome 7 at 30,460,429 bp
  • T to C, chromosome 7 at 64,208,306 bp
  • T to A, chromosome 7 at 66,708,150 bp
  • T to C, chromosome 7 at 86,306,958 bp
  • T to G, chromosome 7 at 105,714,281 bp
  • T to C, chromosome 7 at 110,372,535 bp
  • T to C, chromosome 7 at 143,080,219 bp
  • C to T, chromosome 8 at 24,711,724 bp
  • A to C, chromosome 8 at 64,085,473 bp
  • G to T, chromosome 9 at 8,900,843 bp
  • A to T, chromosome 9 at 20,212,753 bp
  • A to G, chromosome 9 at 21,775,747 bp
  • T to C, chromosome 9 at 38,735,953 bp
  • C to T, chromosome 9 at 61,373,997 bp
  • A to G, chromosome 9 at 64,964,518 bp
  • A to G, chromosome 9 at 66,448,422 bp
  • G to A, chromosome 9 at 75,141,543 bp
  • A to G, chromosome 9 at 106,349,709 bp
  • T to A, chromosome 10 at 8,245,941 bp
  • T to A, chromosome 10 at 81,243,713 bp
  • A to C, chromosome 11 at 5,064,436 bp
  • A to T, chromosome 11 at 5,287,420 bp
  • T to G, chromosome 11 at 49,327,748 bp
  • A to T, chromosome 11 at 69,915,928 bp
  • C to T, chromosome 11 at 78,167,718 bp
  • T to C, chromosome 11 at 100,141,348 bp
  • A to G, chromosome 11 at 103,635,025 bp
  • G to T, chromosome 11 at 109,534,072 bp
  • A to T, chromosome 11 at 119,350,527 bp
  • A to G, chromosome 12 at 99,935,138 bp
  • T to C, chromosome 13 at 11,655,698 bp
  • T to C, chromosome 13 at 13,777,100 bp
  • T to C, chromosome 13 at 50,425,633 bp
  • T to C, chromosome 13 at 67,749,626 bp
  • C to A, chromosome 13 at 100,285,791 bp
  • A to C, chromosome 14 at 31,145,399 bp
  • G to T, chromosome 14 at 32,574,929 bp
  • T to C, chromosome 14 at 75,200,408 bp
  • A to C, chromosome 14 at 84,447,935 bp
  • A to G, chromosome 15 at 23,226,791 bp
  • G to A, chromosome 15 at 37,425,708 bp
  • A to G, chromosome 15 at 58,944,073 bp
  • T to C, chromosome 15 at 79,615,427 bp
  • A to G, chromosome 15 at 85,226,966 bp
  • T to A, chromosome 15 at 98,647,471 bp
  • C to T, chromosome 15 at 99,280,237 bp
  • T to C, chromosome 16 at 11,072,533 bp
  • T to A, chromosome 16 at 20,152,895 bp
  • T to A, chromosome 16 at 26,701,238 bp
  • T to G, chromosome 16 at 34,356,969 bp
  • T to C, chromosome 16 at 36,891,419 bp
  • T to C, chromosome 16 at 62,928,233 bp
  • A to G, chromosome 17 at 32,545,106 bp
  • A to G, chromosome 17 at 36,127,776 bp
  • G to A, chromosome 17 at 43,037,730 bp
  • T to C, chromosome 18 at 9,993,438 bp
  • A to G, chromosome 18 at 25,129,840 bp
  • C to T, chromosome 18 at 38,451,592 bp
  • T to C, chromosome 18 at 61,697,535 bp
  • T to A, chromosome 18 at 71,299,483 bp
  • A to G, chromosome 19 at 10,435,567 bp
  • A to G, chromosome 19 at 41,302,497 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4811 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042430-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.