Strain Name:
C57BL/6J-MtgxR4892Btlr/Mmmh
Stock Number:
042497-MU
Citation ID:
RRID:MMRRC_042497-MU
Other Names:
R4892 (G1), C57BL/6J-MtgxR4892Btlr
Major Collection:

Gene Information

Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Prdx2
Name: peroxiredoxin 2
Synonyms: TPx, thioredoxin reductase, TR, Prx II-1, Trx dependent peroxide reductase 1, thiol specific antioxidant protein, TSA, thioredoxin dependent peroxide reductase 1, TDX1, thioredoxin peroxidase, protector protein, PRP, Tdpx1, PrxII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21672
HGNC: HGNC:9353
Homologene: 21182
Lgals9
Name: lectin, galactose binding, soluble 9
Synonyms: LGALS35, galectin-9, gal-9, Lgals5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16859
Homologene: 134662
Stk17b
Name: serine/threonine kinase 17b (apoptosis-inducing)
Synonyms: Drak2, 3110009A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98267
Homologene: 31231
Kat8
Name: K(lysine) acetyltransferase 8
Synonyms: D7Ertd629e, 5830450F21Rik, 2010203C02Rik, MOF, Myst1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67773
Homologene: 41676
Tnrc6a
Name: trinucleotide repeat containing 6a
Synonyms: CAGH26, 3110054G10Rik, D130023A07Rik, 2010321I05Rik, Tnrc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233833
Homologene: 41399
Dido1
Name: death inducer-obliterator 1
Synonyms: DIO-1, 6720461J16Rik, D130048F08Rik, Datf1, dido, C130092D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Cep131
Name: centrosomal protein 131
Synonyms: AZ1, Azi1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12009
Homologene: 7638
Cpt1c
Name: carnitine palmitoyltransferase 1c
Synonyms: CPT I-C, 9630004I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78070
Homologene: 17561
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Tcf20
Name: transcription factor 20
Synonyms: SPBP, stromelysin 1 PDGF responsive element binding protein, 2810438H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21411
VEGA: 15
Homologene: 4131
Setd1a
Name: SET domain containing 1A
Synonyms: KMT2F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233904
Homologene: 52251
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Ten-m3, 2610100B16Rik, Odz3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23965
Homologene: 22673
Nxf1
Name: nuclear RNA export factor 1
Synonyms: Tip associated protein, TAP, Mex67, Mvb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 53319
HGNC: HGNC:8071
Homologene: 38176
Spryd3
Name: SPRY domain containing 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223918
Homologene: 13138
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Capn11
Name: calpain 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 268958
HGNC: HGNC:1478
Homologene: 21392
Abcc12
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Synonyms: MRP9, 4930467B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244562
Homologene: 57211
Krt73
Name: keratin 73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223915
Homologene: 27875
Mpo
Name: myeloperoxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17523
HGNC: HGNC:7218
Homologene: 55450
Dhx30
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 30
Synonyms: Ddx30, 2810477H02Rik, C130058C04Rik, helG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72831
Homologene: 15779
Mctp1
Name: multiple C2 domains, transmembrane 1
Synonyms: 2810465F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78771
Homologene: 75211
Prelid2
Name: PRELI domain containing 2
Synonyms: 1700003A01Rik, C330008K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 77619
VEGA: 18
Homologene: 45749
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240776
Homologene: 16121
Babam1
Name: BRISC and BRCA1 A complex member 1
Synonyms: 5430437P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 68251
Homologene: 8574
Sgip1
Name: SH3-domain GRB2-like (endophilin) interacting protein 1
Synonyms: 3110007P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73094
Homologene: 13001
Dip2a
Name: disco interacting protein 2 homolog A
Synonyms: Kiaa0184-hp, 4931420H10Rik, Dip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 64451
Homologene: 41012
Ttc29
Name: tetratricopeptide repeat domain 29
Synonyms: 1700031F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 73301
Homologene: 12918
Fmo3
Name: flavin containing monooxygenase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14262
HGNC: HGNC:3771
Homologene: 128199
Or2y1c
Name: olfactory receptor family 2 subfamily Y member 1C
Synonyms: GA_x6K02T2QP88-5964781-5963852, MOR256-50, Olfr1386
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 257888
Homologene: 86692
Gdap1
Name: ganglioside-induced differentiation-associated-protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14545
Homologene: 40713
Apol11a
Name: apolipoprotein L 11a
Synonyms: EG626615
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 626615
VEGA: 15
Homologene: 129975
Ccdc190
Name: coiled-coil domain containing 190
Synonyms: 1700084C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78465
Homologene: 52274
Syndig1
Name: synapse differentiation inducing 1
Synonyms: SynDIG1, Tmem90b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 433485
Homologene: 11771
Gm10729
Name: predicted gene 10729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Or9s27
Name: olfactory receptor family 9 subfamily S member 27
Synonyms: GA_x6K02T2R7CC-81165686-81164721, MOR208-4, Olfr1412
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 258274
Homologene: 115514
Gm27241
Name: predicted gene 27241
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Stk-ps1
Name: serine/threonine kinase, pseudogene 1
Synonyms: LOC240091, LOC333716, Gm318
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 545204
Homologene: 141143
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 17,159,994 bp
  • A to T, chromosome 1 at 53,771,611 bp
  • A to G, chromosome 1 at 92,588,921 bp
  • C to A, chromosome 1 at 140,513,025 bp
  • T to A, chromosome 1 at 162,968,731 bp
  • C to A, chromosome 1 at 169,930,109 bp
  • A to T, chromosome 2 at 149,899,891 bp
  • G to A, chromosome 2 at 180,675,029 bp
  • C to T, chromosome 3 at 51,694,510 bp
  • A to G, chromosome 4 at 102,966,234 bp
  • A to G, chromosome 4 at 139,428,517 bp
  • A to G, chromosome 7 at 30,712,474 bp
  • A to G, chromosome 7 at 44,959,588 bp
  • C to T, chromosome 7 at 123,169,911 bp
  • G to T, chromosome 7 at 127,778,524 bp
  • T to A, chromosome 7 at 127,915,538 bp
  • T to A, chromosome 8 at 48,276,861 bp
  • T to A, chromosome 8 at 71,403,052 bp
  • T to C, chromosome 8 at 78,333,645 bp
  • T to C, chromosome 8 at 84,971,525 bp
  • T to C, chromosome 8 at 86,509,802 bp
  • T to G, chromosome 9 at 59,824,242 bp
  • T to A, chromosome 9 at 72,616,699 bp
  • A to T, chromosome 9 at 110,085,856 bp
  • T to C, chromosome 10 at 10,719,587 bp
  • T to C, chromosome 10 at 76,280,759 bp
  • C to A, chromosome 11 at 49,470,216 bp
  • T to A, chromosome 11 at 78,966,083 bp
  • T to A, chromosome 11 at 87,802,681 bp
  • C to T, chromosome 11 at 120,068,057 bp
  • A to G, chromosome 13 at 77,029,981 bp
  • A to T, chromosome 15 at 77,516,990 bp
  • C to T, chromosome 15 at 82,854,199 bp
  • G to A, chromosome 15 at 101,795,809 bp
  • T to C, chromosome 15 at 102,118,102 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • T to C, chromosome 17 at 36,397,983 bp
  • GACA to GA, chromosome 17 at 45,633,097 bp
  • A to G, chromosome 18 at 41,951,144 bp
  • T to C, chromosome 19 at 8,770,233 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4892 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042497-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.