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Strain Name:
C57BL/6J-MtgxR4907Btlr/Mmmh
Stock Number:
042509-MU
Citation ID:
RRID:MMRRC_042509-MU
Other Names:
R4907 (G1), C57BL/6J-MtgxR4907Btlr
Major Collection:

Strain Information

Llgl2
Name: LLGL2 scribble cell polarity complex component
Synonyms: 9130006H11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217325
HGNC: HGNC:6629
Homologene: 3323
Pck1
Name: phosphoenolpyruvate carboxykinase 1, cytosolic
Synonyms: Pck-1, PEPCK
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18534
HGNC: HGNC:8724
Homologene: 1944
Zfhx3
Name: zinc finger homeobox 3
Synonyms: WBP9, A230102L03Rik, Atbf1, Sci
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Baz2a
Name: bromodomain adjacent to zinc finger domain, 2A
Synonyms: Tip5, Walp3, C030005G16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 116848
VEGA: 10
HGNC: HGNC:962
Homologene: 8393
Rufy3
Name: RUN and FYVE domain containing 3
Synonyms: 2810428M05Rik, 6330416M07Rik, D5Bwg0860e, Rpipx
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52822
Homologene: 87809
Ss18l1
Name: SS18, nBAF chromatin remodeling complex subunit like 1
Synonyms: A230053O16Rik, CREST
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269397
Homologene: 9191
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: c-Cbl-associated protein, CAP, Sh3d5, 9530001P15Rik, 2310065E01Rik, Ponsin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,209,226 bp
  • T to C, chromosome 1 at 37,241,942 bp
  • T to C, chromosome 1 at 39,361,985 bp
  • C to T, chromosome 1 at 45,816,633 bp
  • G to T, chromosome 1 at 57,383,191 bp
  • T to A, chromosome 1 at 110,138,323 bp
  • A to G, chromosome 1 at 126,026,152 bp
  • A to T, chromosome 1 at 127,519,370 bp
  • T to G, chromosome 1 at 173,862,690 bp
  • C to T, chromosome 2 at 29,064,656 bp
  • A to G, chromosome 2 at 30,032,460 bp
  • A to T, chromosome 2 at 36,850,258 bp
  • A to G, chromosome 2 at 105,937,117 bp
  • G to T, chromosome 2 at 139,678,752 bp
  • C to T, chromosome 2 at 173,157,023 bp
  • T to A, chromosome 2 at 175,131,389 bp
  • G to T, chromosome 2 at 180,063,399 bp
  • T to C, chromosome 3 at 8,944,608 bp
  • A to G, chromosome 3 at 19,674,374 bp
  • T to A, chromosome 3 at 38,454,973 bp
  • A to T, chromosome 3 at 38,456,675 bp
  • T to C, chromosome 3 at 158,161,240 bp
  • A to G, chromosome 4 at 117,120,567 bp
  • T to A, chromosome 4 at 141,097,121 bp
  • T to A, chromosome 4 at 148,944,541 bp
  • A to G, chromosome 5 at 5,249,140 bp
  • T to C, chromosome 5 at 14,680,051 bp
  • A to T, chromosome 5 at 30,378,661 bp
  • T to A, chromosome 5 at 64,103,878 bp
  • T to C, chromosome 5 at 67,346,162 bp
  • T to G, chromosome 5 at 88,584,192 bp
  • T to C, chromosome 5 at 100,199,155 bp
  • T to A, chromosome 5 at 108,136,141 bp
  • C to A, chromosome 5 at 147,683,939 bp
  • T to C, chromosome 6 at 39,596,620 bp
  • T to C, chromosome 6 at 40,834,743 bp
  • T to A, chromosome 6 at 121,007,298 bp
  • A to T, chromosome 7 at 12,616,223 bp
  • A to G, chromosome 7 at 30,719,092 bp
  • A to G, chromosome 7 at 103,561,034 bp
  • A to G, chromosome 7 at 104,553,311 bp
  • A to G, chromosome 7 at 104,861,148 bp
  • A to T, chromosome 7 at 139,989,373 bp
  • A to G, chromosome 7 at 141,433,874 bp
  • T to C, chromosome 8 at 3,877,948 bp
  • T to C, chromosome 8 at 47,824,707 bp
  • T to C, chromosome 8 at 69,663,322 bp
  • C to A, chromosome 8 at 84,903,185 bp
  • C to A, chromosome 8 at 106,079,727 bp
  • T to A, chromosome 8 at 108,793,354 bp
  • T to A, chromosome 8 at 109,640,843 bp
  • A to G, chromosome 8 at 109,723,993 bp
  • G to A, chromosome 9 at 8,947,043 bp
  • A to T, chromosome 9 at 40,100,659 bp
  • A to T, chromosome 9 at 48,479,403 bp
  • A to G, chromosome 9 at 72,611,821 bp
  • A to T, chromosome 10 at 27,164,946 bp
  • A to G, chromosome 10 at 76,493,441 bp
  • A to G, chromosome 10 at 128,110,808 bp
  • G to A, chromosome 11 at 70,169,971 bp
  • T to C, chromosome 11 at 99,418,362 bp
  • T to A, chromosome 11 at 115,853,974 bp
  • T to G, chromosome 12 at 80,181,414 bp
  • T to C, chromosome 12 at 83,574,872 bp
  • T to C, chromosome 12 at 87,459,489 bp
  • A to T, chromosome 13 at 6,662,556 bp
  • A to T, chromosome 13 at 61,566,820 bp
  • T to C, chromosome 13 at 62,171,473 bp
  • T to C, chromosome 14 at 70,670,629 bp
  • T to A, chromosome 15 at 36,087,424 bp
  • T to C, chromosome 15 at 60,016,108 bp
  • A to T, chromosome 16 at 11,088,534 bp
  • A to G, chromosome 16 at 20,376,546 bp
  • A to G, chromosome 16 at 36,969,702 bp
  • T to C, chromosome 17 at 20,550,086 bp
  • T to A, chromosome 17 at 25,343,462 bp
  • T to A, chromosome 17 at 25,860,650 bp
  • A to G, chromosome 17 at 75,005,904 bp
  • T to C, chromosome 18 at 31,906,993 bp
  • A to G, chromosome 19 at 13,234,793 bp
  • G to A, chromosome 19 at 40,340,047 bp
  • A to G, chromosome 19 at 44,154,142 bp
  • A to G, chromosome 19 at 46,896,539 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4907 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042509-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.