Strain Name:
C57BL/6J-MtgxR4978Btlr/Mmmh
Stock Number:
042573-MU
Citation ID:
RRID:MMRRC_042573-MU
Other Names:
R4978 (G1), C57BL/6J-MtgxR4978Btlr
Major Collection:

Gene Information

Neurod1
Name: neurogenic differentiation 1
Synonyms: BETA2, Nd1, bHLHa3, Neurod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18012
HGNC: HGNC:7762
Homologene: 1871
Slc25a13
Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
Synonyms: Ctrn, citrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 50799
Homologene: 22800
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Etaa1
Name: Ewing tumor-associated antigen 1
Synonyms: 5730466H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68145
Homologene: 10369
Tcf7l1
Name: transcription factor 7 like 1 (T cell specific, HMG box)
Synonyms: Tcf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21415
Homologene: 7563
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: 5430435M13Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 2610207I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233789
Homologene: 56697
Tep1
Name: telomerase associated protein 1
Synonyms: Tp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21745
VEGA: 14
Homologene: 5157
Fh1
Name: fumarate hydratase 1
Synonyms: fumarase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14194
HGNC: HGNC:3700
Homologene: 115
Capza2
Name: capping protein (actin filament) muscle Z-line, alpha 2
Synonyms: 1110053K06Rik, Cappa2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12343
HGNC: HGNC:1490
Homologene: 55956
N4bp2
Name: NEDD4 binding protein 2
Synonyms: LOC386488, B3bp, LOC333789
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 333789
Homologene: 32396
Dsp
Name: desmoplakin
Synonyms: rul, 2300002E22Rik, DP, 5730453H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Flrt1
Name: fibronectin leucine rich transmembrane protein 1
Synonyms: D630040I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 396184
VEGA: 19
HGNC: HGNC:3760
Homologene: 40864
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: Ccdc132, 8430415E05Rik, 1700034M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 73288
Homologene: 11498
Fbxo9
Name: f-box protein 9
Synonyms: 9030401P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71538
Homologene: 8217
Cspp1
Name: centrosome and spindle pole associated protein 1
Synonyms: 2310020J12Rik, 4930413O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 211660
Homologene: 23487
Ik
Name: IK cytokine
Synonyms: MuRED
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 24010
VEGA: 18
HGNC: HGNC:5958
Homologene: 36193
Plaa
Name: phospholipase A2, activating protein
Synonyms: D4Ertd618e, Ufd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18786
HGNC: HGNC:9043
Homologene: 3138
Limk2
Name: LIM motif-containing protein kinase 2
Synonyms: whe, Limk2b, Limk2a, LIM kinase 2, A930024P04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16886
HGNC: HGNC:6614
Homologene: 55911
Wrnip1
Name: Werner helicase interacting protein 1
Synonyms: WHIP, 4833444L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 78903
Homologene: 10592
Dpys
Name: dihydropyrimidinase
Synonyms: 1200017I10Rik, DHPase, 1300004I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 64705
HGNC: HGNC:3013
Homologene: 20359
Zswim4
Name: zinc finger SWIM-type containing 4
Synonyms: E130119J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212168
Homologene: 18183
Siglecg
Name: sialic acid binding Ig-like lectin G
Synonyms: A630096C01Rik, mSiglec-G
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243958
Homologene: 13228
Avil
Name: advillin
Synonyms: DOC6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11567
Homologene: 38200
Zkscan17
Name: zinc finger with KRAB and SCAN domains 17
Synonyms: Nizp1, Zfp496
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268417
Homologene: 13108
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70853
Homologene: 27053
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Pde9a
Name: phosphodiesterase 9A
Synonyms: PDE9A1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18585
HGNC: HGNC:8795
Homologene: 113565
Zkscan2
Name: zinc finger with KRAB and SCAN domains 2
Synonyms: Zfp694, 9430065N20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210162
Homologene: 19671
Kng2
Name: kininogen 2
Synonyms: Kininogen-II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 385643
HGNC: HGNC:6383
Homologene: 88343
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Umodl1
Name: uromodulin-like 1
Synonyms: D17Ertd488e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 52020
VEGA: 17
Homologene: 45466
Pcdhb22
Name: protocadherin beta 22
Synonyms: Pcdhb15, PcdhbV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Adam39
Name: a disintegrin and metallopeptidase domain 39
Synonyms: 1700056P18Rik, testase 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 546055
HGNC: HGNC:199
Homologene: 128364
Map1a
Name: microtubule-associated protein 1 A
Synonyms: 6330416M19Rik, Mtap-1, Mtap1a, Mtap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Ccdc7b
Name: coiled-coil domain containing 7B
Synonyms: 1700008F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75453
Homologene: 49919
Olfr686
Name: olfactory receptor 686
Synonyms: MOR35-1, GA_x6K02T2PBJ9-7832633-7831680
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259072
Homologene: 17487
Cyp2c50
Name: cytochrome P450, family 2, subfamily c, polypeptide 50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107141
Homologene: 137231
Hcls1
Name: hematopoietic cell specific Lyn substrate 1
Synonyms: HS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 15163
HGNC: HGNC:4844
Homologene: 38034
Vstm2a
Name: V-set and transmembrane domain containing 2A
Synonyms: 9330184N17Rik, Vstm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 211739
Homologene: 17123
Scaf11
Name: SR-related CTD-associated factor 11
Synonyms: 1110061H03Rik, Sfrs2ip, 2610510E10Rik, CASP11, SRRP129, Srsf2ip, SIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72193
VEGA: 15
Homologene: 37957
Gramd1a
Name: GRAM domain containing 1A
Synonyms: D7Bwg0611e, 1300003M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52857
Homologene: 10843
Zfp286
Name: zinc finger protein 286
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192651
Homologene: 56892
Tradd
Name: TNFRSF1A-associated via death domain
Synonyms: 9130005N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71609
Homologene: 2807
Adgrg6
Name: adhesion G protein-coupled receptor G6
Synonyms: 1190004A11Rik, DREG, Gpr126, LOC215798
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215798
Homologene: 10724
Mast1
Name: microtubule associated serine/threonine kinase 1
Synonyms: SAST, 9430008B02Rik, SAST170
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56527
Homologene: 10543
Adam29
Name: a disintegrin and metallopeptidase domain 29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244486
HGNC: HGNC:207
Homologene: 8607
1700101I19Rik
Name: RIKEN cDNA 1700101I19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
B430305J03Rik
Name: RIKEN cDNA B430305J03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Dyrk2
Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Synonyms: 1810038L18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 69181
VEGA: 10
HGNC: HGNC:3093
Homologene: 48437
Vmn1r49
Name: vomeronasal 1, receptor 49
Synonyms: V1rb2, V1r5, VRi2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 24112
Homologene: 113975
Irx1
Name: Iroquois homeobox 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16371
Homologene: 19065
Fam210b
Name: family with sequence similarity 210, member B
Synonyms: 2010011I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67017
Homologene: 32646
Caps2
Name: calcyphosphine 2
Synonyms: D630005B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 353025
Homologene: 72278
Gm7353
Name: predicted pseudogene 7353
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 664817
Rab27b
Name: RAB27B, member RAS oncogene family
Synonyms: 2310021G14Rik, B130064M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 80718
HGNC: HGNC:9767
Homologene: 20879
Vgll3
Name: vestigial like family member 3
Synonyms: 1700110N18Rik, Vito-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 73569
VEGA: 16
Homologene: 53442
1700088E04Rik
Name: RIKEN cDNA 1700088E04 gene
Synonyms: Mus EST J0827E04
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 27660
Homologene: 13062
Cpeb4
Name: cytoplasmic polyadenylation element binding protein 4
Synonyms: 4930447D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67579
Homologene: 12736
Gins2
Name: GINS complex subunit 2 (Psf2 homolog)
Synonyms: 4833427B12Rik, 2210013I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 272551
Homologene: 41105
Reep5
Name: receptor accessory protein 5
Synonyms: Dp1, DP1/TB2, TB2/DP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13476
VEGA: 18
Homologene: 68479
Prl2c1
Name: Prolactin family 2, subfamily c, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 666317
Homologene: 40763
Gm28417
Name: predicted gene 28417
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Gm5436
Name: predicted pseudogene 5436
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 432676
VEGA: 12
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: Dnl1ll, Dnase1ll, G4.8, 2310005K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Spock2
Name: sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
Synonyms: testican-2, Gcap26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 94214
Homologene: 8854
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 10,083,517 bp
  • T to C, chromosome 1 at 34,469,813 bp
  • A to G, chromosome 1 at 34,579,300 bp
  • A to G, chromosome 1 at 37,115,671 bp
  • A to T, chromosome 1 at 175,603,967 bp
  • C to T, chromosome 2 at 79,454,227 bp
  • T to G, chromosome 2 at 121,301,142 bp
  • G to C, chromosome 2 at 172,345,665 bp
  • T to C, chromosome 3 at 61,364,019 bp
  • A to G, chromosome 4 at 94,589,932 bp
  • C to T, chromosome 4 at 148,008,770 bp
  • T to A, chromosome 5 at 14,714,478 bp
  • T to C, chromosome 5 at 65,790,240 bp
  • C to T, chromosome 5 at 137,406,921 bp
  • A to G, chromosome 6 at 3,517,808 bp
  • G to A, chromosome 6 at 6,042,300 bp
  • T to A, chromosome 6 at 17,662,115 bp
  • C to T, chromosome 6 at 72,627,699 bp
  • G to T, chromosome 6 at 90,072,890 bp
  • A to G, chromosome 7 at 3,110,038 bp
  • T to C, chromosome 7 at 31,132,788 bp
  • T to C, chromosome 7 at 43,411,638 bp
  • T to C, chromosome 7 at 105,204,191 bp
  • A to G, chromosome 7 at 118,154,247 bp
  • C to G, chromosome 7 at 123,495,319 bp
  • T to C, chromosome 8 at 40,825,337 bp
  • G to A, chromosome 8 at 55,871,401 bp
  • C to T, chromosome 8 at 84,226,667 bp
  • T to C, chromosome 8 at 84,935,787 bp
  • T to C, chromosome 8 at 105,259,268 bp
  • A to G, chromosome 8 at 120,588,811 bp
  • T to C, chromosome 8 at 129,110,207 bp
  • G to A, chromosome 9 at 78,085,886 bp
  • A to G, chromosome 10 at 14,420,461 bp
  • T to A, chromosome 10 at 60,131,089 bp
  • A to T, chromosome 10 at 112,182,494 bp
  • A to T, chromosome 10 at 118,860,347 bp
  • A to T, chromosome 10 at 127,018,396 bp
  • G to T, chromosome 11 at 3,409,069 bp
  • A to G, chromosome 11 at 16,261,460 bp
  • T to C, chromosome 11 at 17,946,581 bp
  • C to T, chromosome 11 at 31,931,509 bp
  • A to G, chromosome 11 at 59,493,227 bp
  • A to G, chromosome 11 at 62,788,928 bp
  • G to A, chromosome 12 at 84,258,687 bp
  • A to G, chromosome 13 at 27,857,570 bp
  • A to G, chromosome 13 at 32,816,312 bp
  • T to A, chromosome 13 at 38,182,234 bp
  • A to G, chromosome 13 at 71,963,485 bp
  • C to T, chromosome 14 at 50,845,434 bp
  • A to T, chromosome 15 at 39,826,936 bp
  • T to C, chromosome 15 at 79,135,638 bp
  • T to C, chromosome 15 at 96,415,917 bp
  • T to A, chromosome 16 at 22,987,916 bp
  • T to C, chromosome 16 at 36,937,860 bp
  • T to A, chromosome 16 at 65,815,686 bp
  • T to C, chromosome 17 at 30,986,081 bp
  • T to A, chromosome 17 at 31,473,223 bp
  • A to G, chromosome 18 at 34,373,296 bp
  • C to T, chromosome 18 at 36,747,415 bp
  • A to G, chromosome 18 at 37,518,601 bp
  • C to T, chromosome 18 at 69,994,514 bp
  • A to G, chromosome 19 at 7,096,876 bp
  • T to G, chromosome 19 at 40,098,057 bp
  • C to T, chromosome X at 74,277,038 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4978 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042573-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.