Strain Name:
C57BL/6J-MtgxR5040Btlr/Mmmh
Stock Number:
042630-MU
Citation ID:
RRID:MMRRC_042630-MU
Other Names:
R5040 (G1), C57BL/6J-MtgxR5040Btlr
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20370
Homologene: 10948
Areg
Name: amphiregulin
Synonyms: AR, Sdgf, Mcub
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11839
HGNC: HGNC:651
Homologene: 1252
Med1
Name: mediator complex subunit 1
Synonyms: TRAP 220, TRAP220, CRSP210, DRIP205, Pparbp, l11Jus15, PBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Ehmt1
Name: euchromatic histone methyltransferase 1
Synonyms: 9230102N17Rik, KMT1D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 77683
Homologene: 11698
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: eIF4GII, 1500002J22Rik, 4930523M17Rik, G1-419-52, repro8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Virma
Name: vir like m6A methyltransferase associated
Synonyms: 1110037F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66185
Homologene: 41043
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320365
Homologene: 113770
Hnrnpul1
Name: heterogeneous nuclear ribonucleoprotein U-like 1
Synonyms: E1B-AP5, E1BAP5, E130317O14Rik, Hnrnpul, Hnrpul1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232989
Homologene: 31419
Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Synonyms: 8030493P09Rik, 4930429A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208718
Homologene: 62417
Pcmtd1
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
Synonyms: 8430411F12Rik, A030012M09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 319263
Homologene: 14180
Cast
Name: calpastatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 12380
VEGA: 13
HGNC: HGNC:1515
Homologene: 7658
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 5730590C14Rik, 3526402J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 77097
Homologene: 64680
Trp53bp2
Name: transformation related protein 53 binding protein 2
Synonyms: ASPP2, 53BP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 209456
Homologene: 3959
Rbm26
Name: RNA binding motif protein 26
Synonyms: Pro1777, C230097K14Rik, 1700009P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74213
Homologene: 41468
Eif5
Name: eukaryotic translation initiation factor 5
Synonyms: D12Ertd549e, 2810011H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217869
VEGA: 12
HGNC: HGNC:3299
Homologene: 49610
Hipk2
Name: homeodomain interacting protein kinase 2
Synonyms: Stank, 1110014O20Rik, B230339E18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15258
Homologene: 68766
Galnt9
Name: polypeptide N-acetylgalactosaminyltransferase 9
Synonyms: GalNAc-T9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231605
HGNC: HGNC:4131
Homologene: 72793
Arhgef17
Name: Rho guanine nucleotide exchange factor (GEF) 17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 207212
Homologene: 129601
Zfp457
Name: zinc finger protein 457
Synonyms: Rslcan-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 431706
Homologene: 75311
Elapor1
Name: endosome-lysosome associated apoptosis and autophagy regulator 1
Synonyms: Inceptor, Iir, 5330417C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229722
Homologene: 23249
Hhip
Name: Hedgehog-interacting protein
Synonyms: Hip, Hip1, Hhip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 15245
Homologene: 32469
Ap2a1
Name: adaptor-related protein complex 2, alpha 1 subunit
Synonyms: Adtaa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11771
HGNC: HGNC:561
Homologene: 68997
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, Dnchc2, b2b414Clo, m407Asp, m152Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Dusp27
Name: dual specificity phosphatase 27 (putative)
Synonyms: C130085G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240892
Homologene: 18949
Nprl2
Name: NPR2 like, GATOR1 complex subunit
Synonyms: NPR2L, NPRL2, 2810446G01Rik, G21, Tusc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56032
Homologene: 4771
Tamalin
Name: trafficking regulator and scaffold protein tamalin
Synonyms: tamalin, Grasp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 56149
VEGA: 15
Homologene: 32442
Stac3
Name: SH3 and cysteine rich domain 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237611
Homologene: 17039
Gata3
Name: GATA binding protein 3
Synonyms: Gata-3, jal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14462
HGNC: HGNC:4172
Homologene: 1550
Abcc6
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6
Synonyms: DCC, Mrp6, Dyscalc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27421
HGNC: HGNC:57
Homologene: 55559
Supv3l1
Name: suppressor of var1, 3-like 1 (S. cerevisiae)
Synonyms: 6330443E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 338359
Homologene: 2386
Tmco4
Name: transmembrane and coiled-coil domains 4
Synonyms: 4632413C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77056
Homologene: 57112
Mak
Name: male germ cell-associated kinase
Synonyms: A930010O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17152
VEGA: 13
HGNC: HGNC:6816
Homologene: 31344
Zfp366
Name: zinc finger protein 366
Synonyms: DC-SCRIPT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238803
Homologene: 17637
Sh3bp4
Name: SH3-domain binding protein 4
Synonyms: BOG25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98402
Homologene: 8726
Arhgap15
Name: Rho GTPase activating protein 15
Synonyms: 5830480G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76117
Homologene: 41271
Gmcl1
Name: germ cell-less, spermatogenesis associated 1
Synonyms: mglc-1, 2810049L19Rik, Gcl, Btbd13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 23885
Homologene: 8021
Kcnh1
Name: potassium voltage-gated channel, subfamily H (eag-related), member 1
Synonyms: ether a go-go, Eag1, Kv10.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16510
HGNC: HGNC:6250
Homologene: 68242
Mogat2
Name: monoacylglycerol O-acyltransferase 2
Synonyms: Mgat2, DGAT2L5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233549
Homologene: 57020
Slc24a3
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Synonyms: NCKX3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94249
Homologene: 41390
Tmc1
Name: transmembrane channel-like gene family 1
Synonyms: Bth, Beethoven, 4933416G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13409
VEGA: 19
Homologene: 23670
Ccdc154
Name: coiled-coil domain containing 154
Synonyms: LOC207209, ntl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 207209
Homologene: 19361
Myom3
Name: myomesin family, member 3
Synonyms: 8430427K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242702
Homologene: 19432
Ifnl2
Name: interferon lambda 2
Synonyms: EG330496, Il28a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330496
Homologene: 77540
Tcp11l1
Name: t-complex 11 like 1
Synonyms: C130096D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320554
Homologene: 41260
Ilvbl
Name: ilvB (bacterial acetolactate synthase)-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216136
VEGA: 10
HGNC: HGNC:6041
Homologene: 68532
Setdb2
Name: SET domain, bifurcated 2
Synonyms: LOC239122, KMT1F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239122
Homologene: 12903
Scrn2
Name: secernin 2
Synonyms: SES2, D11Moh48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217140
Homologene: 26698
Rnf8
Name: ring finger protein 8
Synonyms: AIP37, 3830404E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 58230
Homologene: 2944
Clec2d
Name: C-type lectin domain family 2, member d
Synonyms: Clr-b, Clrb, Ocil
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93694
Homologene: 136309
Syce1
Name: synaptonemal complex central element protein 1
Synonyms: 4933406J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74075
Homologene: 77044
AF067063
Name: cDNA sequence AF067063
Synonyms: clone L5, clone L2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 380878
Gyg
Name: glycogenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 27357
HGNC: HGNC:4699
Homologene: 31219
Rogdi
Name: rogdi homolog
Synonyms: 0610011C19Rik, Lzf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 66049
Homologene: 11605
Chst11
Name: carbohydrate sulfotransferase 11
Synonyms: C4ST-1, C4ST1, C4ST, chondroitin 4, 1110020P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 58250
Homologene: 56808
Tcp10c
Name: t-complex protein 10c
Synonyms: T66C-a, D17Leh66ca, D17Leh66C, Tcp-10c, Gm9880
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100041352
VEGA: 17
Homologene: 83254
Olfr1456-ps1
Name: olfactory receptor 1456, pseudogene 1
Synonyms: GA_x6K02T2RE5P-3406727-3406027, MOR202-50_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 404516
Gm15457
Name: predicted gene 15457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Gm26883
Name: predicted gene, 26883
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
RP23-6C10.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 7,120,375 bp
  • A to C, chromosome 1 at 37,950,811 bp
  • A to T, chromosome 1 at 86,857,337 bp
  • C to T, chromosome 1 at 89,144,240 bp
  • G to A, chromosome 1 at 166,100,345 bp
  • G to A, chromosome 1 at 182,444,706 bp
  • A to T, chromosome 1 at 192,505,475 bp
  • A to G, chromosome 2 at 9,858,515 bp
  • A to T, chromosome 2 at 24,884,304 bp
  • A to G, chromosome 2 at 29,139,338 bp
  • T to C, chromosome 2 at 43,844,813 bp
  • A to G, chromosome 2 at 104,706,435 bp
  • G to A, chromosome 2 at 145,602,481 bp
  • A to T, chromosome 2 at 169,885,813 bp
  • A to G, chromosome 3 at 20,122,659 bp
  • T to A, chromosome 3 at 108,475,001 bp
  • T to A, chromosome 4 at 11,528,746 bp
  • T to C, chromosome 4 at 135,789,659 bp
  • G to T, chromosome 4 at 138,096,889 bp
  • G to T, chromosome 4 at 139,020,166 bp
  • A to G, chromosome 5 at 21,598,942 bp
  • A to T, chromosome 5 at 91,144,339 bp
  • T to C, chromosome 5 at 110,617,905 bp
  • G to A, chromosome 5 at 150,388,854 bp
  • G to A, chromosome 6 at 38,730,881 bp
  • A to G, chromosome 6 at 86,717,409 bp
  • G to A, chromosome 6 at 129,184,830 bp
  • G to A, chromosome 7 at 25,742,989 bp
  • G to T, chromosome 7 at 28,509,086 bp
  • T to C, chromosome 7 at 44,905,804 bp
  • T to C, chromosome 7 at 46,020,154 bp
  • T to C, chromosome 7 at 99,238,517 bp
  • T to C, chromosome 7 at 100,876,825 bp
  • A to T, chromosome 7 at 140,779,065 bp
  • C to T, chromosome 8 at 45,023,380 bp
  • C to A, chromosome 8 at 79,997,606 bp
  • A to G, chromosome 9 at 6,992,625 bp
  • T to G, chromosome 9 at 107,542,400 bp
  • A to T, chromosome 10 at 62,447,065 bp
  • A to G, chromosome 10 at 78,583,318 bp
  • T to A, chromosome 10 at 83,190,946 bp
  • T to C, chromosome 10 at 127,508,124 bp
  • T to C, chromosome 11 at 77,969,089 bp
  • A to G, chromosome 11 at 97,030,883 bp
  • A to G, chromosome 11 at 98,155,404 bp
  • A to G, chromosome 11 at 105,910,325 bp
  • A to G, chromosome 12 at 111,539,850 bp
  • A to G, chromosome 13 at 41,030,098 bp
  • C to T, chromosome 13 at 67,292,835 bp
  • T to C, chromosome 13 at 74,724,813 bp
  • A to G, chromosome 13 at 99,228,367 bp
  • C to T, chromosome 13 at 119,828,489 bp
  • A to T, chromosome 14 at 59,415,707 bp
  • A to G, chromosome 14 at 105,121,016 bp
  • G to A, chromosome 15 at 101,229,042 bp
  • A to C, chromosome 16 at 5,009,247 bp
  • T to A, chromosome 17 at 13,368,191 bp
  • C to A, chromosome 17 at 24,571,260 bp
  • A to T, chromosome 17 at 25,164,592 bp
  • T to A, chromosome 17 at 29,635,913 bp
  • T to A, chromosome 19 at 13,078,943 bp
  • A to G, chromosome 19 at 20,824,030 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5040 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042630-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.