Strain Name:
C57BL/6J-MtgxR5113Btlr/Mmmh
Stock Number:
042701-MU
Citation ID:
RRID:MMRRC_042701-MU
Other Names:
R5113 (G1), C57BL/6J-MtgxR5113Btlr
Major Collection:

Gene Information

Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217692
VEGA: 12
Homologene: 9189
Gfpt2
Name: glutamine fructose-6-phosphate transaminase 2
Synonyms: GFAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14584
HGNC: HGNC:4242
Homologene: 68439
Hmgcr
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: 3-hydroxy-3-methylglutaryl-CoA reductase, HMG-CoAR, Red
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 15357
HGNC: HGNC:5006
Homologene: 30994
Cltc
Name: clathrin, heavy polypeptide (Hc)
Synonyms: CHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Ski
Name: ski sarcoma viral oncogene homolog (avian)
Synonyms: 2310012I02Rik, 2610001A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 20481
Homologene: 31124
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: P1, p1.m, Mcmd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791
Eefsec
Name: eukaryotic elongation factor, selenocysteine-tRNA-specific
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 65967
Homologene: 11073
Wapl
Name: WAPL cohesin release factor
Synonyms: Wapal, A530089A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218914
Homologene: 41002
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: E430018P19Rik, 8030453L17Rik, KMT2H, chromatin remodeling factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 192195
Homologene: 10225
Aldoa
Name: aldolase A, fructose-bisphosphate
Synonyms: Aldo1, Aldo-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11674
HGNC: HGNC:414
Homologene: 123896
Klf4
Name: Kruppel-like factor 4 (gut)
Synonyms: Zie, EZF, Gklf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16600
HGNC: HGNC:6348
Homologene: 3123
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: ELKS2alpha, CAST, D14Ertd171e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 238988
Homologene: 69188
Ino80
Name: INO80 complex subunit
Synonyms: 4632409L19Rik, 2310079N15Rik, Inoc1, INO80
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 68142
Homologene: 75070
Dapk1
Name: death associated protein kinase 1
Synonyms: 2810425C21Rik, 2310039H24Rik, DAP-Kinase, D13Ucla1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Pcdh12
Name: protocadherin 12
Synonyms: vascular endothelial cadherin-2, VE-cadherin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 53601
HGNC: HGNC:8657
Homologene: 9574
Reg3g
Name: regenerating islet-derived 3 gamma
Synonyms: RegIII (gamma)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 19695
Homologene: 128216
Maob
Name: monoamine oxidase B
Synonyms: MAO-B, 6330414K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 109731
HGNC: HGNC:6834
Homologene: 20251
Cyp4f18
Name: cytochrome P450, family 4, subfamily f, polypeptide 18
Synonyms: 1810054N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 72054
HGNC: HGNC:2645
Homologene: 128623
Alox12e
Name: arachidonate lipoxygenase, epidermal
Synonyms: 8-LOX, Alox12-ps1, Alox12-ps2, Aloxe, e-LOX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11685
Homologene: 105868
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Stradb
Name: STE20-related kinase adaptor beta
Synonyms: Als2cr2, PRO1038, D1Ucla2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227154
Homologene: 10237
Vmn1r28
Name: vomeronasal 1 receptor 28
Synonyms: V1rc25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 171198
Homologene: 138094
Mipol1
Name: mirror-image polydactyly 1
Synonyms: D12Ertd19e, 1700081O04Rik, 6030439O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 73490
Homologene: 16340
Cyp2c66
Name: cytochrome P450, family 2, subfamily c, polypeptide 66
Synonyms: 2010301M18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 69888
HGNC: HGNC:2623
Homologene: 133566
Eml1
Name: echinoderm microtubule associated protein like 1
Synonyms: ELP79, A930030P13Rik, heco, 1110008N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 68519
HGNC: HGNC:3330
Homologene: 20931
Klkb1
Name: kallikrein B, plasma 1
Synonyms: Klk3, PSA, Kal-3, Kal3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 16621
HGNC: HGNC:6371
Homologene: 68097
Gpr142
Name: G protein-coupled receptor 142
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217302
Homologene: 18770
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: KA2, GluRgamma2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Olfr975
Name: olfactory receptor 975
Synonyms: MOR224-2, GA_x6K02T2PVTD-33651220-33650288
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258825
VEGA: 9
Homologene: 27275
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, Vwa6, EG235580, 1110001D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68553
Homologene: 130754
Zfp217
Name: zinc finger protein 217
Synonyms: 4933431C08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228913
Homologene: 4757
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: gp115, EMILIN-1, 5830419M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100952
Homologene: 5117
Tpsab1
Name: tryptase alpha/beta 1
Synonyms: MMCP-7, Mcpt7, Mcp-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 100503895
Pabpc2
Name: poly(A) binding protein, cytoplasmic 2
Synonyms: Pabp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 18459
Homologene: 56509
Kdm4d
Name: lysine (K)-specific demethylase 4D
Synonyms: Jmjd2d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 244694
Homologene: 69244
Chil5
Name: chitinase-like 5
Synonyms: Bclp1, Chi3l7, Bclp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229687
Homologene: 132668
Mst1
Name: macrophage stimulating 1 (hepatocyte growth factor-like)
Synonyms: D9H3F15S2, Hgfl, DNF15S2h, D3F15S2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 15235
HGNC: HGNC:7380
Homologene: 7360
Ano3
Name: anoctamin 3
Synonyms: Tmem16c, B230324K02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228432
Homologene: 57147
Ppm1j
Name: protein phosphatase 1J
Synonyms: 2310008J22Rik, Ppp2cz, PP2Czeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 71887
Homologene: 23632
Olfr1353
Name: olfactory receptor 1353
Synonyms: GA_x6K02T2QGN0-2842591-2841662, MOR139-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 259044
Homologene: 131345
Ttll10
Name: tubulin tyrosine ligase-like family, member 10
Synonyms: 4930595O22Rik, 4833412E22Rik, Ttll5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 330010
Homologene: 51912
Nexn
Name: nexilin
Synonyms: 1110046H09Rik, nF actin binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 68810
Homologene: 44892
Slfn5
Name: schlafen 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 327978
Homologene: 18839
Olfr777
Name: olfactory receptor 777
Synonyms: MOR114-9, GA_x6K02T2PULF-10955551-10954616
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258537
Homologene: 27203
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: E130207I19Rik, NEDL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 94253
VEGA: 13
Homologene: 9004
Olfr748
Name: olfactory receptor 748
Synonyms: MOR106-9P, GA_x6K02T2PMLR-6454789-6455712
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258113
Homologene: 134081
Anks6
Name: ankyrin repeat and sterile alpha motif domain containing 6
Synonyms: Samd6, 2210417J20Rik, LOC269533, SamCystin, b2b1801.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 75691
Homologene: 19545
Tcirg1
Name: T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
Synonyms: OC-116, Atp6i, V-ATPase a3, TIRC7, ATP6a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 27060
Homologene: 4392
Optc
Name: opticin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 269120
HGNC: HGNC:8158
Homologene: 8652
Tex19.1
Name: testis expressed gene 19.1
Synonyms: 2410081M02Rik, Tex19, Tex19.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 73679
Homologene: 75271
Ankef1
Name: ankyrin repeat and EF-hand domain containing 1
Synonyms: Ankrd5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 319196
Homologene: 11130
Cysrt1
Name: cysteine rich tail 1
Synonyms: 2310002J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 67859
Homologene: 12200
Igkv2-109
Name: immunoglobulin kappa variable 2-109
Synonyms: ENSMUSG00000060986
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 628268
Lce1a2
Name: late cornified envelope 1A2
Synonyms: Sprrl2, 1110004E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 73722
Ccpg1os
Name: cell cycle progression 1, opposite strand
Synonyms: Gm5918
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 546143
Homologene: 130394
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,803,681 bp
  • T to C, chromosome 1 at 58,991,174 bp
  • T to C, chromosome 1 at 133,900,977 bp
  • A to T, chromosome 2 at 25,239,351 bp
  • A to T, chromosome 2 at 76,811,243 bp
  • A to T, chromosome 2 at 76,812,900 bp
  • A to T, chromosome 2 at 110,661,480 bp
  • G to T, chromosome 2 at 119,431,945 bp
  • A to G, chromosome 2 at 136,552,441 bp
  • T to C, chromosome 2 at 170,114,058 bp
  • T to C, chromosome 3 at 89,066,275 bp
  • A to T, chromosome 3 at 92,669,135 bp
  • A to G, chromosome 3 at 104,784,674 bp
  • A to T, chromosome 3 at 106,017,978 bp
  • G to A, chromosome 3 at 152,243,888 bp
  • C to T, chromosome 4 at 47,030,795 bp
  • A to G, chromosome 4 at 55,530,481 bp
  • T to C, chromosome 4 at 155,159,392 bp
  • A to G, chromosome 4 at 156,048,506 bp
  • T to C, chromosome 5 at 30,920,620 bp
  • A to G, chromosome 6 at 58,265,858 bp
  • A to G, chromosome 6 at 68,303,085 bp
  • A to T, chromosome 6 at 78,466,561 bp
  • C to A, chromosome 6 at 88,281,575 bp
  • A to G, chromosome 7 at 25,015,527 bp
  • A to G, chromosome 7 at 126,797,696 bp
  • C to A, chromosome 8 at 45,270,697 bp
  • A to G, chromosome 8 at 71,989,058 bp
  • T to C, chromosome 9 at 14,464,113 bp
  • T to C, chromosome 9 at 39,949,925 bp
  • T to A, chromosome 9 at 72,979,893 bp
  • T to A, chromosome 9 at 106,066,960 bp
  • A to G, chromosome 9 at 108,082,247 bp
  • A to G, chromosome 10 at 78,970,203 bp
  • A to G, chromosome 10 at 129,268,666 bp
  • A to G, chromosome 11 at 49,823,799 bp
  • A to G, chromosome 11 at 70,315,995 bp
  • G to A, chromosome 11 at 82,961,696 bp
  • A to T, chromosome 11 at 86,722,321 bp
  • A to T, chromosome 11 at 114,804,317 bp
  • A to G, chromosome 11 at 121,147,799 bp
  • C to T, chromosome 12 at 57,496,499 bp
  • C to T, chromosome 12 at 82,440,908 bp
  • T to C, chromosome 12 at 108,537,337 bp
  • A to T, chromosome 13 at 14,346,029 bp
  • A to G, chromosome 13 at 60,721,778 bp
  • G to A, chromosome 13 at 96,656,732 bp
  • T to C, chromosome 14 at 27,652,872 bp
  • A to G, chromosome 14 at 34,724,754 bp
  • A to C, chromosome 14 at 50,710,914 bp
  • T to C, chromosome 17 at 25,345,399 bp
  • A to G, chromosome 18 at 38,268,880 bp
  • C to A, chromosome 18 at 39,775,383 bp
  • A to G, chromosome 19 at 3,897,723 bp
  • A to G, chromosome 19 at 39,163,438 bp
  • T to C, chromosome X at 16,716,423 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5113 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042701-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.