Strain Name:
C57BL/6J-MtgxR5198Btlr/Mmmh
Stock Number:
042774-MU
Citation ID:
RRID:MMRRC_042774-MU
Other Names:
R5198 (G1), C57BL/6J-MtgxR5198Btlr
Major Collection:

Gene Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, DPEAAE, Cspg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Rfx3
Name: regulatory factor X, 3 (influences HLA class II expression)
Synonyms: MRFX3, C230093O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19726
HGNC: HGNC:9984
Homologene: 7917
Dlc1
Name: deleted in liver cancer 1
Synonyms: p122-RhoGAP, STARD12, Arhgap7, A730069N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Pum1
Name: pumilio RNA-binding family member 1
Synonyms: Pumm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 80912
Homologene: 22830
Iffo2
Name: intermediate filament family orphan 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 212632
Homologene: 102202
Rlf
Name: rearranged L-myc fusion sequence
Synonyms: 9230110M18Rik, MommeD8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109263
Homologene: 8243
Wdr59
Name: WD repeat domain 59
Synonyms: 5430401O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 319481
Homologene: 38685
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
Nemf
Name: nuclear export mediator factor
Synonyms: 4933405E14Rik, 1500011I12Rik, Sdccag1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66244
VEGA: 12
Homologene: 3458
Pacs1
Name: phosphofurin acidic cluster sorting protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107975
VEGA: 19
Homologene: 9970
Gdpd5
Name: glycerophosphodiester phosphodiesterase domain containing 5
Synonyms: Gde2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233552
Homologene: 32741
Il17c
Name: interleukin 17C
Synonyms: IL-17C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234836
HGNC: HGNC:5983
Homologene: 8320
Vkorc1
Name: vitamin K epoxide reductase complex, subunit 1
Synonyms: D7Wsu86e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 27973
Homologene: 11416
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: polycystin-2, C030034P18Rik, TRPP2, PC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Smap2
Name: small ArfGAP 2
Synonyms: 1810031K02Rik, Smap2, Smap1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69780
Homologene: 41489
Cep152
Name: centrosomal protein 152
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99100
Homologene: 37159
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230676
Homologene: 49413
Gata4
Name: GATA binding protein 4
Synonyms: Gata-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14463
HGNC: HGNC:4173
Homologene: 1551
Nacc2
Name: nucleus accumbens associated 2, BEN and BTB (POZ) domain containing
Synonyms: 0610020I02Rik, C030048H19Rik, Btbd14a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67991
Homologene: 75239
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: DM, Dm15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269959
Homologene: 18912
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Slc25a30
Name: solute carrier family 25, member 30
Synonyms: 4933433D23Rik, KMCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67554
VEGA: 14
Homologene: 57046
Abcc9
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Synonyms: SUR2B, SUR2A, Sur2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 435975
Homologene: 104832
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17836
Homologene: 136663
Pcnx2
Name: pecanex homolog 2
Synonyms: E330039K12Rik, Pcnxl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Gpr39
Name: G protein-coupled receptor 39
Synonyms: 4933415E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71111
HGNC: HGNC:4496
Homologene: 20380
Xkr7
Name: X-linked Kx blood group related 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228787
Homologene: 19390
Vmn1r68
Name: vomeronasal 1 receptor 68
Synonyms: Gm6898
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628580
Homologene: 120153
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: B830018M07Rik, Bai1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Zfp616
Name: zinc finger protein 616
Synonyms: Gm12330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 327963
Homologene: 88945
Alox12
Name: arachidonate 12-lipoxygenase
Synonyms: P-12LO, Alox12p, 9930022G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11684
HGNC: HGNC:429
Homologene: 560
Naaa
Name: N-acylethanolamine acid amidase
Synonyms: 2210023K21Rik, 3830414F09Rik, Asahl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67111
HGNC: HGNC:736
Homologene: 8686
Nphp4
Name: nephronophthisis 4 (juvenile) homolog (human)
Synonyms: 4930564O18Rik, nmf192
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 260305
Homologene: 9024
Fbxw15
Name: F-box and WD-40 domain protein 15
Synonyms: Fbxo12J
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382105
Homologene: 110776
Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
Synonyms: Intin3, Itih-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16426
HGNC: HGNC:6168
Homologene: 1669
Tekt3
Name: tektin 3
Synonyms: 4933407G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71062
Homologene: 12896
Cma2
Name: chymase 2, mast cell
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545055
VEGA: 14
Homologene: 115745
Potegl
Name: POTE ankyrin domain family, member G like
Synonyms: 4931423N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70981
Homologene: 86765
Nudt7
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 7
Synonyms: 1300007B24Rik, 2210404C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67528
HGNC: HGNC:8054
Homologene: 41564
Pramel5
Name: PRAME like 5
Synonyms: OTTMUSG00000010540
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 384077
Homologene: 133722
Dus3l
Name: dihydrouridine synthase 3-like (S. cerevisiae)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224907
VEGA: 17
Homologene: 6533
4921504E06Rik
Name: RIKEN cDNA 4921504E06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70909
Homologene: 87049
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57745
Homologene: 49338
Mrps11
Name: mitochondrial ribosomal protein S11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67994
Homologene: 32554
Olfr625-ps1
Name: olfactory receptor 625, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-6416276-6417237, MOR31-15P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258169
Cda
Name: cytidine deaminase
Synonyms: 2210401N16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72269
HGNC: HGNC:1712
Homologene: 1352
Tbcc
Name: tubulin-specific chaperone C
Synonyms: 2810055C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72726
VEGA: 17
Homologene: 2402
Olfr1273-ps
Name: olfactory receptor 1273, pseudogene
Synonyms: GA_x6K02T2Q125-51650793-51649870, MOR227-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258977
Homologene: 133649
Gm16976
Name: predicted gene, 16976
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 102637302
Gm17669
Name: predicted gene, 17669
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 108168363
VEGA: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 125,677,436 bp
  • A to G, chromosome 2 at 19,542,417 bp
  • A to G, chromosome 2 at 20,713,387 bp
  • G to A, chromosome 2 at 23,212,461 bp
  • C to T, chromosome 2 at 26,060,334 bp
  • T to C, chromosome 2 at 90,296,393 bp
  • T to A, chromosome 2 at 125,587,624 bp
  • T to C, chromosome 2 at 153,054,953 bp
  • T to C, chromosome 4 at 118,388,322 bp
  • T to C, chromosome 4 at 121,016,787 bp
  • T to A, chromosome 4 at 121,148,553 bp
  • T to A, chromosome 4 at 130,779,879 bp
  • T to A, chromosome 4 at 138,338,911 bp
  • T to A, chromosome 4 at 139,575,217 bp
  • T to G, chromosome 4 at 144,273,494 bp
  • C to T, chromosome 4 at 152,506,408 bp
  • G to A, chromosome 5 at 92,268,045 bp
  • A to C, chromosome 5 at 104,483,092 bp
  • G to A, chromosome 6 at 121,874,562 bp
  • A to G, chromosome 6 at 142,626,000 bp
  • T to C, chromosome 7 at 10,527,796 bp
  • C to G, chromosome 7 at 19,088,019 bp
  • T to C, chromosome 7 at 24,124,856 bp
  • C to A, chromosome 7 at 42,903,745 bp
  • C to T, chromosome 7 at 78,783,379 bp
  • A to C, chromosome 7 at 82,611,798 bp
  • T to A, chromosome 7 at 99,438,308 bp
  • T to C, chromosome 7 at 103,682,729 bp
  • T to C, chromosome 7 at 127,894,588 bp
  • G to T, chromosome 7 at 141,638,772 bp
  • C to T, chromosome 8 at 36,938,398 bp
  • G to A, chromosome 8 at 111,481,988 bp
  • G to A, chromosome 8 at 114,135,445 bp
  • A to G, chromosome 8 at 122,422,369 bp
  • G to A, chromosome 8 at 125,759,215 bp
  • C to A, chromosome 9 at 109,558,174 bp
  • G to A, chromosome 10 at 27,347,003 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • G to A, chromosome 11 at 63,070,308 bp
  • T to C, chromosome 11 at 70,254,417 bp
  • G to A, chromosome 11 at 74,083,510 bp
  • A to G, chromosome 12 at 69,356,047 bp
  • T to A, chromosome 13 at 89,690,872 bp
  • T to C, chromosome 14 at 30,912,649 bp
  • G to C, chromosome 14 at 44,858,843 bp
  • T to C, chromosome 14 at 55,972,075 bp
  • G to A, chromosome 14 at 63,200,451 bp
  • C to A, chromosome 14 at 75,769,616 bp
  • A to T, chromosome 15 at 74,543,701 bp
  • T to C, chromosome 17 at 46,890,862 bp
  • A to G, chromosome 17 at 56,769,574 bp
  • T to C, chromosome 18 at 67,562,556 bp
  • T to C, chromosome 19 at 5,139,297 bp
  • T to C, chromosome 19 at 27,830,776 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5198 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042774-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.