Strain Name:
C57BL/6J-MtgxR5205Btlr/Mmmh
Stock Number:
042780-MU
Citation ID:
RRID:MMRRC_042780-MU
Other Names:
R5205 (G1), C57BL/6J-MtgxR5205Btlr
Major Collection:

Gene Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: WBE1, Flo, GENA 60, GENA 47, Whi, Mt, Gena 52, Edy, Dz, A730019I05Rik, Todo, Obt, Cyn, Cycn, Lda
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 320790
Homologene: 19067
Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Slc17a5
Name: solute carrier family 17 (anion/sugar transporter), member 5
Synonyms: 4631416G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235504
Homologene: 56571
Ptdss2
Name: phosphatidylserine synthase 2
Synonyms: PSS2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 27388
Homologene: 8462
Slk
Name: STE20-like kinase
Synonyms: SLK, mSLK, Etk4, 9A2, Stk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20874
Homologene: 22515
Rbm6
Name: RNA binding motif protein 6
Synonyms: NY-LU-12, Def-3, g16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 19654
HGNC: HGNC:9903
Homologene: 31336
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 103554
Homologene: 113742
Rbm25
Name: RNA binding motif protein 25
Synonyms: 2610015J01Rik, A130095G20Rik, 2600011C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 67039
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, 2610202A04Rik, D16Ium21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 22129
Homologene: 2487
Zfp985
Name: zinc finger protein 985
Synonyms: Gm13154
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 433804
Homologene: 133076
Lrrc28
Name: leucine rich repeat containing 28
Synonyms: 2310058O11Rik, 1300004K21Rik, 2210012C09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67867
Homologene: 16944
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, C130039F11Rik, nesprin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 64009
VEGA: 10
Homologene: 52329
Tmem43
Name: transmembrane protein 43
Synonyms: 1200015A22Rik, LUMA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 74122
Homologene: 11532
Dennd1b
Name: DENN/MADD domain containing 1B
Synonyms: 4632404N19Rik, 4930467M19Rik, 6820401H01Rik, F730008N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 329260
Homologene: 11739
Ybx1
Name: Y box protein 1
Synonyms: Nsep1, EF1A, YB-1, MSY1, DNA binding protein B, dbpB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 22608
HGNC: HGNC:8014
Homologene: 88707
Fam135a
Name: family with sequence similarity 135, member A
Synonyms: 4921533L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 68187
Homologene: 32665
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: DM, Dm15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Msh4
Name: mutS homolog 4
Synonyms: mMsh4, 4930485C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 55993
HGNC: HGNC:7327
Homologene: 1830
Txndc11
Name: thioredoxin domain containing 11
Synonyms: Txdc11, 2810408E11Rik, EFP1, EF-hand binding protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 106200
Homologene: 9301
Ush2a
Name: usherin
Synonyms: Ush2a, Ushrn, MUSH2A, A930037M10Rik, A930011D15Rik, LOC269160, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22283
Homologene: 66151
Aldh6a1
Name: aldehyde dehydrogenase family 6, subfamily A1
Synonyms: 1110038I05Rik, Mmsdh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 104776
VEGA: 12
HGNC: HGNC:7179
Homologene: 4082
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 245026
Homologene: 18260
Taar2
Name: trace amine-associated receptor 2
Synonyms: Gpr58
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 209512
HGNC: HGNC:4514
Homologene: 110760
Olfr1477
Name: olfactory receptor 1477
Synonyms: GA_x6K02T2RE5P-3834960-3835907, MOR202-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258691
Homologene: 110492
Tbc1d2b
Name: TBC1 domain family, member 2B
Synonyms: 1810061M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 67016
Homologene: 56694
Ppp1r9b
Name: protein phosphatase 1, regulatory subunit 9B
Synonyms: spinophilin, SPL, neurabin II, Spn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217124
HGNC: HGNC:9298
Homologene: 32787
Adgre4
Name: adhesion G protein-coupled receptor E4
Synonyms: EGF-TM7, FIRE, Gpr127, Emr4, D17Ertd479e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 52614
VEGA: 17
Homologene: 64640
Adamts19
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
Synonyms: D230034E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240322
VEGA: 18
Homologene: 15860
Prorp
Name: protein only RNase P catalytic subunit
Synonyms: 1110008L16Rik, Mrpp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 66132
Homologene: 45935
Taar7b
Name: trace amine-associated receptor 7B
Synonyms: LOC209517
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 209517
Homologene: 134040
Nrxn1
Name: neurexin I
Synonyms: neurexin I beta, neurexin I beta, neurexin I alpha, neurexin I alpha, A230068P09Rik, 1700062G21Rik, neurexin I alpha, neurexin I beta, alpha-latrotoxin receptor (calcium-dependent), 9330127H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 12722
Homologene: 77224
Cfh
Name: complement component factor h
Synonyms: Sas1, Sas-1, Mud-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4930428C11Rik, Wdr96, D19Ertd652e, 4930463G05Rik, 4632415N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 100048534
Homologene: 36425
Dnaaf2
Name: dynein, axonemal assembly factor 2
Synonyms: kintoun, Ktu, 1110034A24Rik, 2810020C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 109065
Homologene: 10026
Prss56
Name: protease, serine 56
Synonyms: Prss56, 1700027L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 69453
Homologene: 79885
Majin
Name: membrane anchored junction protein
Synonyms: 1700123I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 622554
Homologene: 78163
Mfhas1
Name: malignant fibrous histiocytoma amplified sequence 1
Synonyms: D8Ertd91e, 2310066G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 52065
Homologene: 3114
Plppr2
Name: phospholipid phosphatase related 2
Synonyms: BC018242, PRG-4, Lppr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235044
Homologene: 11229
Orm1
Name: orosomucoid 1
Synonyms: Agp-1, Agp-2, Orm-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18405
HGNC: HGNC:8499
Homologene: 130632
Klra4
Name: killer cell lectin-like receptor, subfamily A, member 4
Synonyms: Chok, ly49r129, Ly49d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16635
Homologene: 110821
Asb16
Name: ankyrin repeat and SOCS box-containing 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217217
Homologene: 76813
Prox2
Name: prospero homeobox 2
Synonyms: 1700058C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 73422
Homologene: 18421
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 545848
Gm13991
Name: predicted gene 13991
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 433464
A930002I21Rik
Name: RIKEN cDNA A930002I21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
Gm15594
Name: predicted gene 15594
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
Gm16379
Name: predicted pseudogene 16379
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 100040259
Gm11615
Name: predicted gene 11615
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
Ighv2-3
Name: immunoglobulin heavy variable 2-3
Synonyms: Gm16948
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238412
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 24,029,511 bp
  • G to T, chromosome 1 at 87,185,534 bp
  • T to A, chromosome 1 at 139,054,568 bp
  • A to G, chromosome 1 at 140,143,970 bp
  • T to A, chromosome 1 at 188,874,936 bp
  • G to C, chromosome 2 at 116,528,200 bp
  • T to C, chromosome 3 at 107,097,146 bp
  • T to C, chromosome 3 at 144,746,784 bp
  • A to G, chromosome 3 at 153,866,412 bp
  • T to A, chromosome 4 at 8,752,509 bp
  • T to C, chromosome 4 at 63,344,692 bp
  • G to T, chromosome 4 at 119,279,151 bp
  • A to T, chromosome 4 at 147,582,911 bp
  • T to C, chromosome 6 at 18,427,433 bp
  • A to C, chromosome 6 at 69,016,665 bp
  • T to C, chromosome 6 at 91,486,781 bp
  • T to A, chromosome 6 at 130,062,117 bp
  • C to G, chromosome 7 at 19,088,019 bp
  • A to G, chromosome 7 at 67,531,768 bp
  • T to C, chromosome 7 at 141,143,171 bp
  • G to A, chromosome 8 at 35,591,007 bp
  • A to T, chromosome 9 at 14,845,472 bp
  • A to T, chromosome 9 at 21,941,074 bp
  • A to G, chromosome 9 at 78,578,617 bp
  • A to G, chromosome 9 at 90,207,810 bp
  • A to T, chromosome 9 at 105,782,033 bp
  • A to G, chromosome 9 at 107,788,343 bp
  • C to A, chromosome 10 at 5,052,295 bp
  • A to C, chromosome 10 at 23,940,976 bp
  • A to T, chromosome 10 at 24,000,018 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • T to A, chromosome 11 at 30,832,666 bp
  • T to A, chromosome 11 at 95,001,298 bp
  • A to G, chromosome 11 at 101,265,138 bp
  • G to A, chromosome 11 at 102,268,994 bp
  • T to A, chromosome 12 at 55,304,441 bp
  • C to T, chromosome 12 at 69,192,924 bp
  • T to A, chromosome 12 at 83,672,869 bp
  • T to A, chromosome 12 at 84,439,644 bp
  • T to A, chromosome 12 at 85,095,320 bp
  • T to C, chromosome 12 at 113,611,275 bp
  • A to G, chromosome 16 at 11,128,665 bp
  • T to A, chromosome 16 at 94,448,059 bp
  • G to T, chromosome 17 at 55,794,727 bp
  • A to T, chromosome 17 at 90,163,874 bp
  • G to A, chromosome 18 at 58,968,808 bp
  • T to C, chromosome 19 at 6,195,759 bp
  • T to C, chromosome 19 at 13,502,799 bp
  • T to A, chromosome 19 at 47,625,460 bp
  • C to A, chromosome 19 at 47,897,548 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5205 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042780-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.