Strain Name:
C57BL/6J-MtgxR5205Btlr/Mmmh
Stock Number:
042780-MU
Citation ID:
RRID:MMRRC_042780-MU
Other Names:
R5205 (G1), C57BL/6J-MtgxR5205Btlr
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: Todo, Gena 52, GENA 60, Dz, Cycn, Cyn, Obt, Mt, Whi, GENA 47, A730019I05Rik, Lda, Flo, Edy, WBE1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Otx1
Name: orthodenticle homeobox 1
Synonyms: jv, A730044F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Slc17a5
Name: solute carrier family 17 (anion/sugar transporter), member 5
Synonyms: 4631416G20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235504
Homologene: 56571
Ptdss2
Name: phosphatidylserine synthase 2
Synonyms: PSS2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27388
Homologene: 8462
Slk
Name: STE20-like kinase
Synonyms: SLK, 9A2, mSLK, Etk4, Stk2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20874
Homologene: 22515
Rbm6
Name: RNA binding motif protein 6
Synonyms: g16, NY-LU-12, Def-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19654
HGNC: HGNC:9903
Homologene: 31336
Psme4
Name: proteasome (prosome, macropain) activator subunit 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103554
Homologene: 113742
Rbm25
Name: RNA binding motif protein 25
Synonyms: A130095G20Rik, 2600011C06Rik, 2610015J01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67039
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, D16Ium21, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Zfp985
Name: zinc finger protein 985
Synonyms: Gm13154
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433804
Homologene: 133076
Lrrc28
Name: leucine rich repeat containing 28
Synonyms: 2310058O11Rik, 2210012C09Rik, 1300004K21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67867
Homologene: 16944
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Tmem43
Name: transmembrane protein 43
Synonyms: 1200015A22Rik, LUMA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74122
Homologene: 11532
Dennd1b
Name: DENN domain containing 1B
Synonyms: F730008N07Rik, 6820401H01Rik, 4930467M19Rik, 4632404N19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329260
Homologene: 11739
Ybx1
Name: Y box protein 1
Synonyms: YB-1, DNA binding protein B, EF1A, dbpB, Nsep1, MSY1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22608
HGNC: HGNC:8014
Homologene: 88707
Fam135a
Name: family with sequence similarity 135, member A
Synonyms: 4921533L14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68187
Homologene: 32665
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: DM, Dm15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Msh4
Name: mutS homolog 4
Synonyms: mMsh4, 4930485C04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 55993
HGNC: HGNC:7327
Homologene: 1830
Txndc11
Name: thioredoxin domain containing 11
Synonyms: Txdc11, EFP1, 2810408E11Rik, EF-hand binding protein 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106200
Homologene: 9301
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Aldh6a1
Name: aldehyde dehydrogenase family 6, subfamily A1
Synonyms: Mmsdh, 1110038I05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104776
VEGA: 12
HGNC: HGNC:7179
Homologene: 4082
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245026
Homologene: 18260
Taar2
Name: trace amine-associated receptor 2
Synonyms: Gpr58
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209512
HGNC: HGNC:4514
Homologene: 110760
Or5b120
Name: olfactory receptor family 5 subfamily B member 120
Synonyms: GA_x6K02T2RE5P-3834960-3835907, Olfr1477, MOR202-10
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258691
Homologene: 110492
Tbc1d2b
Name: TBC1 domain family, member 2B
Synonyms: 1810061M12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67016
Homologene: 56694
Ppp1r9b
Name: protein phosphatase 1, regulatory subunit 9B
Synonyms: SPL, neurabin II, Spn, spinophilin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217124
HGNC: HGNC:9298
Homologene: 32787
Adgre4
Name: adhesion G protein-coupled receptor E4
Synonyms: D17Ertd479e, Emr4, Gpr127, FIRE, EGF-TM7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52614
VEGA: 17
Homologene: 64640
Adamts19
Name: ADAM metallopeptidase with thrombospondin type 1 motif 19
Synonyms: D230034E10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240322
VEGA: 18
Homologene: 15860
Prorp
Name: protein only RNase P catalytic subunit
Synonyms: 1110008L16Rik, Mrpp3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66132
Homologene: 45935
Taar7b
Name: trace amine-associated receptor 7B
Synonyms: LOC209517
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 209517
Homologene: 134040
Nrxn1
Name: neurexin I
Synonyms: alpha-latrotoxin receptor (calcium-dependent), 1700062G21Rik, neurexin I alpha, 9330127H16Rik, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I alpha, neurexin I beta, A230068P09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12722
HGNC: HGNC:2017
Homologene: 77224
Cfh
Name: complement component factor h
Synonyms: Mud-1, Sas-1, Sas1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4632415N18Rik, D19Ertd652e, 4930428C11Rik, Wdr96, 4930463G05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100048534
Homologene: 36425
Dnaaf2
Name: dynein, axonemal assembly factor 2
Synonyms: Ktu, 2810020C19Rik, 1110034A24Rik, kintoun
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109065
Homologene: 10026
Prss56
Name: serine protease 56
Synonyms: Prss56, 1700027L20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69453
Homologene: 79885
Majin
Name: membrane anchored junction protein
Synonyms: 1700123I01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 622554
Homologene: 78163
Mfhas1
Name: malignant fibrous histiocytoma amplified sequence 1
Synonyms: D8Ertd91e, 2310066G09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52065
Homologene: 3114
Plppr2
Name: phospholipid phosphatase related 2
Synonyms: Lppr2, BC018242, PRG-4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235044
Homologene: 11229
Orm1
Name: orosomucoid 1
Synonyms: Orm-1, Agp-2, Agp-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18405
Homologene: 130632
Klra4
Name: killer cell lectin-like receptor, subfamily A, member 4
Synonyms: Ly49d, Chok, ly49r129
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16635
Homologene: 110821
Asb16
Name: ankyrin repeat and SOCS box-containing 16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217217
Homologene: 76813
Prox2
Name: prospero homeobox 2
Synonyms: 1700058C01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73422
Homologene: 18421
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 545848
Gm13991
Name: predicted gene 13991
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 433464
A930002I21Rik
Name: RIKEN cDNA A930002I21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Gm15594
Name: predicted gene 15594
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Mif-ps6
Name: macrophage migration inhibitory factor, pseudogene 6
Synonyms: Gm16379
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100040259
Gm11615
Name: predicted gene 11615
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Ighv2-3
Name: immunoglobulin heavy variable 2-3
Synonyms: Gm16948
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238412
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 24,029,511 bp
  • G to T, chromosome 1 at 87,185,534 bp
  • T to A, chromosome 1 at 139,054,568 bp
  • A to G, chromosome 1 at 140,143,970 bp
  • T to A, chromosome 1 at 188,874,936 bp
  • G to C, chromosome 2 at 116,528,200 bp
  • T to C, chromosome 3 at 107,097,146 bp
  • T to C, chromosome 3 at 144,746,784 bp
  • A to G, chromosome 3 at 153,866,412 bp
  • T to A, chromosome 4 at 8,752,509 bp
  • T to C, chromosome 4 at 63,344,692 bp
  • G to T, chromosome 4 at 119,279,151 bp
  • A to T, chromosome 4 at 147,582,911 bp
  • T to C, chromosome 6 at 18,427,433 bp
  • A to C, chromosome 6 at 69,016,665 bp
  • T to C, chromosome 6 at 91,486,781 bp
  • T to A, chromosome 6 at 130,062,117 bp
  • C to G, chromosome 7 at 19,088,019 bp
  • A to G, chromosome 7 at 67,531,768 bp
  • T to C, chromosome 7 at 141,143,171 bp
  • G to A, chromosome 8 at 35,591,007 bp
  • A to T, chromosome 9 at 14,845,472 bp
  • A to T, chromosome 9 at 21,941,074 bp
  • A to G, chromosome 9 at 78,578,617 bp
  • A to G, chromosome 9 at 90,207,810 bp
  • A to T, chromosome 9 at 105,782,033 bp
  • A to G, chromosome 9 at 107,788,343 bp
  • C to A, chromosome 10 at 5,052,295 bp
  • A to C, chromosome 10 at 23,940,976 bp
  • A to T, chromosome 10 at 24,000,018 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • T to A, chromosome 11 at 30,832,666 bp
  • T to A, chromosome 11 at 95,001,298 bp
  • A to G, chromosome 11 at 101,265,138 bp
  • G to A, chromosome 11 at 102,268,994 bp
  • T to A, chromosome 12 at 55,304,441 bp
  • C to T, chromosome 12 at 69,192,924 bp
  • T to A, chromosome 12 at 83,672,869 bp
  • T to A, chromosome 12 at 84,439,644 bp
  • T to A, chromosome 12 at 85,095,320 bp
  • T to C, chromosome 12 at 113,611,275 bp
  • A to G, chromosome 16 at 11,128,665 bp
  • T to A, chromosome 16 at 94,448,059 bp
  • G to T, chromosome 17 at 55,794,727 bp
  • A to T, chromosome 17 at 90,163,874 bp
  • G to A, chromosome 18 at 58,968,808 bp
  • T to C, chromosome 19 at 6,195,759 bp
  • T to C, chromosome 19 at 13,502,799 bp
  • T to A, chromosome 19 at 47,625,460 bp
  • C to A, chromosome 19 at 47,897,548 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5205 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042780-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.