Strain Name:
C57BL/6J-MtgxR5226Btlr/Mmmh
Stock Number:
042799-MU
Citation ID:
RRID:MMRRC_042799-MU
Other Names:
R5226 (G1), C57BL/6J-MtgxR5226Btlr
Major Collection:

Gene Information

Slc1a3
Name: solute carrier family 1 (glial high affinity glutamate transporter), member 3
Synonyms: MGluT1, Eaat1, B430115D02Rik, GLAST, Gmt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20512
Homologene: 20882
Epb41l4a
Name: erythrocyte membrane protein band 4.1 like 4a
Synonyms: NBL4, Epb4.1l4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13824
VEGA: 18
Homologene: 8398
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: eIF4GII, 1500002J22Rik, 4930523M17Rik, G1-419-52, repro8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Atad5
Name: ATPase family, AAA domain containing 5
Synonyms: LOC237877, C130052G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237877
Homologene: 32611
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Recql4
Name: RecQ protein-like 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 79456
VEGA: 15
HGNC: HGNC:9949
Homologene: 3144
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208628
Homologene: 32227
Cux1
Name: cut-like homeobox 1
Synonyms: Cux, CDP, Cux-1, Cutl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, mBSC2, Nkcc1, sy-ns
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Rpap3
Name: RNA polymerase II associated protein 3
Synonyms: 2310042P20Rik, D15Ertd682e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71919
VEGA: 15
Homologene: 11613
Top2a
Name: topoisomerase (DNA) II alpha
Synonyms: DNA Topoisomerase II alpha, Top-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21973
Homologene: 830
Plcg2
Name: phospholipase C, gamma 2
Synonyms: Plcg-2, PLCgamma2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234779
HGNC: HGNC:9066
Homologene: 55671
Parn
Name: poly(A)-specific ribonuclease (deadenylation nuclease)
Synonyms: DAN, 1200003I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74108
VEGA: 16
HGNC: HGNC:8609
Homologene: 31098
Brat1
Name: BRCA1-associated ATM activator 1
Synonyms: Baat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231841
Homologene: 16776
Dsp
Name: desmoplakin
Synonyms: DP, 2300002E22Rik, 5730453H04Rik, rul
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Pum2
Name: pumilio RNA-binding family member 2
Synonyms: Pumm2, 5730503J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 80913
Homologene: 69183
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268878
Homologene: 77451
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
Snrnp48
Name: small nuclear ribonucleoprotein 48 (U11/U12)
Synonyms: 1110050F08Rik, 6530403A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67797
VEGA: 13
Homologene: 12191
Zbtb11
Name: zinc finger and BTB domain containing 11
Synonyms: ZNF-U69274, 9230110G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 271377
Homologene: 8678
Slfn4
Name: schlafen 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20558
Homologene: 133236
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Prkg2
Name: protein kinase, cGMP-dependent, type II
Synonyms: cGK-II, Prkgr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19092
HGNC: HGNC:9416
Homologene: 4556
Elf3
Name: E74-like factor 3
Synonyms: jen, ESX, ESE-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13710
HGNC: HGNC:3318
Homologene: 3265
Ppfia4
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Synonyms: 1110008G13Rik, LOC100042382, Liprin-alpha4, Gm3812
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68507
HGNC: HGNC:9248
Homologene: 66200
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: oxygen-regulated protein 1, Orp1, mG145, Dcdc3, Rp1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19888
Homologene: 4564
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 624765
Homologene: 83483
Rufy4
Name: RUN and FYVE domain containing 4
Synonyms: F930048N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 435626
Homologene: 52359
L3mbtl4
Name: L3MBTL4 histone methyl-lysine binding protein
Synonyms: D930040M24Rik, A730037L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 320858
Homologene: 114383
Atrnl1
Name: attractin like 1
Synonyms: Alp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226255
VEGA: 19
Homologene: 45809
Pdzrn3
Name: PDZ domain containing RING finger 3
Synonyms: semaphorin cytoplasmic domain-associated protein 3A, 1110020C07Rik, LNX3, Semcap3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 55983
Homologene: 10328
Lrit2
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
Synonyms: A930010E21Rik, Lrrc22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239038
VEGA: 14
Homologene: 18292
Dao
Name: D-amino acid oxidase
Synonyms: DAO, Dao-1, Dao1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13142
HGNC: HGNC:2671
Homologene: 37553
Rab26
Name: RAB26, member RAS oncogene family
Synonyms: A830020M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 328778
Homologene: 25655
Cyp3a57
Name: cytochrome P450, family 3, subfamily a, polypeptide 57
Synonyms: EG622127
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 622127
Homologene: 135775
Gm10722
Name: predicted gene 10722
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Ctla2b
Name: cytotoxic T lymphocyte-associated protein 2 beta
Synonyms: Ctla-2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13025
VEGA: 13
Homologene: 130627
Man1c1
Name: mannosidase, alpha, class 1C, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230815
Homologene: 69303
Zfp948
Name: zinc finger protein 948
Synonyms: BC049807
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 381066
VEGA: 17
Akr1d1
Name: aldo-keto reductase family 1, member D1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 208665
HGNC: HGNC:388
Homologene: 55943
Vmn1r115
Name: vomeronasal 1 receptor 115
Synonyms: Gm8549
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 667273
Homologene: 104166
Tlx2
Name: T cell leukemia, homeobox 2
Synonyms: Enx, Ncx1, Hox11l1, NCX, Hox11L.1, Tlx1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21909
HGNC: HGNC:5057
Homologene: 7575
Plin1
Name: perilipin 1
Synonyms: 6030432J05Rik, perilipin B, perilipin A, Peri, Plin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 103968
HGNC: HGNC:9076
Homologene: 2001
Tmem132a
Name: transmembrane protein 132A
Synonyms: 6720481D13Rik, Hspa5bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 98170
Homologene: 75076
Wnt10b
Name: wingless-type MMTV integration site family, member 10B
Synonyms: Wnt12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22410
VEGA: 15
Homologene: 20721
Btnl7-ps
Name: butyrophilin-like 7, pseudogene
Synonyms: Btnl7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 195349
Nt5c2
Name: 5'-nucleotidase, cytosolic II
Synonyms: cN-II, PNT5, NT5B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76952
HGNC: HGNC:8022
Homologene: 8158
Fgl1
Name: fibrinogen-like protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234199
HGNC: HGNC:3695
Homologene: 37927
Bend7
Name: BEN domain containing 7
Synonyms: 1110017O21Rik, E130319B15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209645
Homologene: 17660
Ankrd63
Name: ankyrin repeat domain 63
Synonyms: LOC383787, Gm1337
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 383787
Homologene: 19774
Cbx4
Name: chromobox 4
Synonyms: MPc2, PC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12418
HGNC: HGNC:1554
Homologene: 2712
Ptgir
Name: prostaglandin I receptor (IP)
Synonyms: prostacyclin receptor, IP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19222
HGNC: HGNC:9602
Homologene: 7496
Gpr132
Name: G protein-coupled receptor 132
Synonyms: G2 accumulation, G2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56696
VEGA: 12
Homologene: 8350
Dynlt4
Name: dynein light chain Tctex-type 4
Synonyms: 4833401D15Rik, Tctex1d4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242646
Homologene: 18398
Tnfrsf23
Name: tumor necrosis factor receptor superfamily, member 23
Synonyms: Tnfrh1, mSOB, mDcTrailr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 79201
Homologene: 84848
Oxgr1
Name: oxoglutarate (alpha-ketoglutarate) receptor 1
Synonyms: LOC239283, Gpr99, P2Y15, Gpr80, Cysltr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239283
VEGA: 14
HGNC: HGNC:4531
Homologene: 25878
4933414I15Rik
Name: RIKEN cDNA 4933414I15 gene
Synonyms: ENSMUSG00000051192
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74408
Gm26672
Name: predicted gene, 26672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
2010315B03Rik
Name: RIKEN cDNA 2010315B03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 630836
Homologene: 136499
Gm15511
Name: predicted gene 15511
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102642202
Mir6989
Name: microRNA 6989
Synonyms: mmu-mir-6989
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 102465598
VEGA: 19
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 4,348,033 bp
  • T to C, chromosome 1 at 74,147,663 bp
  • C to A, chromosome 1 at 134,304,286 bp
  • G to A, chromosome 1 at 135,257,239 bp
  • C to A, chromosome 2 at 4,752,978 bp
  • T to C, chromosome 2 at 31,457,073 bp
  • T to C, chromosome 2 at 118,703,255 bp
  • A to G, chromosome 4 at 117,128,093 bp
  • A to T, chromosome 4 at 134,578,369 bp
  • C to A, chromosome 4 at 138,096,794 bp
  • A to C, chromosome 5 at 98,976,462 bp
  • A to T, chromosome 5 at 114,021,033 bp
  • T to C, chromosome 5 at 115,588,067 bp
  • A to G, chromosome 5 at 123,794,172 bp
  • T to C, chromosome 5 at 136,370,173 bp
  • C to T, chromosome 5 at 140,714,846 bp
  • T to C, chromosome 5 at 145,365,697 bp
  • T to A, chromosome 6 at 37,536,014 bp
  • C to T, chromosome 6 at 83,068,930 bp
  • C to T, chromosome 6 at 101,153,311 bp
  • T to A, chromosome 7 at 16,908,720 bp
  • C to T, chromosome 7 at 20,844,244 bp
  • A to G, chromosome 7 at 79,722,699 bp
  • C to A, chromosome 7 at 143,685,785 bp
  • T to A, chromosome 8 at 41,196,999 bp
  • A to T, chromosome 8 at 117,577,874 bp
  • T to C, chromosome 9 at 3,000,937 bp
  • A to G, chromosome 9 at 67,945,553 bp
  • T to A, chromosome 9 at 69,364,141 bp
  • T to C, chromosome 9 at 124,294,076 bp
  • A to G, chromosome 10 at 79,194,040 bp
  • A to T, chromosome 11 at 50,942,589 bp
  • T to C, chromosome 11 at 80,095,062 bp
  • A to T, chromosome 11 at 83,187,549 bp
  • A to G, chromosome 11 at 99,004,205 bp
  • T to C, chromosome 11 at 119,081,928 bp
  • C to T, chromosome 12 at 8,713,458 bp
  • T to C, chromosome 12 at 112,852,148 bp
  • A to G, chromosome 13 at 38,186,770 bp
  • G to A, chromosome 13 at 38,205,117 bp
  • C to T, chromosome 13 at 60,896,332 bp
  • A to G, chromosome 14 at 37,072,353 bp
  • A to G, chromosome 14 at 120,022,253 bp
  • C to T, chromosome 15 at 8,642,225 bp
  • T to C, chromosome 15 at 76,710,129 bp
  • T to A, chromosome 15 at 97,703,223 bp
  • G to T, chromosome 15 at 98,776,614 bp
  • A to G, chromosome 16 at 13,625,552 bp
  • G to T, chromosome 16 at 29,248,279 bp
  • T to C, chromosome 16 at 56,007,148 bp
  • A to G, chromosome 17 at 21,588,243 bp
  • T to A, chromosome 17 at 24,534,133 bp
  • A to T, chromosome 17 at 34,533,287 bp
  • A to T, chromosome 17 at 46,983,270 bp
  • T to A, chromosome 17 at 68,764,722 bp
  • C to T, chromosome 18 at 33,810,313 bp
  • T to C, chromosome 18 at 37,752,524 bp
  • C to A, chromosome 18 at 57,879,020 bp
  • A to G, chromosome 19 at 6,346,504 bp
  • A to G, chromosome 19 at 10,867,144 bp
  • A to C, chromosome 19 at 46,898,629 bp
  • G to T, chromosome 19 at 57,650,335 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5226 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
042799-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.