Strain Name:
C57BL/6J-MtgxR5101Btlr/Mmmh
Stock Number:
042852-MU
Citation ID:
RRID:MMRRC_042852-MU
Other Names:
R5101 (G1), C57BL/6J-MtgxR5101Btlr
Major Collection:

Gene Information

Cdh3
Name: cadherin 3
Synonyms: P-cadherin, Pcad, Cadp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12560
HGNC: HGNC:1762
Homologene: 20425
Gpd2
Name: glycerol phosphate dehydrogenase 2, mitochondrial
Synonyms: Gdm1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14571
HGNC: HGNC:4456
Homologene: 352
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20269
Homologene: 56005
Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Nek7
Name: NIMA (never in mitosis gene a)-related expressed kinase 7
Synonyms: 2810460C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 59125
Homologene: 69340
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 328329
Homologene: 42094
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Akap9
Name: A kinase (PRKA) anchor protein (yotiao) 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Ago2
Name: argonaute RISC catalytic subunit 2
Synonyms: argonaute 2, 1110029L17Rik, 2310051F07Rik, Eif2c2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239528
HGNC: HGNC:3263
Homologene: 81825
Smc4
Name: structural maintenance of chromosomes 4
Synonyms: 2500002A22Rik, Smc4l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70099
Homologene: 4015
Nr2c2
Name: nuclear receptor subfamily 2, group C, member 2
Synonyms: TAK1, Tr4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 22026
HGNC: HGNC:7972
Homologene: 2475
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Lpin2
Name: lipin 2
Synonyms: 2610511G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 64898
Homologene: 8769
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Pms2
Name: PMS1 homolog2, mismatch repair system component
Synonyms: mismatch repair, DNA mismatch repair
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18861
HGNC: HGNC:9122
Homologene: 133560
Smad4
Name: SMAD family member 4
Synonyms: DPC4, Smad 4, Dpc4, D18Wsu70e, Madh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 17128
HGNC: HGNC:6770
Homologene: 31310
Adam17
Name: a disintegrin and metallopeptidase domain 17
Synonyms: Tace, CD156b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11491
HGNC: HGNC:195
Homologene: 2395
Tmem131l
Name: transmembrane 131 like
Synonyms: D930015E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229473
Homologene: 9057
Sugp2
Name: SURP and G patch domain containing 2
Synonyms: Sfrs14, Srsf14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234373
Homologene: 8923
Clec4d
Name: C-type lectin domain family 4, member d
Synonyms: mMCL, Mpcl, Clecsf8, mcl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17474
Homologene: 7844
Entpd3
Name: ectonucleoside triphosphate diphosphohydrolase 3
Synonyms: NTPDase-3, HB6, Cd39l3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215446
HGNC: HGNC:3365
Homologene: 68171
Syn2
Name: synapsin II
Synonyms: 2900074L19Rik, Synapsin IIb, Synapsin IIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20965
Homologene: 49348
Myo6
Name: myosin VI
Synonyms: Tlc, Myo6rsv, rsv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17920
HGNC: HGNC:7605
Homologene: 56417
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Slc22a1
Name: solute carrier family 22 (organic cation transporter), member 1
Synonyms: Lx1, Oct1, Orct, Oct1, Orct1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20517
VEGA: 17
Homologene: 20665
Dock3
Name: dedicator of cyto-kinesis 3
Synonyms: PBP, Moca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208869
HGNC: HGNC:2989
Homologene: 21030
4931408C20Rik
Name: RIKEN cDNA 4931408C20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210940
Homologene: 86827
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637896
Homologene: 115466
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Or51ab3
Name: olfactory receptor family 51 subfamily AB member 3
Synonyms: GA_x6K02T2PBJ9-6275524-6276477, GA_x6K02T2PBJ9-6271959-6272393, MOR20-1, MOR20-1, Olfr614, Olfr613
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259104
Homologene: 17505
Syde2
Name: synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
Synonyms: C430017H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 214804
Homologene: 19035
Gm4787
Name: predicted gene 4787
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 214321
Homologene: 86950
Ildr2
Name: immunoglobulin-like domain containing receptor 2
Synonyms: 3110063L10Rik, 2810478N18Rik, OTTMUSG00000021748, ENSMUSG00000040612, Dbsm1, D1Ertd471e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100039795
Homologene: 52388
Cytip
Name: cytohesin 1 interacting protein
Synonyms: Cbp, A130053M09Rik, Pscdbp, Cybr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227929
HGNC: HGNC:9506
Homologene: 3167
Adgrg3
Name: adhesion G protein-coupled receptor G3
Synonyms: Pb99, A030001G24Rik, Gpr97
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54672
Homologene: 18129
Gp1ba
Name: glycoprotein 1b, alpha polypeptide
Synonyms: GP Ib-alpha, GPIb-alpha, GPIba
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14723
HGNC: HGNC:4439
Homologene: 143
Psapl1
Name: prosaposin-like 1
Synonyms: 2310020A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 76943
Homologene: 105928
Nme8
Name: NME/NM23 family member 8
Synonyms: 1700056P15Rik, Sptrx-2, Txndc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 73412
Homologene: 9593
Krt87
Name: keratin 87
Synonyms: Krt2-25, Krt83
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 406219
VEGA: 15
Homologene: 133804
Lats1
Name: large tumor suppressor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16798
VEGA: 10
HGNC: HGNC:6514
Homologene: 55843
Cyp2c23
Name: cytochrome P450, family 2, subfamily c, polypeptide 23
Synonyms: Cyp2c44
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226143
Homologene: 115563
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 636808
Homologene: 43974
Nid1
Name: nidogen 1
Synonyms: entactin, entactin 1, nidogen-1, entactin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18073
VEGA: 13
HGNC: HGNC:7821
Homologene: 1878
Vmn2r17
Name: vomeronasal 2, receptor 17
Synonyms: EG384221
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 384221
Homologene: 104825
Or2ag18
Name: olfactory receptor family 2 subfamily AG member 18
Synonyms: GA_x6K02T2PBJ9-9184187-9183237, MOR283-4, Olfr700
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258593
Homologene: 64895
Or9g19
Name: olfactory receptor family 9 subfamily G member 19
Synonyms: GA_x6K02T2Q125-47248551-47249468, MOR213-2, Olfr1013
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258757
Homologene: 74096
Uba1y
Name: ubiquitin-activating enzyme, Chr Y
Synonyms: A1s9Y-1, Ube-2, Ube1y-1, Sby, Ube1y1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
NCBI: 22202
Homologene: 129435
Ctsw
Name: cathepsin W
Synonyms: lymphopain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13041
VEGA: 19
HGNC: HGNC:2546
Homologene: 37471
Or1e16
Name: olfactory receptor family 1 subfamily E member 16
Synonyms: MOR135-13, GA_x6K02T2P1NL-3556334-3555390, I54, Olfr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258923
Homologene: 115482
Or4x11
Name: olfactory receptor family 4 subfamily X member 11
Synonyms: GA_x6K02T2Q125-51469027-51469956, MOR228-2, Olfr1265
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258340
Homologene: 133727
C1qtnf7
Name: C1q and tumor necrosis factor related protein 7
Synonyms: 5530401N20Rik, 8430425G24Rik, CTRP7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 109323
Homologene: 12900
Gvin-ps5
Name: GTPase, very large interferon inducible, pseudogene 5
Synonyms: Gm8989, Gm21911
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668128
Smco4
Name: single-pass membrane protein with coiled-coil domains 4
Synonyms: BC017612
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 170748
VEGA: 9
Homologene: 136181
Igkv11-125
Name: immunoglobulin kappa variable 11-125
Synonyms: ENSMUSG00000050218
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243428
HGNC: HGNC:5753
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 26,683,336 bp
  • C to T, chromosome 1 at 116,442,296 bp
  • A to G, chromosome 1 at 138,515,693 bp
  • A to G, chromosome 1 at 166,307,762 bp
  • T to A, chromosome 2 at 57,355,901 bp
  • A to T, chromosome 2 at 58,147,899 bp
  • A to T, chromosome 2 at 65,461,506 bp
  • A to G, chromosome 2 at 85,769,924 bp
  • A to G, chromosome 2 at 90,037,047 bp
  • T to C, chromosome 3 at 69,028,512 bp
  • T to C, chromosome 3 at 83,937,504 bp
  • T to C, chromosome 3 at 146,015,638 bp
  • T to G, chromosome 5 at 4,001,748 bp
  • T to A, chromosome 5 at 36,204,150 bp
  • T to A, chromosome 5 at 43,615,972 bp
  • A to T, chromosome 5 at 109,428,351 bp
  • A to G, chromosome 5 at 124,832,513 bp
  • A to G, chromosome 5 at 143,928,188 bp
  • T to A, chromosome 6 at 67,913,740 bp
  • T to C, chromosome 6 at 92,154,516 bp
  • T to C, chromosome 6 at 115,263,899 bp
  • A to G, chromosome 6 at 123,267,112 bp
  • T to C, chromosome 7 at 86,922,355 bp
  • G to A, chromosome 7 at 103,551,943 bp
  • T to C, chromosome 7 at 106,329,889 bp
  • A to T, chromosome 7 at 106,806,213 bp
  • A to G, chromosome 8 at 70,260,489 bp
  • T to C, chromosome 8 at 95,036,935 bp
  • G to A, chromosome 8 at 95,760,187 bp
  • C to T, chromosome 8 at 106,541,392 bp
  • A to G, chromosome 9 at 15,544,672 bp
  • G to T, chromosome 9 at 80,270,039 bp
  • A to T, chromosome 9 at 106,969,781 bp
  • A to G, chromosome 9 at 120,566,542 bp
  • T to A, chromosome 10 at 7,712,584 bp
  • T to A, chromosome 10 at 76,709,906 bp
  • G to A, chromosome 11 at 70,641,399 bp
  • AGCGGTCGTAGGC to AGC, chromosome 11 at 73,395,654 bp
  • T to C, chromosome 12 at 8,011,934 bp
  • T to C, chromosome 12 at 21,373,405 bp
  • G to C, chromosome 12 at 81,377,830 bp
  • T to C, chromosome 12 at 103,112,510 bp
  • T to C, chromosome 12 at 111,299,115 bp
  • T to A, chromosome 13 at 13,483,754 bp
  • A to G, chromosome 13 at 19,690,847 bp
  • T to A, chromosome 13 at 93,091,603 bp
  • T to C, chromosome 13 at 102,736,356 bp
  • A to G, chromosome 15 at 73,119,490 bp
  • A to G, chromosome 15 at 101,487,510 bp
  • C to T, chromosome 17 at 12,667,242 bp
  • G to A, chromosome 17 at 71,243,970 bp
  • A to G, chromosome 18 at 73,675,860 bp
  • A to G, chromosome 19 at 5,465,675 bp
  • T to C, chromosome 19 at 44,029,183 bp
  • T to G, chromosome Y at 821,447 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5101 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042852-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.