Strain Name:
C57BL/6J-MtgxR5283Btlr/Mmmh
Stock Number:
042868-MU
Citation ID:
RRID:MMRRC_042868-MU
Other Names:
R5283 (G1), C57BL/6J-MtgxR5283Btlr
Major Collection:

Strain Information

Grm1
Name: glutamate receptor, metabotropic 1
Synonyms: mGluR1, Grm1, Gprc1a, nmf373, rcw, 4930455H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14816
HGNC: HGNC:4593
Homologene: 649
Gon4l
Name: gon-4-like (C.elegans)
Synonyms: 1500041I23Rik, 2610100B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76022
Homologene: 13002
Glo1
Name: glyoxalase 1
Synonyms: Glo-1s, Glo-1r, Glo-1, Qglo, Glo1-s, Glo1-r, 0610009E22Rik, 2510049H23Rik, 1110008E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 109801
VEGA: 17
HGNC: HGNC:4323
Homologene: 4880
Rps8
Name: ribosomal protein S8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 20116
Homologene: 133143
Mapkap1
Name: mitogen-activated protein kinase associated protein 1
Synonyms: D230039K05Rik, Sin1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227743
Homologene: 11473
Szrd1
Name: SUZ RNA binding domain containing 1
Synonyms: D4Ertd22e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 213491
Homologene: 9213
Ndc80
Name: NDC80 kinetochore complex component
Synonyms: HEC1, 2610020P18Rik, Kntc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67052
VEGA: 17
Homologene: 38141
Stk4
Name: serine/threonine kinase 4
Synonyms: Ysk3, Kas-2, Mst1, sterile 20-like kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58231
Homologene: 55965
Kpna2
Name: karyopherin (importin) alpha 2
Synonyms: pendulin, m-importin, m-importin-alpha-P1, Rch1, 2410044B12Rik, Importin alpha, importin alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16647
HGNC: HGNC:6395
Homologene: 1708
Ptpn2
Name: protein tyrosine phosphatase, non-receptor type 2
Synonyms: Ptpt, TC-PTP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 19255
HGNC: HGNC:9650
Homologene: 7497
Ints1
Name: integrator complex subunit 1
Synonyms: 1110015K06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68510
Homologene: 53111
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 2410104C19Rik, 9530048I21Rik, 3010027A04Rik, Yod
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 77087
Homologene: 69134
Pde7a
Name: phosphodiesterase 7A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18583
HGNC: HGNC:8791
Homologene: 1956
Crh
Name: corticotropin releasing hormone
Synonyms: CRF, corticotropin releasing factor, LOC383938, corticotropin-releasing factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12918
HGNC: HGNC:2355
Homologene: 599
Rffl
Name: ring finger and FYVE like domain containing protein
Synonyms: 4930516L10Rik, fring, rififylin, 1700051E09Rik, Carp-2, Carp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67338
Homologene: 12116
Vars
Name: valyl-tRNA synthetase
Synonyms: G7a, D17H6S56E, Bat-6, Bat6, Vars2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22321
Homologene: 4587
Atp5h
Name: ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D
Synonyms: 0610009D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71679
HGNC: HGNC:845
Homologene: 130552
Amotl1
Name: angiomotin-like 1
Synonyms: 4932416D09Rik, JEAP, 2310067L22Rik, 2310010G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75723
Homologene: 43977
Tbr1
Name: T-box brain transcription factor 1
Synonyms: T-box brain gene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21375
Homologene: 4807
Slit2
Name: slit guidance ligand 2
Synonyms: Slil3, Drad-1, E130320P19Rik, E030015M03Rik, b2b1200.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20563
Homologene: 3516
Aamp
Name: angio-associated migratory protein
Synonyms: Aamp-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227290
HGNC: HGNC:18
Homologene: 846
Plekhg1
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 1
Synonyms: D10Ertd733e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 213783
Homologene: 18897
Mrpl2
Name: mitochondrial ribosomal protein L2
Synonyms: MRP-L14, CGI-22, Rpml14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 27398
Homologene: 69198
Notch1
Name: notch 1
Synonyms: lin-12, Tan1, Mis6, 9930111A19Rik, Motch A, N1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Rmnd5b
Name: required for meiotic nuclear division 5 homolog B
Synonyms: 0610039K22Rik, Gid2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66089
Homologene: 100777
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930516E05Rik, D330038K10Rik, 4930543C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Ssh1
Name: slingshot protein phosphatase 1
Synonyms: mSSH-1L, LOC384311
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231637
Homologene: 41299
Olfml2b
Name: olfactomedin-like 2B
Synonyms: 1110018N05Rik, 4832415H08Rik, photomedin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320078
Homologene: 18546
Col4a4
Name: collagen, type IV, alpha 4
Synonyms: [a]4(IV), E130010M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12829
HGNC: HGNC:2206
Homologene: 20071
Has3
Name: hyaluronan synthase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 15118
HGNC: HGNC:4820
Homologene: 68461
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Rap1gap2
Name: RAP1 GTPase activating protein 2
Synonyms: LOC380710, Garnl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380711
Homologene: 56695
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: hy-3, hy3, 1700034M11Rik, 4930545D19Rik, hyrh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Zc3h12a
Name: zinc finger CCCH type containing 12A
Synonyms: Mcpip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230738
Homologene: 11824
Rtn4ip1
Name: reticulon 4 interacting protein 1
Synonyms: NIMP, D10Ertd690e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 170728
Homologene: 13105
Fhod1
Name: formin homology 2 domain containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234686
Homologene: 136406
Mab21l4
Name: mab-21-like 4
Synonyms: 2310007B03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71874
Homologene: 11761
Slc35b1
Name: solute carrier family 35, member B1
Synonyms: Ugalt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 110172
Homologene: 4252
Vmn2r110
Name: vomeronasal 2, receptor 110
Synonyms: EG224582
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224582
Homologene: 129678
Stk33
Name: serine/threonine kinase 33
Synonyms: 4921505G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 117229
Homologene: 75307
Gm15130
Name: predicted gene 15130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Ccdc13
Name: coiled-coil domain containing 13
Synonyms: 2900041A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100502861
Homologene: 87213
Vmn2r98
Name: vomeronasal 2, receptor 98
Synonyms: EG224552
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224552
Homologene: 115024
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: 5830419M17Rik, gp115, EMILIN-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100952
Homologene: 5117
Tkt
Name: transketolase
Synonyms: p68
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21881
Homologene: 68154
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102747
Homologene: 9782
Tmem236
Name: transmembrane protein 236
Synonyms: 2010003H20Rik, Fam23a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 625286
Homologene: 46598
Cstdc6
Name: cystatin domain containing 6
Synonyms: Gm1975, BC117090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 100038854
VEGA: 16
HGNC: HGNC:2481
Homologene: 104045
Plin4
Name: perilipin 4
Synonyms: S3-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57435
Homologene: 69311
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329679
Homologene: 46417
Muc21
Name: mucin 21
Synonyms: epiglycanin, Gm9573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 672682
Apbb1ip
Name: amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
Synonyms: proline-rich protein 48, Prp48, 9930118P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 54519
Homologene: 32434
Samhd1
Name: SAM domain and HD domain, 1
Synonyms: E330031J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56045
Homologene: 9160
Ehd3
Name: EH-domain containing 3
Synonyms: Ehd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57440
HGNC: HGNC:3244
Homologene: 81837
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: THAM, Dpp-4, Cd26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Tll1
Name: tolloid-like
Synonyms: Tll-1, b2b2476Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21892
Homologene: 49202
Lrr1
Name: leucine rich repeat protein 1
Synonyms: 2410005L11Rik, LRR-1, Ppil5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69706
VEGA: 12
Homologene: 32677
Gm11595
Name: predicted gene 11595
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100040276
Homologene: 124486
B230325K18Rik
Name: RIKEN cDNA B230325K18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Tas2r136
Name: taste receptor, type 2, member 136
Synonyms: mt2r52, Tas2r36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 353165
Homologene: 136304
Or6b9
Name: olfactory receptor family 6 subfamily B member 9
Synonyms: MOR103-16, GA_x6K02T2PBJ9-9337331-9336381, M50, Olfr6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233670
Homologene: 28439
Guca1b
Name: guanylate cyclase activator 1B
Synonyms: GCAP2 (retina), GCAP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 107477
HGNC: HGNC:4679
Homologene: 1586
Prp2
Name: proline rich protein 2
Synonyms: MP14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 83380
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 74,284,006 bp
  • C to T, chromosome 1 at 82,493,591 bp
  • C to T, chromosome 1 at 93,159,853 bp
  • C to T, chromosome 1 at 170,681,189 bp
  • A to G, chromosome 2 at 14,174,833 bp
  • G to A, chromosome 2 at 22,867,671 bp
  • A to G, chromosome 2 at 26,468,626 bp
  • A to G, chromosome 2 at 34,444,348 bp
  • A to T, chromosome 2 at 61,804,900 bp
  • G to A, chromosome 2 at 62,360,336 bp
  • A to C, chromosome 2 at 111,135,409 bp
  • T to C, chromosome 2 at 157,109,492 bp
  • C to T, chromosome 2 at 164,110,279 bp
  • T to C, chromosome 3 at 19,260,256 bp
  • T to C, chromosome 3 at 19,694,007 bp
  • A to T, chromosome 3 at 79,465,708 bp
  • T to C, chromosome 3 at 88,887,590 bp
  • G to C, chromosome 4 at 117,155,155 bp
  • T to C, chromosome 4 at 125,126,765 bp
  • T to C, chromosome 4 at 141,115,786 bp
  • G to A, chromosome 5 at 22,011,163 bp
  • G to C, chromosome 5 at 30,919,910 bp
  • C to T, chromosome 5 at 47,984,965 bp
  • A to G, chromosome 5 at 113,950,545 bp
  • A to C, chromosome 5 at 139,764,382 bp
  • C to T, chromosome 6 at 132,600,643 bp
  • A to T, chromosome 6 at 132,777,411 bp
  • T to A, chromosome 7 at 106,956,748 bp
  • T to C, chromosome 7 at 109,336,127 bp
  • T to A, chromosome 7 at 127,985,547 bp
  • T to C, chromosome 8 at 64,101,966 bp
  • A to G, chromosome 8 at 105,331,091 bp
  • A to G, chromosome 8 at 106,874,115 bp
  • G to T, chromosome 8 at 110,451,980 bp
  • A to C, chromosome 8 at 122,884,182 bp
  • T to C, chromosome 9 at 14,558,484 bp
  • A to T, chromosome 9 at 60,687,178 bp
  • T to A, chromosome 9 at 121,808,188 bp
  • G to A, chromosome 10 at 3,956,654 bp
  • C to A, chromosome 10 at 10,733,192 bp
  • T to C, chromosome 10 at 43,902,465 bp
  • A to T, chromosome 11 at 51,627,060 bp
  • G to A, chromosome 11 at 74,395,825 bp
  • T to C, chromosome 11 at 82,812,789 bp
  • G to T, chromosome 11 at 95,384,988 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • G to A, chromosome 11 at 106,990,832 bp
  • T to C, chromosome 11 at 115,415,785 bp
  • T to C, chromosome 12 at 69,174,654 bp
  • C to T, chromosome 14 at 30,560,618 bp
  • T to C, chromosome 16 at 36,321,843 bp
  • T to C, chromosome 17 at 19,080,719 bp
  • T to C, chromosome 17 at 20,580,637 bp
  • T to C, chromosome 17 at 30,600,073 bp
  • G to A, chromosome 17 at 35,013,752 bp
  • A to G, chromosome 17 at 35,621,332 bp
  • C to T, chromosome 17 at 46,649,066 bp
  • T to C, chromosome 17 at 47,391,270 bp
  • T to A, chromosome 17 at 56,106,777 bp
  • A to G, chromosome 17 at 71,521,135 bp
  • G to T, chromosome 17 at 73,820,503 bp
  • A to G, chromosome 18 at 67,681,569 bp
  • T to A, chromosome 19 at 16,677,970 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5283 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042868-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.