Strain Name:
C57BL/6J-MtgxR5355Btlr/Mmmh
Stock Number:
042934-MU
Citation ID:
RRID:MMRRC_042934-MU
Other Names:
R5355 (G1), C57BL/6J-MtgxR5355Btlr
Major Collection:

Strain Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Spry2
Name: sprouty RTK signaling antagonist 2
Synonyms: sprouty2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 24064
VEGA: 14
Homologene: 4267
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72313
Homologene: 103956
Sfswap
Name: splicing factor SWAP
Synonyms: 6330437E22Rik, 1190005N23Rik, Sfrs8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231769
Homologene: 134548
Usp25
Name: ubiquitin specific peptidase 25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 30940
VEGA: 16
Homologene: 8374
Parn
Name: poly(A)-specific ribonuclease (deadenylation nuclease)
Synonyms: DAN, 1200003I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74108
VEGA: 16
HGNC: HGNC:8609
Homologene: 31098
Atxn10
Name: ataxin 10
Synonyms: TEG-169, E46, Sca10, Tex169
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54138
VEGA: 15
Homologene: 40858
Itgb2
Name: integrin beta 2
Synonyms: Mac-1 beta, 2E6, Cd18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16414
HGNC: HGNC:6155
Homologene: 20092
Mfn2
Name: mitofusin 2
Synonyms: hypertension related protein 1, D630023P19Rik, Fzo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 170731
Homologene: 8915
Cdc45
Name: cell division cycle 45
Synonyms: Cdc45l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12544
HGNC: HGNC:1739
Homologene: 2616
Slc6a3
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
Synonyms: DAT, Dat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13162
VEGA: 13
Homologene: 55547
Cryab
Name: crystallin, alpha B
Synonyms: alpha B-crystallin, Crya-2, Crya2, HspB5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12955
VEGA: 9
HGNC: HGNC:2389
Homologene: 68209
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Adam12
Name: a disintegrin and metallopeptidase domain 12 (meltrin alpha)
Synonyms: Mltna, ADAM12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11489
HGNC: HGNC:190
Homologene: 74862
Mvk
Name: mevalonate kinase
Synonyms: 2310010A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 17855
HGNC: HGNC:7530
Homologene: 372
Gm5121
Name: predicted gene 5121
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 101154638
VEGA: 9
Mmadhc
Name: methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
Synonyms: 2010311D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109129
Homologene: 9248
Cuzd1
Name: CUB and zona pellucida-like domains 1
Synonyms: UTCZP, UO-44, ERG-1, Itmap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16433
Homologene: 7389
Fchsd1
Name: FCH and double SH3 domains 1
Synonyms: A030002D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 319262
Homologene: 14127
Pwp2
Name: PWP2 periodic tryptophan protein homolog (yeast)
Synonyms: Pwp2, 6530411D08Rik, Pwp2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110816
VEGA: 10
HGNC: HGNC:9711
Homologene: 3702
Zscan22
Name: zinc finger and SCAN domain containing 22
Synonyms: D530006B18Rik, Hkr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232878
HGNC: HGNC:4929
Homologene: 68122
Lemd3
Name: LEM domain containing 3
Synonyms: Man1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 380664
Homologene: 8633
C8b
Name: complement component 8, beta polypeptide
Synonyms: 4930439B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 110382
HGNC: HGNC:1353
Homologene: 48
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Mmp9
Name: matrix metallopeptidase 9
Synonyms: gelatinase B, Gel B, MMP-9, B/MMP9, Clg4b, Gelatinase B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17395
HGNC: HGNC:7176
Homologene: 3659
Col11a2
Name: collagen, type XI, alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12815
HGNC: HGNC:2187
Homologene: 22547
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 195046
Homologene: 133820
Gm8251
Name: predicted gene 8251
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 102636082
VEGA: 1
Homologene: 141149
Zfp747
Name: zinc finger protein 747
Synonyms: 6430604K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269997
Homologene: 118005
Gm4787
Name: predicted gene 4787
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 214321
Homologene: 86950
Col4a2
Name: collagen, type IV, alpha 2
Synonyms: Col4a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12827
HGNC: HGNC:2203
Homologene: 1390
Dthd1
Name: death domain containing 1
Synonyms: Gm17384
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100322896
Homologene: 123510
Disp2
Name: dispatched RND tramsporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214240
Homologene: 24916
Mep1a
Name: meprin 1 alpha
Synonyms: meprin A alpha-subunit, Mep-1a, Mep-1, meprin alpha, Mep1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17287
HGNC: HGNC:7015
Homologene: 31323
Cdr2l
Name: cerebellar degeneration-related protein 2-like
Synonyms: D030068L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237988
Homologene: 35390
Slc7a13
Name: solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
Synonyms: XAT2, AGT1, AGT-1, 0610009O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74087
Homologene: 23656
Adra1d
Name: adrenergic receptor, alpha 1d
Synonyms: Adra1, Gpcr8, Adra1a, Adra-1, alpha1D-AR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11550
HGNC: HGNC:280
Homologene: 551
Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
Synonyms: LXR alpha, Unr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22259
HGNC: HGNC:7966
Homologene: 21165
Parva
Name: parvin, alpha
Synonyms: CH-ILKBP, 5430400F08Rik, 2010012A22Rik, actopaxin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57342
Homologene: 10077
Parp8
Name: poly (ADP-ribose) polymerase family, member 8
Synonyms: 2810430O08Rik, D13Ertd275e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 52552
VEGA: 13
Homologene: 11621
Ift88
Name: intraflagellar transport 88
Synonyms: Tg737, polaris, Oak Ridge polycystic kidneys, orpk, IFT88, fxo, TgN737Rpw, Tg737Rpw, Ttc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21821
Homologene: 4761
Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Synonyms: mdr-3, Mdr1a, P-gp, P-glycoprotein, Pgy-3, Pgy3, multiple drug resistant 1a, MDR3, Pgp, Evi32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Zp3r
Name: zona pellucida 3 receptor
Synonyms: SP56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22789
HGNC: HGNC:1325
Homologene: 7609
H2bc13
Name: H2B clustered histone 13
Synonyms: Hist1h2bl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319185
HGNC: HGNC:4748
Homologene: 136773
Sccpdh
Name: saccharopine dehydrogenase (putative)
Synonyms: C330023F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 109232
Homologene: 9334
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: PSD93, Chapsyn-110, A330103J02Rik, B330007M19Rik, LOC382816, Dlgh2, B230218P12Rik, Gm21505
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Gm10330
Name: predicted gene 10330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Or8k39
Name: olfactory receptor family 8 subfamily K member 39
Synonyms: GA_x6K02T2Q125-48226321-48225386, MOR193-1, Olfr1089
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257933
Homologene: 79354
Dusp29
Name: dual specificity phosphatase 29
Synonyms: EG435391, Dupd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 435391
VEGA: 14
Homologene: 51120
Nlrp1c-ps
Name: NLR family, pyrin domain containing 1C, pseudogene
Synonyms: Nalp1c, OTTMUSG00000006090
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 627984
Isoc2b
Name: isochorismatase domain containing 2b
Synonyms: 0610042E07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67441
Homologene: 85975
Or4f7d-ps1
Name: olfactory receptor family 4 subfamily F member 7D, pseudogene 1
Synonyms: GA_x6K02T2N82Q-12713-13766, MOR245-17P, Gm13931, Olfr268-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668825
Homologene: 138901
Or2a55-ps1
Name: olfactory receptor family 2 subfamily A member5, pseudogene 1
Synonyms: GA_x6K02T2P3E9-4463886-4462972, MOR261-8P, Olfr443-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258106
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 44,057,979 bp
  • A to G, chromosome 1 at 130,596,781 bp
  • T to C, chromosome 1 at 179,686,578 bp
  • A to G, chromosome 2 at 50,291,424 bp
  • A to T, chromosome 2 at 69,454,838 bp
  • A to T, chromosome 2 at 86,733,336 bp
  • A to G, chromosome 2 at 91,191,908 bp
  • C to A, chromosome 2 at 111,851,802 bp
  • G to A, chromosome 2 at 118,786,911 bp
  • A to G, chromosome 2 at 131,561,087 bp
  • C to A, chromosome 2 at 164,950,992 bp
  • A to T, chromosome 2 at 180,181,651 bp
  • A to G, chromosome 3 at 126,944,049 bp
  • C to A, chromosome 4 at 19,839,267 bp
  • A to G, chromosome 4 at 104,780,663 bp
  • A to G, chromosome 4 at 147,894,578 bp
  • T to C, chromosome 5 at 8,726,873 bp
  • A to C, chromosome 5 at 62,839,387 bp
  • T to C, chromosome 5 at 73,073,904 bp
  • T to G, chromosome 5 at 114,452,438 bp
  • C to T, chromosome 5 at 129,539,746 bp
  • A to G, chromosome 6 at 17,491,362 bp
  • C to T, chromosome 6 at 43,094,664 bp
  • A to G, chromosome 7 at 4,849,358 bp
  • C to A, chromosome 7 at 12,906,508 bp
  • G to T, chromosome 7 at 91,449,803 bp
  • T to C, chromosome 7 at 112,544,268 bp
  • A to G, chromosome 7 at 127,374,597 bp
  • G to A, chromosome 7 at 131,316,124 bp
  • T to C, chromosome 7 at 133,887,942 bp
  • G to A, chromosome 8 at 11,445,984 bp
  • A to T, chromosome 9 at 50,753,451 bp
  • G to A, chromosome 9 at 57,334,368 bp
  • G to T, chromosome 10 at 77,558,052 bp
  • A to C, chromosome 10 at 78,175,544 bp
  • A to T, chromosome 10 at 120,933,633 bp
  • T to G, chromosome 11 at 55,282,166 bp
  • T to A, chromosome 11 at 71,124,251 bp
  • C to A, chromosome 11 at 71,258,013 bp
  • T to C, chromosome 11 at 115,393,570 bp
  • T to A, chromosome 12 at 23,780,130 bp
  • T to A, chromosome 12 at 81,377,465 bp
  • A to T, chromosome 13 at 21,715,860 bp
  • A to G, chromosome 13 at 73,560,959 bp
  • A to G, chromosome 13 at 116,862,204 bp
  • G to A, chromosome 14 at 21,677,023 bp
  • T to A, chromosome 14 at 57,438,242 bp
  • A to G, chromosome 14 at 105,893,278 bp
  • T to A, chromosome 15 at 85,462,314 bp
  • A to G, chromosome 16 at 13,668,022 bp
  • C to T, chromosome 16 at 18,795,897 bp
  • A to G, chromosome 16 at 77,050,454 bp
  • A to G, chromosome 17 at 34,051,801 bp
  • T to C, chromosome 17 at 43,477,146 bp
  • C to T, chromosome 18 at 37,959,873 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5355 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042934-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.