Strain Name:
C57BL/6J-MtgxR5441Btlr/Mmmh
Stock Number:
043006-MU
Citation ID:
RRID:MMRRC_043006-MU
Other Names:
R5441 (G1), C57BL/6J-MtgxR5441Btlr
Major Collection:

Strain Information

Zic4
Name: zinc finger protein of the cerebellum 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22774
Homologene: 32075
Cdh11
Name: cadherin 11
Synonyms: osteoblast-cadherin, Cad11, OB-cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12552
HGNC: HGNC:1750
Homologene: 1361
Unc93b1
Name: unc-93 homolog B1, TLR signaling regulator
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54445
Homologene: 41325
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4833417A11Rik, 4832428G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: PTP36, OTTMUSG00000022087, C130080N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941
Msi2
Name: musashi RNA-binding protein 2
Synonyms: msi2h, Musashi2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76626
Homologene: 62199
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217342
Homologene: 11113
Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: SCAN1, Gm40556, 2810481F14Rik, 4921509N21Rik, E430034L06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104884
Homologene: 5424
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), C130002K18Rik, 5430435M13Rik, 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Stim2
Name: stromal interaction molecule 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 116873
Homologene: 32490
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: Garnl1, Tulip1, 4930400K19Rik, 2310003F20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Slc25a40
Name: solute carrier family 25, member 40
Synonyms: B230315F11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319653
Homologene: 6040
Ptcd3
Name: pentatricopeptide repeat domain 3
Synonyms: 2610034F17Rik, 2810422B04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69956
Homologene: 41211
Vav2
Name: vav 2 oncogene
Synonyms: 2810040F13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22325
Homologene: 2530
Tpd52
Name: tumor protein D52
Synonyms: mD52
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21985
Homologene: 38007
Zfp748
Name: zinc finger protein 748
Synonyms: mszf54, KRAB-O, 2610014M12Rik, Zfp208
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212276
Homologene: 134552
Fzd5
Name: frizzled class receptor 5
Synonyms: 5330434N09Rik, Fz5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14367
HGNC: HGNC:4043
Homologene: 2590
Ltbr
Name: lymphotoxin B receptor
Synonyms: LTbetaR, Tnfrsf3, TNFRrp, TNF receptor-related protein, LT-beta receptor, LT beta-R, Tnfbr, TNF-R-III, TNFCR, TNFR2-RP, Ltar
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17000
HGNC: HGNC:6718
Homologene: 1753
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Ropn1
Name: ropporin, rhophilin associated protein 1
Synonyms: RHPNAP1, ODF6, 1700008N21Rik, ropporin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 76378
Homologene: 57119
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Nlrp4a
Name: NLR family, pyrin domain containing 4A
Synonyms: Nalp-eta, E330028A19Rik, Nalp4a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243880
Homologene: 79696
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Atmin
Name: ATM interactor
Synonyms: Asciz, gpg6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234776
Homologene: 35321
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Tbx19
Name: T-box 19
Synonyms: D1Ertd754e, Tpit
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 83993
Homologene: 3779
Gm2962
Name: predicted pseudogene 2962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100504052
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Fer1l4
Name: fer-1 like family member 4
Synonyms: 9130402C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74562
Homologene: 19075
Plppr5
Name: phospholipid phosphatase related 5
Synonyms: 4833424O15Rik, Lppr5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75769
Homologene: 25279
Plbd2
Name: phospholipase B domain containing 2
Synonyms: 66.3 kDa, 1300012G16Rik, p76
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71772
Homologene: 41528
Or5m13
Name: olfactory receptor family 5 subfamily M member 13
Synonyms: GA_x6K02T2Q125-47397266-47398205, Olfr1025, MOR196-5P, MOR196-6_p
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258083
Cspg5
Name: chondroitin sulfate proteoglycan 5
Synonyms: CALEB, neuroglycan C, NGC
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 29873
HGNC: HGNC:2467
Homologene: 4795
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: Prss7, enterokinase, A130097D21Rik, enteropeptidase
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Tmprss11f
Name: transmembrane protease, serine 11f
Synonyms: 4732406D01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243083
Homologene: 65356
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: 5830419M17Rik, EMILIN-1, gp115
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100952
Homologene: 5117
Cers5
Name: ceramide synthase 5
Synonyms: 2310081H14Rik, Lass5, CerS5, Trh4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71949
Homologene: 23634
Sh3bgr
Name: SH3-binding domain glutamic acid-rich protein
Synonyms: 5430437A18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50795
Homologene: 56376
Scgb2b27
Name: secretoglobin, family 2B, member 27
Synonyms: Abpbg27, Abpb, C2a, Scgb2b5, Abpbg5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233099
Homologene: 83171
Thsd4
Name: thrombospondin, type I, domain containing 4
Synonyms: B230114P05Rik, ADAMTSL6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 207596
Homologene: 49796
Or10g1
Name: olfactory receptor family 10 subfamily G member 1
Synonyms: GA_x6K02T2RJGY-583652-584608, MOR223-6, Olfr1510
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258423
HGNC: HGNC:8170
Homologene: 87788
Or9a2
Name: olfactory receptor family 9 subfamily A member 2
Synonyms: GA_x6K02T2P3E9-5780974-5781915, MOR120-1, Olfr459
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258569
Homologene: 83448
Car1
Name: carbonic anhydrase 1
Synonyms: CA I, Car-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12346
HGNC: HGNC:1368
Homologene: 20414
Or6ae1
Name: olfactory receptor family 6 subfamily AE member 1
Synonyms: Olfr522, MOR103-5, GA_x6K02T2PBJ9-42315125-42314187
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258954
Homologene: 62435
Hk3
Name: hexokinase 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212032
HGNC: HGNC:4925
Homologene: 55633
Rpe65
Name: retinal pigment epithelium 65
Synonyms: Mord1, A930029L06Rik, rd12
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19892
Homologene: 20108
Ap5s1
Name: adaptor-related protein 5 complex, sigma 1 subunit
Synonyms: 2310035K24Rik, 0610038L13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69596
Homologene: 23095
Or12d13
Name: olfactory receptor family 12 subfamily D member 13
Synonyms: GA_x6K02T2PSCP-1798423-1797482, MOR250-3, MOR250-8_p, Olfr103
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258830
Homologene: 115555
Aspa
Name: aspartoacylase
Synonyms: Acy-2, aspartoacylase, Acy2, nur7, small lethargic
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11484
HGNC: HGNC:756
Homologene: 33
Chad
Name: chondroadherin
Synonyms: SLRR4A
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12643
HGNC: HGNC:1909
Homologene: 36063
Vmn1r207
Name: vomeronasal 1 receptor 207
Synonyms: Vmn1r207-ps, Gm11312
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 432735
Homologene: 110880
Gm7664
Name: predicted gene 7664
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 118568050
Homologene: 86613
Lysmd2
Name: LysM, putative peptidoglycan-binding, domain containing 2
Synonyms: 2210402C18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70082
VEGA: 9
Homologene: 12347
Gm15396
Name: predicted gene 15396
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102632404
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 64,735,417 bp
  • A to G, chromosome 1 at 71,295,056 bp
  • T to C, chromosome 1 at 165,153,680 bp
  • T to A, chromosome 1 at 170,925,422 bp
  • T to C, chromosome 1 at 189,798,570 bp
  • A to T, chromosome 2 at 27,270,110 bp
  • G to A, chromosome 2 at 31,406,416 bp
  • T to A, chromosome 2 at 85,918,590 bp
  • C to T, chromosome 2 at 131,212,702 bp
  • T to A, chromosome 2 at 156,023,257 bp
  • A to T, chromosome 3 at 9,003,406 bp
  • G to C, chromosome 3 at 14,776,304 bp
  • A to T, chromosome 3 at 117,662,471 bp
  • G to T, chromosome 3 at 159,604,401 bp
  • T to C, chromosome 5 at 8,449,690 bp
  • A to G, chromosome 5 at 30,920,757 bp
  • T to A, chromosome 5 at 54,075,370 bp
  • A to T, chromosome 5 at 86,528,203 bp
  • A to T, chromosome 5 at 93,636,597 bp
  • T to A, chromosome 5 at 120,499,082 bp
  • T to A, chromosome 5 at 137,436,751 bp
  • C to T, chromosome 6 at 41,771,848 bp
  • A to G, chromosome 6 at 71,881,521 bp
  • G to A, chromosome 6 at 125,312,794 bp
  • T to A, chromosome 7 at 26,454,153 bp
  • C to T, chromosome 7 at 28,156,914 bp
  • T to C, chromosome 7 at 34,013,157 bp
  • T to A, chromosome 7 at 44,581,393 bp
  • T to C, chromosome 7 at 118,195,081 bp
  • T to C, chromosome 7 at 140,162,651 bp
  • T to C, chromosome 8 at 102,647,546 bp
  • T to C, chromosome 8 at 110,565,109 bp
  • T to A, chromosome 8 at 116,957,957 bp
  • C to A, chromosome 9 at 53,516,467 bp
  • T to C, chromosome 9 at 59,979,783 bp
  • C to T, chromosome 9 at 75,625,972 bp
  • C to A, chromosome 9 at 91,384,200 bp
  • T to C, chromosome 9 at 110,246,643 bp
  • A to T, chromosome 11 at 73,305,594 bp
  • A to G, chromosome 11 at 88,479,992 bp
  • G to A, chromosome 11 at 88,718,095 bp
  • A to T, chromosome 11 at 94,568,292 bp
  • G to A, chromosome 11 at 116,544,442 bp
  • G to A, chromosome 11 at 119,409,020 bp
  • A to C, chromosome 12 at 55,719,623 bp
  • G to A, chromosome 12 at 75,989,143 bp
  • T to A, chromosome 12 at 99,910,285 bp
  • T to C, chromosome 13 at 22,726,516 bp
  • T to C, chromosome 13 at 55,015,056 bp
  • T to A, chromosome 13 at 62,528,650 bp
  • C to A, chromosome 13 at 67,540,618 bp
  • T to A, chromosome 14 at 52,409,957 bp
  • T to A, chromosome 15 at 66,696,520 bp
  • T to A, chromosome 15 at 99,751,238 bp
  • A to G, chromosome 16 at 34,666,797 bp
  • T to A, chromosome 16 at 79,071,447 bp
  • T to C, chromosome 16 at 96,205,917 bp
  • T to C, chromosome 17 at 37,336,268 bp
  • T to C, chromosome 19 at 3,943,703 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5441 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043006-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.