Strain Name:
C57BL/6J-MtgxR5441Btlr/Mmmh
Stock Number:
043006-MU
Citation ID:
RRID:MMRRC_043006-MU
Other Names:
R5441 (G1), C57BL/6J-MtgxR5441Btlr
Major Collection:

Gene Information

Zic4
Name: zinc finger protein of the cerebellum 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22774
Homologene: 32075
Cdh11
Name: cadherin 11
Synonyms: osteoblast-cadherin, OB-cadherin, Cad11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12552
HGNC: HGNC:1750
Homologene: 1361
Unc93b1
Name: unc-93 homolog B1, TLR signaling regulator
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 54445
Homologene: 41325
Abca12
Name: ATP-binding cassette, sub-family A (ABC1), member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74591
Homologene: 45441
Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: OTTMUSG00000022087, PTP36, C130080N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941
Msi2
Name: musashi RNA-binding protein 2
Synonyms: Musashi2, msi2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76626
Homologene: 62199
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Ube2o
Name: ubiquitin-conjugating enzyme E2O
Synonyms: B230113M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217342
Homologene: 11113
Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: SCAN1, E430034L06Rik, 4921509N21Rik, 2810481F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104884
Homologene: 5424
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: 5430435M13Rik, 2610207I05Rik, C130002K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233789
Homologene: 56697
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 21819
Homologene: 2430
Stim2
Name: stromal interaction molecule 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 116873
Homologene: 32490
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: Garnl1, Tulip1, 4930400K19Rik, 2310003F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Slc25a40
Name: solute carrier family 25, member 40
Synonyms: B230315F11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 319653
Homologene: 6040
Ptcd3
Name: pentatricopeptide repeat domain 3
Synonyms: 2810422B04Rik, 2610034F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69956
Homologene: 41211
Vav2
Name: vav 2 oncogene
Synonyms: 2810040F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22325
Homologene: 2530
Tpd52
Name: tumor protein D52
Synonyms: mD52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 21985
Homologene: 38007
Zfp748
Name: zinc finger protein 748
Synonyms: mszf54, KRAB-O, 2610014M12Rik, Zfp208
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 212276
Homologene: 134552
Fzd5
Name: frizzled class receptor 5
Synonyms: Fz5, 5330434N09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14367
HGNC: HGNC:4043
Homologene: 2590
Ltbr
Name: lymphotoxin B receptor
Synonyms: LT beta-R, Tnfrsf3, LT-beta receptor, TNF receptor-related protein, TNFRrp, LTbetaR, TNFR2-RP, TNFCR, TNF-R-III, Ltar, Tnfbr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17000
HGNC: HGNC:6718
Homologene: 1753
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 665700
Homologene: 90772
Ropn1
Name: ropporin, rhophilin associated protein 1
Synonyms: RHPNAP1, 1700008N21Rik, ropporin, ODF6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 76378
Homologene: 57119
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 1700034M11Rik, hyrh, hy3, hy-3, 4930545D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244653
Homologene: 52118
Nlrp4a
Name: NLR family, pyrin domain containing 4A
Synonyms: E330028A19Rik, Nalp4a, Nalp-eta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243880
Homologene: 79696
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: syne-2, diminished cone electroretinogram, Cpfl8, dice, Nesp2g, nesprin-2, 6820443O06Rik, D12Ertd777e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Atmin
Name: ATM interactor
Synonyms: gpg6, Asciz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234776
Homologene: 35321
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 672511
Homologene: 45439
Tbx19
Name: T-box 19
Synonyms: Tpit, D1Ertd754e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 83993
Homologene: 3779
Gm2962
Name: predicted pseudogene 2962
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100504052
9530053A07Rik
Name: RIKEN cDNA 9530053A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319482
Homologene: 130055
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Fer1l4
Name: fer-1-like 4 (C. elegans)
Synonyms: 9130402C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74562
Homologene: 19075
Plppr5
Name: phospholipid phosphatase related 5
Synonyms: Lppr5, 4833424O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 75769
Homologene: 25279
Plbd2
Name: phospholipase B domain containing 2
Synonyms: p76, 66.3 kDa, 1300012G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71772
Homologene: 41528
Olfr1025-ps1
Name: olfactory receptor 1025, pseudogene 1
Synonyms: GA_x6K02T2Q125-47397266-47398205, MOR196-5P, MOR196-6_p
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258083
Cspg5
Name: chondroitin sulfate proteoglycan 5
Synonyms: NGC, CALEB, neuroglycan C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 29873
HGNC: HGNC:2467
Homologene: 4795
Tmprss15
Name: transmembrane protease, serine 15
Synonyms: enteropeptidase, Prss7, A130097D21Rik, enterokinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19146
HGNC: HGNC:9490
Homologene: 2075
Tmprss11f
Name: transmembrane protease, serine 11f
Synonyms: 4732406D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243083
Homologene: 65356
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: 5830419M17Rik, gp115, EMILIN-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100952
Homologene: 5117
Cers5
Name: ceramide synthase 5
Synonyms: Lass5, Trh4, 2310081H14Rik, CerS5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71949
Homologene: 23634
Sh3bgr
Name: SH3-binding domain glutamic acid-rich protein
Synonyms: 5430437A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 50795
Homologene: 56376
Scgb2b27
Name: secretoglobin, family 2B, member 27
Synonyms: Abpb, Scgb2b5, C2a, Abpbg5, Abpbg27
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233099
Homologene: 83171
Thsd4
Name: thrombospondin, type I, domain containing 4
Synonyms: ADAMTSL6, B230114P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 207596
Homologene: 49796
Olfr1510
Name: olfactory receptor 1510
Synonyms: GA_x6K02T2RJGY-583652-584608, MOR223-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258423
HGNC: HGNC:8170
Homologene: 87788
Olfr459
Name: olfactory receptor 459
Synonyms: MOR120-1, GA_x6K02T2P3E9-5780974-5781915
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 258569
Homologene: 83448
Car1
Name: carbonic anhydrase 1
Synonyms: Car-1, CA I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12346
HGNC: HGNC:1368
Homologene: 20414
Olfr522
Name: olfactory receptor 522
Synonyms: MOR103-5, GA_x6K02T2PBJ9-42315125-42314187
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258954
Homologene: 62435
Hk3
Name: hexokinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 212032
HGNC: HGNC:4925
Homologene: 55633
Rpe65
Name: retinal pigment epithelium 65
Synonyms: rd12, Mord1, A930029L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 19892
Homologene: 20108
Ap5s1
Name: adaptor-related protein 5 complex, sigma 1 subunit
Synonyms: 0610038L13Rik, 2310035K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69596
Homologene: 23095
Olfr103
Name: olfactory receptor 103
Synonyms: MOR250-3, MOR250-8_p, GA_x6K02T2PSCP-1798423-1797482
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258830
Homologene: 115555
Aspa
Name: aspartoacylase
Synonyms: small lethargic, aspartoacylase, nur7, Acy-2, Acy2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11484
HGNC: HGNC:756
Homologene: 33
Chad
Name: chondroadherin
Synonyms: SLRR4A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12643
HGNC: HGNC:1909
Homologene: 36063
C87414
Name: expressed sequence C87414
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 381654
Homologene: 133100
Vmn1r207
Name: vomeronasal 1 receptor 207
Synonyms: Gm11312, Vmn1r207-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 432735
Homologene: 110880
Gm7664
Name: predicted gene 7664
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 665503
Homologene: 86613
Lysmd2
Name: LysM, putative peptidoglycan-binding, domain containing 2
Synonyms: 2210402C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70082
VEGA: 9
Homologene: 12347
Gm15396
Name: predicted gene 15396
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 102632404
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 64,735,417 bp
  • A to G, chromosome 1 at 71,295,056 bp
  • T to C, chromosome 1 at 165,153,680 bp
  • T to A, chromosome 1 at 170,925,422 bp
  • T to C, chromosome 1 at 189,798,570 bp
  • A to T, chromosome 2 at 27,270,110 bp
  • G to A, chromosome 2 at 31,406,416 bp
  • T to A, chromosome 2 at 85,918,590 bp
  • C to T, chromosome 2 at 131,212,702 bp
  • T to A, chromosome 2 at 156,023,257 bp
  • A to T, chromosome 3 at 9,003,406 bp
  • G to C, chromosome 3 at 14,776,304 bp
  • A to T, chromosome 3 at 117,662,471 bp
  • G to T, chromosome 3 at 159,604,401 bp
  • T to C, chromosome 5 at 8,449,690 bp
  • A to G, chromosome 5 at 30,920,757 bp
  • T to A, chromosome 5 at 54,075,370 bp
  • A to T, chromosome 5 at 86,528,203 bp
  • A to T, chromosome 5 at 93,636,597 bp
  • T to A, chromosome 5 at 120,499,082 bp
  • T to A, chromosome 5 at 137,436,751 bp
  • C to T, chromosome 6 at 41,771,848 bp
  • A to G, chromosome 6 at 71,881,521 bp
  • G to A, chromosome 6 at 125,312,794 bp
  • T to A, chromosome 7 at 26,454,153 bp
  • C to T, chromosome 7 at 28,156,914 bp
  • T to C, chromosome 7 at 34,013,157 bp
  • T to A, chromosome 7 at 44,581,393 bp
  • T to C, chromosome 7 at 118,195,081 bp
  • T to C, chromosome 7 at 140,162,651 bp
  • T to C, chromosome 8 at 102,647,546 bp
  • T to C, chromosome 8 at 110,565,109 bp
  • T to A, chromosome 8 at 116,957,957 bp
  • C to A, chromosome 9 at 53,516,467 bp
  • T to C, chromosome 9 at 59,979,783 bp
  • C to T, chromosome 9 at 75,625,972 bp
  • C to A, chromosome 9 at 91,384,200 bp
  • T to C, chromosome 9 at 110,246,643 bp
  • A to T, chromosome 11 at 73,305,594 bp
  • A to G, chromosome 11 at 88,479,992 bp
  • G to A, chromosome 11 at 88,718,095 bp
  • A to T, chromosome 11 at 94,568,292 bp
  • G to A, chromosome 11 at 116,544,442 bp
  • G to A, chromosome 11 at 119,409,020 bp
  • A to C, chromosome 12 at 55,719,623 bp
  • G to A, chromosome 12 at 75,989,143 bp
  • T to A, chromosome 12 at 99,910,285 bp
  • T to C, chromosome 13 at 22,726,516 bp
  • T to C, chromosome 13 at 55,015,056 bp
  • T to A, chromosome 13 at 62,528,650 bp
  • C to A, chromosome 13 at 67,540,618 bp
  • T to A, chromosome 14 at 52,409,957 bp
  • T to A, chromosome 15 at 66,696,520 bp
  • T to A, chromosome 15 at 99,751,238 bp
  • A to G, chromosome 16 at 34,666,797 bp
  • T to A, chromosome 16 at 79,071,447 bp
  • T to C, chromosome 16 at 96,205,917 bp
  • T to C, chromosome 17 at 37,336,268 bp
  • T to C, chromosome 19 at 3,943,703 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5441 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043006-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.