Strain Name:
C57BL/6J-MtgxR5471Btlr/Mmmh
Stock Number:
043032-MU
Citation ID:
RRID:MMRRC_043032-MU
Other Names:
R5471 (G1), C57BL/6J-MtgxR5471Btlr
Major Collection:

Gene Information

Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: trkB, Tkrb, C030027L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Dlc1
Name: deleted in liver cancer 1
Synonyms: Arhgap7, p122-RhoGAP, STARD12, A730069N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Arhgef10
Name: Rho guanine nucleotide exchange factor (GEF) 10
Synonyms: 6430549H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234094
Homologene: 22827
Gpr1
Name: G protein-coupled receptor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241070
HGNC: HGNC:4463
Homologene: 21094
Tmem87b
Name: transmembrane protein 87B
Synonyms: 2810431I02Rik, 2610301K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72477
Homologene: 69513
Exoc6
Name: exocyst complex component 6
Synonyms: hbd, Sec15, Sec15l1, msec15, 4833405E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 107371
VEGA: 19
Homologene: 41305
Txnl1
Name: thioredoxin-like 1
Synonyms: TRP32, 32kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 53382
VEGA: 18
Homologene: 3515
Trappc12
Name: trafficking protein particle complex 12
Synonyms: D930014A20Rik, Ttc15, CGI-87
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217449
VEGA: 12
Homologene: 34805
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 27103
Homologene: 40891
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11736
Homologene: 9491
Nav2
Name: neuron navigator 2
Synonyms: Unc53H2, HELAD1, POMFIL2, 5330421F07Rik, RAINB2, Rainb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78286
Homologene: 52330
Fam83h
Name: family with sequence similarity 83, member H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105732
VEGA: 15
Homologene: 15890
Bcam
Name: basal cell adhesion molecule
Synonyms: Lu, 1200005K12Rik, B-CAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 57278
HGNC: HGNC:6722
Homologene: 21149
Npnt
Name: nephronectin
Synonyms: POEM, 1110009H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 114249
Homologene: 14138
Cd72
Name: CD72 antigen
Synonyms: Lyb-2, Ly-19, Ly-m19, Ly-32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12517
HGNC: HGNC:1696
Homologene: 1350
Slit2
Name: slit guidance ligand 2
Synonyms: E130320P19Rik, Slil3, b2b1200.1Clo, Drad-1, E030015M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20563
Homologene: 3516
Fgfr1op2
Name: FGFR1 oncogene partner 2
Synonyms: 1500031J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67529
Homologene: 9222
Neto2
Name: neuropilin (NRP) and tolloid (TLL)-like 2
Synonyms: 5530601C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74513
Homologene: 32387
Gcnt2
Name: glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
Synonyms: IGnTB, IGnTC, IGnT, IGnTA, 5330430K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14538
VEGA: 13
HGNC: HGNC:4204
Homologene: 41535
Saal1
Name: serum amyloid A-like 1
Synonyms: 5031425D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 78935
Homologene: 34706
Ptpn4
Name: protein tyrosine phosphatase, non-receptor type 4
Synonyms: PTPMEG, hPTP-MEG, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), TEP/mPTPMEG, testis-enriched phosphatase, TEP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19258
HGNC: HGNC:9656
Homologene: 2120
Alox12e
Name: arachidonate lipoxygenase, epidermal
Synonyms: e-LOX1, Alox12-ps1, Aloxe, 8-LOX, Alox12-ps2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11685
Homologene: 105868
Trim9
Name: tripartite motif-containing 9
Synonyms: C030048G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94090
VEGA: 12
Homologene: 9045
Gm11992
Name: predicted gene 11992
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 626870
Homologene: 77951
Acsm1
Name: acyl-CoA synthetase medium-chain family member 1
Synonyms: Macs, Bucs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 117147
Homologene: 24930
Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Synonyms: CP12, aromatic compound inducible, P450-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13077
VEGA: 9
HGNC: HGNC:2596
Homologene: 68082
Gm5114
Name: predicted gene 5114
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330513
Homologene: 45597
Nr1h5
Name: nuclear receptor subfamily 1, group H, member 5
Synonyms: FXRB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 381463
Homologene: 131277
Olfr205
Name: olfactory receptor 205
Synonyms: MOR182-11P, GA_x54KRFPKG5P-55543875-55542958
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 257881
Homologene: 79469
Baiap2l1
Name: BAI1-associated protein 2-like 1
Synonyms: IRTKS, 1300006M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66898
Homologene: 23123
Stox2
Name: storkhead box 2
Synonyms: 4933409N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71069
Homologene: 18414
Topaz1
Name: testis and ovary specific PAZ domain containing 1
Synonyms: Gm9524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 671232
VEGA: 9
Homologene: 19835
Fam20b
Name: family with sequence similarity 20, member B
Synonyms: C530043G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 215015
Homologene: 8909
Lhpp
Name: phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Synonyms: 2310007H09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76429
Homologene: 41469
Cwh43
Name: cell wall biogenesis 43 C-terminal homolog
Synonyms: C130090K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231293
Homologene: 5474
Padi2
Name: peptidyl arginine deiminase, type II
Synonyms: Pdi2, PAD type II, Pdi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18600
Homologene: 7214
Smarcal1
Name: SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Synonyms: Mharp, 6030401P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54380
Homologene: 8558
Ptgis
Name: prostaglandin I2 (prostacyclin) synthase
Synonyms: Pgi2, Pgis, Cyp8a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19223
HGNC: HGNC:9603
Homologene: 37374
Slco4c1
Name: solute carrier organic anion transporter family, member 4C1
Synonyms: PRO2176, C330017E21Rik, OATP-M1, OATP4C1, SLC21A20, OATP-H
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227394
Homologene: 62654
Elmo1
Name: engulfment and cell motility 1
Synonyms: CED-12, 6330578D22Rik, C230095H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 140580
Homologene: 56685
Olfr802
Name: olfactory receptor 802
Synonyms: MOR111-1, GA_x6K02T2PULF-11361362-11360424
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258934
HGNC: HGNC:8355
Homologene: 105151
Olfr319
Name: olfactory receptor 319
Synonyms: GA_x6K02T2NKPP-708319-707399, MOR285-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258493
Saxo1
Name: stabilizer of axonemal microtubules 1
Synonyms: 4930500O09Rik, Fam154a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75811
Homologene: 27548
Gnat3
Name: guanine nucleotide binding protein, alpha transducing 3
Synonyms: Ggust, alpha-gustducin, Gtn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242851
Homologene: 24284
Mrgprb8
Name: MAS-related GPR, member B8
Synonyms: MrgB8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404240
Homologene: 83620
Clec4n
Name: C-type lectin domain family 4, member n
Synonyms: Clecsf10, Nkcl, dectin-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56620
Homologene: 84615
Slc7a12
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
Synonyms: XAT1, asc-type amino acid transporter 2, Asc-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 140918
Homologene: 76812
Slfn9
Name: schlafen 9
Synonyms: 9830137M10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237886
Homologene: 45432
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Ubald1
Name: UBA-like domain containing 1
Synonyms: Fam100a, 1500031H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207740
Homologene: 17055
Vsx1
Name: visual system homeobox 1
Synonyms: CHX10-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 114889
Homologene: 8743
Zfp397
Name: zinc finger protein 397
Synonyms: 6720480F11Rik, 2810411K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 69256
VEGA: 18
Homologene: 117445
Vash1
Name: vasohibin 1
Synonyms: D930046M13Rik, G630009D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238328
Homologene: 8941
Igkv1-133
Name: immunoglobulin kappa variable 1-133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 628027
Gm8674
Name: predicted gene 8674
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 667507
VEGA: 13
Homologene: 140547
Ighv1-86
Name: immunoglobulin heavy variable 1-86
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 668599
Gm815
Name: predicted gene 815
Synonyms: LOC329047
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 329047
VEGA: 19
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 63,183,899 bp
  • A to G, chromosome 1 at 72,591,253 bp
  • C to A, chromosome 1 at 96,872,045 bp
  • A to T, chromosome 1 at 119,765,919 bp
  • T to C, chromosome 1 at 156,705,729 bp
  • A to G, chromosome 2 at 118,474,132 bp
  • T to G, chromosome 2 at 128,851,320 bp
  • T to C, chromosome 2 at 150,683,066 bp
  • C to A, chromosome 2 at 167,224,119 bp
  • G to A, chromosome 3 at 14,480,875 bp
  • T to C, chromosome 3 at 102,949,126 bp
  • T to G, chromosome 3 at 132,914,387 bp
  • T to C, chromosome 4 at 43,448,345 bp
  • G to A, chromosome 4 at 86,445,724 bp
  • A to G, chromosome 4 at 140,933,208 bp
  • T to A, chromosome 5 at 17,991,324 bp
  • T to A, chromosome 5 at 48,189,555 bp
  • T to A, chromosome 5 at 73,408,231 bp
  • T to G, chromosome 5 at 144,282,141 bp
  • T to C, chromosome 6 at 67,725,547 bp
  • T to A, chromosome 6 at 123,232,186 bp
  • A to T, chromosome 6 at 146,597,362 bp
  • T to A, chromosome 7 at 3,735,515 bp
  • T to A, chromosome 7 at 19,766,957 bp
  • C to A, chromosome 7 at 39,409,110 bp
  • C to T, chromosome 7 at 46,699,648 bp
  • T to A, chromosome 7 at 48,388,723 bp
  • A to G, chromosome 7 at 49,548,169 bp
  • C to T, chromosome 7 at 119,660,606 bp
  • G to T, chromosome 7 at 132,634,122 bp
  • A to G, chromosome 8 at 14,999,677 bp
  • G to T, chromosome 8 at 36,584,725 bp
  • G to T, chromosome 8 at 47,193,513 bp
  • T to C, chromosome 8 at 85,640,760 bp
  • A to T, chromosome 9 at 57,679,020 bp
  • T to G, chromosome 9 at 122,791,416 bp
  • A to T, chromosome 10 at 93,028,660 bp
  • A to G, chromosome 10 at 129,682,056 bp
  • A to T, chromosome 11 at 9,068,333 bp
  • T to C, chromosome 11 at 58,702,325 bp
  • T to C, chromosome 11 at 70,320,024 bp
  • T to A, chromosome 11 at 72,728,791 bp
  • T to G, chromosome 11 at 82,982,787 bp
  • G to A, chromosome 12 at 28,691,500 bp
  • A to G, chromosome 12 at 70,346,792 bp
  • G to A, chromosome 12 at 86,689,128 bp
  • T to C, chromosome 12 at 116,009,813 bp
  • A to G, chromosome 13 at 20,572,385 bp
  • A to G, chromosome 13 at 40,860,719 bp
  • A to G, chromosome 13 at 49,900,813 bp
  • T to C, chromosome 13 at 58,871,760 bp
  • T to C, chromosome 15 at 76,002,903 bp
  • G to A, chromosome 16 at 4,875,841 bp
  • T to G, chromosome 16 at 59,328,631 bp
  • A to G, chromosome 18 at 23,960,024 bp
  • A to G, chromosome 18 at 63,676,926 bp
  • A to G, chromosome 19 at 26,888,369 bp
  • A to G, chromosome 19 at 37,599,617 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5471 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043032-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.