Strain Name:
C57BL/6J-MtgxR5472Btlr/Mmmh
Stock Number:
043033-MU
Citation ID:
RRID:MMRRC_043033-MU
Other Names:
R5472 (G1), C57BL/6J-MtgxR5472Btlr
Major Collection:

Gene Information

Tlr9
Name: toll-like receptor 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 81897
Homologene: 68126
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11426
Homologene: 136191
Tns3
Name: tensin 3
Synonyms: TEM6, Tens1, F830010I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 319939
Homologene: 49713
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alpha-fodrin, Spna2, Spna-2, 2610027H02Rik, alphaII-spectrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20740
Homologene: 2353
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 4733401D09Rik, 9630045K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 52184
Homologene: 12011
Tsnax
Name: translin-associated factor X
Synonyms: Trax
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 53424
Homologene: 4374
S1pr3
Name: sphingosine-1-phosphate receptor 3
Synonyms: S1P3, Edg3, LPb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 13610
VEGA: 13
HGNC: HGNC:3167
Homologene: 3829
Cxcr4
Name: chemokine (C-X-C motif) receptor 4
Synonyms: b2b220Clo, PB-CKR, fusin, Cmkar4, CD184, Sdf1r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12767
HGNC: HGNC:2561
Homologene: 20739
Lrsam1
Name: leucine rich repeat and sterile alpha motif containing 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227738
Homologene: 44526
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: Carmil, Lrrc16, Lrrc16a, 1110037D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 68732
Homologene: 9757
Lin9
Name: lin-9 homolog (C. elegans)
Synonyms: 2700022J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 72568
Homologene: 35252
Nup35
Name: nucleoporin 35
Synonyms: 2310006I24Rik, 5330402E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 69482
Homologene: 44517
Fancl
Name: Fanconi anemia, complementation group L
Synonyms: B230118H11Rik, gcd, Pog, 2010322C19Rik, Phf9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67030
Homologene: 9987
Ppp1r12a
Name: protein phosphatase 1, regulatory subunit 12A
Synonyms: 5730577I22Rik, Mypt1, 1200015F06Rik, D10Ertd625e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 17931
VEGA: 10
HGNC: HGNC:7618
Homologene: 1855
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: Sfprp8l, Prp8, DBF3/PRP8, D11Bwg0410e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192159
Homologene: 4706
Mdh1
Name: malate dehydrogenase 1, NAD (soluble)
Synonyms: Mor-2, B230377B03Rik, MDH-s, Mor2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17449
HGNC: HGNC:6970
Homologene: 4324
Msh6
Name: mutS homolog 6
Synonyms: Gtmbp, Msh6, GTBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 17688
VEGA: 17
HGNC: HGNC:7329
Homologene: 149
Raf1
Name: v-raf-leukemia viral oncogene 1
Synonyms: v-Raf, Craf1, Raf-1, c-Raf, sarcoma 3611 oncogene, 6430402F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 110157
HGNC: HGNC:9829
Homologene: 48145
Gcnt2
Name: glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
Synonyms: IGnTC, IGnTB, IGnTA, 5330430K10Rik, IGnT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 14538
VEGA: 13
HGNC: HGNC:4204
Homologene: 41535
Txndc5
Name: thioredoxin domain containing 5
Synonyms: PC-TRP, ERp46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 105245
Homologene: 11125
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: D330050P16Rik, A230048G03Rik, 2010013B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 320473
VEGA: 17
Homologene: 25536
Akap11
Name: A kinase (PRKA) anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Jag1
Name: jagged 1
Synonyms: Ozz, Serrate-1, Gsfabe2, Htu, ABE2, Headturner
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16449
HGNC: HGNC:6188
Homologene: 180
Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms: Xpg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22592
HGNC: HGNC:3437
Homologene: 133551
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: (alpha)1 subunit, L-type Cav1.2, Cav1.2, Cchl1a1, D930026N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
BC067074
Name: cDNA sequence BC067074
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 408066
Eif3f
Name: eukaryotic translation initiation factor 3, subunit F
Synonyms: Eif3s5, 0610037M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 66085
HGNC: HGNC:3275
Homologene: 2783
Inhba
Name: inhibin beta-A
Synonyms: activin beta-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 16323
VEGA: 13
HGNC: HGNC:6066
Homologene: 1653
Brinp3
Name: bone morphogenetic protein/retinoic acid inducible neural specific 3
Synonyms: B830045N13Rik, Fam5c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 215378
Homologene: 17786
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Slx4
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms: D16Bwg1016e, Btbd12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 52864
Homologene: 23770
Dpp7
Name: dipeptidylpeptidase 7
Synonyms: QPP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 83768
Homologene: 22748
Rasal3
Name: RAS protein activator like 3
Synonyms: A430107D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 320484
Homologene: 18901
Vwde
Name: von Willebrand factor D and EGF domains
Synonyms: LOC232585
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232585
Homologene: 35456
Gm973
Name: predicted gene 973
Synonyms: LOC381260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 381260
Homologene: 124277
Kcna2
Name: potassium voltage-gated channel, shaker-related subfamily, member 2
Synonyms: Akr6a4, Mk-2, Kca1-2, Kv1.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 16490
HGNC: HGNC:6220
Homologene: 21034
Sp7
Name: Sp7 transcription factor 7
Synonyms: osterix, 6430578P22Rik, Osx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 170574
VEGA: 15
Homologene: 15607
Col16a1
Name: collagen, type XVI, alpha 1
Synonyms: [a]1 (XVI) collagen, 2700007F12Rik, A530052M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 107581
HGNC: HGNC:2193
Homologene: 1397
Pcolce
Name: procollagen C-endopeptidase enhancer protein
Synonyms: Astt2, Astt-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 18542
HGNC: HGNC:8738
Homologene: 1946
Ube2q1
Name: ubiquitin-conjugating enzyme E2Q family member 1
Synonyms: NICE-5, PRO3094, 2310012M18Rik, 1110002C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 70093
Homologene: 9730
Pramef20
Name: PRAME family member 20
Synonyms: Gm13125, EG627009
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 627009
Homologene: 133194
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: C130090D05Rik, Kv12.1, ELK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 211468
Homologene: 14332
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 665255
Homologene: 129605
Olfr822
Name: olfactory receptor 822
Synonyms: GA_x6K02T2PULF-11745102-11746040, MOR113-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258666
Homologene: 133890
Zfp109
Name: zinc finger protein 109
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56869
Wdr35
Name: WD repeat domain 35
Synonyms: 4930459M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 74682
Homologene: 10814
Setd7
Name: SET domain containing (lysine methyltransferase) 7
Synonyms: Set7, 1600028F23Rik, KMT7, Set7/9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 73251
Homologene: 12741
Ajm1
Name: apical junction component 1
Synonyms: LOC381353, Gm996
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 381353
Homologene: 19943
Tmem117
Name: transmembrane protein 117
Synonyms: B930062P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 320709
VEGA: 15
Homologene: 12992
Gm765
Name: predicted gene 765
Synonyms: LOC330390
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330390
Homologene: 66631
Mrps22
Name: mitochondrial ribosomal protein S22
Synonyms: 3100002P07Rik, Rpms22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 64655
Homologene: 57030
Tmem45b
Name: transmembrane protein 45b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235135
VEGA: 9
Homologene: 16349
Ifi213
Name: interferon activated gene 213
Synonyms: Pyr-A, Pydc4, E030037K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 623121
HGNC: HGNC:5395
Homologene: 115929
Cdk2ap2
Name: CDK2-associated protein 2
Synonyms: 5830466O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 52004
Homologene: 4272
Gm10044
Name: predicted gene 10044
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218695
Homologene: 141165
Ighv1-20
Name: immunoglobulin heavy variable V1-20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 668497
Nlrp5-ps
Name: NLR family, pyrin domain containing 5, pseudogene
Synonyms: Gm18756
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 100417675
Irx3os
Name: iroquois homeobox 3, opposite strand
Synonyms: D230002A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 319388
Gm11733
Name: predicted gene 11733
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 432615
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 44,180,872 bp
  • A to G, chromosome 1 at 59,628,287 bp
  • C to A, chromosome 1 at 128,589,625 bp
  • A to T, chromosome 1 at 146,901,459 bp
  • A to T, chromosome 1 at 173,567,272 bp
  • A to G, chromosome 1 at 180,688,382 bp
  • A to G, chromosome 2 at 25,353,751 bp
  • T to C, chromosome 2 at 25,579,702 bp
  • T to A, chromosome 2 at 30,030,423 bp
  • ACC to AC, chromosome 2 at 32,945,858 bp
  • C to T, chromosome 2 at 80,658,401 bp
  • G to A, chromosome 2 at 91,162,730 bp
  • C to A, chromosome 2 at 137,084,995 bp
  • G to A, chromosome 3 at 51,521,465 bp
  • A to G, chromosome 3 at 89,777,241 bp
  • T to C, chromosome 3 at 107,105,309 bp
  • G to T, chromosome 3 at 145,146,866 bp
  • T to C, chromosome 4 at 123,450,061 bp
  • T to C, chromosome 4 at 130,092,771 bp
  • T to C, chromosome 4 at 144,377,157 bp
  • G to A, chromosome 5 at 137,605,581 bp
  • A to T, chromosome 6 at 13,193,118 bp
  • A to T, chromosome 6 at 98,238,276 bp
  • A to G, chromosome 6 at 115,626,706 bp
  • A to G, chromosome 6 at 118,638,446 bp
  • C to T, chromosome 7 at 5,487,944 bp
  • G to A, chromosome 7 at 14,580,975 bp
  • A to T, chromosome 7 at 24,228,621 bp
  • A to G, chromosome 7 at 108,938,396 bp
  • G to T, chromosome 8 at 91,799,480 bp
  • A to G, chromosome 8 at 125,015,762 bp
  • T to A, chromosome 9 at 31,428,044 bp
  • C to T, chromosome 9 at 98,598,122 bp
  • T to A, chromosome 9 at 106,224,313 bp
  • C to T, chromosome 10 at 108,240,112 bp
  • A to T, chromosome 10 at 130,075,029 bp
  • A to G, chromosome 11 at 8,451,092 bp
  • A to T, chromosome 11 at 21,559,786 bp
  • G to T, chromosome 11 at 26,469,677 bp
  • A to C, chromosome 11 at 75,503,643 bp
  • A to T, chromosome 11 at 117,484,496 bp
  • T to A, chromosome 12 at 9,016,619 bp
  • A to T, chromosome 12 at 114,723,851 bp
  • A to G, chromosome 13 at 16,026,786 bp
  • C to T, chromosome 13 at 24,155,471 bp
  • G to A, chromosome 13 at 38,513,125 bp
  • T to C, chromosome 13 at 40,953,579 bp
  • T to A, chromosome 13 at 51,419,647 bp
  • A to G, chromosome 13 at 113,319,169 bp
  • A to G, chromosome 14 at 7,791,483 bp
  • T to C, chromosome 14 at 78,513,429 bp
  • T to A, chromosome 15 at 95,094,513 bp
  • G to A, chromosome 15 at 102,359,314 bp
  • C to T, chromosome 16 at 3,991,540 bp
  • C to A, chromosome 17 at 32,396,669 bp
  • A to T, chromosome 17 at 52,977,816 bp
  • A to T, chromosome 17 at 78,801,660 bp
  • G to A, chromosome 17 at 87,984,561 bp
  • C to A, chromosome 19 at 4,098,048 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5472 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043033-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.