Strain Name:
C57BL/6J-MtgxR5500Btlr/Mmmh
Stock Number:
043061-MU
Citation ID:
RRID:MMRRC_043061-MU
Other Names:
R5500 (G1), C57BL/6J-MtgxR5500Btlr
Major Collection:

Gene Information

Upp1
Name: uridine phosphorylase 1
Synonyms: UdRPase, UPase, Up
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 22271
Homologene: 2524
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: Her-2 Tg, WAP-Her-2, AS3, Tg(Wap-ERBB2)229Wzw, Aprin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100710
Homologene: 41001
Rnf111
Name: ring finger 111
Synonyms: Arkadia
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 93836
VEGA: 9
Homologene: 9741
Ywhah
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
Synonyms: 14-3-3 eta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22629
Homologene: 37767
Kpnb1
Name: karyopherin (importin) beta 1
Synonyms: Impnb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16211
HGNC: HGNC:6400
Homologene: 1707
Kdsr
Name: 3-ketodihydrosphingosine reductase
Synonyms: Fvt1, 6330410P18Rik, 9430079B08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 70750
HGNC: HGNC:4021
Homologene: 1539
Recql4
Name: RecQ protein-like 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 79456
VEGA: 15
HGNC: HGNC:9949
Homologene: 3144
Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Synonyms: 4930429A22Rik, 8030493P09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 208718
Homologene: 62417
Prpf40a
Name: pre-mRNA processing factor 40A
Synonyms: FBP11, 2810012K09Rik, Fnbp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56194
Homologene: 6377
Neo1
Name: neogenin
Synonyms: Igdcc2, 2610028H22Rik, D930014N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18007
VEGA: 9
HGNC: HGNC:7754
Homologene: 1870
Lpar1
Name: lysophosphatidic acid receptor 1
Synonyms: LPA1, Edg2, Gpcr26, vzg-1, Kdt2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14745
HGNC: HGNC:3166
Homologene: 1072
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: Ankrd15, D330024H06Rik, A930031B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 107351
Homologene: 17706
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 386750
Homologene: 8955
Ighmbp2
Name: immunoglobulin mu binding protein 2
Synonyms: AEP, Catf1, sma, p110 subunit, RIPE3b1, Smbp-2, Smbp2, Smubp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 20589
HGNC: HGNC:5542
Homologene: 1642
Farsb
Name: phenylalanyl-tRNA synthetase, beta subunit
Synonyms: Farslb, Frsb, PheRS alpha, Farsl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 23874
Homologene: 4160
Fam169b
Name: family with sequence similarity 169, member B
Synonyms: EG434197
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 434197
Homologene: 79038
Amy1
Name: amylase 1, salivary
Synonyms: Amy-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 11722
Homologene: 20179
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: USH1D, mdfw, ahl, nmf112, nmf181, nmf252, 4930542A03Rik, sals, bob
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22295
Homologene: 11142
Zbed5
Name: zinc finger, BED type containing 5
Synonyms: 2410018M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71970
Homologene: 84838
Slc45a2
Name: solute carrier family 45, member 2
Synonyms: Oca4, bls, Matp, Aim1, Dbr, blanc-sale, Aim-1, dominant brown
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22293
Homologene: 9412
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Gm4847
Name: predicted gene 4847
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226604
Homologene: 101040
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
AI182371
Name: expressed sequence AI182371
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 98870
Homologene: 87268
Pgm2l1
Name: phosphoglucomutase 2-like 1
Synonyms: BM32A, 4931406N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 70974
Homologene: 12374
Ddx60
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 234311
Homologene: 23031
Osbpl3
Name: oxysterol binding protein-like 3
Synonyms: 1200014M06Rik, 6720421I08Rik, ORP3, OSBP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 71720
Homologene: 49422
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 72371
Homologene: 89234
Krtap31-2
Name: keratin associated protein 31-2
Synonyms: OTTMUSG00000002177
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 432602
Homologene: 134336
Ric8a
Name: RIC8 guanine nucleotide exchange factor A
Synonyms: synembryn, RIC-8, Ric8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101489
Homologene: 23331
Evi5l
Name: ecotropic viral integration site 5 like
Synonyms: 2310039H16Rik, 3110007G05Rik, B130050I23Rik, 1700084G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 213027
Homologene: 134635
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: C130090D05Rik, Kv12.1, ELK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 211468
Homologene: 14332
Usp9y
Name: ubiquitin specific peptidase 9, Y chromosome
Synonyms: Fafl2, Dffry
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
NCBI: 107868
Homologene: 68408
Tlr1
Name: toll-like receptor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21897
Homologene: 20694
Rcbtb2
Name: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
Synonyms: 2810420M18Rik, Chc1l, Rc/btb2, 2610028E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 105670
HGNC: HGNC:1914
Homologene: 970
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 74691
Homologene: 14311
Slc2a12
Name: solute carrier family 2 (facilitated glucose transporter), member 12
Synonyms: Glut12, GLUT-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 353169
Homologene: 59263
Gm4951
Name: predicted gene 4951
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240327
Slc35f1
Name: solute carrier family 35, member F1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 215085
Homologene: 33552
Wdyhv1
Name: WDYHV motif containing 1
Synonyms: 2410187C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 76773
VEGA: 15
Homologene: 9968
Rhbdl1
Name: rhomboid like 1
Synonyms: Rhbdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 214951
Homologene: 2946
Sh3bp5
Name: SH3-domain binding protein 5 (BTK-associated)
Synonyms: Sab
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 24056
Homologene: 23450
4930449A18Rik
Name: RIKEN cDNA 4930449A18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
Klhl41
Name: kelch-like 41
Synonyms: LOC228003, Kbtbd10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228003
Homologene: 4421
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 78,471,124 bp
  • T to C, chromosome 1 at 87,021,119 bp
  • A to G, chromosome 1 at 106,759,644 bp
  • A to G, chromosome 1 at 166,635,042 bp
  • A to G, chromosome 2 at 35,100,638 bp
  • C to A, chromosome 2 at 52,162,067 bp
  • A to T, chromosome 2 at 53,145,284 bp
  • A to G, chromosome 2 at 69,683,529 bp
  • T to A, chromosome 3 at 59,846,285 bp
  • T to C, chromosome 3 at 73,050,347 bp
  • A to T, chromosome 3 at 113,562,722 bp
  • G to A, chromosome 4 at 58,486,573 bp
  • T to A, chromosome 5 at 33,026,592 bp
  • G to T, chromosome 5 at 64,927,098 bp
  • T to A, chromosome 5 at 129,901,982 bp
  • T to C, chromosome 5 at 150,794,285 bp
  • G to A, chromosome 6 at 50,297,020 bp
  • A to G, chromosome 7 at 68,350,369 bp
  • T to G, chromosome 7 at 100,268,133 bp
  • T to C, chromosome 7 at 140,858,315 bp
  • T to A, chromosome 8 at 4,191,658 bp
  • A to G, chromosome 8 at 61,950,451 bp
  • A to G, chromosome 9 at 58,917,054 bp
  • C to A, chromosome 9 at 70,476,043 bp
  • G to A, chromosome 10 at 22,665,137 bp
  • A to T, chromosome 10 at 52,933,222 bp
  • T to C, chromosome 10 at 60,314,311 bp
  • G to A, chromosome 11 at 9,131,774 bp
  • G to A, chromosome 11 at 97,173,111 bp
  • A to G, chromosome 11 at 99,936,347 bp
  • T to C, chromosome 12 at 112,023,268 bp
  • A to T, chromosome 13 at 77,303,389 bp
  • C to A, chromosome 14 at 31,377,495 bp
  • T to C, chromosome 14 at 73,177,040 bp
  • C to T, chromosome 15 at 11,027,785 bp
  • T to C, chromosome 15 at 58,152,610 bp
  • A to G, chromosome 15 at 76,705,578 bp
  • T to C, chromosome 17 at 25,836,554 bp
  • G to A, chromosome 17 at 52,725,980 bp
  • A to T, chromosome 18 at 12,456,764 bp
  • G to A, chromosome 18 at 60,246,020 bp
  • T to C, chromosome 19 at 3,268,687 bp
  • A to T, chromosome 19 at 25,424,332 bp
  • A to G, chromosome Y at 1,341,875 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5500 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043061-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.