Strain Name:
C57BL/6J-MtgxR5693Btlr/Mmmh
Stock Number:
043180-MU
Citation ID:
RRID:MMRRC_043180-MU
Other Names:
R5693 (G1), C57BL/6J-MtgxR5693Btlr
Major Collection:

Gene Information

Ptprf
Name: protein tyrosine phosphatase, receptor type, F
Synonyms: LAR, RPTP-LAR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Orc1
Name: origin recognition complex, subunit 1
Synonyms: MmORC1, Orc1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18392
HGNC: HGNC:8487
Homologene: 31221
Tiparp
Name: TCDD-inducible poly(ADP-ribose) polymerase
Synonyms: DDF1, PARP-7, PARP7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99929
Homologene: 9167
Rfx1
Name: regulatory factor X, 1 (influences HLA class II expression)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 19724
HGNC: HGNC:9982
Homologene: 2189
Armc8
Name: armadillo repeat containing 8
Synonyms: HSPC056, 1200015K23Rik, Gid5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74125
Homologene: 9121
Snx16
Name: sorting nexin 16
Synonyms: 4930522N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74718
Homologene: 11169
Abcb8
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 8
Synonyms: 4833412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74610
HGNC: HGNC:49
Homologene: 5203
Abr
Name: active BCR-related gene
Synonyms: 6330400K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 109934
HGNC: HGNC:81
Homologene: 11081
Gpc1
Name: glypican 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 14733
HGNC: HGNC:4449
Homologene: 20477
Oprd1
Name: opioid receptor, delta 1
Synonyms: DOR-1, Nbor, mDOR, DOR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18386
HGNC: HGNC:8153
Homologene: 20252
Dcc
Name: deleted in colorectal carcinoma
Synonyms: C030036D22Rik, Igdcc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13176
HGNC: HGNC:2701
Homologene: 21081
Tjp1
Name: tight junction protein 1
Synonyms: ZO-1, ZO1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 21872
Homologene: 2445
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 6330406J24Rik, 5430439G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71389
Homologene: 32772
Thyn1
Name: thymocyte nuclear protein 1
Synonyms: D730042P09Rik, Thy28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77862
VEGA: 9
Homologene: 8575
Gata4
Name: GATA binding protein 4
Synonyms: Gata-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14463
HGNC: HGNC:4173
Homologene: 1551
Srcap
Name: Snf2-related CREBBP activator protein
Synonyms: B930091H02Rik, F630004O05Rik, D030022P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043597
Homologene: 38213
Abca13
Name: ATP-binding cassette, sub-family A (ABC1), member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 268379
Homologene: 27991
Myo6
Name: myosin VI
Synonyms: Tlc, Myo6rsv, rsv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17920
HGNC: HGNC:7605
Homologene: 56417
Rasef
Name: RAS and EF hand domain containing
Synonyms: RAB45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242505
Homologene: 28424
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Zfp654
Name: zinc finger protein 654
Synonyms: 1810008K20Rik, 1600021C16Rik, Gm5488
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 72020
Homologene: 10114
Vmn1r167
Name: vomeronasal 1 receptor 167
Synonyms: Gm6279
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 622032
Homologene: 128341
Pik3r5
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: Foap2, p101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320207
Homologene: 8627
Tyro3
Name: TYRO3 protein tyrosine kinase 3
Synonyms: Sky, Dtk, Etk-2, Tif, Brt, Sky, Rse
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22174
Homologene: 4585
Lpin3
Name: lipin 3
Synonyms: 9130206L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64899
Homologene: 84844
Parp9
Name: poly (ADP-ribose) polymerase family, member 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 80285
Homologene: 12720
Slc14a2
Name: solute carrier family 14 (urea transporter), member 2
Synonyms: UT-A3, UT-A5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 27411
VEGA: 18
Homologene: 5183
Clip3
Name: CAP-GLY domain containing linker protein 3
Synonyms: 1500005P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76686
Homologene: 9176
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Tmem168
Name: transmembrane protein 168
Synonyms: 5730526F17Rik, 8430437G11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101118
Homologene: 11202
Pacs2
Name: phosphofurin acidic cluster sorting protein 2
Synonyms: 6720425G15Rik, Pacs1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217893
VEGA: 12
Homologene: 15016
Evc
Name: EvC ciliary complex subunit 1
Synonyms: Ellis van Creveld gene syndrome
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 59056
HGNC: HGNC:3497
Homologene: 10949
Vmn1r183
Name: vomeronasal 1 receptor 183
Synonyms: LOC209824, V1rd15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 209824
Homologene: 104166
Prkar1b
Name: protein kinase, cAMP dependent regulatory, type I beta
Synonyms: RIbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19085
HGNC: HGNC:9390
Homologene: 37665
Slc10a2
Name: solute carrier family 10, member 2
Synonyms: ASBT, 9130221J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 20494
Homologene: 390
Olfr798
Name: olfactory receptor 798
Synonyms: GA_x6K02T2PULF-11304679-11303744, MOR108-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258549
Homologene: 133881
Med24
Name: mediator complex subunit 24
Synonyms: Trap100, D11Ertd307e, R75526, 100kDa, DRIP100, Gse2, Pparb2, Thrap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23989
Homologene: 40795
Zfp263
Name: zinc finger protein 263
Synonyms: 1200014J04Rik, NT2, mFPM315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74120
Homologene: 4197
Dmrtb1
Name: DMRT-like family B with proline-rich C-terminal, 1
Synonyms: Dmrt6, Prp13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56296
Homologene: 13207
Rnf183
Name: ring finger protein 183
Synonyms: 5830442J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76072
Homologene: 44917
Gm26919
Name: predicted gene, 26919
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Homologene: 134227
Plscr5
Name: phospholipid scramblase family, member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100504689
Homologene: 28688
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 92,857,899 bp
  • T to G, chromosome 2 at 119,810,868 bp
  • A to G, chromosome 2 at 160,895,400 bp
  • A to T, chromosome 2 at 160,965,265 bp
  • T to C, chromosome 3 at 10,420,258 bp
  • T to C, chromosome 3 at 65,553,492 bp
  • A to G, chromosome 4 at 62,428,516 bp
  • T to C, chromosome 4 at 73,769,839 bp
  • G to A, chromosome 4 at 107,684,169 bp
  • G to A, chromosome 4 at 108,613,079 bp
  • G to A, chromosome 4 at 118,236,177 bp
  • G to A, chromosome 4 at 132,144,410 bp
  • C to T, chromosome 5 at 24,400,139 bp
  • A to G, chromosome 5 at 37,320,240 bp
  • A to G, chromosome 5 at 139,127,645 bp
  • T to C, chromosome 6 at 13,602,321 bp
  • T to A, chromosome 6 at 130,676,738 bp
  • A to T, chromosome 7 at 23,505,221 bp
  • C to T, chromosome 7 at 24,054,802 bp
  • A to G, chromosome 7 at 30,298,931 bp
  • G to A, chromosome 7 at 65,342,663 bp
  • C to A, chromosome 7 at 127,519,816 bp
  • C to A, chromosome 8 at 5,105,128 bp
  • C to A, chromosome 8 at 84,073,904 bp
  • G to T, chromosome 9 at 27,005,215 bp
  • G to A, chromosome 9 at 80,266,180 bp
  • A to T, chromosome 9 at 92,205,511 bp
  • A to G, chromosome 9 at 99,496,149 bp
  • T to C, chromosome 10 at 129,625,527 bp
  • A to G, chromosome 11 at 9,316,233 bp
  • C to T, chromosome 11 at 68,494,251 bp
  • T to C, chromosome 11 at 76,463,577 bp
  • A to G, chromosome 11 at 98,709,544 bp
  • T to C, chromosome 12 at 113,049,906 bp
  • A to G, chromosome 14 at 63,241,145 bp
  • T to C, chromosome 15 at 98,603,989 bp
  • C to T, chromosome 16 at 3,744,560 bp
  • A to G, chromosome 16 at 32,776,807 bp
  • T to A, chromosome 16 at 35,945,837 bp
  • T to C, chromosome 16 at 64,785,926 bp
  • G to A, chromosome 18 at 71,575,082 bp
  • T to A, chromosome 18 at 78,147,014 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5693 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043180-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.