Strain Name:
C57BL/6J-MtgxR5721Btlr/Mmmh
Stock Number:
043189-MU
Citation ID:
RRID:MMRRC_043189-MU
Other Names:
R5721 (G1), C57BL/6J-MtgxR5721Btlr
Major Collection:

Gene Information

Atl3
Name: atlastin GTPase 3
Synonyms: 4633402C03Rik, 5730596K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 109168
VEGA: 19
Homologene: 9149
Eps8
Name: epidermal growth factor receptor pathway substrate 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13860
HGNC: HGNC:3420
Homologene: 3272
Ccdc91
Name: coiled-coil domain containing 91
Synonyms: 1700086G08Rik, 1810060J02Rik, p56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67015
Homologene: 10131
Cenpc1
Name: centromere protein C1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12617
HGNC: HGNC:1854
Homologene: 1371
Zc3h7b
Name: zinc finger CCCH type containing 7B
Synonyms: Scrg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20286
VEGA: 15
Homologene: 9735
Faf1
Name: Fas-associated factor 1
Synonyms: Fam, Dffrx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14084
HGNC: HGNC:3578
Homologene: 5120
Dvl2
Name: dishevelled segment polarity protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13543
HGNC: HGNC:3086
Homologene: 20927
Mcph1
Name: microcephaly, primary autosomal recessive 1
Synonyms: 5430437K10Rik, BRIT1, D030046N04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244329
HGNC: HGNC:6954
Homologene: 32586
Prdm15
Name: PR domain containing 15
Synonyms: Zfp298, E130018M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 114604
Homologene: 56941
Cog8
Name: component of oligomeric golgi complex 8
Synonyms: C87832
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 97484
Homologene: 13018
Kif23
Name: kinesin family member 23
Synonyms: 3110001D19Rik, MKLP-1, MKLP1, CHO1, Knsl5, C87313
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71819
VEGA: 9
HGNC: HGNC:6392
Homologene: 11491
Jcad
Name: junctional cadherin 5 associated
Synonyms: 9430020K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240185
VEGA: 18
Homologene: 19370
Numbl
Name: numb-like
Synonyms: nbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18223
HGNC: HGNC:8061
Homologene: 68413
Lsg1
Name: large 60S subunit nuclear export GTPase 1
Synonyms: D16Bwg1547e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224092
Homologene: 5917
Rundc3a
Name: RUN domain containing 3A
Synonyms: Rpip8, Rap2ip
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 51799
Homologene: 4871
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, D830007G01Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Zfand4
Name: zinc finger, AN1-type domain 4
Synonyms: 2810002D23Rik, Anubl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67492
VEGA: 6
Homologene: 18373
Drc7
Name: dynein regulatory complex subunit 7
Synonyms: LOC330830, SRG-L, Ccdc135
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 330830
Homologene: 12996
Ciz1
Name: CDKN1A interacting zinc finger protein 1
Synonyms: 0610038H21Rik, 2900056O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68379
Homologene: 8112
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 242838
Homologene: 18247
Rab11fip2
Name: RAB11 family interacting protein 2 (class I)
Synonyms: Rab11-FIP2, nRip11, 4930470G04Rik, A830046J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74998
Homologene: 8937
P2ry14
Name: purinergic receptor P2Y, G-protein coupled, 14
Synonyms: A330108O13Rik, P2Y14, Gpr105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 140795
Homologene: 15769
Papss2
Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Synonyms: Sk2, Atpsk2, 1810018P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 23972
VEGA: 19
HGNC: HGNC:8604
Homologene: 55840
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381157
Homologene: 73393
Osgepl1
Name: O-sialoglycoprotein endopeptidase-like 1
Synonyms: MGC13061, 2610001M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 72085
Homologene: 5561
Tbc1d16
Name: TBC1 domain family, member 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207592
Homologene: 10380
Or13d1
Name: olfactory receptor family 13 subfamily D member 1
Synonyms: GA_x6K02T2N78B-7025964-7025020, MOR262-9, Olfr270
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 258600
Homologene: 17313
5031439G07Rik
Name: RIKEN cDNA 5031439G07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223739
HGNC: HGNC:1314
Homologene: 15140
Mpv17l
Name: Mpv17 transgene, kidney disease mutant-like
Synonyms: M-LP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 93734
Homologene: 13547
Vmn1r84
Name: vomeronasal 1 receptor 84
Synonyms: V1rg11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 171267
Homologene: 74328
Plekha8
Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
Synonyms: FAPP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 231999
Homologene: 32284
Suox
Name: sulfite oxidase
Synonyms: SO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 211389
VEGA: 10
Homologene: 394
Or10a5
Name: olfactory receptor family 10 subfamily A member 5
Synonyms: GA_x6K02T2PBJ9-9415724-9416677, MOR263-1, P3, Olfr713
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259036
Homologene: 17470
Fbxo40
Name: F-box protein 40
Synonyms: 9830003A13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 207215
Homologene: 9459
Gm11595
Name: predicted gene 11595
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100040276
Homologene: 124486
Slc6a20b
Name: solute carrier family 6 (neurotransmitter transporter), member 20B
Synonyms: XT3, Xtrp3, Sit1, Slc6a20
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22599
Homologene: 130652
Ttc30a1
Name: tetratricopeptide repeat domain 30A1
Synonyms: 4930506L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78802
Homologene: 136638
Pacsin3
Name: protein kinase C and casein kinase substrate in neurons 3
Synonyms: 4921507A02Rik, 6330413E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 80708
HGNC: HGNC:8572
Homologene: 41117
Tmem269
Name: transmembrane protein 269
Synonyms: 4930538K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 75180
Homologene: 28290
Ctsr
Name: cathepsin R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56835
VEGA: 13
HGNC: HGNC:2537
Homologene: 75127
A330041J22Rik
Name: RIKEN cDNA A330041J22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 319556
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 53,321,200 bp
  • C to T, chromosome 2 at 32,376,040 bp
  • A to T, chromosome 2 at 75,981,371 bp
  • G to A, chromosome 2 at 76,728,567 bp
  • T to A, chromosome 2 at 91,264,235 bp
  • T to C, chromosome 3 at 59,115,031 bp
  • G to T, chromosome 4 at 52,971,068 bp
  • T to C, chromosome 4 at 109,935,666 bp
  • T to C, chromosome 4 at 119,209,949 bp
  • T to C, chromosome 5 at 3,850,619 bp
  • A to G, chromosome 5 at 86,047,669 bp
  • T to A, chromosome 6 at 54,613,106 bp
  • C to G, chromosome 6 at 116,287,995 bp
  • G to A, chromosome 6 at 137,539,290 bp
  • C to G, chromosome 6 at 147,575,503 bp
  • C to A, chromosome 7 at 12,362,226 bp
  • T to A, chromosome 7 at 27,276,685 bp
  • T to C, chromosome 7 at 107,036,358 bp
  • G to A, chromosome 8 at 18,671,207 bp
  • T to C, chromosome 8 at 95,074,333 bp
  • T to C, chromosome 8 at 107,050,148 bp
  • C to G, chromosome 9 at 61,944,216 bp
  • A to T, chromosome 9 at 86,699,879 bp
  • C to A, chromosome 9 at 123,611,989 bp
  • A to T, chromosome 10 at 51,614,980 bp
  • T to C, chromosome 10 at 128,671,293 bp
  • A to G, chromosome 11 at 70,005,993 bp
  • G to A, chromosome 11 at 99,772,555 bp
  • C to T, chromosome 11 at 102,399,654 bp
  • C to T, chromosome 11 at 119,158,730 bp
  • C to T, chromosome 13 at 61,161,853 bp
  • T to C, chromosome 15 at 81,773,298 bp
  • A to T, chromosome 15 at 84,960,597 bp
  • T to C, chromosome 16 at 13,946,794 bp
  • C to T, chromosome 16 at 30,561,775 bp
  • T to A, chromosome 16 at 36,968,934 bp
  • A to T, chromosome 16 at 97,807,096 bp
  • A to T, chromosome 18 at 4,676,044 bp
  • G to A, chromosome 18 at 10,542,427 bp
  • T to A, chromosome 19 at 7,529,011 bp
  • A to G, chromosome 19 at 32,660,664 bp
  • A to G, chromosome 19 at 59,935,610 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5721 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043189-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.