Strain Name:
C57BL/6J-MtgxR5755Btlr/Mmmh
Stock Number:
043202-MU
Citation ID:
RRID:MMRRC_043202-MU
Other Names:
R5755 (G1), C57BL/6J-MtgxR5755Btlr
Major Collection:

Gene Information

Kcnj10
Name: potassium inwardly-rectifying channel, subfamily J, member 10
Synonyms: BIR10, BIRK-1, Kir4.1, Kir4.1, Kir1.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 16513
HGNC: HGNC:6256
Homologene: 1689
Eno2
Name: enolase 2, gamma neuronal
Synonyms: D6Ertd375e, Eno-2, NSE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 13807
HGNC: HGNC:3353
Homologene: 74414
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Styx
Name: serine/threonine/tyrosine interaction protein
Synonyms: STNS (alternatively spliced intron of Styx), 0610039A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 56291
VEGA: 14
Homologene: 41331
Syngr3
Name: synaptogyrin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20974
Homologene: 3101
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: 3110031G15Rik, GMAP-210, TRIP230, 6030460N08Rik, 2610511G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 109181
Homologene: 20897
Snx8
Name: sorting nexin 8
Synonyms: B130023O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231834
Homologene: 8338
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: 4930541M15Rik, Camsap1l1, 1600013L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67886
Homologene: 18927
Dtna
Name: dystrobrevin alpha
Synonyms: a-DB-1, 87K protein, 2210407P21Rik, alpha-dystrobrevin, A0, adbn, Dtn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13527
VEGA: 18
HGNC: HGNC:3057
Homologene: 20362
Ehmt2
Name: euchromatic histone lysine N-methyltransferase 2
Synonyms: G9a, NG36, D17Ertd710e, Bat8, KMT1C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 110147
Homologene: 48460
Ambn
Name: ameloblastin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 11698
HGNC: HGNC:452
Homologene: 7625
Atp2b1
Name: ATPase, Ca++ transporting, plasma membrane 1
Synonyms: E130111D10Rik, 2810442I22Rik, PMCA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67972
VEGA: 10
HGNC: HGNC:814
Homologene: 55597
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: p600, A930005E13Rik, 1810009A16Rik, LOC381562, D930005K06Rik, Zubr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 69116
Homologene: 10804
Notch1
Name: notch 1
Synonyms: lin-12, Tan1, N1, Motch A, 9930111A19Rik, Mis6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Pi4kb
Name: phosphatidylinositol 4-kinase beta
Synonyms: Pik4cb, ESTM41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 107650
HGNC: HGNC:8984
Homologene: 6741
Zfp398
Name: zinc finger protein 398
Synonyms: 5730513I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 272347
Homologene: 12358
Zbtb11
Name: zinc finger and BTB domain containing 11
Synonyms: 9230110G02Rik, ZNF-U69274
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 271377
Homologene: 8678
Sp8
Name: trans-acting transcription factor 8
Synonyms: D930049B17Rik, mBtd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 320145
VEGA: 12
Homologene: 18548
Jag1
Name: jagged 1
Synonyms: Ozz, Serrate-1, Gsfabe2, Htu, ABE2, Headturner
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 16449
HGNC: HGNC:6188
Homologene: 180
Abca3
Name: ATP-binding cassette, sub-family A (ABC1), member 3
Synonyms: ABC-C, Abc3, 1810036E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 27410
HGNC: HGNC:33
Homologene: 37437
Spata31d1c
Name: spermatogenesis associated 31 subfamily D, member 1C
Synonyms: 4932441B19Rik, Fam75d1c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 238683
VEGA: 13
HGNC: null
Homologene: null
Rasgrp3
Name: RAS, guanyl releasing protein 3
Synonyms: LOC240168
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 240168
VEGA: 17
Homologene: 15019
Fyco1
Name: FYVE and coiled-coil domain containing 1
Synonyms: 2810409M01Rik, Mem2, ZFYVE7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17281
Homologene: 11561
Parvg
Name: parvin, gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 64099
Homologene: 11151
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: 1110004P15Rik, 2310047C17Rik, DY6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Zcchc4
Name: zinc finger, CCHC domain containing 4
Synonyms: 4930449I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 78796
Homologene: 14632
Dcaf12
Name: DDB1 and CUL4 associated factor 12
Synonyms: 5830424K06Rik, Wdr40a, 1500001L20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68970
Homologene: 49418
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll2, Mll4, C430014K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Hadhb
Name: hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit
Synonyms: 4930479F15Rik, Mtpb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231086
HGNC: HGNC:4803
Homologene: 153
Neto1
Name: neuropilin (NRP) and tolloid (TLL)-like 1
Synonyms: C130005O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 246317
VEGA: 18
Homologene: 16367
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 22625
Homologene: 19318
Axl
Name: AXL receptor tyrosine kinase
Synonyms: Ufo, Ark, Tyro7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26362
HGNC: HGNC:905
Homologene: 7583
F830016B08Rik
Name: RIKEN cDNA F830016B08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240328
VEGA: 18
HGNC: null
Homologene: 129714
Plag1
Name: pleiomorphic adenoma gene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56711
HGNC: HGNC:9045
Homologene: 1993
Ccdc144b
Name: coiled-coil domain containing 144B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 241943
HGNC: null
Homologene: 87263
Klhl11
Name: kelch-like 11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217194
Homologene: 10030
Olfr378
Name: olfactory receptor 378
Synonyms: MOR135-2, GA_x6K02T2P1NL-3586282-3585338
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 259026
HGNC: null
Homologene: 74110
Slc7a10
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 10
Synonyms: D7Bwg0847e, Asc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 53896
Homologene: 56767
Aloxe3
Name: arachidonate lipoxygenase 3
Synonyms: e-LOX-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 23801
Homologene: 8013
Vmn2r113
Name: vomeronasal 2, receptor 113
Synonyms: EG434701
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 434701
HGNC: null
Homologene: null
Olfr263
Name: olfactory receptor 263
Synonyms: MOR256-61, MOR256-31, IA3, Olfr42, GA_x6K02T2N5E5-9379-8514, Olfr263-ps1, MOR256-37P, GA_x6K02T2QHY8-12114828-12113875
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 18341
HGNC: HGNC:8281
Homologene: 12791
Gm16573
Name: predicted gene 16573
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 102635191
HGNC: null
Homologene: null
Gm15457
Name: predicted gene 15457
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: null
HGNC: null
Homologene: null
C2cd6b
Name: C2 calcium dependent domain containing 6B
Synonyms: Gm33589, Als2cr11b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Znrd1
Name: zinc ribbon domain containing 1
Synonyms: 1110014N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 66136
Homologene: 40960
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 37,949,760 bp
  • A to T, chromosome 1 at 59,004,047 bp
  • T to C, chromosome 1 at 68,560,519 bp
  • T to C, chromosome 1 at 127,822,381 bp
  • C to T, chromosome 1 at 136,282,327 bp
  • A to G, chromosome 1 at 172,369,594 bp
  • T to C, chromosome 2 at 26,473,692 bp
  • T to A, chromosome 2 at 137,088,690 bp
  • A to T, chromosome 3 at 36,017,693 bp
  • A to T, chromosome 3 at 94,994,297 bp
  • T to C, chromosome 4 at 3,904,492 bp
  • T to C, chromosome 4 at 41,313,356 bp
  • A to G, chromosome 4 at 139,460,095 bp
  • A to G, chromosome 5 at 30,181,043 bp
  • T to C, chromosome 5 at 52,816,169 bp
  • T to A, chromosome 5 at 88,464,491 bp
  • T to G, chromosome 5 at 140,353,041 bp
  • T to C, chromosome 6 at 47,835,857 bp
  • A to T, chromosome 6 at 124,762,996 bp
  • G to A, chromosome 7 at 25,787,565 bp
  • A to T, chromosome 7 at 35,198,911 bp
  • A to G, chromosome 9 at 123,828,708 bp
  • T to C, chromosome 10 at 98,994,809 bp
  • A to G, chromosome 10 at 99,003,170 bp
  • A to G, chromosome 11 at 69,132,749 bp
  • T to A, chromosome 11 at 73,425,731 bp
  • T to A, chromosome 11 at 100,464,351 bp
  • C to T, chromosome 12 at 101,885,665 bp
  • G to T, chromosome 12 at 118,849,087 bp
  • T to A, chromosome 13 at 21,133,525 bp
  • C to A, chromosome 13 at 65,036,527 bp
  • C to A, chromosome 14 at 45,368,453 bp
  • T to C, chromosome 14 at 56,610,855 bp
  • T to C, chromosome 15 at 84,331,096 bp
  • G to T, chromosome 15 at 98,863,646 bp
  • T to A, chromosome 16 at 56,000,713 bp
  • A to T, chromosome 17 at 22,957,981 bp
  • T to A, chromosome 17 at 24,398,454 bp
  • A to G, chromosome 17 at 24,686,535 bp
  • T to C, chromosome 17 at 34,908,238 bp
  • T to A, chromosome 17 at 36,958,157 bp
  • A to C, chromosome 17 at 75,524,945 bp
  • T to A, chromosome 18 at 23,621,463 bp
  • T to A, chromosome 18 at 60,300,806 bp
  • T to C, chromosome 18 at 86,499,094 bp
  • A to G, chromosome 19 at 9,001,732 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5755 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043202-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.