Strain Name:
C57BL/6J-MtgxR5830Btlr/Mmmh
Stock Number:
043219-MU
Citation ID:
RRID:MMRRC_043219-MU
Other Names:
R5830 (G1), C57BL/6J-MtgxR5830Btlr
Major Collection:

Strain Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: N-CoR, Rxrip13, A230020K14Rik, 5730405M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Apobec3
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
Synonyms: Rfv-3, CEM15, Rfv3, Gm20117
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 80287
Homologene: 105420
Ldb1
Name: LIM domain binding 1
Synonyms: CLIM2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16825
HGNC: HGNC:6532
Homologene: 2891
Ep400
Name: E1A binding protein p400
Synonyms: p400, mDomino, 1700020J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75560
Homologene: 38779
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94187
Homologene: 9010
Lims1
Name: LIM and senescent cell antigen-like domains 1
Synonyms: 2310016J22Rik, 4921524A02Rik, Lims1l, PINCH1, C430041B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 110829
HGNC: HGNC:6616
Homologene: 68428
Gfpt2
Name: glutamine fructose-6-phosphate transaminase 2
Synonyms: GFAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14584
HGNC: HGNC:4242
Homologene: 68439
Cdyl2
Name: chromodomain protein, Y chromosome-like 2
Synonyms: 1700029M19Rik, 4930453I21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75796
Homologene: 41779
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Kdsr
Name: 3-ketodihydrosphingosine reductase
Synonyms: 6330410P18Rik, 9430079B08Rik, Fvt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70750
HGNC: HGNC:4021
Homologene: 1539
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227648
Homologene: 10533
Sel1l
Name: sel-1 suppressor of lin-12-like (C. elegans)
Synonyms: Sel1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20338
Homologene: 31286
Iqgap2
Name: IQ motif containing GTPase activating protein 2
Synonyms: 4933417J23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544963
VEGA: 13
HGNC: HGNC:6111
Homologene: 101543
Epha8
Name: Eph receptor A8
Synonyms: EphA8, Hek3, Eek
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13842
HGNC: HGNC:3391
Homologene: 22436
Syt7
Name: synaptotagmin VII
Synonyms: B230112P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 54525
VEGA: 19
Homologene: 20889
Mtmr2
Name: myotubularin related protein 2
Synonyms: 6030445P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77116
HGNC: HGNC:7450
Homologene: 22951
Hnrnpk
Name: heterogeneous nuclear ribonucleoprotein K
Synonyms: hnRNPK, Hnrpk, KBBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15387
HGNC: HGNC:5044
Homologene: 81909
Gpr155
Name: G protein-coupled receptor 155
Synonyms: DEPDC3, PGR22, 1110017O10Rik, F730029F15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68526
Homologene: 16584
Pink1
Name: PTEN induced putative kinase 1
Synonyms: 1190006F07Rik, brpk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68943
Homologene: 32672
Wdr87-ps
Name: WD repeat domain 87, pseudogene
Synonyms: 4932431P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114675
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2.3, NaG, Nav2, 1110034K09Rik, Scn6a, Nax
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20272
Homologene: 55706
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: Vps15, p150
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
Zkscan2
Name: zinc finger with KRAB and SCAN domains 2
Synonyms: 9430065N20Rik, Zfp694
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210162
Homologene: 19671
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 434341
Homologene: 88935
Obox6
Name: oocyte specific homeobox 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 252830
Tmem132c
Name: transmembrane protein 132C
Synonyms: 4632425D07Rik, 2810482M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208213
Homologene: 76567
Gmip
Name: Gem-interacting protein
Synonyms: 5031419I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 78816
Homologene: 9570
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: TJ6s, ATP6a2, Atp6n2, Tj6, 8430408C20Rik, V-ATPase a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21871
Homologene: 56523
Ccdc40
Name: coiled-coil domain containing 40
Synonyms: B930008I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207607
Homologene: 27890
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Cacna2, Ca(v)alpha2delta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Inpp5e
Name: inositol polyphosphate-5-phosphatase E
Synonyms: 1200002L24Rik, 72kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64436
Homologene: 56863
Pde8b
Name: phosphodiesterase 8B
Synonyms: B230331L10Rik, C030047E14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218461
HGNC: HGNC:8794
Homologene: 2758
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68655
Dipk1c
Name: divergent protein kinase domain 1C
Synonyms: B230399E16Rik, Fam69c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240479
Homologene: 45477
Mrps15
Name: mitochondrial ribosomal protein S15
Synonyms: 1500003E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66407
Homologene: 32636
Il34
Name: interleukin 34
Synonyms: 2010004A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 76527
Homologene: 12648
Lrr1
Name: leucine rich repeat protein 1
Synonyms: 2410005L11Rik, LRR-1, Ppil5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 69706
VEGA: 12
Homologene: 32677
Or5k17
Name: olfactory receptor family 5 subfamily K member 17
Synonyms: GA_x54KRFPKG5P-55145984-55145034, MOR184-4, Olfr181
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 259001
Homologene: 74112
Chmp2a
Name: charged multivesicular body protein 2A
Synonyms: 1500016L11Rik, chromatin modifying protein 2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68953
Homologene: 6382
Ndst1
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Synonyms: glucosaminyl N-deacetylase/N-sulfotransferase 1, Hsst, 1200015G06Rik, Ndst-1, b2b2230Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 15531
VEGA: 18
HGNC: HGNC:7680
Homologene: 20386
Zfp358
Name: zinc finger protein 358
Synonyms: Zfend
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 140482
Homologene: 9996
4833413E03Rik
Name: RIKEN cDNA 4833413E03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Arl14ep
Name: ADP-ribosylation factor-like 14 effector protein
Synonyms: 4930448O08Rik, 2700007P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 212772
Homologene: 17546
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 106,747,532 bp
  • A to G, chromosome 2 at 26,400,415 bp
  • A to T, chromosome 2 at 26,440,841 bp
  • A to T, chromosome 2 at 66,714,051 bp
  • A to G, chromosome 2 at 73,370,089 bp
  • T to C, chromosome 2 at 106,969,194 bp
  • T to C, chromosome 4 at 126,051,430 bp
  • G to A, chromosome 4 at 136,936,390 bp
  • A to T, chromosome 4 at 138,316,014 bp
  • A to T, chromosome 5 at 16,340,790 bp
  • A to T, chromosome 5 at 110,683,996 bp
  • C to T, chromosome 5 at 124,641,547 bp
  • T to A, chromosome 5 at 127,551,613 bp
  • T to C, chromosome 7 at 13,032,112 bp
  • G to A, chromosome 7 at 15,834,457 bp
  • G to A, chromosome 7 at 29,537,775 bp
  • T to C, chromosome 7 at 123,480,100 bp
  • G to T, chromosome 8 at 3,495,846 bp
  • C to T, chromosome 8 at 69,817,435 bp
  • T to C, chromosome 8 at 87,859,471 bp
  • A to G, chromosome 8 at 94,472,914 bp
  • A to G, chromosome 8 at 110,748,691 bp
  • A to G, chromosome 8 at 116,595,084 bp
  • A to G, chromosome 9 at 13,801,978 bp
  • C to A, chromosome 9 at 105,644,824 bp
  • A to T, chromosome 10 at 58,418,782 bp
  • A to G, chromosome 11 at 49,809,061 bp
  • T to C, chromosome 11 at 62,344,763 bp
  • C to A, chromosome 11 at 119,242,746 bp
  • T to A, chromosome 12 at 69,178,671 bp
  • A to T, chromosome 12 at 91,833,171 bp
  • G to A, chromosome 12 at 111,345,582 bp
  • A to T, chromosome 13 at 58,397,734 bp
  • A to T, chromosome 13 at 95,041,890 bp
  • C to T, chromosome 13 at 95,675,372 bp
  • A to T, chromosome 15 at 79,899,067 bp
  • T to A, chromosome 16 at 58,926,094 bp
  • C to A, chromosome 17 at 7,789,086 bp
  • T to G, chromosome 17 at 31,557,726 bp
  • A to G, chromosome 18 at 58,114,469 bp
  • A to G, chromosome 18 at 60,703,838 bp
  • A to G, chromosome 18 at 84,730,037 bp
  • T to A, chromosome 19 at 10,421,787 bp
  • T to A, chromosome 19 at 46,034,118 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5830 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043219-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.