Strain Name:
C57BL/6J-MtgxR5856Btlr/Mmmh
Stock Number:
043230-MU
Citation ID:
RRID:MMRRC_043230-MU
Other Names:
R5856 (G1), C57BL/6J-MtgxR5856Btlr
Major Collection:

Strain Information

Ighm
Name: immunoglobulin heavy constant mu
Synonyms: IgM, Ig mu, muH, Igh6, Igh-M
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16019
HGNC: HGNC:5541
Pou2f1
Name: POU domain, class 2, transcription factor 1
Synonyms: oct-1, Oct-1A, Otf-1, Oct-1C, 2810482H01Rik, Oct-1z, Oct1, Oct-1B, Otf1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18986
HGNC: HGNC:9212
Homologene: 37658
Upf1
Name: UPF1 RNA helicase and ATPase
Synonyms: Rent1, B430202H16Rik, PNORF-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19704
HGNC: HGNC:9962
Homologene: 2185
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 4921505C17Rik, 6030405M08Rik, D530039E11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Nsmce2
Name: NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
Synonyms: 1110014D18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68501
VEGA: 15
Homologene: 12271
Srr
Name: serine racemase
Synonyms: M100034, Rgsc34
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27364
Homologene: 22775
Zfp638
Name: zinc finger protein 638
Synonyms: Np220, Zfml
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18139
Homologene: 7447
Dctn1
Name: dynactin 1
Synonyms: Glued, p150glued, p150
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13191
HGNC: HGNC:2711
Homologene: 3011
Tet2
Name: tet methylcytosine dioxygenase 2
Synonyms: E130014J05Rik, Ayu17-449
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214133
Homologene: 49498
Arhgap32
Name: Rho GTPase activating protein 32
Synonyms: p200RhoGAP, PX-RICS, 3426406O18Rik, Grit, GC-GAP
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330914
Homologene: 8812
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: 2700017A04Rik, C730024G01Rik, Brctd1, Brctx, Ankrd32
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105377
Homologene: 13000
Ccp110
Name: centriolar coiled coil protein 110
Synonyms: 6330503K22Rik, CP110
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101565
Homologene: 8810
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Plaa
Name: phospholipase A2, activating protein
Synonyms: D4Ertd618e, Ufd3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18786
HGNC: HGNC:9043
Homologene: 3138
Cdc23
Name: CDC23 cell division cycle 23
Synonyms: D18Ertd243e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52563
HGNC: HGNC:1724
Homologene: 3426
Tmem11
Name: transmembrane protein 11
Synonyms: 5730466P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216821
Homologene: 2879
Car3
Name: carbonic anhydrase 3
Synonyms: Car-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12350
HGNC: HGNC:1374
Homologene: 31298
Peli1
Name: pellino 1
Synonyms: A930031K15Rik, D11Ertd676e, 2810468L03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67245
HGNC: HGNC:8827
Homologene: 23243
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: 8430401C09Rik, Gpr116
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, hyrh, hy-3, hy3, 1700034M11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Slc9a5
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 5
Synonyms: LOC277973
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 277973
Homologene: 31247
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: SM2, SM1, smMHC
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Slc44a5
Name: solute carrier family 44, member 5
Synonyms: LOC242259
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242259
Homologene: 72094
Or13c3
Name: olfactory receptor family 13 subfamily C member 3
Synonyms: GA_x6K02T2N78B-7137430-7138383, Olfr273, MOR262-8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258821
Homologene: 73999
Atg4b
Name: autophagy related 4B, cysteine peptidase
Synonyms: Apg4b, autophagin 1, 2510009N07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66615
Homologene: 100868
Atp13a4
Name: ATPase type 13A4
Synonyms: 9330174J19Rik, 4631413J11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224079
Homologene: 75330
Sema5b
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
Synonyms: SemG, SemG, Semag
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20357
Homologene: 8427
Rxfp1
Name: relaxin/insulin-like family peptide receptor 1
Synonyms: LOC381489, Lgr7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381489
Homologene: 11007
BC028528
Name: cDNA sequence BC028528
Synonyms: L259
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229600
Homologene: 49773
4930553M12Rik
Name: RIKEN cDNA 4930553M12 gene
Type: Gene
Species: Mouse
Chromosome: 4
Sox5
Name: SRY (sex determining region Y)-box 5
Synonyms: A730017D01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20678
Homologene: 21378
Ano5
Name: anoctamin 5
Synonyms: Tmem16e, Gdd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233246
Homologene: 100071
Hyou1
Name: hypoxia up-regulated 1
Synonyms: Orp150, Cab140, CBP-140, Grp170, 140 kDa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12282
Homologene: 4658
Tas2r115
Name: taste receptor, type 2, member 115
Synonyms: Tas2r15, T2R15, mGR15, mt2r49
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353325
Arhgap11a
Name: Rho GTPase activating protein 11A
Synonyms: GAP (1-12), 6530401L14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228482
Homologene: 8862
BC051665
Name: cDNA sequence BC051665
Synonyms: cathepsin L-like
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218275
VEGA: 13
Homologene: 74298
Or4c115
Name: olfactory receptor family 4 subfamily C member 115
Synonyms: GA_x6K02T2Q125-50579531-50578596, Olfr1220, MOR233-5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258902
Homologene: 74242
Loxl4
Name: lysyl oxidase-like 4
Synonyms: 4833426I20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67573
Homologene: 12977
Cnot11
Name: CCR4-NOT transcription complex, subunit 11
Synonyms: D1Bwg0212e, 2410015L18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 52846
Homologene: 9711
Zfp703
Name: zinc finger protein 703
Synonyms: End2, 1110032O19Rik, Zeppo1, Csmn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 353310
Homologene: 81391
Slc35f3
Name: solute carrier family 35, member F3
Synonyms: B230375D17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 210027
Homologene: 62481
Gm5444
Name: predicted gene 5444
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Gm19965
Name: predicted gene, 19965
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 39,537,453 bp
  • T to C, chromosome 1 at 93,786,026 bp
  • A to G, chromosome 1 at 116,821,849 bp
  • C to T, chromosome 1 at 165,915,130 bp
  • T to A, chromosome 2 at 89,097,910 bp
  • A to T, chromosome 2 at 113,833,771 bp
  • G to A, chromosome 3 at 14,871,641 bp
  • T to A, chromosome 3 at 79,663,313 bp
  • T to C, chromosome 3 at 95,888,828 bp
  • A to G, chromosome 3 at 133,486,640 bp
  • T to C, chromosome 3 at 154,258,392 bp
  • T to A, chromosome 4 at 52,856,516 bp
  • T to C, chromosome 4 at 88,868,359 bp
  • A to G, chromosome 4 at 94,583,487 bp
  • A to G, chromosome 6 at 83,197,865 bp
  • C to T, chromosome 6 at 83,977,065 bp
  • T to A, chromosome 6 at 132,737,538 bp
  • T to A, chromosome 6 at 144,209,362 bp
  • T to C, chromosome 7 at 51,585,326 bp
  • A to G, chromosome 7 at 118,732,926 bp
  • C to A, chromosome 7 at 141,745,644 bp
  • C to T, chromosome 8 at 26,979,205 bp
  • T to C, chromosome 8 at 70,334,762 bp
  • A to G, chromosome 8 at 105,357,165 bp
  • A to T, chromosome 8 at 110,541,842 bp
  • G to T, chromosome 8 at 126,321,080 bp
  • T to A, chromosome 9 at 32,247,552 bp
  • C to T, chromosome 9 at 44,381,344 bp
  • A to T, chromosome 9 at 53,495,955 bp
  • T to C, chromosome 11 at 21,148,094 bp
  • T to C, chromosome 11 at 60,864,858 bp
  • G to A, chromosome 11 at 74,913,012 bp
  • A to T, chromosome 12 at 113,421,602 bp
  • A to G, chromosome 13 at 4,771,684 bp
  • T to A, chromosome 13 at 60,784,500 bp
  • A to T, chromosome 13 at 77,106,087 bp
  • G to A, chromosome 15 at 6,794,006 bp
  • A to G, chromosome 15 at 59,378,943 bp
  • T to C, chromosome 16 at 14,205,976 bp
  • T to C, chromosome 16 at 29,433,987 bp
  • T to G, chromosome 16 at 35,646,386 bp
  • A to G, chromosome 17 at 43,446,120 bp
  • A to T, chromosome 18 at 34,645,106 bp
  • G to T, chromosome 19 at 42,595,366 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5856 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043230-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.