Strain Name:
C57BL/6J-MtgxR5605Btlr
Stock Number:
043270-MU
Citation ID:
RRID:MMRRC_043270-MU
Other Names:
R5605 (G1)
Major Collection:

Gene Information

D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330286
Homologene: 19782
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: D230004K18Rik, b2b1625.2Clo, Gp330, Megalin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Pdzd2
Name: PDZ domain containing 2
Synonyms: A930022H17Rik, Pdzk3, 4930537L06Rik, LOC223364, Gm21706
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68070
Homologene: 23393
Ylpm1
Name: YLP motif containing 1
Synonyms: Zap3, A930013E17Rik, ZAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56531
Homologene: 87707
Stk4
Name: serine/threonine kinase 4
Synonyms: Ysk3, Kas-2, Mst1, sterile 20-like kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58231
Homologene: 55965
Nfyc
Name: nuclear transcription factor-Y gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18046
HGNC: HGNC:7806
Homologene: 7440
Nedd4l
Name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Synonyms: Nedd4-2, 1300012C07Rik, Nedd4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 83814
VEGA: 18
HGNC: HGNC:7728
Homologene: 86986
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212285
Homologene: 9064
Mdn1
Name: midasin AAA ATPase 1
Synonyms: 4833432B22Rik, LOC213784, D4Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100019
Homologene: 39689
Rbm34
Name: RNA binding motif protein 34
Synonyms: D8Ertd233e, 4930547K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52202
Homologene: 56691
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: Emv66, par, 2310036I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Map3k12
Name: mitogen-activated protein kinase kinase kinase 12
Synonyms: MUK, DLK, Zpk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 26404
HGNC: HGNC:6851
Homologene: 4592
Coq5
Name: coenzyme Q5 methyltransferase
Synonyms: 1810014G04Rik, D5Ertd33e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52064
Homologene: 6559
Tpm1
Name: tropomyosin 1, alpha
Synonyms: alpha-TM, TM2, Tpm-1, Tm3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22003
Homologene: 128637
Nup88
Name: nucleoporin 88
Synonyms: Nup84, Prei2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19069
HGNC: HGNC:8067
Homologene: 1901
Ncstn
Name: nicastrin
Synonyms: 9430068N19Rik, Nct, D1Dau13e, nicastrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 59287
Homologene: 41029
Pbrm1
Name: polybromo 1
Synonyms: BAF180, Pb1, 2310032M22Rik, 2610016F04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66923
Homologene: 10044
Tbl3
Name: transducin (beta)-like 3
Synonyms: 9430070M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213773
Homologene: 4711
Med20
Name: mediator complex subunit 20
Synonyms: Trfp, 2410115I17Rik, 1110011O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56771
Homologene: 3158
Pcsk2
Name: proprotein convertase subtilisin/kexin type 2
Synonyms: Nec2, PC2, Nec-2, prohormone convertase 2, SPC2, Phpp-2, 6330411F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18549
HGNC: HGNC:8744
Homologene: 37640
Gbp5
Name: guanylate binding protein 5
Synonyms: 5330409J06Rik, Gbp5a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229898
Homologene: 14183
Gdpd4
Name: glycerophosphodiester phosphodiesterase domain containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233537
Homologene: 18606
Stxbp5
Name: syntaxin binding protein 5 (tomosyn)
Synonyms: LGL3, 4930565N16Rik, 0710001E20Rik, tomosyn 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 78808
Homologene: 16402
Vwce
Name: von Willebrand factor C and EGF domains
Synonyms: 1300015B04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 71768
VEGA: 19
Homologene: 17651
Serpina3g
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3G
Synonyms: Spi2A, Spi2/eb.1, alpha-1 antiproteinase, 2A2, alpha-1 antiproteinase,, Spi2-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20715
HGNC: HGNC:16
Homologene: 115927
Lrrc10
Name: leucine rich repeat containing 10
Synonyms: Serdin1, D330003I11Rik, Hrlrrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237560
VEGA: 10
Homologene: 17154
Dsg1b
Name: desmoglein 1 beta
Synonyms: Dsg5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225256
HGNC: HGNC:3048
Homologene: 1463
Erich6
Name: glutamate rich 6
Synonyms: Fam194a, 4932431H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 545527
Homologene: 65043
Nt5dc1
Name: 5'-nucleotidase domain containing 1
Synonyms: Nt5c2l1, 6030401B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319638
Homologene: 16281
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 268527
Homologene: 8780
Spef2
Name: sperm flagellar 2
Synonyms: C230086A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320277
Homologene: 23371
Dennd4b
Name: DENN/MADD domain containing 4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229541
Homologene: 28281
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: nmf12, Tyro 12, Nyk, Eyk, Mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 665210
Homologene: 115024
Tinag
Name: tubulointerstitial nephritis antigen
Synonyms: TIN-ag
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 26944
Homologene: 8082
Polr1e
Name: polymerase (RNA) I polypeptide E
Synonyms: Paf53, Praf1, D030019D19Rik, 53kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64424
Homologene: 41486
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240776
Homologene: 16121
Doc2b
Name: double C2, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13447
HGNC: HGNC:2986
Homologene: 20796
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: Trs4, 4932408B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 214704
Homologene: 44790
Galnt6
Name: polypeptide N-acetylgalactosaminyltransferase 6
Synonyms: GalNAc-T6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 207839
HGNC: HGNC:4128
Homologene: 5218
Mrvi1
Name: MRV integration site 1
Synonyms: Ris1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
Usp17lb
Name: ubiquitin specific peptidase 17-like B
Synonyms: Dub1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381944
Homologene: 131315
Ceacam5
Name: carcinoembryonic antigen-related cell adhesion molecule 5
Synonyms: Psg30, 1600029H12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73250
Homologene: 115938
Clvs1
Name: clavesin 1
Synonyms: 4933402J24Rik, Rlbp1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74438
Homologene: 65267
Rftn1
Name: raftlin lipid raft linker 1
Synonyms: 2310015N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76438
Homologene: 18745
Prima1
Name: proline rich membrane anchor 1
Synonyms: B230212M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 170952
Homologene: 15783
Mcub
Name: mitochondrial calcium uniporter dominant negative beta subunit
Synonyms: Ccdc109b, 9030408N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66815
Homologene: 23056
Npdc1
Name: neural proliferation, differentiation and control 1
Synonyms: NPDC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18146
HGNC: HGNC:7899
Homologene: 32050
Septin1
Name: septin 1
Synonyms: PNUTL3, Diff6, Sept1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54204
HGNC: HGNC:2879
Homologene: 23009
Gm340
Name: predicted gene 340
Synonyms: LOC381224
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
H2-Eb1
Name: histocompatibility 2, class II antigen E beta
Synonyms: Ia4, Ia-4, H-2Eb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14969
HGNC: HGNC:4953
Homologene: 101524
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Olfr5
Name: olfactory receptor 5
Synonyms: MOR103-8, GA_x6K02T2QGBW-3210997-3210059
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18349
Homologene: 72037
Catsper2
Name: cation channel, sperm associated 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 212670
Homologene: 77423
Gm2075
Name: predicted gene 2075
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100039162
VEGA: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 46,798,235 bp
  • A to T, chromosome 1 at 54,415,926 bp
  • A to T, chromosome 1 at 140,574,743 bp
  • A to G, chromosome 1 at 172,081,150 bp
  • G to A, chromosome 2 at 25,408,945 bp
  • C to T, chromosome 2 at 69,523,299 bp
  • G to A, chromosome 2 at 121,397,052 bp
  • T to C, chromosome 2 at 128,738,307 bp
  • T to C, chromosome 2 at 143,749,245 bp
  • T to C, chromosome 2 at 164,079,566 bp
  • A to G, chromosome 3 at 58,625,119 bp
  • G to A, chromosome 3 at 90,268,368 bp
  • T to C, chromosome 3 at 129,917,009 bp
  • T to C, chromosome 3 at 142,501,276 bp
  • A to G, chromosome 4 at 9,281,751 bp
  • T to C, chromosome 4 at 32,765,664 bp
  • A to G, chromosome 4 at 45,018,723 bp
  • A to G, chromosome 4 at 120,790,489 bp
  • A to T, chromosome 5 at 62,615,067 bp
  • T to C, chromosome 5 at 115,283,717 bp
  • T to C, chromosome 6 at 24,505,621 bp
  • A to T, chromosome 6 at 38,191,764 bp
  • C to T, chromosome 6 at 58,857,727 bp
  • C to T, chromosome 7 at 6,480,326 bp
  • T to C, chromosome 7 at 17,747,236 bp
  • T to C, chromosome 7 at 98,006,300 bp
  • T to C, chromosome 7 at 104,840,640 bp
  • C to T, chromosome 7 at 110,946,002 bp
  • C to T, chromosome 7 at 127,215,426 bp
  • T to C, chromosome 8 at 126,949,419 bp
  • T to C, chromosome 9 at 67,049,035 bp
  • A to G, chromosome 9 at 77,045,412 bp
  • A to G, chromosome 10 at 9,769,746 bp
  • C to T, chromosome 10 at 34,403,695 bp
  • C to A, chromosome 10 at 117,045,900 bp
  • A to T, chromosome 11 at 70,944,070 bp
  • T to C, chromosome 11 at 75,771,960 bp
  • A to T, chromosome 12 at 16,708,726 bp
  • G to A, chromosome 12 at 85,028,853 bp
  • T to A, chromosome 12 at 88,011,998 bp
  • T to A, chromosome 12 at 103,199,904 bp
  • T to C, chromosome 12 at 104,241,040 bp
  • T to A, chromosome 14 at 31,035,992 bp
  • A to T, chromosome 15 at 9,609,520 bp
  • A to T, chromosome 15 at 12,592,350 bp
  • C to T, chromosome 15 at 100,697,225 bp
  • G to T, chromosome 15 at 102,503,865 bp
  • A to G, chromosome 17 at 18,136,501 bp
  • T to C, chromosome 17 at 24,700,759 bp
  • T to C, chromosome 17 at 34,309,833 bp
  • C to A, chromosome 17 at 47,623,144 bp
  • T to G, chromosome 17 at 50,047,407 bp
  • C to T, chromosome 18 at 20,399,539 bp
  • T to C, chromosome 18 at 65,174,244 bp
  • C to A, chromosome 18 at 67,442,355 bp
  • A to T, chromosome 19 at 10,658,038 bp
  • T to A, chromosome 19 at 41,582,863 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5605 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043270-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.