Strain Name:
C57BL/6J-MtgxR5723Btlr
Stock Number:
043341-MU
Citation ID:
RRID:MMRRC_043341-MU
Other Names:
R5723 (G1)
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: PC-1, PC1, polycystin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Kif5a
Name: kinesin family member 5A
Synonyms: Kns, D10Bwg0738e, Khc, Kif5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16572
VEGA: 10
HGNC: HGNC:6323
Homologene: 55861
Cyrib
Name: CYFIP related Rac1 interactor B
Synonyms: 0910001A06Rik, Fam49b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223601
VEGA: 15
Homologene: 9599
Kat8
Name: K(lysine) acetyltransferase 8
Synonyms: 2010203C02Rik, Myst1, D7Ertd629e, MOF, 5830450F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67773
Homologene: 41676
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: 140kDa, RFC140, Recc1, Alp145
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Mreg
Name: melanoregulin
Synonyms: LOC381269, Wdt2, dsu
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381269
Homologene: 9954
Abcg2
Name: ATP binding cassette subfamily G member 2 (Junior blood group)
Synonyms: 4930430M16Rik, Bcrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 26357
HGNC: HGNC:74
Homologene: 55852
Prom1
Name: prominin 1
Synonyms: 4932416E19Rik, Prom-1, Prom, CD133, AC133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Sfrp4
Name: secreted frizzled-related protein 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20379
VEGA: 13
Homologene: 2267
Vamp4
Name: vesicle-associated membrane protein 4
Synonyms: D1Ertd147e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53330
Homologene: 37847
Tusc3
Name: tumor suppressor candidate 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 80286
Homologene: 6937
Akr1c18
Name: aldo-keto reductase family 1, member C18
Synonyms: 20alpha-hydroxysteroid dehydrogenase, 20alpha-HSD
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105349
Homologene: 128661
Ddr2
Name: discoidin domain receptor family, member 2
Synonyms: Ntrkr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18214
HGNC: HGNC:2731
Homologene: 68505
Stat5a
Name: signal transducer and activator of transcription 5A
Synonyms: STAT5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20850
Homologene: 20680
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545370
Homologene: 23741
Zfp831
Name: zinc finger protein 831
Synonyms: ENSMUSG00000050600, OTTMUSG00000017459
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 100043757
Homologene: 19013
Zfp941
Name: zinc finger protein 941
Synonyms: BC066028
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 407812
Poteg
Name: POTE ankyrin domain family, member G
Synonyms: 4930456F22Rik, 4921537P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70952
Homologene: 134158
Ifit1bl2
Name: interferon induced protein with tetratricopeptide repeats 1B like 2
Synonyms: 2010002M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 112419
Homologene: 78213
Efna5
Name: ephrin A5
Synonyms: RAGS, LERK-7, Ephrin-A5, EFL-5, AL-1, Epl7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 13640
HGNC: HGNC:3225
Homologene: 1482
Actl7a
Name: actin-like 7a
Synonyms: Tact2, t-actin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11470
HGNC: HGNC:161
Homologene: 7613
Abca8b
Name: ATP-binding cassette, sub-family A member 8b
Synonyms: Abca8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27404
HGNC: HGNC:38
Homologene: 56029
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74424
Homologene: 11713
Or56a3
Name: olfactory receptor family 56 subfamily A member 3
Synonyms: Olfr679, MOR40-2, GA_x6K02T2PBJ9-7714499-7715446
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259046
Homologene: 81538
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 333315
Homologene: 35388
Serpina3i
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3I
Synonyms: 2B2, Gm6930, alpha-1 antiproteinase, antitrypsin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 628900
HGNC: HGNC:16
Homologene: 115927
Cyp2b23
Name: cytochrome P450, family 2, subfamily b, polypeptide 23
Synonyms: EG243881
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243881
HGNC: HGNC:2615
Homologene: 117483
Serpina3m
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3M
Synonyms: Spi2-rs1, MMSPi2.4, Spi2.4, Spi-2l, MMCM7, 3e46, Spi-2rs1, alpha-1 antiproteinase, antitrypsin, contrapsin-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20717
HGNC: HGNC:16
Homologene: 111129
Rilp
Name: Rab interacting lysosomal protein
Synonyms: LOC333615
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 280408
Homologene: 19596
Gramd1a
Name: GRAM domain containing 1A
Synonyms: 1300003M23Rik, D7Bwg0611e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52857
Homologene: 10843
Clcn4
Name: chloride channel, voltage-sensitive 4
Synonyms: Clcn4-2, Clc4-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12727
HGNC: HGNC:2022
Homologene: 68207
Or52ad1
Name: olfactory receptor family 52 subfamily AD member 1
Synonyms: GA_x6K02T2PBJ9-6056235-6055291, MOR39-1, Olfr600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259048
Homologene: 17476
Akt1
Name: thymoma viral proto-oncogene 1
Synonyms: PKB/Akt, Akt, PKBalpha, PKB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11651
HGNC: HGNC:391
Homologene: 3785
C9
Name: complement component 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12279
HGNC: HGNC:1358
Homologene: 74406
Krt16
Name: keratin 16
Synonyms: K16, Krt1-16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16666
HGNC: HGNC:6423
Homologene: 21145
Fkbpl
Name: FK506 binding protein-like
Synonyms: DIR1, NG7, Ppiase-X, WISp39, WAF-1/CIP1 stabilizing protein 39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56299
Homologene: 10529
Nox4
Name: NADPH oxidase 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 50490
HGNC: HGNC:7891
Homologene: 41065
Or3a1d
Name: olfactory receptor family 3 subfamily A member 1D
Synonyms: Olfr411, MOR255-3, GA_x6K02T2P1NL-4481525-4480578
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258704
Homologene: 74999
Endov
Name: endonuclease V
Synonyms: A730011L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 338371
Homologene: 15562
Upb1
Name: ureidopropionase, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103149
Homologene: 9471
Cd163
Name: CD163 antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 93671
HGNC: HGNC:1631
Homologene: 128811
Cers6
Name: ceramide synthase 6
Synonyms: Lass6, similar to TRH1, 4732462C07Rik, T1L, CerS6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241447
Homologene: 72228
Pgap6
Name: post-glycosylphosphatidylinositol attachment to proteins 6
Synonyms: M83, Tmem8, Rxylt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 60455
Homologene: 10944
Tex29
Name: testis expressed 29
Synonyms: 1700018L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75528
Ubqln3
Name: ubiquilin 3
Synonyms: 4933400K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244178
Homologene: 9700
Acbd7
Name: acyl-Coenzyme A binding domain containing 7
Synonyms: 9230116B18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78245
Homologene: 82242
Nans
Name: N-acetylneuraminic acid synthase (sialic acid synthase)
Synonyms: N-acetylneuraminic acid phosphate synthase, Sas, 4632418E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 94181
Homologene: 10343
Krtap5-2
Name: keratin associated protein 5-2
Synonyms: 4833428E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71623
Or5k15
Name: olfactory receptor family 5 subfamily J member 15
Synonyms: Olfr178, GA_x54KRFPKG5P-55108059-55107100, MOR184-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258999
Homologene: 79412
Zfp583
Name: zinc finger protein 583
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 213011
Homologene: 65048
Bcas2
Name: BCAS2 pre-mRNA processing factor
Synonyms: 6430539P16Rik, C76366, breast carcinoma amplified sequence 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68183
HGNC: HGNC:975
Homologene: 4291
Crisp3
Name: cysteine-rich secretory protein 3
Synonyms: CRS3, CRISP-3, SGP28, Aeg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 11572
Homologene: 135665
Gm43302
Name: predicted gene 43302
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 72,162,368 bp
  • C to T, chromosome 1 at 150,694,849 bp
  • T to C, chromosome 1 at 162,574,363 bp
  • A to T, chromosome 1 at 169,988,520 bp
  • A to G, chromosome 2 at 3,340,418 bp
  • T to A, chromosome 2 at 69,108,445 bp
  • A to C, chromosome 2 at 174,645,407 bp
  • A to G, chromosome 3 at 103,177,292 bp
  • T to C, chromosome 4 at 46,499,083 bp
  • A to G, chromosome 4 at 56,744,310 bp
  • T to G, chromosome 5 at 44,014,894 bp
  • T to C, chromosome 5 at 65,277,426 bp
  • T to A, chromosome 5 at 105,217,486 bp
  • C to T, chromosome 6 at 58,678,351 bp
  • A to G, chromosome 6 at 124,319,063 bp
  • C to A, chromosome 7 at 6,323,675 bp
  • A to G, chromosome 7 at 7,291,682 bp
  • A to G, chromosome 7 at 26,681,396 bp
  • A to T, chromosome 7 at 31,134,483 bp
  • T to C, chromosome 7 at 87,304,973 bp
  • A to T, chromosome 7 at 103,346,619 bp
  • G to A, chromosome 7 at 104,141,467 bp
  • C to A, chromosome 7 at 105,091,102 bp
  • T to A, chromosome 7 at 118,672,193 bp
  • G to A, chromosome 7 at 127,924,816 bp
  • G to A, chromosome 7 at 140,812,850 bp
  • A to T, chromosome 7 at 142,175,005 bp
  • A to T, chromosome 8 at 11,854,279 bp
  • T to C, chromosome 8 at 27,449,992 bp
  • G to A, chromosome 8 at 39,071,497 bp
  • A to T, chromosome 8 at 80,613,397 bp
  • A to T, chromosome 10 at 75,428,271 bp
  • GGGTTGGT to GGGT, chromosome 10 at 127,231,029 bp
  • C to A, chromosome 11 at 74,347,128 bp
  • A to G, chromosome 11 at 75,512,861 bp
  • A to G, chromosome 11 at 100,248,446 bp
  • A to G, chromosome 11 at 100,882,074 bp
  • T to C, chromosome 11 at 109,953,619 bp
  • G to T, chromosome 11 at 119,499,849 bp
  • A to G, chromosome 12 at 104,265,500 bp
  • T to C, chromosome 12 at 104,393,911 bp
  • T to C, chromosome 12 at 112,657,270 bp
  • A to T, chromosome 13 at 4,144,329 bp
  • T to C, chromosome 13 at 19,623,698 bp
  • T to A, chromosome 15 at 6,486,816 bp
  • A to T, chromosome 15 at 63,956,598 bp
  • A to T, chromosome 16 at 58,889,613 bp
  • A to G, chromosome 17 at 24,565,523 bp
  • CGGGG to CGGGGG, chromosome 17 at 26,120,562 bp
  • G to A, chromosome 17 at 34,645,329 bp
  • A to C, chromosome 17 at 40,235,913 bp
  • T to A, chromosome 17 at 62,607,463 bp
  • A to G, chromosome 19 at 34,620,058 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5723 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
043341-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.