Strain Name:
C57BL/6J-MtgxR5729Btlr
Stock Number:
043346-MU
Citation ID:
RRID:MMRRC_043346-MU
Other Names:
R5729 (G1)
Major Collection:

Gene Information

Wrn
Name: Werner syndrome RecQ like helicase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 22427
Homologene: 6659
Pitpnc1
Name: phosphatidylinositol transfer protein, cytoplasmic 1
Synonyms: 5830436L09Rik, 1110020B03Rik, RDGB-BETA, C330017I21Rik, RDGBB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 71795
Homologene: 138301
Pigv
Name: phosphatidylinositol glycan anchor biosynthesis, class V
Synonyms: D430024F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230801
Homologene: 5354
Dnajc21
Name: DnaJ heat shock protein family (Hsp40) member C21
Synonyms: 9930116P15Rik, 4930461P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 78244
Homologene: 6752
Plxnd1
Name: plexin D1
Synonyms: 6230425C21Rik, b2b553Clo, b2b1863Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67784
HGNC: HGNC:9107
Homologene: 22866
Mat2b
Name: methionine adenosyltransferase II, beta
Synonyms: MATIIbeta, 2410018D16Rik, 1110064C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 108645
HGNC: HGNC:6905
Homologene: 8323
Spop
Name: speckle-type BTB/POZ protein
Synonyms: Pcif1, TEF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20747
Homologene: 68354
Cdc5l
Name: cell division cycle 5-like (S. pombe)
Synonyms: PCDC5RP, 1200002I02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 71702
VEGA: 17
HGNC: HGNC:1743
Homologene: 13291
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: Alp145, 140kDa, RFC140, Recc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Stx16
Name: syntaxin 16
Synonyms: 6330500A18Rik, SYN16, 5430410K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228960
Homologene: 2791
Ppp2ca
Name: protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Synonyms: PP2A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 19052
HGNC: HGNC:9299
Homologene: 37660
Senp1
Name: SUMO1/sentrin specific peptidase 1
Synonyms: 2310046A20Rik, E330036L07Rik, D15Ertd528e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223870
Homologene: 8731
Naa16
Name: N(alpha)-acetyltransferase 16, NatA auxiliary subunit
Synonyms: Narg1l, 1300019C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 66897
Homologene: 134838
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: DGKdelta, dgkd-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Adss
Name: adenylosuccinate synthetase, non muscle
Synonyms: AS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 11566
HGNC: HGNC:292
Homologene: 875
Gprc5c
Name: G protein-coupled receptor, family C, group 5, member C
Synonyms: 1110028I06Rik, 3200002M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70355
Homologene: 11099
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: Sema6A-1, sema, A730020P05Rik, VIa, Semaq
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 20358
Homologene: 32426
Rbm14
Name: RNA binding motif protein 14
Synonyms: p16, 1300007E16Rik, PSP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 56275
Homologene: 4614
AU040320
Name: expressed sequence AU040320
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100317
Homologene: 11764
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Skor2
Name: SKI family transcriptional corepressor 2
Synonyms: Corl2, Gm7348, Fussel18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 664805
VEGA: 18
Homologene: 64797
Stag3
Name: stromal antigen 3
Synonyms: stromalin 3, SA-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 50878
Homologene: 40844
Mapk3
Name: mitogen-activated protein kinase 3
Synonyms: p44mapk, Mtap2k, p44erk1, Prkm3, Esrk1, Erk-1, p44 MAP kinase, Erk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26417
HGNC: HGNC:6877
Homologene: 55682
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Oat
Name: ornithine aminotransferase
Synonyms: rhg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18242
HGNC: HGNC:8091
Homologene: 231
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2.3, 1110034K09Rik, Nax, Scn6a, Nav2, NaG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20272
Homologene: 55706
Zfp646
Name: zinc finger protein 646
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233905
Homologene: 8802
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: 4930505G06Rik, nmf247, A930002K18Rik, 4930401L23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 77945
Homologene: 10679
Krt86
Name: keratin 86
Synonyms: Krt2-10, MHb4, Krt2-11, Khb4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16679
VEGA: 15
HGNC: HGNC:6463
Homologene: 1717
Tbc1d2b
Name: TBC1 domain family, member 2B
Synonyms: 1810061M12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 67016
Homologene: 56694
Irf2bp1
Name: interferon regulatory factor 2 binding protein 1
Synonyms: 6330414O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 272359
Homologene: 32276
Aldoart2
Name: aldolase 1 A, retrogene 2
Synonyms: Aldoa-ps1, Aldo1-ps1, 4933425L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 79459
Homologene: 134148
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 329421
Homologene: 51393
Vmn2r53
Name: vomeronasal 2, receptor 53
Synonyms: EG637908
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 637908
Homologene: 104040
Cracr2a
Name: calcium release activated channel regulator 2A
Synonyms: Efcab4b, LOC381812, LOC243645
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 381812
Homologene: 41883
Atp1a2
Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms: Atpa-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 98660
HGNC: HGNC:800
Homologene: 47947
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Ca(v)alpha2delta1, Cacna2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Gm5499
Name: predicted pseudogene 5499
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 433144
Ube4a
Name: ubiquitination factor E4A
Synonyms: 4732444G18Rik, UFD2b, 9930123J21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 140630
Homologene: 3517
Usp9y
Name: ubiquitin specific peptidase 9, Y chromosome
Synonyms: Fafl2, Dffry
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
NCBI: 107868
Homologene: 68408
Tead2
Name: TEA domain family member 2
Synonyms: TEAD-2, TEF-4, Etdf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 21677
Homologene: 19662
Olfr1423
Name: olfactory receptor 1423
Synonyms: GA_x6K02T2RE5P-2393361-2392429, MOR239-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258675
Homologene: 128078
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 58909
Homologene: 135847
Gabrg2
Name: gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
Synonyms: Gabrg-2, GABAA-R, gamma2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14406
HGNC: HGNC:4087
Homologene: 22443
Slc38a11
Name: solute carrier family 38, member 11
Synonyms: 9330158F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320106
Homologene: 5775
Sp110
Name: Sp110 nuclear body protein
Synonyms: Ifi75, Ipr1, 5031415C07Rik, 5830484A20Rik, 52kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 109032
HGNC: HGNC:5401
Homologene: 82192
Pcdh1
Name: protocadherin 1
Synonyms: 2010005A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 75599
HGNC: HGNC:8655
Homologene: 12613
Rhcg
Name: Rhesus blood group-associated C glycoprotein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56315
Homologene: 32310
Snai3
Name: snail family zinc finger 3
Synonyms: Smuc, Zfp293, Snail-related gene from muscle cells
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 30927
Homologene: 8500
Lats2
Name: large tumor suppressor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50523
HGNC: HGNC:6515
Homologene: 56678
Rasa4
Name: RAS p21 protein activator 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 54153
Homologene: 5080
Cybb
Name: cytochrome b-245, beta polypeptide
Synonyms: Nox2, gp91phox, gp91phox, Cgd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
NCBI: 13058
HGNC: HGNC:2578
Homologene: 68054
Rragc
Name: Ras-related GTP binding C
Synonyms: Gtr2, YGR163W, TIB929
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 54170
Homologene: 39141
Bend7
Name: BEN domain containing 7
Synonyms: 1110017O21Rik, E130319B15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 209645
Homologene: 17660
Sra1
Name: steroid receptor RNA activator 1
Synonyms: Srap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 24068
Homologene: 11906
Mos
Name: Moloney sarcoma oncogene
Synonyms: c-mos
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 17451
HGNC: HGNC:7199
Homologene: 3919
Tmem53
Name: transmembrane protein 53
Synonyms: 1110038M16Rik, 1500001P22Rik, 1700012A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 68777
Homologene: 41573
Psg29
Name: pregnancy-specific glycoprotein 29
Synonyms: cea17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 114872
Homologene: 83380
Ccdc103
Name: coiled-coil domain containing 103
Synonyms: 1700039D13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 73293
Homologene: 45831
Spag6
Name: sperm associated antigen 6
Synonyms: BC061194, Spag6l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 381350
Homologene: 133723
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to G, chromosome 1 at 85,589,118 bp
  • C to T, chromosome 1 at 87,936,332 bp
  • A to G, chromosome 1 at 172,293,371 bp
  • A to T, chromosome 1 at 177,796,258 bp
  • T to C, chromosome 2 at 4,763,274 bp
  • C to T, chromosome 2 at 18,715,714 bp
  • A to T, chromosome 2 at 65,317,021 bp
  • A to G, chromosome 2 at 66,741,957 bp
  • A to G, chromosome 2 at 70,105,739 bp
  • G to A, chromosome 2 at 174,093,499 bp
  • A to G, chromosome 4 at 3,870,971 bp
  • C to A, chromosome 4 at 117,268,472 bp
  • A to G, chromosome 4 at 123,924,852 bp
  • T to A, chromosome 4 at 126,830,415 bp
  • A to T, chromosome 4 at 133,664,823 bp
  • T to A, chromosome 5 at 15,935,039 bp
  • A to T, chromosome 5 at 65,277,452 bp
  • T to C, chromosome 5 at 136,093,162 bp
  • T to A, chromosome 5 at 138,290,223 bp
  • T to C, chromosome 6 at 14,719,763 bp
  • T to G, chromosome 6 at 58,939,307 bp
  • A to G, chromosome 6 at 115,965,877 bp
  • T to C, chromosome 6 at 127,607,236 bp
  • T to C, chromosome 7 at 12,600,806 bp
  • A to T, chromosome 7 at 17,210,534 bp
  • G to T, chromosome 7 at 19,005,247 bp
  • A to G, chromosome 7 at 30,712,426 bp
  • A to G, chromosome 7 at 45,220,742 bp
  • A to T, chromosome 7 at 79,600,623 bp
  • A to T, chromosome 7 at 126,764,807 bp
  • G to A, chromosome 7 at 127,885,454 bp
  • A to T, chromosome 7 at 132,558,255 bp
  • T to C, chromosome 8 at 33,268,778 bp
  • G to A, chromosome 8 at 122,454,890 bp
  • A to T, chromosome 9 at 44,933,329 bp
  • G to C, chromosome 9 at 90,207,872 bp
  • A to T, chromosome 11 at 40,682,546 bp
  • A to G, chromosome 11 at 41,967,623 bp
  • G to A, chromosome 11 at 52,118,029 bp
  • A to G, chromosome 11 at 95,485,849 bp
  • A to T, chromosome 11 at 102,883,078 bp
  • G to T, chromosome 11 at 107,337,438 bp
  • G to T, chromosome 11 at 114,864,267 bp
  • T to C, chromosome 12 at 55,565,905 bp
  • A to G, chromosome 14 at 52,160,160 bp
  • A to T, chromosome 14 at 57,722,735 bp
  • A to G, chromosome 14 at 79,355,780 bp
  • A to T, chromosome 15 at 10,449,596 bp
  • G to T, chromosome 15 at 98,066,531 bp
  • T to G, chromosome 15 at 101,476,548 bp
  • T to C, chromosome 17 at 45,426,569 bp
  • A to T, chromosome 17 at 87,078,516 bp
  • A to T, chromosome 18 at 36,667,443 bp
  • A to T, chromosome 18 at 38,202,946 bp
  • C to T, chromosome 18 at 47,281,343 bp
  • A to G, chromosome 18 at 76,858,883 bp
  • A to G, chromosome 19 at 4,802,549 bp
  • A to T, chromosome 19 at 12,035,908 bp
  • C to G, chromosome X at 9,450,750 bp
  • A to T, chromosome Y at 1,381,339 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5729 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043346-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.