Strain Name:
STOCK Ptf1atm1.1(cre)Cvw/Mmnc
Stock Number:
Citation ID:
Other Names:

Strain Information

Name: pancreas specific transcription factor, 1a; targeted mutation 1.1, Christopher VE Wright
Synonyms: P48-Cre, Ptf1a-cre, P48Cre, Ptf1atm1(cre)Wri, Ptf1aCre
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Knock-In
Name: cre recombinase
Type: Gene
Species: Enterobacteria phage P1 (bacteriophage P1)
Alteration at locus: Knock-In
Name: pancreas specific transcription factor, 1a
Synonyms: PTF1-p48, bHLHa29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Knock-In
NCBI: 19213
Homologene: 10304
Genetic Alterations
Protein coding regions of Cre and Ptf1a were exchanged at the translation initiation codons.
Genotype Determination
  • Genotyping Protocol(s)
  • Center protocol and contact for technical support will be shipped with mice.
  • ES Cell Line
    R1 derived from (129X1/SvJ x 129S1/Sv)F1-Kitl+
    Homozygous: altered pancreatic development with loss of exocrine acini.
    Mammalian Phenotype Terms
    Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw (Genetic Background: involves: 129S1/Sv * 129X1/SvJ )

    MeSH Terms
    • Animals
    • Animals, Genetically Modified
    • Cell Differentiation
    • Cell Lineage
    • Duodenum/cytology
    • Duodenum/embryology
    • Gene Expression Regulation
    • Homeodomain Proteins
    • Mice
    • Pancreas/cytology
    • Pancreas/embryology
    • Trans-Activators/metabolism
    • Transcription Factors/physiology
    Strain Development
    The floxed neo cassette was excised from mice carrying Ptf1atm1(cre)Cvw by in vivo cre-mediated recombination. The previously inserted cre recombinase remained in place of the entire endogenous coding region.
    MMRRC Genetic QC Summary
    The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact Older strains may not have this information.
    • Diabetes/Obesity
    • Endocrine Deficiency
    Chris V. Wright, Ph.D., Vanderbilt University Medical Center.
    Primary Reference
    Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet. 2002 Sep;32(1):128-34. Epub 2002 Aug 19. (Medline PMID: 12185368)

    Colony and Husbandry Information

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email .
    MMRRC Breeding System
    Breeding Scheme(s)

    The line was maintained on B6D2 in the donor's laboratory.

    Overall Breeding Performance
    Viability and Fertility: Female Male Comments
    Homozygotes are viable: No No
    Homozygotes are fertile: Yes Yes (Info provided by donor; unclear how homs are fertile and not viable at the same time)
    Heterozygotes are fertile: Yes Yes
    Age Reproductive Decline: Unknown Unknown
    Average litter size
    8 pups
    Recommended wean age
    3 weeks

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Cryopreserved material may be available upon request, please inquire to for more information.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $)
    *Shipping & Handling not included*
    Units Notes
    000435-UNC-SPERM Cryo-preserved spermatozoa $564.00 / $937.00
    Non-Profit / For-Profit
    Aliquot Approximate quantity3
    000435-UNC-RESUS Litter recovered from cryo-archive $2,914.00 / $4,837.00
    Non-Profit / For-Profit
    Litter Recovered litter4; additional fees for any special requests.
    Cryopreserved material may be available upon request, please inquire to for more information.

    3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.