Strain Name:
Stock Number:
Citation ID:
Other Names:
Rgs12(delta5-8), RGS12-null

Gene Information

Allele Symbol: Rgs12tm1.1Dski (Mus musculus (mouse))
Alteration at locus: Targeted Mutation
Monarch Initiative (Disease and Phenotype Associations):
Gene Symbol: Rgs12 (Mus musculus (mouse))
Name: regulator of G-protein signaling 12
Synonyms: 4632412M04Rik, 1200016K18Rik
Chromosome: 5
Alteration at locus: Targeted Mutation
Monarch Initiative (Disease and Phenotype Associations): MGI:1918979
Genetic Alterations
Homologous recombination, replacing exons 5 through 8 of Rgs12 with a beta-galactosidase/neomycin-resistance gene fusion cassette.
Genotype Determination
ES Cell Line
AB2.2 derived from 129S7/SvEvBrd-Hprtb-m2

Homozygous: Complete RGS12 loss significantly decreases hyperlocomotion to lower doses of both amphetamine and cocaine, reflective of observed increase in dopamine transporter levels in the ventral, but not dorsal, striatum of RGS12-null mice.

Hetero/Hemizygous: Not tested

MeSH Terms
    Strain Development
    Obtained as mixed 129/SvEvBrd x C57BL/6 background from TIGM (Project #TG0086) in 2009; back-crossed for 12 generations to C57BL/6J (as obtained from Jackson Laboratory); transferred from UNC to WVU; maintained by non-sib, intra-strain mating of heterozygous males to heterozygous females.
    Suggested Control Mice
    Wild-type littermates
    • Models for Human Disease
    • Neurobiology
    • Sensorineural
    Siderovski [Ph.D.], David
    Primary Reference

    Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants. Gross JD, Kaski SW, Schroer AB, Wix KA, Siderovski DP, Setola V. J Psychopharmacol. 2018 Jan 1:269881117742100. doi: 10.1177/0269881117742100.

    Gross JD, Kaski SW, Schroer AB, Wix KA, Siderovski DP, Setola V. Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum andlocomotor responses to psychostimulants. J Psychopharmacol. 2018 Jan1:269881117742100. doi: 10.1177/0269881117742100. [Epub ahead of print] (Medline PMID: 29364035)

    Colony and Husbandry Information

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email .
    Coat Color
    nonagouti (a/a); "black"
    MMRRC Breeding System
    Random intra-strain mating
    Overall Breeding Performance
    Viability and Fertility: Female Male Comments
    Homozygotes are viable: Yes Yes
    Homozygotes are fertile: Yes Yes
    Heterozygotes are fertile: Yes Yes
    Age Reproductive Decline: 8 to 12 months Greater than 12 months
    Bred to Homozygosity
    Average litter size
    Recommended wean age
    3 weeks
    Average Pups Weaned

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The donor or their institution limits the distribution to non-profit institutions only.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
    043848-UCD-RESUS Litter recovered from cryo-archive $3,033.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.

    1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.