Strain Name:
C57BL/6J-MtgxR5846Btlr
Stock Number:
044064-MU
Citation ID:
RRID:MMRRC_044064-MU
Other Names:
R5846 (G1)
Major Collection:

Gene Information

Tk1
Name: thymidine kinase 1
Synonyms: Tk-1, D530002A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21877
Homologene: 37749
Pi4k2a
Name: phosphatidylinositol 4-kinase type 2 alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 84095
VEGA: 19
Homologene: 101681
Ptch1
Name: patched 1
Synonyms: Ptc, Patched 1, Ptc1, A230106A15Rik, wig
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Magi1
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms: WWP3, Gukmi1, AIP3, BAP1, Baiap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14924
HGNC: HGNC:946
Homologene: 31257
Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: Nezha, 2310057J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69697
Homologene: 18966
BC004004
Name: cDNA sequence BC004004
Synonyms: 2400006G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 80748
Homologene: 12728
Ssr2
Name: signal sequence receptor, beta
Synonyms: TRAPbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66256
Homologene: 2369
Usp15
Name: ubiquitin specific peptidase 15
Synonyms: Gcap18, 4921514G19Rik, E430033I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14479
VEGA: 10
Homologene: 101542
Lrch4
Name: leucine-rich repeats and calponin homology (CH) domain containing 4
Synonyms: 2900069C24Rik, LRRN4, LRN, 2810008P14Rik, SAP25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231798
HGNC: HGNC:6691
Homologene: 20532
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: A630086P08Rik, opm, b2b327Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 212285
Homologene: 9064
Dock4
Name: dedicator of cytokinesis 4
Synonyms: EST N28122, 6330411N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Smurf1
Name: SMAD specific E3 ubiquitin protein ligase 1
Synonyms: 4930431E10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75788
Homologene: 10712
Cct4
Name: chaperonin containing Tcp1, subunit 4 (delta)
Synonyms: A45, TCP-1 delta, T complex protein 1, delta, Cctd, 2610204B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12464
HGNC: HGNC:1617
Homologene: 4695
Tmem245
Name: transmembrane protein 245
Synonyms: A630051L19Rik, D730040F13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242474
HGNC: HGNC:1363
Homologene: 41841
Mafa
Name: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)
Synonyms: RIPE3b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 378435
VEGA: 15
Homologene: 65867
Numb
Name: NUMB endocytic adaptor protein
Synonyms: m-numb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18222
HGNC: HGNC:8060
Homologene: 2775
Slc18a3
Name: solute carrier family 18 (vesicular monoamine), member 3
Synonyms: VAChT, VAT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20508
Homologene: 11022
Hpgd
Name: hydroxyprostaglandin dehydrogenase 15 (NAD)
Synonyms: 15-PGDH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 15446
HGNC: HGNC:5154
Homologene: 68095
Mtpn
Name: myotrophin
Synonyms: V1, Gcdp, 5033418D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14489
Homologene: 40607
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: Rme8, LOC382100, D030002L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235567
Homologene: 13574
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, diminished cone electroretinogram, dice, Cpfl8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
P3h3
Name: prolyl 3-hydroxylase 3
Synonyms: Grcb, Leprel2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14789
Homologene: 8401
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241431
Homologene: 19388
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380698
Homologene: 70869
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Mprip
Name: myosin phosphatase Rho interacting protein
Synonyms: RIP3, p116Rip, p116 Rho interacting protein, Rhoip3, Gm34094
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 26936
Homologene: 9034
Trim30b
Name: tripartite motif-containing 30B
Synonyms: Trim30-1, A530023O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244183
Chrm2
Name: cholinergic receptor, muscarinic 2, cardiac
Synonyms: M2, AChR M2, muscarinic acetylcholine receptor 2, Chrm-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243764
HGNC: HGNC:1951
Homologene: 20190
C1s1
Name: complement component 1, s subcomponent 1
Synonyms: C1s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 50908
HGNC: HGNC:1247
Homologene: 1314
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Olfr804
Name: olfactory receptor 804
Synonyms: GA_x6K02T2PULF-11383575-11384519, MOR110-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258068
Homologene: 133581
Tgfbr3
Name: transforming growth factor, beta receptor III
Synonyms: betaglycan, TBRIII, 1110036H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 21814
Homologene: 2436
Tsks
Name: testis-specific serine kinase substrate
Synonyms: clone 4, Tssks1, Tsks, Stk22s1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22116
Homologene: 7984
Vmn2r55
Name: vomeronasal 2, receptor 55
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042499
Homologene: 104040
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 330222
Homologene: 27395
Itih2
Name: inter-alpha trypsin inhibitor, heavy chain 2
Synonyms: Intin2, Itih-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16425
HGNC: HGNC:6167
Homologene: 1668
Fndc7
Name: fibronectin type III domain containing 7
Synonyms: E230011A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 320181
Homologene: 18551
Klhl35
Name: kelch-like 35
Synonyms: 2810406K13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72184
Homologene: 27849
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75721
Homologene: 138468
Hook3
Name: hook microtubule tethering protein 3
Synonyms: E330005F07Rik, 5830454D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 320191
Homologene: 13022
Fbxw22
Name: F-box and WD-40 domain protein 22
Synonyms: Gm5164
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382156
Homologene: 110776
Olfr1371
Name: olfactory receptor 1371
Synonyms: GA_x6K02T2QP88-3214035-3214970, MOR256-58
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 276865
Catsperb
Name: cation channel sperm associated auxiliary subunit beta
Synonyms: 4932415G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 271036
VEGA: 12
Homologene: 81904
Fads3
Name: fatty acid desaturase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 60527
VEGA: 19
HGNC: HGNC:3576
Homologene: 11025
C1s2
Name: complement component 1, s subcomponent 2
Synonyms: Gm5077
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 317677
HGNC: HGNC:1247
Homologene: 1314
Adgra1
Name: adhesion G protein-coupled receptor A1
Synonyms: 2900059M17Rik, D7Ertd680e, Gpr123
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52389
Homologene: 18582
Atp13a2
Name: ATPase type 13A2
Synonyms: 1110012E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74772
Homologene: 56940
Apmap
Name: adipocyte plasma membrane associated protein
Synonyms: 2310001A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71881
Homologene: 41380
Tmtc2
Name: transmembrane and tetratricopeptide repeat containing 2
Synonyms: D330034A10Rik, 8430438D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 278279
Homologene: 25521
Dnaaf3
Name: dynein, axonemal assembly factor 3
Synonyms: 6030429G01Rik, b2b1739Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 436022
Homologene: 16205
Ace3
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 3
Synonyms: EG217246
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217246
Homologene: 80337
Foxd1
Name: forkhead box D1
Synonyms: BF-2, Hfh10, FREAC4, Hfhbf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15229
HGNC: HGNC:3802
Homologene: 3290
Eef1a2
Name: eukaryotic translation elongation factor 1 alpha 2
Synonyms: Eef1a, S1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13628
HGNC: HGNC:3192
Homologene: 121568
Havcr2
Name: hepatitis A virus cellular receptor 2
Synonyms: Tim3, Timd3, TIM-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 171285
Homologene: 129541
H4c2
Name: H4 clustered histone 2
Synonyms: Hist1h4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 326620
HGNC: HGNC:4794
Homologene: 134466
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 34,195,861 bp
  • T to C, chromosome 2 at 10,097,903 bp
  • T to A, chromosome 2 at 67,509,243 bp
  • T to C, chromosome 2 at 68,732,033 bp
  • T to A, chromosome 2 at 76,903,468 bp
  • T to C, chromosome 2 at 150,608,421 bp
  • T to C, chromosome 2 at 181,152,983 bp
  • C to T, chromosome 3 at 88,581,072 bp
  • A to G, chromosome 3 at 108,881,391 bp
  • A to T, chromosome 4 at 56,903,241 bp
  • T to C, chromosome 4 at 140,995,596 bp
  • T to C, chromosome 5 at 62,649,773 bp
  • C to A, chromosome 5 at 107,140,655 bp
  • T to A, chromosome 5 at 124,823,373 bp
  • C to T, chromosome 5 at 137,394,376 bp
  • C to G, chromosome 5 at 137,633,657 bp
  • T to C, chromosome 5 at 142,114,393 bp
  • T to C, chromosome 5 at 144,879,380 bp
  • A to G, chromosome 6 at 3,376,754 bp
  • C to T, chromosome 6 at 35,512,290 bp
  • A to T, chromosome 6 at 36,523,450 bp
  • A to G, chromosome 6 at 93,685,603 bp
  • G to A, chromosome 6 at 124,540,953 bp
  • T to A, chromosome 6 at 124,631,164 bp
  • A to T, chromosome 6 at 124,857,194 bp
  • A to T, chromosome 7 at 4,523,687 bp
  • A to T, chromosome 7 at 12,670,565 bp
  • A to G, chromosome 7 at 44,943,988 bp
  • G to A, chromosome 7 at 99,472,887 bp
  • A to G, chromosome 7 at 104,357,371 bp
  • TTCCTC to TTC, chromosome 7 at 119,951,021 bp
  • T to A, chromosome 7 at 139,875,280 bp
  • A to G, chromosome 8 at 3,603,980 bp
  • T to A, chromosome 8 at 26,044,327 bp
  • T to A, chromosome 8 at 56,307,667 bp
  • T to C, chromosome 9 at 104,190,385 bp
  • T to A, chromosome 9 at 109,386,761 bp
  • A to G, chromosome 10 at 105,271,441 bp
  • A to G, chromosome 10 at 123,181,742 bp
  • A to T, chromosome 10 at 129,704,887 bp
  • T to C, chromosome 11 at 23,001,354 bp
  • T to C, chromosome 11 at 46,469,516 bp
  • A to G, chromosome 11 at 52,213,054 bp
  • A to G, chromosome 11 at 59,038,609 bp
  • A to T, chromosome 11 at 59,758,554 bp
  • A to T, chromosome 11 at 105,998,362 bp
  • G to T, chromosome 11 at 117,815,922 bp
  • A to T, chromosome 12 at 40,817,736 bp
  • A to C, chromosome 12 at 51,773,835 bp
  • G to T, chromosome 12 at 76,028,124 bp
  • G to T, chromosome 12 at 83,876,747 bp
  • A to T, chromosome 12 at 101,602,766 bp
  • T to C, chromosome 13 at 23,757,232 bp
  • T to C, chromosome 13 at 63,565,454 bp
  • T to A, chromosome 13 at 68,738,588 bp
  • T to C, chromosome 13 at 98,355,041 bp
  • T to A, chromosome 14 at 32,463,923 bp
  • A to G, chromosome 15 at 75,747,778 bp
  • A to T, chromosome 17 at 29,282,308 bp
  • G to T, chromosome 19 at 10,053,033 bp
  • A to G, chromosome 19 at 42,115,038 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5846 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044064-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.