Strain Name:
C57BL/6J-MtgxR5866Btlr
Stock Number:
044075-MU
Citation ID:
RRID:MMRRC_044075-MU
Other Names:
R5866 (G1)
Major Collection:

Gene Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Tln2
Name: talin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: 1110067B02Rik, Sema6D-6, Sema6D-5, Sema6D-4, Sema6D-2, Sema6D-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 214968
Homologene: 16195
Nos1
Name: nitric oxide synthase 1, neuronal
Synonyms: nNOS, bNOS, Nos-1, NO, 2310005C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18125
HGNC: HGNC:7872
Homologene: 37327
Zfp97
Name: zinc finger protein 97
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22759
Homologene: 133884
Utp20
Name: UTP20 small subunit processome component
Synonyms: DRIM, mDRIM, 3830408P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Arfgef2
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99371
Homologene: 111880
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231326
Homologene: 71711
Sf3b3
Name: splicing factor 3b, subunit 3
Synonyms: 5730409A01Rik, 1810061H24Rik, SAP130, RSE1, D8Ertd633e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 101943
Homologene: 6579
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227648
Homologene: 10533
Stat1
Name: signal transducer and activator of transcription 1
Synonyms: 2010005J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20846
Homologene: 21428
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, Ndrp, 2810004D21Rik, 4632404O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83946
Homologene: 41209
Abcb8
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 8
Synonyms: 4833412N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74610
HGNC: HGNC:49
Homologene: 5203
Rasa2
Name: RAS p21 protein activator 2
Synonyms: GAP1m, 5430433H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 114713
HGNC: HGNC:9872
Homologene: 4745
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235627
Homologene: 86422
Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Synonyms: Hif1b, ESTM42, D3Ertd557e, bHLHe2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11863
HGNC: HGNC:700
Homologene: 1261
Rad52
Name: RAD52 homolog, DNA repair protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19365
HGNC: HGNC:9824
Homologene: 31118
Stn1
Name: STN1, CST complex subunit
Synonyms: 2310057J23Rik, 0610009H20Rik, Obfc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 108689
Homologene: 11788
Ldah
Name: lipid droplet associated hydrolase
Synonyms: 1110057K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68832
VEGA: 12
Homologene: 41453
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930516E05Rik, D330038K10Rik, 4930543C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Tbc1d2
Name: TBC1 domain family, member 2
Synonyms: LOC381605, PARIS-1, PARIS1, A630005A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381605
Homologene: 10190
Atl1
Name: atlastin GTPase 1
Synonyms: AD-FSP, SPG3, FSP1, Spg3a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73991
VEGA: 12
Homologene: 9302
Amy1
Name: amylase 1, salivary
Synonyms: Amy-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 11722
Homologene: 20179
Rel
Name: reticuloendotheliosis oncogene
Synonyms: c-Rel
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19696
HGNC: HGNC:9954
Homologene: 2182
Ephb3
Name: Eph receptor B3
Synonyms: Sek4, MDK5, HEK2, Etk2, Tyro6, Cek10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13845
HGNC: HGNC:3394
Homologene: 20938
3110009E18Rik
Name: RIKEN cDNA 3110009E18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 73103
Homologene: 41754
Ugt2a3
Name: UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms: 2010321J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72094
Homologene: 55988
Dennd5a
Name: DENN/MADD domain containing 5A
Synonyms: ORF37, 1500012B19Rik, Rab6ip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19347
Homologene: 14584
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234311
Homologene: 23031
Spp2
Name: secreted phosphoprotein 2
Synonyms: spp24, 0610038O04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75396
Homologene: 5058
Ppp1r36
Name: protein phosphatase 1, regulatory subunit 36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 210762
VEGA: 12
Homologene: 52094
Vsig10
Name: V-set and immunoglobulin domain containing 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231668
Homologene: 10414
A730018C14Rik
Name: RIKEN cDNA A730018C14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 100504733
VEGA: 12
Fam83d
Name: family with sequence similarity 83, member D
Synonyms: 2310007D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71878
Homologene: 23715
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: Kv12.1, ELK1, C130090D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 211468
Homologene: 14332
Stap1
Name: signal transducing adaptor family member 1
Synonyms: STAP-1, Brdg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56792
Homologene: 8103
Slc24a5
Name: solute carrier family 24, member 5
Synonyms: NCX5, F630045L20Rik, NCKX5, Oca6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 317750
Homologene: 18400
Gramd3
Name: GRAM domain containing 3
Synonyms: 9030613F08Rik, 9130427A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 107022
VEGA: 18
Homologene: 32570
Cyp4f17
Name: cytochrome P450, family 4, subfamily f, polypeptide 17
Synonyms: EG208285
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 208285
VEGA: 17
Homologene: 129713
A530084C06Rik
Name: RIKEN cDNA A530084C06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Defb34
Name: defensin beta 34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 360211
Pdlim7
Name: PDZ and LIM domain 7
Synonyms: 1110003B01Rik, 2410002J21Rik, Enigma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67399
Homologene: 3980
Hax1
Name: HCLS1 associated X-1
Synonyms: mHAX-1s, HAX-1, Silg111, Hs1bp1, HS1-associated protein X-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 23897
Homologene: 4463
Tmem59
Name: transmembrane protein 59
Synonyms: thymic dendritic cell-derived factor 1, MTDCF1, 3110046P06Rik, 1110001M20Rik, D4Ertd20e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 56374
HGNC: HGNC:1239
Homologene: 3583
Cracd
Name: capping protein inhibiting regulator of actin
Synonyms: C530008M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320827
Homologene: 136278
BC061237
Name: cDNA sequence BC061237
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 385138
Homologene: 128452
Ace3
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 3
Synonyms: EG217246
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217246
Homologene: 80337
Olfr127
Name: olfactory receptor 127
Synonyms: MOR218-7, GA_x6K02T2PSCP-2354126-2355093
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258374
Homologene: 134080
Tagap
Name: T cell activation Rho GTPase activating protein
Synonyms: tcs-1, Tcd-1, tcs1, TRD, Tcd1, Tcd1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72536
Homologene: 44943
Apol11b
Name: apolipoprotein L 11b
Synonyms: A330102K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 328563
Homologene: 129975
Pigb
Name: phosphatidylinositol glycan anchor biosynthesis, class B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 55981
HGNC: HGNC:8959
Homologene: 3570
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 52,139,264 bp
  • A to T, chromosome 1 at 88,412,303 bp
  • A to G, chromosome 1 at 120,169,084 bp
  • G to A, chromosome 2 at 26,419,638 bp
  • C to A, chromosome 2 at 124,664,342 bp
  • T to A, chromosome 2 at 125,085,671 bp
  • T to A, chromosome 2 at 158,779,830 bp
  • T to A, chromosome 2 at 166,836,257 bp
  • A to G, chromosome 3 at 89,995,728 bp
  • T to A, chromosome 3 at 95,490,726 bp
  • A to T, chromosome 3 at 113,561,920 bp
  • T to C, chromosome 4 at 46,637,715 bp
  • T to A, chromosome 4 at 107,190,557 bp
  • C to T, chromosome 5 at 24,402,103 bp
  • A to G, chromosome 5 at 76,857,537 bp
  • G to T, chromosome 5 at 76,876,211 bp
  • A to G, chromosome 5 at 86,078,047 bp
  • G to A, chromosome 5 at 87,336,547 bp
  • A to T, chromosome 5 at 117,352,749 bp
  • A to G, chromosome 5 at 117,895,902 bp
  • G to A, chromosome 6 at 119,912,946 bp
  • T to C, chromosome 7 at 109,919,360 bp
  • T to C, chromosome 8 at 19,126,452 bp
  • A to G, chromosome 8 at 61,940,740 bp
  • C to T, chromosome 8 at 110,814,634 bp
  • A to T, chromosome 9 at 67,266,868 bp
  • C to T, chromosome 9 at 73,029,684 bp
  • T to A, chromosome 9 at 82,890,150 bp
  • T to A, chromosome 9 at 96,545,770 bp
  • A to G, chromosome 9 at 110,631,492 bp
  • G to A, chromosome 10 at 88,772,559 bp
  • A to T, chromosome 11 at 23,742,724 bp
  • C to A, chromosome 11 at 105,997,504 bp
  • G to A, chromosome 12 at 8,220,614 bp
  • T to C, chromosome 12 at 69,926,011 bp
  • T to C, chromosome 12 at 76,426,805 bp
  • T to C, chromosome 12 at 112,415,038 bp
  • G to A, chromosome 13 at 31,559,195 bp
  • T to A, chromosome 13 at 55,498,688 bp
  • A to T, chromosome 14 at 44,501,273 bp
  • C to T, chromosome 15 at 77,640,547 bp
  • T to C, chromosome 15 at 89,167,572 bp
  • T to C, chromosome 16 at 21,211,379 bp
  • C to T, chromosome 17 at 7,933,453 bp
  • T to A, chromosome 17 at 17,144,825 bp
  • A to T, chromosome 17 at 24,580,961 bp
  • T to C, chromosome 17 at 32,506,913 bp
  • C to T, chromosome 17 at 37,903,809 bp
  • T to C, chromosome 17 at 52,956,776 bp
  • A to G, chromosome 18 at 56,474,036 bp
  • T to C, chromosome 19 at 16,680,023 bp
  • T to C, chromosome 19 at 47,517,129 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5866 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044075-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.