Strain Name:
C57BL/6J-MtgxR6006Btlr
Stock Number:
044183-MU
Citation ID:
RRID:MMRRC_044183-MU
Other Names:
R6006 (G1)
Major Collection:

Gene Information

Colgalt2
Name: collagen beta(1-O)galactosyltransferase 2
Synonyms: Glt25d2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 269132
Homologene: 22865
Cd14
Name: CD14 antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12475
VEGA: 18
HGNC: HGNC:1628
Homologene: 493
Ep400
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, p400, mDomino
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75560
Homologene: 38779
Rgs3
Name: regulator of G-protein signaling 3
Synonyms: PDZ-RGS3, C2PA-RGS3, 4930506N09Rik, C2pa, RGS3S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 50780
HGNC: HGNC:9999
Homologene: 32440
Smc2
Name: structural maintenance of chromosomes 2
Synonyms: Smc2l1, 5730502P04Rik, Fin16, CAP-E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14211
Homologene: 4705
S1pr3
Name: sphingosine-1-phosphate receptor 3
Synonyms: Edg3, S1P3, LPb3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13610
VEGA: 13
HGNC: HGNC:3167
Homologene: 3829
Morc3
Name: microrchidia 3
Synonyms: D16Jhu32e, 1110051N18Rik, 1110051N18Rik, Zcwcc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 338467
Homologene: 32257
Numa1
Name: nuclear mitotic apparatus protein 1
Synonyms: NuMA, 6720401E04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101706
HGNC: HGNC:8059
Homologene: 38150
Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Synonyms: p50 subunit of NF kappaB, p50/p105, NF-kappaB p50, NF-kappaB, NF kappaB1, nuclear factor kappaB p50, p50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18033
HGNC: HGNC:7794
Homologene: 2971
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 6430526O11Rik, 2900074J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237898
Homologene: 13066
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67958
Homologene: 13964
Utp18
Name: UTP18 small subunit processome component
Synonyms: 6230425C22Rik, Wdr50
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217109
Homologene: 41087
Cdc73
Name: cell division cycle 73, Paf1/RNA polymerase II complex component
Synonyms: C130030P16Rik, Hrpt2, 8430414L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214498
Homologene: 11571
Camkmt
Name: calmodulin-lysine N-methyltransferase
Synonyms: 1700106N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 73582
VEGA: 17
Homologene: 11704
Wwc1
Name: WW, C2 and coiled-coil domain containing 1
Synonyms: Kibra
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 211652
Homologene: 69180
Actr8
Name: ARP8 actin-related protein 8
Synonyms: 5730542K05Rik, ARP8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 56249
VEGA: 14
Homologene: 11286
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 404710
Homologene: 26400
Cand1
Name: cullin associated and neddylation disassociated 1
Synonyms: 6330512O03Rik, D10Ertd516e, 2310038O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71902
Homologene: 10202
Cnpy3
Name: canopy FGF signaling regulator 3
Synonyms: ERDA5, Tnrc5, 2410050O22Rik, 1600025D17Rik, CAG4A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 72029
Homologene: 4803
Pdcd1lg2
Name: programmed cell death 1 ligand 2
Synonyms: PD-L2, Btdc, B7-DC, F730015O22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 58205
Homologene: 10973
Dhtkd1
Name: dehydrogenase E1 and transketolase domain containing 1
Synonyms: C330018I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 209692
Homologene: 10278
Pkp1
Name: plakophilin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18772
HGNC: HGNC:9023
Homologene: 253
Abcb4
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
Synonyms: Mdr2, mdr-2, Pgy2, Pgy-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18670
HGNC: HGNC:45
Homologene: 136368
Arhgap20
Name: Rho GTPase activating protein 20
Synonyms: A530023E23Rik, 6530403F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244867
Homologene: 18938
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: A830096D10Rik, Bai3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Fer1l6
Name: fer-1-like 6 (C. elegans)
Synonyms: EG631797
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 631797
Homologene: 53396
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Setmar
Name: SET domain without mariner transposase fusion
Synonyms: Etet2, 5830404F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74729
Homologene: 68519
Tigd2
Name: tigger transposable element derived 2
Synonyms: 3632410O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 68140
Homologene: 129603
Olfr670
Name: olfactory receptor 670
Synonyms: GA_x6K02T2PBJ9-7589577-7588639, MOR32-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384703
Homologene: 105163
Btn2a2
Name: butyrophilin, subfamily 2, member A2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238555
HGNC: HGNC:1137
Homologene: 56012
Pbk
Name: PDZ binding kinase
Synonyms: D14Ertd732e, 2810434B10Rik, TOPK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 52033
Homologene: 32415
Col22a1
Name: collagen, type XXII, alpha 1
Synonyms: 2310067L16Rik, C80743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 69700
Homologene: 43567
Acad12
Name: acyl-Coenzyme A dehydrogenase family, member 12
Synonyms: 9330129D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 338350
Vmn1r216
Name: vomeronasal 1 receptor 216
Synonyms: V1ri10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171279
Homologene: 110880
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17837
Homologene: 136663
Adamts18
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
Synonyms: E130314N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 208936
Homologene: 65241
Mlxip
Name: MLX interacting protein
Synonyms: Mondoa, bHLHe36, Mir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208104
Homologene: 22851
Tmprss9
Name: transmembrane protease, serine 9
Synonyms: Serase-1B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432478
VEGA: 10
Homologene: 115302
Zfp955a
Name: zinc finger protein 955A
Synonyms: AI842447
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77652
VEGA: 17
Homologene: 104925
Lats1
Name: large tumor suppressor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16798
VEGA: 10
HGNC: HGNC:6514
Homologene: 55843
Adam7
Name: a disintegrin and metallopeptidase domain 7
Synonyms: EAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11500
HGNC: HGNC:214
Homologene: 2830
Abcb10
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 10
Synonyms: ABC-me
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56199
HGNC: HGNC:41
Homologene: 6474
Bco1
Name: beta-carotene oxygenase 1
Synonyms: betaCMOOX, beta-CD, Bcmo1, Bcdo1, Bcdo, Cmoi
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 63857
Homologene: 41172
Cdk14
Name: cyclin-dependent kinase 14
Synonyms: Pftk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18647
HGNC: HGNC:8883
Homologene: 7888
Glis1
Name: GLIS family zinc finger 1
Synonyms: GliH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230587
Homologene: 77390
Cchcr1
Name: coiled-coil alpha-helical rod protein 1
Synonyms: Hcr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240084
Homologene: 10396
Rela
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Synonyms: p65, p65 NF kappaB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19697
HGNC: HGNC:9955
Homologene: 32064
Zfp3
Name: zinc finger protein 3
Synonyms: Zfp-3, Fnp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 193043
Homologene: 27406
Ttc30a1
Name: tetratricopeptide repeat domain 30A1
Synonyms: 4930506L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78802
Homologene: 136638
Cpsf4l
Name: cleavage and polyadenylation specific factor 4-like
Synonyms: 1500000C01Rik, D11Ertd636e, 0610010C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52670
Homologene: 32669
Usp18
Name: ubiquitin specific peptidase 18
Synonyms: UBP43, 1110058H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 24110
Homologene: 8047
Ssr1
Name: signal sequence receptor, alpha
Synonyms: SSR, TRAPalpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 107513
VEGA: 13
Homologene: 2368
Sertad2
Name: SERTA domain containing 2
Synonyms: Sei2, Trip-Br2, SEI-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 58172
Homologene: 8843
Mtx1
Name: metaxin 1
Synonyms: Gcap6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17827
HGNC: HGNC:7504
Homologene: 37623
Mup8
Name: major urinary protein 8
Synonyms: Gm12809
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100041687
Homologene: 74304
Gm35339
Name: predicted gene, 35339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 102638882
Homologene: 131539
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 25,826,531 bp
  • C to A, chromosome 1 at 90,768,383 bp
  • C to G, chromosome 1 at 135,877,668 bp
  • A to T, chromosome 1 at 143,617,439 bp
  • A to G, chromosome 1 at 152,473,161 bp
  • G to A, chromosome 2 at 5,904,025 bp
  • A to G, chromosome 2 at 75,981,488 bp
  • T to A, chromosome 3 at 88,091,547 bp
  • C to T, chromosome 3 at 89,210,306 bp
  • A to T, chromosome 3 at 135,603,761 bp
  • A to G, chromosome 4 at 52,459,024 bp
  • T to C, chromosome 4 at 60,220,403 bp
  • G to A, chromosome 4 at 62,623,906 bp
  • T to C, chromosome 4 at 107,567,906 bp
  • C to T, chromosome 5 at 5,249,211 bp
  • C to A, chromosome 5 at 8,946,026 bp
  • A to G, chromosome 5 at 110,704,959 bp
  • C to T, chromosome 5 at 121,599,236 bp
  • T to C, chromosome 5 at 123,445,658 bp
  • A to G, chromosome 6 at 59,210,777 bp
  • T to C, chromosome 6 at 108,076,426 bp
  • A to T, chromosome 6 at 121,262,822 bp
  • G to C, chromosome 6 at 122,083,500 bp
  • G to A, chromosome 7 at 101,992,719 bp
  • T to G, chromosome 7 at 104,960,663 bp
  • A to T, chromosome 8 at 113,706,974 bp
  • A to G, chromosome 8 at 117,113,591 bp
  • A to G, chromosome 8 at 123,968,065 bp
  • T to A, chromosome 9 at 51,850,126 bp
  • T to C, chromosome 9 at 95,479,307 bp
  • T to C, chromosome 10 at 7,705,595 bp
  • T to A, chromosome 10 at 80,883,721 bp
  • A to G, chromosome 10 at 119,210,028 bp
  • G to A, chromosome 11 at 20,647,884 bp
  • A to T, chromosome 11 at 35,870,982 bp
  • T to C, chromosome 11 at 35,889,273 bp
  • A to T, chromosome 11 at 70,771,764 bp
  • A to C, chromosome 11 at 84,992,451 bp
  • T to C, chromosome 11 at 93,885,623 bp
  • A to G, chromosome 11 at 113,699,927 bp
  • C to A, chromosome 13 at 23,099,758 bp
  • A to T, chromosome 13 at 23,486,363 bp
  • TCTCTTTC to T, chromosome 13 at 37,985,996 bp
  • A to G, chromosome 13 at 51,419,695 bp
  • T to A, chromosome 14 at 29,984,142 bp
  • C to T, chromosome 14 at 65,816,645 bp
  • A to C, chromosome 14 at 68,511,396 bp
  • T to C, chromosome 15 at 58,647,044 bp
  • A to G, chromosome 15 at 71,973,836 bp
  • T to C, chromosome 15 at 76,357,172 bp
  • T to G, chromosome 16 at 93,866,493 bp
  • A to G, chromosome 17 at 33,241,686 bp
  • A to G, chromosome 17 at 35,524,700 bp
  • A to C, chromosome 17 at 46,736,864 bp
  • A to T, chromosome 17 at 85,452,238 bp
  • T to C, chromosome 18 at 36,726,282 bp
  • A to G, chromosome 19 at 5,639,939 bp
  • T to A, chromosome 19 at 29,454,505 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6006 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
044183-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.