Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR6048Btlr/Mmmh
Stock Number:
044216-MU
Citation ID:
RRID:MMRRC_044216-MU
Other Names:
R6048 (G1)
Major Collection:

Strain Information

Sipa1l1
Name: signal-induced proliferation-associated 1 like 1
Synonyms: 4931426N11Rik, Spar
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217692
VEGA: 12
Homologene: 9189
Clcnka
Name: chloride channel, voltage-sensitive Ka
Synonyms: CLC-K1, Clcnk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12733
Homologene: 65
Aopep
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72061
HGNC: HGNC:1361
Homologene: 66273
Pdzd2
Name: PDZ domain containing 2
Synonyms: 4930537L06Rik, LOC223364, A930022H17Rik, Pdzk3, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Snx5
Name: sorting nexin 5
Synonyms: 1810032P22Rik, 0910001N05Rik, D2Ertd52e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69178
Homologene: 40944
Tanc2
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms: 5730590C14Rik, 3526402J09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77097
Homologene: 64680
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,741,043 bp
  • A to T, chromosome 1 at 74,478,136 bp
  • A to G, chromosome 1 at 88,701,628 bp
  • A to G, chromosome 1 at 191,621,412 bp
  • A to G, chromosome 2 at 36,859,841 bp
  • T to A, chromosome 2 at 67,508,243 bp
  • T to A, chromosome 2 at 121,024,408 bp
  • T to C, chromosome 2 at 144,259,153 bp
  • T to C, chromosome 2 at 146,434,845 bp
  • T to C, chromosome 3 at 79,405,885 bp
  • G to T, chromosome 3 at 86,905,965 bp
  • T to C, chromosome 4 at 129,593,352 bp
  • T to A, chromosome 4 at 141,394,487 bp
  • A to G, chromosome 4 at 149,263,629 bp
  • G to T, chromosome 5 at 36,027,988 bp
  • G to T, chromosome 5 at 43,818,964 bp
  • A to G, chromosome 5 at 128,269,117 bp
  • A to G, chromosome 5 at 143,068,904 bp
  • A to T, chromosome 6 at 9,247,103 bp
  • C to A, chromosome 6 at 86,650,984 bp
  • C to T, chromosome 6 at 88,482,991 bp
  • T to C, chromosome 6 at 113,470,108 bp
  • A to C, chromosome 7 at 6,440,355 bp
  • T to C, chromosome 7 at 12,176,521 bp
  • T to C, chromosome 7 at 88,026,550 bp
  • A to G, chromosome 7 at 103,051,319 bp
  • T to A, chromosome 7 at 114,508,267 bp
  • C to T, chromosome 8 at 40,528,322 bp
  • T to C, chromosome 8 at 62,000,582 bp
  • T to C, chromosome 8 at 80,613,433 bp
  • C to T, chromosome 9 at 20,807,619 bp
  • T to A, chromosome 9 at 40,771,109 bp
  • T to C, chromosome 9 at 62,844,626 bp
  • T to C, chromosome 9 at 71,261,767 bp
  • A to G, chromosome 9 at 116,006,701 bp
  • T to C, chromosome 10 at 24,660,254 bp
  • C to T, chromosome 10 at 77,021,842 bp
  • A to T, chromosome 10 at 89,645,486 bp
  • T to A, chromosome 10 at 93,707,266 bp
  • A to G, chromosome 10 at 129,945,826 bp
  • A to G, chromosome 11 at 20,648,436 bp
  • A to C, chromosome 11 at 23,891,815 bp
  • A to T, chromosome 11 at 74,335,135 bp
  • G to A, chromosome 11 at 78,075,783 bp
  • A to G, chromosome 11 at 104,944,433 bp
  • G to A, chromosome 11 at 105,867,717 bp
  • A to T, chromosome 12 at 82,440,869 bp
  • A to G, chromosome 13 at 22,042,836 bp
  • G to A, chromosome 13 at 49,273,748 bp
  • T to A, chromosome 13 at 49,653,684 bp
  • T to A, chromosome 13 at 63,240,325 bp
  • T to A, chromosome 14 at 16,242,308 bp
  • A to G, chromosome 14 at 30,929,823 bp
  • G to A, chromosome 14 at 55,503,845 bp
  • A to T, chromosome 15 at 12,592,570 bp
  • G to A, chromosome 15 at 102,111,411 bp
  • C to T, chromosome 16 at 59,283,979 bp
  • A to G, chromosome 17 at 14,197,305 bp
  • G to A, chromosome 17 at 22,454,840 bp
  • A to G, chromosome 17 at 25,816,993 bp
  • C to A, chromosome 17 at 86,493,347 bp
  • T to C, chromosome 19 at 11,520,370 bp
  • A to G, chromosome 19 at 23,675,882 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6048 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044216-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.