Strain Name:
C57BL/6J-MtgxR6134Btlr/Mmmh
Stock Number:
044281-MU
Citation ID:
RRID:MMRRC_044281-MU
Other Names:
R6134 (G1)
Major Collection:

Strain Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: A730044F23Rik, jv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Brd2
Name: bromodomain containing 2
Synonyms: Ring3, Frg-1, D17H6S113E, Fsrg1, Rnf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14312
HGNC: HGNC:1103
Homologene: 74540
Fasn
Name: fatty acid synthase
Synonyms: FAS, A630082H08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Rbbp6
Name: retinoblastoma binding protein 6, ubiquitin ligase
Synonyms: 4933422O15Rik, C030034J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19647
HGNC: HGNC:9889
Homologene: 136812
Map3k20
Name: mitogen-activated protein kinase kinase kinase 20
Synonyms: MLTKbeta, MLTKalpha, B230120H23Rik, Zak
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 65964
Homologene: 32331
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, par, Emv66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Garem1
Name: GRB2 associated regulator of MAPK1 subtype 1
Synonyms: LOC381126, Fam59a, Garem
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381126
VEGA: 18
Homologene: 11237
Coch
Name: cochlin
Synonyms: Coch-5B2, D12H14S564E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Pgr
Name: progesterone receptor
Synonyms: NR3C3, PR, 9930019P03Rik, PR-B, PR-A, ENSMUSG00000074510
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18667
HGNC: HGNC:8910
Homologene: 713
Arl4c
Name: ADP-ribosylation factor-like 4C
Synonyms: A630084M22Rik, Arl7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320982
HGNC: HGNC:698
Homologene: 4193
Aktip
Name: AKT interacting protein
Synonyms: Ft1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14339
Homologene: 7721
2810021J22Rik
Name: RIKEN cDNA 2810021J22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69944
Homologene: 138400
Numbl
Name: numb-like
Synonyms: nbl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18223
HGNC: HGNC:8061
Homologene: 68413
Rasa1
Name: RAS p21 protein activator 1
Synonyms: p120-rasGAP, Gap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218397
HGNC: HGNC:9871
Homologene: 2168
Zfp60
Name: zinc finger protein 60
Synonyms: Mfg-3, Mfg3, 6330516O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22718
Homologene: 137228
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: TIF2/GRIP-1, Grip1, D1Ertd433e, glucocorticoid receptor-interacting protein 1, TIF2, TIF-2, SRC-2, KAT13C, bHLHe75
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Nid2
Name: nidogen 2
Synonyms: entactin-2, entactin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18074
VEGA: 14
Homologene: 40575
Septin9
Name: septin 9
Synonyms: SL3-3 integration site 1, Sint1, Msf, MSF1, PNUTL4, Sept9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53860
HGNC: HGNC:7323
Homologene: 90949
Lnpep
Name: leucyl/cystinyl aminopeptidase
Synonyms: gp160, vp165, IRAP, 4732490P18Rik, 2010309L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240028
VEGA: 17
HGNC: HGNC:6656
Homologene: 21148
Trpv1
Name: transient receptor potential cation channel, subfamily V, member 1
Synonyms: capsaicin receptor, VR-1, OTRPC1, Vr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 193034
Homologene: 12920
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Fhip1a
Name: FHF complex subunit HOOK interacting protein 1A
Synonyms: 9930021J17Rik, Fam160a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229488
Homologene: 85149
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20259
Homologene: 36296
Clcn3
Name: chloride channel, voltage-sensitive 3
Synonyms: Clc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12725
HGNC: HGNC:2021
Homologene: 20435
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 672511
Homologene: 45439
Cdh16
Name: cadherin 16
Synonyms: KSP-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12556
HGNC: HGNC:1755
Homologene: 2997
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Vmn2r26
Name: vomeronasal 2, receptor 26
Synonyms: V2r1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 56552
Homologene: 135915
Insr
Name: insulin receptor
Synonyms: IR, CD220, 4932439J01Rik, D630014A15Rik, IR-B, IR-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16337
HGNC: HGNC:6091
Homologene: 20090
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81877
Homologene: 49589
Oas3
Name: 2'-5' oligoadenylate synthetase 3
Synonyms: 2'-5' oligoadenylate synthetase-like 10, Oasl10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 246727
HGNC: HGNC:8088
Homologene: 4510
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cav2.3, Cchra1, alpha1E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Phtf1
Name: putative homeodomain transcription factor 1
Synonyms: Phft
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18685
HGNC: HGNC:8939
Homologene: 4817
Lypd11
Name: Ly6/PLAUR domain containing 11
Synonyms: Gm4763
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210155
H2-Q2
Name: histocompatibility 2, Q region locus 2
Synonyms: H-2Q2, Gm11132
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15013
Homologene: 128352
Speer4f1
Name: spermatogenesis associated glutamate (E)-rich protein 4F1
Synonyms: SPEER-4F, 4922502J04Rik, Speer4f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70935
Homologene: 69402
Rgs22
Name: regulator of G-protein signalling 22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 626596
Homologene: 75047
Aoah
Name: acyloxyacyl hydrolase
Synonyms: 4930433E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 27052
VEGA: 13
HGNC: HGNC:548
Homologene: 1238
Pck2
Name: phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Synonyms: 9130022B02Rik, 1810010O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74551
VEGA: 14
HGNC: HGNC:8725
Homologene: 3356
Ttll6
Name: tubulin tyrosine ligase-like family, member 6
Synonyms: t8130b59, 4932418K24Rik, D11Moh43e, D11Moh44e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237930
Homologene: 18229
Crx
Name: cone-rod homeobox
Synonyms: Crx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12951
HGNC: HGNC:2383
Homologene: 467
Pcdhb21
Name: protocadherin beta 21
Synonyms: Pcdhb18, PcdhbU
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93892
Homologene: 134302
Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Synonyms: Cox-1, cyclooxygenase 1, Pghs1, COX1, Cox-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19224
HGNC: HGNC:9604
Homologene: 743
Miga2
Name: mitoguardin 2
Synonyms: R74766, 5730472N09Rik, Fam73b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 108958
Homologene: 13125
Anxa10
Name: annexin A10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26359
HGNC: HGNC:534
Homologene: 21409
Chit1
Name: chitinase 1 (chitotriosidase)
Synonyms: 2300002L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71884
HGNC: HGNC:1936
Homologene: 68318
Or8b36
Name: olfactory receptor family 8 subfamily B member 36
Synonyms: GA_x6K02T2PVTD-31705144-31706073, MOR162-6, Olfr883
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258414
Homologene: 86689
Slc1a7
Name: solute carrier family 1 (glutamate transporter), member 7
Synonyms: EAAT5, A930031E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242607
Homologene: 21327
Nova2
Name: NOVA alternative splicing regulator 2
Synonyms: LOC384569
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384569
HGNC: HGNC:7887
Homologene: 134398
Prokr1
Name: prokineticin receptor 1
Synonyms: Pkr1, EG-VEGFR1, Gpr73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58182
HGNC: HGNC:4524
Homologene: 10968
Muc3a
Name: mucin 3A, cell surface associated
Synonyms: A630081J09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 619309
HGNC: HGNC:7513
Homologene: 133536
RP24-388A6.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 13,174,371 bp
  • A to T, chromosome 1 at 88,701,430 bp
  • A to G, chromosome 1 at 134,144,060 bp
  • G to A, chromosome 1 at 154,701,291 bp
  • A to G, chromosome 2 at 30,371,217 bp
  • T to C, chromosome 2 at 36,251,178 bp
  • C to T, chromosome 2 at 72,410,159 bp
  • T to C, chromosome 3 at 85,673,344 bp
  • A to T, chromosome 3 at 104,004,405 bp
  • A to G, chromosome 4 at 108,012,436 bp
  • A to T, chromosome 5 at 16,824,685 bp
  • G to A, chromosome 5 at 17,476,142 bp
  • A to G, chromosome 5 at 120,769,048 bp
  • A to T, chromosome 5 at 137,210,122 bp
  • C to A, chromosome 6 at 4,538,035 bp
  • T to C, chromosome 6 at 87,588,855 bp
  • T to C, chromosome 6 at 124,061,485 bp
  • A to T, chromosome 7 at 15,868,107 bp
  • G to A, chromosome 7 at 18,957,869 bp
  • G to A, chromosome 7 at 24,726,056 bp
  • G to C, chromosome 7 at 27,281,314 bp
  • T to C, chromosome 7 at 27,749,898 bp
  • T to C, chromosome 7 at 122,997,311 bp
  • A to T, chromosome 8 at 3,192,572 bp
  • T to C, chromosome 8 at 60,934,573 bp
  • G to T, chromosome 8 at 62,077,943 bp
  • T to A, chromosome 8 at 91,129,760 bp
  • A to T, chromosome 8 at 104,616,065 bp
  • T to C, chromosome 9 at 8,900,739 bp
  • ATTGCTGTTT to ATTGCTGTTTGCTGTTT, chromosome 9 at 38,026,540 bp
  • T to C, chromosome 10 at 76,607,144 bp
  • A to T, chromosome 11 at 21,999,406 bp
  • G to A, chromosome 11 at 58,876,793 bp
  • A to G, chromosome 11 at 73,244,317 bp
  • C to T, chromosome 11 at 96,139,742 bp
  • C to T, chromosome 11 at 115,984,157 bp
  • T to C, chromosome 11 at 117,352,161 bp
  • A to T, chromosome 11 at 119,411,470 bp
  • A to T, chromosome 11 at 120,822,186 bp
  • G to A, chromosome 12 at 40,060,579 bp
  • T to A, chromosome 12 at 51,602,753 bp
  • C to T, chromosome 13 at 20,911,123 bp
  • A to G, chromosome 13 at 85,226,626 bp
  • T to C, chromosome 14 at 19,778,783 bp
  • T to A, chromosome 14 at 55,543,962 bp
  • C to T, chromosome 14 at 64,030,096 bp
  • A to G, chromosome 15 at 36,107,048 bp
  • A to G, chromosome 17 at 17,553,192 bp
  • A to T, chromosome 17 at 34,113,695 bp
  • A to T, chromosome 17 at 34,672,012 bp
  • A to C, chromosome 17 at 35,343,241 bp
  • A to T, chromosome 18 at 21,129,824 bp
  • T to A, chromosome 18 at 37,514,408 bp
  • G to T, chromosome 18 at 67,421,259 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6134 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044281-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.